Myocytes smooth muscle. Medical search. Frequent questions

Caffeine-activated large-conductance plasma membrane cation channels in cardiac myocytes: characteristics and significance. (umassmed.edu)
In adult tissues, RAGE is expressed at low levels in multiple tissues including endothelial and smooth muscle cells, mononuclear phagocytes, pericytes, microglia, neurons, cardiac myocytes and hepatocytes (6). (rndsystems.com)
A subset of epicardial cells undergoes EMT, migrates into the developing heart, and differentiates into cardiac fibroblast, vascular endothelial, and smooth muscle cells. (arizona.edu)
4 The deposition of ceramide trihexoside in lysosomes is found predominantly in vascular endothelial cells, smooth muscle cells, cardiac myocytes, leukocytes, fibroblasts, and epithelial cells of ganglion, corneal, and renal origins. (hcplive.com)
Troponins are protein molecules that are part of cardiac and skeletal muscle. (medscape.com)
An initial small elevation occurs when troponins are released from the cytosolic pool, when troponin molecules in the cytosol of cardiac muscle diffuse across the sarcolemma into the surrounding lymphatics and blood vessels, becoming detectable in blood. (medscape.com)

In this study, the effects of JTE-013, a specific antagonist of the migration-inhibitory receptor EDG-5, on Sph-1-P-elicited responses were examined in human umbilical vein endothelial cells (HUVECs) and vascular smooth muscle cells (SMCs), which expressed EDG-5 protein weakly and abundantly, respectively. (nih.gov)
citation needed] In lower animals, the muscle cells themselves are photosensitive causing iris action without brain input. (wikipedia.org)
Ca(2+) spark sites in smooth muscle cells are numerous and differ in number of ryanodine receptors, large-conductance K(+) channels, and coupling ratio between them. (umassmed.edu)
Oscillating calcium signals in smooth muscle cells underlie the persistent basal tone of internal anal sphincter. (umassmed.edu)
NO is generated by macrophages and smooth muscles cells in the inflamed portions of the colon, inhibiting smooth muscle tone and leading to colonic dilatation. (medscape.com)
Scholars@Duke publication: Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak/Stat pathway. (duke.edu)
We observed through zymograms that treatment of male rat aortic vascular smooth muscle cells (RASMC) with an aqueous extract of cigarette smoke (CSE) for 24 hours resulted in a significant increase in pro-MMP9 (P = .005) and a modest increase in pro-MMP2 (P = .055) production. (duke.edu)
Smooth muscle cells express Kv7.4 and Kv7.5 voltage-dependent potassium channels, which have each been implicated as regulators of smooth muscle contractility, though they display different sensitivities to signaling via cAMP/protein kinase A (PKA) and protein kinase C (PKC). (aspetjournals.org)
We expressed chimeric channels composed of different components of the Kv7.4 and Kv7.5 α -subunits in vascular smooth muscle cells to determine which components are essential for enhancement or inhibition of channel activity. (aspetjournals.org)
Smooth muscle cells commonly express two functional Kv7 α -subunits, Kv7.4 and Kv7.5, which have different sensitivities to inhibitory and stimulatory signaling ( Byron and Brueggemann, 2018 ). (aspetjournals.org)
We developed an improved protocol for isolating embryonic myocyte cells, for use in co-cultures with epicardial cells. (arizona.edu)
This gene subfamily is constitutively active at physiological resting membrane potentials in excitable cells, including smooth muscle cells, and has been particularly linked to the human pulmonary circulation. (ersjournals.com)
En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
For example, arteries from spontaneously hypertensive rats (SHR) have an increased contractile sensitivity to extracellular Ca 2+ and intracellular Ca 2+ levels are elevated in aortic smooth muscle cells of SHR. (elsevierpure.com)
CONCLUSIONS The large accumulation of mast cells in the muscle layer of strictured bowel suggests a functional role for these cells in the hypertrophic and fibrotic response of the smooth muscle cells. (bmj.com)
The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)
Deposition of collagen and proliferation of smooth muscle cells are the response to chronic inflammation and injury of the submucosa leading to fibrosis and thickening of the submucosa and the smooth muscle layers of the bowel wall. (bmj.com)
1 In Crohn's disease, smooth muscle cells are considered to be the predominant cells involved in the process of stricture formation. (bmj.com)
Among these is the vanilloid TRP (TRPV) comprised of 6 members including TRPV4 which is found to be expressed in the vasculature, endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) according to western blotting, RT-PCR and immunohistochemistry studies (3, 4). (herts.ac.uk)
Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats. (ouhsc.edu)
Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts. (ouhsc.edu)
Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency. (ouhsc.edu)
Mechanosensitive production of reactive oxygen species in endothelial and smooth muscle cells: role in microvascular remodeling? (ouhsc.edu)
Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment. (ouhsc.edu)
Smooth muscle cells do not contain troponins. (medscape.com)

