• Tissue
  • However, smooth muscle tissue tends to demonstrate greater elasticity and function within a larger length-tension curve than striated muscle. (wikipedia.org)
  • A myocyte (also known as a muscle cell) is the type of cell found in muscle tissue. (wikipedia.org)
  • With the myocardium now recognized as a tissue with limited regenerating potential, harbouring eCSCs that can be isolated and amplified in vitro for regenerative protocols of cell transplantation or stimulated to replicate and differentiate in situ in response to growth factors, it has become reasonable to exploit this endogenous regenerative potential to replace lost/damaged cardiac muscle with autologous functional myocardium. (wikipedia.org)
  • Specifically, in smooth muscle tissue, PKG promotes the opening of calcium-activated potassium channels, leading to cell hyperpolarization and relaxation, and blocks agonist activity of phospholipase C, reducing liberation of stored calcium ions by inositol triphosphate. (wikipedia.org)
  • airway smooth muscle
  • The control and mechanisms of airway smooth muscle cell (SMC) contraction were investigated with a sequential series of lung slices from different generations of the same airway from the cardiac lobe of the mouse lung. (umassmed.edu)
  • Transforming growth factor-B (TGF-B), found to be overexpressed in airway smooth muscle (ASM) from asthmatic and chronic obstructive pulmonary disease patients, may be a pivotal regulator of abnormal ASM cell (ASMC) function in these diseases. (edu.au)
  • arterial
  • In arterial myocytes, β1 subunits are stored within highly mobile rab11A-positive recycling endosomes. (physiology.org)
  • These data indicate that rab4A-positive early endosomes traffic BKα to the plasma membrane in arterial myocytes. (physiology.org)
  • These data describe a unique mechanism by which ANG II inhibits arterial myocyte BK currents, by reducing surface channel number, to induce vasoconstriction. (physiology.org)
  • Arterial smooth muscle cell (myocyte) BK channels serve as a negative regulator of pressure-induced vasoconstriction (the myogenic response) and are modulated by multiple vasoconstrictor and vasodilator agonists and stimuli ( 11 , 24 , 31 - 33 ). (physiology.org)
  • β1 Subunits elevate channel apparent Ca 2+ sensitivity into a micromolar concentration range sufficient to permit sensing of local intracellular Ca 2+ transients termed Ca 2+ sparks, which control BK channel activity in arterial myocytes ( 18 - 20 ). (physiology.org)
  • Arterial myocytes also express LRRC26, an auxiliary γ subunit that elevates channel voltage sensitivity to induce vasodilation ( 12 ). (physiology.org)
  • currents
  • ANG II-mediated BK channel degradation reduced BK currents in isolated myocytes and functional responses to iberiotoxin, a BK channel blocker, and NS1619, a BK activator, in pressurized (60 mmHg) cerebral arteries. (physiology.org)
  • Muscle depolarization results in large gating currents, but anomalously low calcium flux, which is now explained by the very slow activation of the ionic currents. (wikipedia.org)
  • receptors
  • Most smooth muscles exhibit both fast and slow junction potentials typically mediated by different classes of metabotropic receptors with different kinetics. (wikipedia.org)
  • metabolism
  • It phosphorylates a number of biologically important targets and is implicated in the regulation of smooth muscle relaxation, platelet function, sperm metabolism, cell division, and nucleic acid synthesis. (wikipedia.org)
  • junctional
  • The junctional layer appears to function like a circular muscle layer, capable of peristaltic and anti-peristaltic activity, equivalent to the muscular layer of the intestines. (wikipedia.org)
  • As noted for the macrostructure of uterine smooth muscle, the junctional layer appears be capable of both peristaltic and anti-peristaltic activity. (wikipedia.org)
  • Thus, wide junctional transmission has been described in many smooth muscles such as vas deferens, urinary bladder, blood vessels, gut as well as the nervous systems including ENS, autonomic ganglia and the CNS. (wikipedia.org)
  • Arteries
  • Here, using biotinylation, immunofluorescence resonance energy transfer (immunoFRET) microscopy, and RNAi-mediated knockdown, we demonstrate that rab4A-positive early endosomes traffic BKα to the plasma membrane in myocytes of resistance-size cerebral arteries. (physiology.org)
  • clarification needed] Most smooth muscle is of the single-unit variety, that is, either the whole muscle contracts or the whole muscle relaxes, but there is multiunit smooth muscle in the trachea, the large elastic arteries, and the iris of the eye. (wikipedia.org)
  • Single unit smooth muscle, however, is most common and lines blood vessels (except large elastic arteries), the urinary tract, and the digestive tract. (wikipedia.org)
  • isoforms
  • In smooth muscle, there is a single gene (MYH11) that codes for the heavy chains myosin II, but there are splice variants of this gene that result in four distinct isoforms. (wikipedia.org)
  • Neurons express either the PKG-Iα or the PKG-Iβ isoform, platelets predominantly Iβ, and both isoforms are present in smooth muscle. (wikipedia.org)
  • neointimal
  • Histological evaluation showed expression of smooth muscle α-actin and significantly increased expression of TNF-α in neointimal lesions. (nih.gov)
  • iris
  • The short ciliary nerves then run forward and pierce the sclera at the back of the eye, traveling between the sclera and the choroid to innervate the iris sphincter muscle. (wikipedia.org)
  • found
  • Enaptin is a nuclear envelope protein found in human myocytes and synapses, which is made up of 8,797 amino acids. (wikipedia.org)
  • blood
  • A positive benefit to early breastfeeding is a stimulation of this reflex to reduce further blood loss and facilitate a swift return to prepregnancy uterine and abdominal muscle tone. (wikipedia.org)
  • structures
  • Different combinations of heavy and light chains allow for up to hundreds of different types of myosin structures, but it is unlikely that more than a few such combinations are actually used or permitted within a specific smooth muscle bed. (wikipedia.org)