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  • Genes
  • This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. (genecards.org)
  • A number of genes of small risk for AD were identified in genome-wide association studies (GWAS), including genes coding for proteins involved in endocytosis, PICALM, BIN-1, and sorLA (sorting protein-related receptor) (20). (deepdyve.com)
  • These fragments then assemble into different multi-protein complexes that regulate the transcription of specific target genes, including many of the HOX genes. (wikipedia.org)
  • By classifying mouse and human leukemias according to Evi1/EVI1 and Erg/ERG expression, reflecting aggressiveness and cell of origin, and performing comparative transcriptomics, we identified several EMT-related genes that were significantly associated with poor overall survival of AML patients. (ox.ac.uk)
  • During development, TrxG proteins maintain activation of required genes, particularly the Hox genes, after maternal factors are depleted. (wikipedia.org)
  • For many genes and their corresponding proteins, an assortment of alternate names is in use across the scientific literature and public biological databases, posing a challenge to effective organization and exchange of biological information. (wikipedia.org)
  • But owing to the nature of how science has developed (with knowledge being uncovered bit by bit over decades), proteins and their corresponding genes have not always been discovered simultaneously (and not always physiologically understood when discovered), which is the largest reason why protein and gene names do not always match, or why scientists tend to favor one symbol or name for the protein and another for the gene. (wikipedia.org)
  • Also owing to the nature of how scientific knowledge has unfolded, proteins and their corresponding genes often have several names and symbols that are synonymous. (wikipedia.org)
  • Lastly, some proteins and protein complexes are built from the products of several genes (each gene contributing a polypeptide subunit), which means that the protein or complex will not have the same name or symbol as any one gene. (wikipedia.org)
  • molecular
  • Our data highlight the clinical and molecular convergence between the KMT2 and EHMT protein families, which may contribute to a molecular network underlying a larger group of intellectual disability / autism spectrum disorder -related disorders. (nih.gov)
  • They can be categorized into 3 general classes based on molecular function: histone-modifying TrxG proteins chromatin-remodeling TrxG proteins DNA-binding TrxG proteins, plus other TrxG proteins not categorized in the first three classes. (wikipedia.org)
  • vesicle proteins
  • Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins. (nih.gov)
  • In D. melanogaster it was also shown that AP180 is also required for either recycling vesicle proteins and/or maintaining the distribution of both vesicle and synaptic proteins in the nerve terminal. (wikipedia.org)
  • PICALM
  • Title: The PICALM protein plays a key role in iron homeostasis and cell proliferation. (nih.gov)
  • novel
  • In this study, we compared the activity of several PPARγ ligands including BRL49653 (rosiglitazone), 15-deoxy-Δ12,14-prostaglandin J 2 , and the novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid on leukemia cells. (aacrjournals.org)
  • N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. (embl-heidelberg.de)
  • endocytic
  • Confinement within the presynaptic bouton is mediated in part by synaptic vesicle protein association with the clathrin-based endocytic machinery to limit diffusional spread of newly exocytosed SV proteins. (nih.gov)
  • We hypothesized that endocytic protein expression is altered during ageing, thus influencing the likelihood of developing AD by increasing Aβ production. (deepdyve.com)
  • It is present at the NH2-terminus of proteins that often contain consensus sequences for binding to clathrin coat components and their accessory factors, and therefore function as endocytic adaptors. (embl-heidelberg.de)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • apoptosis
  • Exposure to these PPARγ ligands induced apoptosis in myeloid (U937 and HL-60) and lymphoid (Su-DHL, Sup-M2, Ramos, Raji, Hodgkin's cell lines, and primary chronic lymphocytic leukemia) cells. (aacrjournals.org)
  • In Bcl-2-overexpressing chronic lymphocytic leukemia cells, the small-molecule Bcl-2 inhibitor HA14-1 sensitized these cells to 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-induced apoptosis. (aacrjournals.org)
  • Human
  • Recombinant protein encompassing a sequence within the center region of human CIP29. (genetex.com)
  • The main isoform of the human protein is 1801 amino acid long, a total of 200,072 Da. (wikipedia.org)
