• genes
  • This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. (genecards.org)
  • A number of genes of small risk for AD were identified in genome-wide association studies (GWAS), including genes coding for proteins involved in endocytosis, PICALM, BIN-1, and sorLA (sorting protein-related receptor) (20). (deepdyve.com)
  • By classifying mouse and human leukemias according to Evi1/EVI1 and Erg/ERG expression, reflecting aggressiveness and cell of origin, and performing comparative transcriptomics, we identified several EMT-related genes that were significantly associated with poor overall survival of AML patients. (ox.ac.uk)
  • These fragments then assemble into different multi-protein complexes that regulate the transcription of specific target genes, including many of the HOX genes. (wikipedia.org)
  • During development, TrxG proteins maintain activation of required genes, particularly the Hox genes, after maternal factors are depleted. (wikipedia.org)
  • For many genes and their corresponding proteins, an assortment of alternate names is in use across the scientific literature and public biological databases, posing a challenge to effective organization and exchange of biological information. (wikipedia.org)
  • But owing to the nature of how science has developed (with knowledge being uncovered bit by bit over decades), proteins and their corresponding genes have not always been discovered simultaneously (and not always physiologically understood when discovered), which is the largest reason why protein and gene names do not always match, or why scientists tend to favor one symbol or name for the protein and another for the gene. (wikipedia.org)
  • Also owing to the nature of how scientific knowledge has unfolded, proteins and their corresponding genes often have several names and symbols that are synonymous. (wikipedia.org)
  • Lastly, some proteins and protein complexes are built from the products of several genes (each gene contributing a polypeptide subunit), which means that the protein or complex will not have the same name or symbol as any one gene. (wikipedia.org)
  • molecular
  • Our data highlight the clinical and molecular convergence between the KMT2 and EHMT protein families, which may contribute to a molecular network underlying a larger group of intellectual disability / autism spectrum disorder -related disorders. (nih.gov)
  • Heat shock protein 90 (Hsp90) is a highly conserved, constitutively expressed molecular chaperone that facilitates folding of client proteins such as BCR-ABL, and affects the stability of these proteins. (bloodjournal.org)
  • They can be categorized into 3 general classes based on molecular function: histone-modifying TrxG proteins chromatin-remodeling TrxG proteins DNA-binding TrxG proteins, plus other TrxG proteins not categorized in the first three classes. (wikipedia.org)
  • Mice
  • Treatment with IPI-504 resulted in BCR-ABL protein degradation, decreased numbers of leukemia stem cells, and prolonged survival of leukemic mice bearing the T315I mutation. (bloodjournal.org)
  • Hsp90 inhibition more potently suppressed T315I-expressing leukemia clones relative to the wild-type (WT) clones in mice. (bloodjournal.org)
  • Overexpression of miR-125a or miR-125b is frequent in human acute myeloid leukemia (AML), and the overexpression of these miRNAs in mice leads to expansion of hematopoietic stem cells accompanied by perturbed hematopoiesis with mostly myeloproliferative phenotypes. (nih.gov)
  • and thus scientists naturally often use the same symbol and name for a given protein in one species (for example, mice) as in another species (for example, humans). (wikipedia.org)
  • vesicle proteins
  • In D. melanogaster it was also shown that AP180 is also required for either recycling vesicle proteins and/or maintaining the distribution of both vesicle and synaptic proteins in the nerve terminal. (wikipedia.org)
  • leukemic cells
  • The BCR-ABL TKI, imatinib mesylate, induces a complete hematologic and cytogenetic response in the majority of chronic-phase CML patients, 2 but is unable to completely eradicate BCR-ABL-expressing leukemic cells, 3 , 4 suggesting that leukemia stem cells are not eliminated. (bloodjournal.org)
  • endocytosis
  • Amyloid-β (Aβ) is produced from amyloid precursor protein (APP) primarily after APP is internalized by clathrin-mediated or clathrin-independent endocytosis. (deepdyve.com)