Early investigators postulated that there was an intrinsic airway smooth muscle abnormality at the root of the asthmatic diathesis. (jci.org)
The transmembrane protein 16A Ca(2+)-activated Cl- channel in airway smooth muscle contributes to airway hyperresponsiveness. (umassmed.edu)
A close association of RyRs with highly dense clusters of Ca2+-activated Cl- channels underlies the activation of STICs by Ca2+ sparks in mouse airway smooth muscle. (umassmed.edu)
However, whether AELL has a similar relaxant role on airway smooth muscle (ASM) remains unknown. (biomedcentral.com)
Airway smooth muscle (ASM), a particular cell type in the airway system, plays a vital role in airway obstruction during asthma and COPD. (biomedcentral.com)
Through the regulation of signal pathways related to G protein-coupled receptors, the reduction of intracellular calcium, and the subsequent opening of VDCC/NSCC, airway smooth muscle tone could be relaxed [ 6 , 7 ]. (biomedcentral.com)

Smooth muscle cell-specific TMEM16A deletion does not alter Ca2+ signaling, uterine contraction, gestation length, or litter size in mice? (umassmed.edu)
Guyton and Hall 2006) (See Figure 6 below) ( Smooth muscle contraction is controlled by muscarinic receptors, which are different and will be discussed later. (cdc.gov)
Calcium ions (Ca 2+ ) trigger the contraction of vascular myocytes and the level of free intracellular Ca 2+ within the myocyte is precisely regulated by sequestration and extrusion mechanisms. (elsevierpure.com)
Development of this condition arises from increased muscularity and contraction of pulmonary vessels, associated with increases in pulmonary arterial smooth muscle cell (PASMC) intracellular pH (pH i ) and Ca 2+ concentration ([Ca 2+ ] i ). (johnshopkins.edu)

The pathophysiology behind hypertension in the elderly is a complex process that is not entirely understood, but it is attributed to an increase in peripheral vascular resistance caused by decreased elasticity and increased stiffness due to smooth muscle hypertrophy in arterial walls. (uspharmacist.com)
3) intracellular Ca 2+ concentration is abnormally increased in vascular myocytes from hypertensive animals following treatment with Ca 2+ channel agonists and depolarizing interventions, and 4) using the voltage-clamp technique, the inward Ca 2+ current in arterial myocytes from hypertensive rats is nearly twice as large as that from myocytes of normotensive rats. (elsevierpure.com)

T, p.V183F) displayed only askeletal muscle pathology and a mild impairment of membrane trafficking of both POPDC isoforms. (imperial.ac.uk)

The nicotinic receptors are cylindrically-shaped proteins imbedded in synaptic walls that act as chemically-controlled sodium channels (also called ligand-gated sodium channels) that penetrate through the cell walls of post-synaptic nerves and myocytes at the skeletal neuromuscular junctions. (cdc.gov)
Neuromuscular junctions of skeletal muscles. (cdc.gov)