  • MLL4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
  • Regarding the second duality (a given protein is endogenous in many kinds of organisms), the nomenclatural systems also provide for at least human-versus-nonhuman specificity by using different capitalization, although scientists often ignore this distinction, given that it is often biologically irrelevant. (wikipedia.org)
  • GATA2 is a human gene which makes a protein called GATA binding protein 2 - a transcription factor. (wikipedia.org)
  • overexpression
  • p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)
  • malignancies
  • Epigenetic drugs are in the process of approval for therapy of myeloid malignancies. (dfg.de)
  • The clinical experience with these drugs as well as the possibility to analyse the clinical specimens, with regard to changes in epigenetic markers, will be crucial for the understanding and utilisation of epigenetic strategies in myeloid malignancies. (dfg.de)
  • proliferation
  • When bound by its proper ligand, Platelet-derived growth factor (PDGF), it [tyrosine kinase]] becomes active in phosphorylating proteins that, among other functions, promote cell growth and proliferation. (wikipedia.org)
  • Immunochemical study of mouse tissue indicates that FANCA is present at a higher level in lymphoid tissues, the testis and the ovary, and though the significance of this is unclear, it suggests that the presence of FA proteins might be related to cellular proliferation. (wikipedia.org)
  • Two of the five PDGF isoforms activate PDGFRβ (PDGF-B and PDGF-D). The activated receptor phosphorylates itself and other proteins, and thereby engages intracellular signaling pathways that trigger cellular responses such as migration and proliferation. (wikipedia.org)
  • tumors
  • It may also be used to diagnose tumors of endothelial origin, such as angiosarcoma, variants of hemangioma, Kaposi sarcoma, and staging AML lymphoid tumors. (biocare.net)
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • Wright's group were the first to demonstrate use of the drug in solid tumors, as opposed to leukemias, which are a cancer of the marrow. (wikipedia.org)
  • genes
  • More than twenty distinct IFN genes and proteins have been identified in animals, including humans. (wikipedia.org)
  • Another cellular enzyme, RNAse L-also induced by interferon action-destroys RNA within the cells to further reduce protein synthesis of both viral and host genes. (wikipedia.org)
  • In addition, interferons induce production of hundreds of other proteins-known collectively as interferon-stimulated genes (ISGs)-that have roles in combating viruses and other actions produced by interferon. (wikipedia.org)
  • FIP1L1 gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or Retinoic acid receptor alpha (RARA) genes are causes of certain human diseases associated with pathologically increased levels of blood eosinophils and/or Leukemias. (wikipedia.org)
  • The RUNX1 and CBFB genes are targets of chromosome rearrangements that create oncogenic fusion genes in leukemia. (wikipedia.org)
  • These genes, in turn, increase the risk that more mutations will occur in developing lymphoid cells. (wikipedia.org)
  • Other genetic abnormalities in PDGFRB lead to various forms of potentially malignant bone marrow disorders: small deletions in and chromosome translocations causing fusions between PDGFRB and anyone of at least 30 genes can cause Myeloproliferative neoplasms that commonly involve eosinophilia, eosinophil-induced organ injury, and possible progression to aggressive leukemia (see blow). (wikipedia.org)
  • Human chromosome translocations between the PDGFRB gene and at least any one of 30 genes on other chromosomes lead to myeloid and/or lymphoid neoplasms that are many ways similar to the neoplasm caused by the fusion of the PDGFRA (i.e. platelet derived growth factor receptor A or alpha-type-platelet derived growth factor receptor) gene with the FIP1L1 gene (see FIP1L1-PDGFRA fusion gene. (wikipedia.org)
  • chromosome
  • The human FIP1L1 gene is located on chromosome 4 at position q12 (4q12), contains 19 exons, and codes for a complete protein consisting of 594 amino acids. (wikipedia.org)
  • The pericentric chromosome inversion inv(16)(p13q22) creates the CBFB-MYH11 fusion gene, which encodes the CBFβ-SMMHC fusion protein The inv(16) is present in all M4Eo subtype AML, representing one of the most common change in AML, and accounting for ~12% of de novo human AML. (wikipedia.org)
  • The gene is located on human chromosome 33 at the p13 position, consists of 14 exons, and is well-known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. (wikipedia.org)
  • kinase
  • Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. (uni-koeln.de)
  • In response to interferon, cells produce large amounts of an enzyme known as protein kinase R (PKR). (wikipedia.org)
  • FIP1L1-PDGFRA fusion proteins retain PDGFRA-related Tyrosine kinase activity but, unlike PDGFRA, their tyrosine kinase is constitutive, i.e. continuously active: the fusion proteins lack the intact protein's 3'-end that includes its juxtamembrane domain which normally blocks tyrosine kinase activity unless PDGFRA is bound to its activating ligand, platelet-derived growth factor. (wikipedia.org)
  • The PDGFRB gene encodes a typical receptor tyrosine kinase, which is a transmembrane protein consisting of an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. (wikipedia.org)
  • cells
  • To address this question, we study the detailed architecture of protein aggregates inside cells using advanced cryo electron microscopy techniques. (lmu.de)
  • GENTAUR suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as Anti_Human, mab Resistin Source Mouse. (antibody-antibodies.com)
  • CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells(APC). (creative-biolabs.com)
  • Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites, and also tumor cells. (wikipedia.org)
  • IFNs belong to the large class of proteins known as cytokines, molecules used for communication between cells to trigger the protective defenses of the immune system that help eradicate pathogens. (wikipedia.org)
  • Inhibited protein synthesis destroys both the virus and infected host cells. (wikipedia.org)
  • This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. (wikipedia.org)
  • In cells, FANCA involvement in this 'FA core complex' is required for the activation of the FANCD2 protein to a monoubiquitinated isoform (FANCD2-Ub) in response to DNA damage, catalysing activation of the FA/BRCA DNA damage-response pathway, leading to repair. (wikipedia.org)
  • For example, in human immortalized lymphoblasts and leukaemia cells, FA proteins are readily detectable by immunoprecipitation. (wikipedia.org)
  • The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells. (wikipedia.org)
  • RUNX1
  • AI-10-49 allosterically binds to CBFβ-SMMHC and disrupts protein-protein interaction between CBFβ-SMMHC and tumor suppressor RUNX1. (wikipedia.org)
  • Point-mutations in RUNX1 gene have been reported in patients with familial platelet disorder, myeloid dysplastic syndrome, and chronic myelomonocytic leukemia. (wikipedia.org)
  • Current treatment for inv(16) AML uses chemotherapy drugs, such as doxorubicin and cytarabine, with an estimated 5-year overall survival of 60% in young patients and only 20% in the elderly CBFβ-SMMHC outcompetes CBFβ for binding to RUNX1 by direct protein-protein interaction. (wikipedia.org)
  • Using a fluorescence resonance energy transfer (FRET) based assay, AI-4-57 was discovered as the lead compound which can inhibit CBFβ-SMHHC -RUNX1 protein-protein interaction. (wikipedia.org)
  • Overall, these findings validate inhibition of RUNX1- CBFβ-SMMHC protein-protein interaction as a novel therapeutic avenue for leukemia with inv(16) and AI-10-49 as a specific inhibitor of CBFβ-SMHHC oncoprotein. (wikipedia.org)
  • myeloma
  • At one end of this spectrum of hematological disorders, detection of one of these myeloma proteins in an individual's blood or urine indicates the presence of a common and clinically silent disorder termed MGUS, i.e. monoclonal gammopathy of undetermined significance. (wikipedia.org)
  • At the other end of this spectrum, detection of the myeloid protein indicates the presence of a hematological malignancy, i.e. multiple myeloma, Waldenström's macroglobulinemia, or other B cell-associated neoplasm, that derives stepwise from its MGUS precursors. (wikipedia.org)
  • The overproduced Ig's, termed myeloma proteins, commonly circulate in blood, may accumulate in urine, and are the hallmarks of plasma cell dyscrasias including their most malignant forms viz. (wikipedia.org)
  • profound
  • Autopsies of the victims suggested that profound lymphoid and myeloid suppression had occurred after exposure. (wikipedia.org)
  • This syndrome is a unique type of myelodysplastic syndrome characterized by a prolonged disease course, a low rate of transformation to an aggressive form of leukemia, and an anemia which in many patients is profound, refractory to traditional therapies (e.g. iron supplements, Erythropoietin), and requiring maintenance red blood cell transfusions. (wikipedia.org)
  • commonly
  • Farber met resistance to conducting his studies at a time when the commonly held medical belief was that leukemia was incurable, and that the children should be allowed to die in peace. (wikipedia.org)