  • This age-related increase in endocytic protein expression, not described previously, suggests an age-related upregulation of endocytosis which could predispose older individuals to develop AD by increasing APP internalization and Aβ generation. (deepdyve.com)
  • AP180 is a protein that plays an important role in clathrin-mediated endocytosis of synaptic vesicles. (wikipedia.org)
  • adaptor
  • These domains define two families of adaptor proteins which function in membrane traffic and whose interaction with membranes is regulated, in part, by phosphoinositides. (embl-heidelberg.de)
  • Based on previous observations in yeast, we propose that N4WBP5 may act as an adaptor for Nedd4-like proteins and their putative targets to control ubiquitin-dependent protein sorting and trafficking. (embl-heidelberg.de)
  • This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles. (wikipedia.org)
  • Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2 and NUMB. (wikipedia.org)
  • novel
  • In this study, we compared the activity of several PPARγ ligands including BRL49653 (rosiglitazone), 15-deoxy-Δ12,14-prostaglandin J 2 , and the novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid on leukemia cells. (aacrjournals.org)
  • N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. (embl-heidelberg.de)
  • 20 We therefore evaluated the therapeutic effect of Hsp90 inhibition by using a novel water-soluble inhibitor, IPI-504, 22 in drug-resistant animal models of leukemia induced by BCR-ABL-WT and T315I. (bloodjournal.org)
  • chronic lymphocy
  • Exposure to these PPARγ ligands induced apoptosis in myeloid (U937 and HL-60) and lymphoid (Su-DHL, Sup-M2, Ramos, Raji, Hodgkin's cell lines, and primary chronic lymphocytic leukemia) cells. (aacrjournals.org)
  • In Bcl-2-overexpressing chronic lymphocytic leukemia cells, the small-molecule Bcl-2 inhibitor HA14-1 sensitized these cells to 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-induced apoptosis. (aacrjournals.org)
  • Human
  • Age, Amyloid precursor protein, Amyloid-β, Human brain Alzheimer's disease (AD) is the most common form of dementia accounting for an estimated 60%-80% of all cases (1). (deepdyve.com)
  • Recombinant protein encompassing a sequence within the center region of human CIP29. (genetex.com)
  • MiR-125b expression enhances VEGFA expression and production from leukemia cells, in part by suppressing TET2 Recombinant VEGFA recapitulates the leukemia-promoting effects of miR-125b , whereas knockdown of VEGFA or inhibition of VEGF receptor 2 abolishes the effects of miR-125b In addition, significant correlation between miR-125b and VEGFA expression is observed in human AMLs. (nih.gov)
  • The main isoform of the human protein is 1801 amino acid long, a total of 200,072 Da. (wikipedia.org)
  • MLL4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
  • Regarding the second duality (a given protein is endogenous in many kinds of organisms), the nomenclatural systems also provide for at least human-versus-nonhuman specificity by using different capitalization, although scientists often ignore this distinction, given that it is often biologically irrelevant. (wikipedia.org)
  • GATA2 is a human gene which makes a protein called GATA binding protein 2 - a transcription factor. (wikipedia.org)
  • overexpression
  • p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)
  • However, whether and how miR-125 family miRNAs cooperate with known AML oncogenes in vivo, and how the resultant leukemia is dependent on miR-125 overexpression, are not well understood. (nih.gov)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • apoptosis
  • Aside from gene regulation, evidence suggests TrxG proteins are also involved in other processes including apoptosis, cancer, and stress responses. (wikipedia.org)
  • stem
  • These results provide a rationale for use of an Hsp90 inhibitor as a first-line treatment in CML by inhibiting leukemia stem cells and preventing the emergence of imatinib-resistant clones in patients. (bloodjournal.org)
  • coat
  • It is present at the NH2-terminus of proteins that often contain consensus sequences for binding to clathrin coat components and their accessory factors, and therefore function as endocytic adaptors. (embl-heidelberg.de)
  • The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. (wikipedia.org)