• Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immune cells from the myeloid lineage (a family of cells that originate from bone marrow stem cells). (wikipedia.org)
  • The size of the myeloid suppressor compartment is considered to be an important factor in the success or failure of cancer immunotherapy, highlighting the importance of this cell type for human pathophysiology. (wikipedia.org)
  • Furthermore, we describe a subset of myeloid cells with immunosuppressive activity (known as myeloid-derived suppressor cells). (hindawi.com)
  • In addition to TAMs, solid tumors are also infiltrated by immunosuppressive, immature myeloid progenitor cells, commonly referred to as monocytic or polymorphonuclear myeloid-derived suppressor cells (M/PMN-MDSC) ( 11 - 13 ). (frontiersin.org)
  • Myeloid-derived suppressor cells (MDSCs) have a strong immunosuppressive character that allows them to regulate immune responses and hinder overt inflammatory responses. (lu.se)
  • Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that expand during benign and cancer-associated inflammation. (purdue.edu)
  • Myeloid-derived suppressor cells (MDSC) are early, immature myeloid cells that are potent inhibitors of the immune system. (databasefootball.com)
  • These findings are described in the article entitled Circulating myeloid-derived suppressor cells increase in patients undergoing neo-adjuvant chemotherapy for breast cancer , recently published in the journal Cancer Immunology, Immunotherapy . (databasefootball.com)
  • This process is epitomized by myeloid-derived suppressor cells (MDSC). (aacrjournals.org)
  • Myeloid derived suppressor cells (MDSC) are immune cells that dampen immune responses. (iospress.com)
  • An immune cell in the tumor microenvironment that may be important for inhibiting the immune response against bladder cancer is the myeloid derived suppressor cell (MDSC). (iospress.com)
  • Tumors frequently induce immature myeloid cells (iMC), which suppress specific and unrelated cytotoxic T lymphocyte (CTL) responses and are termed myeloid derived suppressor cells (MDSC). (mdc-berlin.de)
  • Myeloid suppressor cells with high arginase activity are found in tumors and spleen of mice with colon and lung cancer. (aacrjournals.org)
  • The goal of this study was to determine whether myeloid suppressor cells producing high arginase existed in renal cell carcinoma patients. (aacrjournals.org)
  • Furthermore, CD4(+) T cells were diminished in the periphery of anti-PC mice, whereas various CD11b(+) populations were increased, notably the myeloid-derived suppressor cells (MDSCs), a CD11b(+) subset characterized as potent T cell suppressors. (listlabs.com)
  • There is increasing evidence that myeloid-derived suppressor cells (MDSCs) contribute to the progression of cancer by inhibiting tumor-directed immune responses and producing mediators that promote the growth and survival of tumor cells. (bmj.com)
  • Myeloid-derived suppressor cells (MDSC) are pathologically activated neutrophils or monocytes that are absent in healthy individuals, but appear in patients with cancer and conditions associated with chronic inflammation or stress. (beckman.com)
  • 2021) Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity. (beckman.com)
  • 2020) Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer. (beckman.com)
  • Myeloid-derived suppressor cells (MDSCs) play a pivotal role in promoting tumor growth and metastasis and can even decrease the efficacy of immunotherapy. (oncotarget.com)
  • Carbon nanotube s enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells. (cdc.gov)
  • The effect is mediated by increased local and systemic accumulation of myeloid-derived suppressor cells (MDSC), as their depletion abrogated pro-tumor activity in vivo. (cdc.gov)
  • Studies are needed to determine whether MDSCs are a population of immature myeloid cells that have stopped differentiation or a distinct myeloid lineage. (wikipedia.org)
  • MDSCs migrate as immature cells from the bone marrow to peripheral tissues (or tumors), where they differentiate into mature macrophages, dendritic cells, and neutrophils without suppressive phenotypes under homeostatic conditions, but become polarized when exposed to pro-inflammatory compounds, chemokines, and cytokines. (wikipedia.org)
  • The classical definition of MDSCs as immature myeloid cells blocked from differentiating has been challenged by recent studies suggesting that Mo-MDSCs and G-MDSCs may represent monocytes and granulocytes that have acquired immunosuppressive properties. (lu.se)
  • These cells, described as macrophages or immature dendritic cells, deplete arginine and impair T cell proliferation and cytokine production. (aacrjournals.org)
  • Immature myeloid cells, identified as Gr1+CD11b+ cells, are expanded in tumor bearing host, and promote distant organ metastasis in tumor bearing host through production of immunosuppressive cytokines and chemokines. (nih.gov)
  • To examine whether miRs130a and 145 inhibit lung metastasis via down-regulation of T¿RII in immature myeloid cells, we used 2 different mouse models with myeloid specific miR130a or miR145 overexpression: 1) 4T1 tumor model transplanted with CD11b driven-miR130a or miR145 engineered bone marrow haematopoietic stem /progenitor cells and 2) Lewis lung carcinoma model with doxycycline-inducible myeloid specific miR130a transgenic mice. (nih.gov)