  • miR-223 is commonly repressed in hepatocellular carcinoma and leukemia. (wikipedia.org)
  • transmembrane
  • NCR (natural cytotoxicity receptors), a type of type 1 transmembrane proteins of the immunoglobulin superfamily, upon stimulation, mediate NK killing and release of IFNγ. (wikipedia.org)
  • distinct
  • However, alternative splicing of its Precursor mRNA results in multiple transcript variants encoding distinct FIP1L1 protein isoforms. (wikipedia.org)
  • cancers
  • The Priority Programme will run for a period of six years and the main aim is to investigate mechanisms of epigenetic control of normal myeloid development and their disturbances in myeloid cancers, both in vitro and in vivo. (dfg.de)
  • Fanconi anaemia is an inherited autosomal recessive disorder, the main features of which are aplastic anaemia in childhood, multiple congenital abnormalities, susceptibility to leukemia and other cancers, and cellular hypersensitivity to interstrand DNA cross-linking agents. (wikipedia.org)
  • binds
  • CPSF1 is an RNA processing protein that binds to uracil-rich sequences in pre-mRNA, concurrently binds with and stimulates POPOLA, i.e. (wikipedia.org)
  • cellular
  • However, the mechanisms linking protein aggregation to cellular toxicity and death remain poorly understood. (lmu.de)
  • mRNA
  • also termed Pre-mRNA 3'-end-processing factor FIP1) is a protein that in humans is encoded by the FIP1L1 gene (also known as Rhe, FIP1, and hFip1). (wikipedia.org)
  • As a result, these mRNA molecules are silenced, by one or more of the following processes: Cleavage of the mRNA strand into two pieces, Destabilization of the mRNA through shortening of its poly(A) tail, and Less efficient translation of the mRNA into proteins by ribosomes. (wikipedia.org)
  • isolated the lin-4 gene, they found that instead of producing an mRNA encoding a protein, it produced short non-coding RNAs, one of which was a ~22-nucleotide RNA that contained sequences partially complementary to multiple sequences in the 3' UTR of the lin-14 mRNA. (wikipedia.org)
  • This complementarity was proposed to inhibit the translation of the lin-14 mRNA into the LIN-14 protein. (wikipedia.org)
  • In particular, overexpression of miR-223 reduces FBXW7 mRNA levels while increasing endogenous cyclin E protein and activity levels. (wikipedia.org)
  • cell
  • the phosphorylated eIF-2 forms an inactive complex with another protein, called eIF2B, to reduce protein synthesis within the cell. (wikipedia.org)
  • Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. (wikipedia.org)
  • Central nervous system (CNS) symptoms such cranial neuropathies due to meningeal infiltration are identified in less than 10% of adults and less than 5% of children, particularly mature B-cell ALL (Burkitt leukemia) at presentation. (wikipedia.org)
  • The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. (wikipedia.org)
  • These changes can often be tracked by monitoring the presence of proteins on the surface of the cell. (wikipedia.org)
  • common
  • they are related by their assembly into a common nuclear protein complex. (wikipedia.org)
  • A structural feature common to all IAP family proteins is that they all contain at least one baculoviral IAP repeat (BIR) domain characterized by a conserved zinc-coordinating Cys/His motif at the N-terminal half of the protein. (wikipedia.org)
  • Targeting
  • Targeting protein-protein interaction with small molecule is known to be extremely difficult due to the fact that binding regions consist of wide, shallow surfaces. (wikipedia.org)
  • interaction
  • The biophysicists participating in QBM (Braun, Jungmann, Rädler, Schwille) bring a wealth of advanced expertise and novel methodologies, permitting the high-resolution quantitative and dynamic analysis of regulatory processes, including protein folding/conformation and the interaction of proteins with small molecules, nucleic acids, or other proteins in different settings (single molecule, purified/crude extracts). (lmu.de)
  • This interaction has been proposed as essential for the stability and nuclear localization of FA core complex proteins. (wikipedia.org)
  • aggregation
  • Protein aggregation is a hallmark of many neurodegenerative diseases such as Alzheimer's or Parkinson's. (lmu.de)
  • molecular
  • Am J Med Genet A. doi:10.1002/ajmg.a.34122 Melko M, Douguet D, Bensaid M, Zongaro S, Verheggen C, Gecz J, Bardoni B (2011) Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability. (wikipedia.org)
  • The molecular mechanisms of survivin regulation are still not well understood, but regulation of survivin seems to be linked to the p53 protein. (wikipedia.org)
  • The molecular mass of the mature, glycosylated PDGFRβ protein is approximately 180 kDa. (wikipedia.org)