Spatial organization of RYRs and BK channels underlying the activation of STOCs by Ca(2+) sparks in airway myocytes. (umassmed.edu)
SIGNIFICANCE STATEMENT Kv7.4 and Kv7.5 channels are known signal transduction intermediates and drug targets for regulation of smooth muscle tone. (aspetjournals.org)
These findings may improve our understanding of the roles of these channels in smooth muscle physiology and disease, particularly in conditions where Kv7.4 and Kv7.5 are differentially expressed. (aspetjournals.org)
Furthermore, AELL-induced smooth muscle relaxation was partially mediated by blocking voltage-dependent Ca 2+ channels (VDCC) and non-selective cation channels (NSCC). (biomedcentral.com)

With the use of proliferating cell nuclear antigen immunohistochemistry on day 3, VCL had no effect on smooth muscle cell (SMC) proliferation. (bgu.ac.il)

myocyte enhancer factor 2B [S. (gsea-msigdb.org)

This co-culture system allows investigation into the effects of myocyte derived soluble factors uponepicardial EMT and mesenchymal cell differentiation. (arizona.edu)
A spectral analysis approach was developed for detailed study of time-resolved, dynamic changes in vascular smooth muscle cell (VSMC) elasticity and adhesion to identify differences in VSMC from young and aged monkeys. (researchwithrutgers.com)

As inflammation progresses into the smooth-muscle layers of the colon, NO and local inflammatory modulators appear to be involved in toxic megacolon pathogenesis. (medscape.com)

The short ciliary nerves then run forward and pierce the sclera at the back of the eye, traveling between the sclera and the choroid to innervate the iris sphincter muscle. (wikipedia.org)

However, many studies with airway myocytes in culture have not corroborated this contention. (jci.org)

We hypothesize that these changes are due to an increase in membrane Ca 2+ channel density and possibly function in vascular myocytes from hypertensive animals. (elsevierpure.com)

Neutrophils invade the muscle layer in toxic megacolon and directly damage the myocytes by the release of proteolytic enzymes, cytokines, and leukotriene B 4 . (medscape.com)

citation needed] All the myocytes are of the smooth muscle type. (wikipedia.org)

Whereas the typical ulcerative colitis inflammatory response is limited to the mucosa, toxic megacolon is characterized by severe inflammation extending into the smooth muscle layer, thus paralyzing the colonic smooth muscle and leading to dilatation. (medscape.com)

Muscle biopsies of affected patients display impaired membranetrafficking of both POPDC isoforms. (imperial.ac.uk)

Li, XY, Ran, PX & Wang, J 2016, ' Bone morphogenetic protein 4 increases canonical transient receptor potential protein expression by activating bone morphogenetic protein receptor Ⅱ/Smad signaling pathways in pulmonary arterial smooth muscle cells ', Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases , vol. 39, no. 7, pp. 539-545. (johnshopkins.edu)
Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. (nih.gov)

Adult skeletal muscle contains mainly CK-MM, cardiac muscle CK-MB, and smooth muscle CK-BB. (medscape.com)
Each skeletal muscle is a discrete organ that connects with our skeleton," says Putrino, "and is responsible for allowing our bodies to move. (popsci.com)

Guyton and Hall 2006) (See Figure 6 below) ( Smooth muscle contraction is controlled by muscarinic receptors, which are different and will be discussed later. (cdc.gov)
These filaments slide past each other during a muscle contraction, shortening the fiber. (dummies.com)

9. MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation. (nih.gov)
13. Connexin37 reduces smooth muscle cell proliferation and intimal hyperplasia in a mouse model of carotid artery ligation. (nih.gov)

Of course, as you know, calcium ion plays important roles in blood clotting, neurotransmitter release (the topic you're asking about), muscle tone, etc. (brainmass.com)
Action potentials in neurons and muscles rely on the same influx of Na+ ions to depolarize, and it is this depolarization that stimulates Ca2+ channels on the sacrolemma to open and release stored calcium . (brainmass.com)

The effect of nitrosactive compounds (sodium nitroprusside and sodium nitrite) on the polarization level of the uterus myocytes inner mitochondrial membrane using the confocal laser microscopy and fluorescent probe potentialsensitive DiOC 6 (3) (3,3′-dihexyloxacarbocyanine) was ivestigated. (ukrbiochemjournal.org)

