• molecular
  • Our data highlight the clinical and molecular convergence between the KMT2 and EHMT protein families, which may contribute to a molecular network underlying a larger group of intellectual disability / autism spectrum disorder -related disorders. (nih.gov)
  • Heat shock protein 90 (Hsp90) is a highly conserved, constitutively expressed molecular chaperone that facilitates folding of client proteins such as BCR-ABL, and affects the stability of these proteins. (bloodjournal.org)
  • They can be categorized into 3 general classes based on molecular function: histone-modifying TrxG proteins chromatin-remodeling TrxG proteins DNA-binding TrxG proteins, plus other TrxG proteins not categorized in the first three classes. (wikipedia.org)
  • chronic lymphocy
  • Exposure to these PPARγ ligands induced apoptosis in myeloid (U937 and HL-60) and lymphoid (Su-DHL, Sup-M2, Ramos, Raji, Hodgkin's cell lines, and primary chronic lymphocytic leukemia) cells. (aacrjournals.org)
  • In Bcl-2-overexpressing chronic lymphocytic leukemia cells, the small-molecule Bcl-2 inhibitor HA14-1 sensitized these cells to 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-induced apoptosis. (aacrjournals.org)
  • genes
  • By classifying mouse and human leukemias according to Evi1/EVI1 and Erg/ERG expression, reflecting aggressiveness and cell of origin, and performing comparative transcriptomics, we identified several EMT-related genes that were significantly associated with poor overall survival of AML patients. (ox.ac.uk)
  • During development, TrxG proteins maintain activation of required genes, particularly the Hox genes, after maternal factors are depleted. (wikipedia.org)
  • For many genes and their corresponding proteins, an assortment of alternate names is in use across the scientific literature and public biological databases, posing a challenge to effective organization and exchange of biological information. (wikipedia.org)
  • But owing to the nature of how science has developed (with knowledge being uncovered bit by bit over decades), proteins and their corresponding genes have not always been discovered simultaneously (and not always physiologically understood when discovered), which is the largest reason why protein and gene names do not always match, or why scientists tend to favor one symbol or name for the protein and another for the gene. (wikipedia.org)
  • Also owing to the nature of how scientific knowledge has unfolded, proteins and their corresponding genes often have several names and symbols that are synonymous. (wikipedia.org)
  • tyrosine kinase
  • Rather than inhibiting kinase activity, elimination of mutant kinases provides a new therapeutic strategy for treating BCR-ABL-induced leukemia as well as other cancers resistant to treatment with tyrosine kinase inhibitors. (bloodjournal.org)
  • Janus kinases (JAK) are cytoplasmic protein tyrosine kinases that are constitutively associated with several cytokine and growth hormone-like receptors that by themselves lack intrinsic tyrosine kinase activity. (aacrjournals.org)
  • adaptor proteins
  • These domains define two families of adaptor proteins which function in membrane traffic and whose interaction with membranes is regulated, in part, by phosphoinositides. (embl-heidelberg.de)
  • Subsequently, they phosphorylate specific tyrosine motifs within the cytoplasmic tail of the receptor chains, which then act as recruitment sites for other signaling molecules such as signal transducer and activator of transcription (STAT) factors, Src kinases, protein tyrosine phosphatases, and several adaptor proteins ( 2 ). (aacrjournals.org)
  • Hodgkin's
  • Constitutive or enhanced JAK activation has been implicated in neoplastic transformation and abnormal cell proliferation in various hematologic malignancies including lymphoid and myeloid leukemias, Hodgkin's lymphoma, and various B-cell non-Hodgkin's lymphomas ( 3 , 4 ). (aacrjournals.org)
  • vesicle proteins
  • In D. melanogaster it was also shown that AP180 is also required for either recycling vesicle proteins and/or maintaining the distribution of both vesicle and synaptic proteins in the nerve terminal. (wikipedia.org)
  • leukemic cells
  • The BCR-ABL TKI, imatinib mesylate, induces a complete hematologic and cytogenetic response in the majority of chronic-phase CML patients, 2 but is unable to completely eradicate BCR-ABL-expressing leukemic cells, 3 , 4 suggesting that leukemia stem cells are not eliminated. (bloodjournal.org)
  • nuclear
  • We have found that β-arrestin2, which typically shows a cytoplasmic localization owing to constitutive nuclear export, appears in the nucleus after stimulation of the G-protein-coupled odorant receptor hOR17-4. (biologists.org)
  • novel
  • In this study, we compared the activity of several PPARγ ligands including BRL49653 (rosiglitazone), 15-deoxy-Δ12,14-prostaglandin J 2 , and the novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid on leukemia cells. (aacrjournals.org)
  • N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. (embl-heidelberg.de)
  • 20 We therefore evaluated the therapeutic effect of Hsp90 inhibition by using a novel water-soluble inhibitor, IPI-504, 22 in drug-resistant animal models of leukemia induced by BCR-ABL-WT and T315I. (bloodjournal.org)
  • endocytic
  • It is present at the NH2-terminus of proteins that often contain consensus sequences for binding to clathrin coat components and their accessory factors, and therefore function as endocytic adaptors. (embl-heidelberg.de)
  • receptor protein
  • To investigate whether odorant receptor activation leads to the recruitment of β-arrestin2 to the receptor protein, we tagged β-arrestin2 with GFP and visualized its redistribution upon activation of hOR17-4 with bourgeonal in HEK293 cells. (biologists.org)
  • zinc
  • This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. (wikipedia.org)
  • murine
  • As an alternative approach to kinase inhibition, an orally administered heat shock protein 90 (Hsp90) inhibitor, IPI-504, was evaluated in a murine model of CML. (bloodjournal.org)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • apoptosis
  • Aside from gene regulation, evidence suggests TrxG proteins are also involved in other processes including apoptosis, cancer, and stress responses. (wikipedia.org)
  • mutations
  • p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)
  • Mutations in MLL1 cause Wiedemann-Steiner syndrome and Acute lymphoblastic leukemia. (wikipedia.org)
  • Multiple mutations on GATA2 gene have been recently implicated as the cause of primary immunodeficiency in patients with MonoMAC Syndrome, and cases of dendritic cell, monocyte, B NK lymphoid deficiency and leukemia. (wikipedia.org)
  • Mutations in this gene have also been associated with familial myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) and lymphedema, deafness and myelodysplasia (Emberger syndrome). (wikipedia.org)