• Tissue
  • However, smooth muscle tissue tends to demonstrate greater elasticity and function within a larger length-tension curve than striated muscle. (wikipedia.org)
  • A myocyte (also known as a muscle cell) is the type of cell found in muscle tissue. (wikipedia.org)
  • With the myocardium now recognized as a tissue with limited regenerating potential, harbouring eCSCs that can be isolated and amplified in vitro for regenerative protocols of cell transplantation or stimulated to replicate and differentiate in situ in response to growth factors, it has become reasonable to exploit this endogenous regenerative potential to replace lost/damaged cardiac muscle with autologous functional myocardium. (wikipedia.org)
  • Specifically, in smooth muscle tissue, PKG promotes the opening of calcium-activated potassium channels, leading to cell hyperpolarization and relaxation, and blocks agonist activity of phospholipase C, reducing liberation of stored calcium ions by inositol triphosphate. (wikipedia.org)
  • isoform
  • We have identified a new cyclic-nucleotide phosphodiesterase isoform, PDE3A, and cloned its cDNA from cultured aortic myocytes. (lu.se)
  • Our results suggest that a vascular smooth-muscle isoform ('PDE3A2') is a product of the same gene as the longer myocardial ('PDE3A1') and the shorter placental ('PDE3A3') isoforms and is generated pre-translationally in a manner that results in the absence of the 145 N-terminal amino acids of PDE3A1. (lu.se)
  • article{ed537726-b305-4972-b009-5950d1f53f7e, abstract = {We have identified a new cyclic-nucleotide phosphodiesterase isoform, PDE3A, and cloned its cDNA from cultured aortic myocytes. (lu.se)
  • Neurons express either the PKG-Iα or the PKG-Iβ isoform, platelets predominantly Iβ, and both isoforms are present in smooth muscle. (wikipedia.org)
  • contractile
  • Each muscle fiber contains myofibrils, which are very long chains of sarcomeres, the contractile units of the cell. (wikipedia.org)
  • However, they have not changed the well-established fact that the working myocardium is mainly constituted of terminally differentiated contractile myocytes. (wikipedia.org)
  • Uterine smooth muscle has a phasic pattern, shifting between a contractile pattern and maintenance of a resting tone with discrete, intermittent contractions of varying frequency, amplitude and duration. (wikipedia.org)
  • metabolism
  • It phosphorylates a number of biologically important targets and is implicated in the regulation of smooth muscle relaxation, platelet function, sperm metabolism, cell division, and nucleic acid synthesis. (wikipedia.org)
  • junctional
  • The junctional layer appears to function like a circular muscle layer, capable of peristaltic and anti-peristaltic activity, equivalent to the muscular layer of the intestines. (wikipedia.org)
  • As noted for the macrostructure of uterine smooth muscle, the junctional layer appears be capable of both peristaltic and anti-peristaltic activity. (wikipedia.org)
  • Thus, wide junctional transmission has been described in many smooth muscles such as vas deferens, urinary bladder, blood vessels, gut as well as the nervous systems including ENS, autonomic ganglia and the CNS. (wikipedia.org)
  • Arteries
  • clarification needed] Most smooth muscle is of the single-unit variety, that is, either the whole muscle contracts or the whole muscle relaxes, but there is multiunit smooth muscle in the trachea, the large elastic arteries, and the iris of the eye. (wikipedia.org)
  • Single unit smooth muscle, however, is most common and lines blood vessels (except large elastic arteries), the urinary tract, and the digestive tract. (wikipedia.org)
  • myosin
  • Myosin is primarily class II in smooth muscle. (wikipedia.org)
  • In smooth muscle, there is a single gene (MYH11) that codes for the heavy chains myosin II, but there are splice variants of this gene that result in four distinct isoforms. (wikipedia.org)
  • Different combinations of heavy and light chains allow for up to hundreds of different types of myosin structures, but it is unlikely that more than a few such combinations are actually used or permitted within a specific smooth muscle bed. (wikipedia.org)
  • A shift in the myosin expression of the uterine smooth muscle may be responsible for changes in the directions of uterine contractions during the menstrual cycle. (wikipedia.org)
  • iris
  • The short ciliary nerves then run forward and pierce the sclera at the back of the eye, traveling between the sclera and the choroid to innervate the iris sphincter muscle. (wikipedia.org)
  • blood
  • A positive benefit to early breastfeeding is a stimulation of this reflex to reduce further blood loss and facilitate a swift return to prepregnancy uterine and abdominal muscle tone. (wikipedia.org)
  • cell
  • Our goal was to demonstrate that Ca 2+ entry through voltage-gated I CaL channels can stimulate adjacent K Ca channels by a localized interaction in enzymatically isolated rabbit coronary arterial myocytes voltage clamped in whole-cell or in cell-attached patch clamp mode. (ahajournals.org)
  • The cell membrane of a myocyte has several specialized regions, which may include the intercalated disk and the transverse tubular system. (wikipedia.org)
  • A cell from the biceps brachii muscle may contain 100,000 sarcomeres. (wikipedia.org)
  • Neuroeffector junctions are known as neuromuscular junctions when the target cell is a muscle fiber. (wikipedia.org)
  • human
  • 118 kDa band in Western blots of homogenates of human aortic myocytes, whereas antibodies against residues 29-42 (nt 85-126) do not react with any bands in these homogenates. (lu.se)