5. Pharmacological Targeting of Plasminogen Activator Inhibitor-1 Decreases Vascular Smooth Muscle Cell Migration and Neointima Formation. (nih.gov)
8. Inhibition of Smooth Muscle β-Catenin Hinders Neointima Formation After Vascular Injury. (nih.gov)
12. Mindin regulates vascular smooth muscle cell phenotype and prevents neointima formation. (nih.gov)

The iris sphincter muscle (pupillary sphincter, pupillary constrictor, circular muscle of iris, circular fibers) is a muscle in the part of the eye called the iris. (wikipedia.org)

BBHV and Integrative Myocardial Physiology/Pathophysiology A (MPPA) have shared interests in the area of myocyte cardiac hypertrophy, myocyte interactions, cardiomyocyte contractile function as well at metabolism and energetics aspects of heart disease. (nih.gov)

Using a comprehensive combination of genetically modified fish, electrophysiology and gene expression analysis, we demonstrate that ZF cardiac myocytes (CM) and vascular smooth muscle (VSM) express functional K ATP channels of similar subunit composition, structure and metabolic sensitivity to their mammalian counterparts. (nih.gov)

As with smooth muscle, cardiac muscle tissue contractions occur through the autonomic nervous system (involuntary control). (dummies.com)

Tests for myocarditis may reveal elevated cardiac isoform troponin-I (cTnI) levels, which has the highest specificity for cardiac muscle and is the most reliable serum marker for detection of myocardial damage in patients with inflammatory muscle disease. (medscape.com)
Again, it contains a distinct type of muscle called a cardiac muscle, which is only found in the heart, and makes up the main tissue within it, says Putrino. (popsci.com)

Both cardiac and smooth muscles are involuntary, meaning we can't tell them to tense or relax. (popsci.com)

Cardiac myocytes: Contractile function and mechanical stress generation. (nih.gov)

This protein family is required for myocyte cytoskeletal development. (nih.gov)

In ischemic heart disease, the heart's blood vessels are blocked causing the heart muscle tissue to die, causing less blood to be pumped through the heart, which subsequently results in a decrease in left ventricular ejection fraction (LVEF). (medicalnewstoday.com)

Interestingly, says Putrino, some of us have one or two unique and unusual accessory muscles , "so the number can go up or down based on individual variations in our anatomy. (popsci.com)

That's except for the heart, which contains cardiac muscles (hence the name). (popsci.com)
So, just to clarify, is the heart an organ or a muscle? (popsci.com)

The short ciliary nerves then run forward and pierce the sclera at the back of the eye, traveling between the sclera and the choroid to innervate the iris sphincter muscle. (wikipedia.org)

These events help to explain why the initial phase of toxicity is manifested by over-stimulation (characterized by myoclonic jerks, fasciculations and muscle spasms) followed by weakness progressing to paralysis. (cdc.gov)

They occur automatically when the resting membrane potential of the gastrointestinal smooth muscle becomes more positive than about -40 milivolts. (brainmass.com)

As the name implies, skeletal muscles attach to the skeleton and are controlled throughout by the conscious (voluntary) control function of the central nervous system for movement. (dummies.com)

Smooth muscles line the inside of all our hollow organs like the intestines and the stomach. (popsci.com)

Anatomy71

Organisms16

Diseases13

Chemicals and Drugs90

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes43

Disciplines and Occupations2

Information Science3

Cardiac6

Cells25

Airway smooth muscle6

Contraction4

Arterial2

Pathology1

Skeletal2

Channels4

Proliferation1

Factor1

Cell2

Colon1

Choroid1

Studies1

Membrane1

Damage1

Type1

Layer1

Display1

Arterial smooth muscl2

Skeletal muscle2

Contraction2

Proliferation2

Calcium2

Microscopy1

Neointima3

Fibers1

Metabolism1

Mammalian1

Autonomic nervou1

Cardiac muscle2

Involuntary1

Contractile function1

Protein1

Tissue1

Accessory1

Heart2

Iris1

Weakness1

Resting membrane1

Skeleton1

Stomach1