  • These data suggested that miRs 130a and 145 skewed a pro-tumor toward an anti-tumor microenvironment via reprogrammed immature myeloid cells. (nih.gov)
  • Taken together, these data suggested that miR130a and miR145 reprogramed Gr1+CD11b+ immature myeloid cells, and inhibited tumor metastasis via improvement of anti-tumor immunity. (nih.gov)
  • Restoration of miRs 130a and 145 functions in immature myeloid cells might be useful for reduction of tumor metastasis. (nih.gov)
  • Background Acute myeloid leukemia (AML) is a heterogeneous malignancy characterized by the expansion of immature myeloid cells. (unito.it)
  • Chronic myeloid leukemia (CML) occurs when a pluripotent stem cell undergoes malignant transformation and clonal myeloproliferation, leading to a striking overproduction of mature and immature granulocytes. (msdmanuals.com)
  • Vasculogenesis is the coalescence of new blood vessels from individual endothelial cells or progenitor cells. (hindawi.com)
  • These cells were therefore described as bone marrow derived endothelial progenitor cells (EPCs). (hindawi.com)
  • Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. (cun.es)
  • In this study, we used single cell RNA sequencing (scRNAseq) to characterize an enriched population of human hematopoietic stem and progenitor cells (HSPCs) obtained from young and elderly healthy individuals. (cun.es)
  • Moreover, the CD34 + CD38 - progenitor cells expressed variable amounts of the target receptor CD33, CD133 and c-kit (CD117) [ 20 ]. (researchsquare.com)
  • Myeloid Progenitor Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • This graph shows the total number of publications written about "Myeloid Progenitor Cells" by people in this website by year, and whether "Myeloid Progenitor Cells" was a major or minor topic of these publications. (uchicago.edu)
  • Below are the most recent publications written about "Myeloid Progenitor Cells" by people in Profiles. (uchicago.edu)
  • Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia. (uchicago.edu)
  • The myeloid-differentiation cytokine GM-CSF is a key factor in MDSC production from bone marrow,[unreliable medical source? (wikipedia.org)
  • While monocyte and neutrophil differentiation pathways within the bone marrow are antagonistic and dependent on the relative expression of IRF8 and c/EBP transcription factors (and hence there is not a direct precursor-progeny link between these two myeloid cell types), this seems not to be the case for MDSCs. (wikipedia.org)
  • Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
  • Tumor site monocytic-MDSC lacked the ability to differentiate into other cells types such as osteoclasts and granulocytic-MDSC, whereas the bone marrow and spleen counterparts could form both cell types. (purdue.edu)
  • Induction of p53 signaling elevated the differentiation of the bone marrow MDSC into granulocytic cell types. (purdue.edu)
  • Chronic myeloid leukemia (CML) is a malignancy of the blood and bone marrow that affects children and adults. (spandidos-publications.com)
  • The expression of miR-149-5p in leukemia cell lines, as well as the blood and bone marrow (BM) samples from leukemia patients, were monitored by reverse-transcription polymerase chain reaction (RT-PCR). (medscimonit.com)
  • Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. (haematologica.org)
  • 2 1 There is growing evidence to suggest that primitive CML cells affect the bone marrow (BM) niche, contributing to deregulated cytokine levels. (haematologica.org)
  • We examined the CD45 dim CD34 + CD38 - CD133 + cells on bone marrow samples of hematologic malignancies and healthy controls using four-color flow cytometry experiments. (researchsquare.com)
  • Interestingly, the CD45 dim CD34 + CD38 - CD133 + cells were highly expressed in bone marrow of patients with AML compared to that of healthy controls (HC). (researchsquare.com)
  • In this study, we focused on measuring LSCs easily in the bone marrow cells from AML patients by developing a four-color flow cytometric analysis. (researchsquare.com)
  • Sea-blue histiocytes and Gaucher cells in bone marrow of patients with chronic myeloid leukaemia. (bmj.com)
  • A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy. (genomeweb.com)
  • CD157, an adhesion molecule expressed by myelomonocytic cells, bone marrow stromal cells and selected epithelial cancers, was found expressed in more than 90% of AML both at diagnosis and after relapse, although at variable levels. (unito.it)
  • Acute myeloid leukemia is a cancer of the white blood cells within the blood and bone marrow. (medlineplus.gov)
  • Bone marrow is the soft tissue inside bones that generates all blood components including white blood cells. (medlineplus.gov)
  • AML involves cells in the bone marrow that usually become white blood cells. (medlineplus.gov)
  • These leukemia cells build up in the bone marrow and blood, leaving no space for healthy red and white blood cells and platelets to form. (medlineplus.gov)
  • A diagnosis of AML NOS requires the presence of least 20% leukemic cells in the bone marrow (BM) or peripheral blood (PB). (medscape.com)
  • Patients with acute myeloid leukemia (AML) with minimal differentiation, AML without differentiation, and AML with differentiation usually present with evidence of bone marrow failure (ie, anemia , neutropenia , and/or thrombocytopenia ). (medscape.com)
  • The bcr-abl oncoprotein has uncontrolled tyrosine kinase activity, which deregulates cellular proliferation, decreases adherence of leukemia cells to the bone marrow stroma, and protects leukemic cells from normal programmed cell death (apoptosis). (msdmanuals.com)
  • CML ensues when an abnormal pluripotent hematopoietic progenitor cell initiates excessive production of all myeloid lineage cells, primarily in the bone marrow but also in extramedullary sites (eg, spleen, liver). (msdmanuals.com)
  • An expansion of different myeloid derived suppressive cell (MDSC) subsets can be detected in the blood and secondary lymphoid organs of early and advanced pancreatic ductal adenocarcinoma (PDAC) patients. (nih.gov)
  • MDSC are characterized by their ability to potently inhibit T cell responses. (purdue.edu)
  • We showed that p38-MAPK pathway is involved in the regulation of MDSC-mediated immunoregulatory processes such that inhibition of p38 diminished MDSC expansion at the inflamed prostate, leading to greater numbers of T cells. (purdue.edu)
  • Our studies also demonstrated that the in vitro differentiation capacity of MDSC is restricted to cells at the peripheral sites. (purdue.edu)
  • MDSC that lack CAT2 have reduced capacity to suppress T cell responses both ex vivo and in vivo, as evidenced by increased T cell expansion in prostatitis and decreased tumor growth in cancer models. (purdue.edu)
  • MDSC role is to damp an immune response by inhibiting the function of T cells, natural killer cells and stimulating other inhibitory immune cells like regulatory T cells. (databasefootball.com)
  • From a physiological standpoint, MDSC can be thought of as effectors of a homeostatic mechanism that regulate T cell-mediated inflammatory responses to pathogens [ 5 ]. (iospress.com)
  • In mice, MDSC can be identified by species-specific cell surface markers (CD11b + Gr-1 + ) and may be further classified as monocytic (M-MDSC, Ly-6C hi ) or granulocytic (G-MDSC, Ly-6G + ) based on additional cell surface markers [ 6 ]. (iospress.com)
  • G-MDSC are also referred to as polymorphonuclear (PMN)-MDSC, which differ from conventional neutrophils via expression of lectin-type oxidized LDL receptor 1 (LOX-1), which inhibits T cell proliferation [ 7, 8 ]. (iospress.com)
  • While present at low numbers in the peripheral blood of healthy individuals, levels of circulating MDSC increase in cancer patients as tumors produce factors that drive both the expansion and recruitment of these cells. (bmj.com)
  • MDSCs are a heterogeneous population and include both granulocytic MDSC (G-MDSC) and monocytic MDSC (M-MDSC) sub-populations, each of which can inhibit T cell function through arginase activity and the production of nitric oxide. (bmj.com)
  • TLR8 mRNA levels found in the M-MDSC subpopulation were comparable to those found in monocytes and myeloid dendritic cells (mDC), which express high levels of TLR8 protein and activate in response to motolimod. (bmj.com)
  • The decrease in M-MDSC population was found to be the result of these cells undergoing apoptosis following motolimod treatment. (bmj.com)
  • AVM induced the release of cleaved PARP and cleaved caspase‑3 caused apoptosis and inhibited the viability of these cells. (spandidos-publications.com)
  • This study was aimed to reveal the role of miR-149-5p in acute myeloid leukemia (AML) cells apoptosis and the possible mechanism involved. (medscimonit.com)
  • AML cell line THP-1 was transfected with miR-149-5p mimic or inhibitor, and then cell apoptosis was determined using the APO Percentage assay kit. (medscimonit.com)
  • Further, small interfering RNA (siRNA) against the target gene was co-transfected with miR-149-5p inhibitor, and then the cell apoptosis and the expression of apoptosis-related proteins were assessed. (medscimonit.com)
  • Inhibition of miR-149-5p can induce apoptosis in THP-1 cells. (medscimonit.com)
  • Genome-wide mapping of H4K16ac in terminally differentiated blood cells, along with functional experiments, supported a role for this histone post-translational modification in the regulation of cell differentiation and apoptosis in the hematopoietic system. (csic.es)
  • Our results thus suggest that H4K16ac plays a dual role in myeloid cells as it not only regulates differentiation and apoptosis, but it also exhibits a non-canonical structural role in poising chromatin for cleavage at an early stage of neutrophil cell death. (csic.es)
  • The growth and apoptosis of AML cells were determined using CCK-8, 5-ethynyl-2-deoxyuridine (EdU), flow cytometry, and western blot assays. (ajol.info)
  • Apoptosis increased in KG-1 and HL-60 cells, with enhanced Bax and reduced Bcl-2 protein levels, after transfection with sh-KLF8. (ajol.info)
  • Downregulation of KLF8 inhibits proliferation and glycolysis, and also promotes apoptosis in AML cells via AKT/mTOR pathway. (ajol.info)
  • Chronic myeloid leukemia (CML) results from BCR-ABL oncogene, which blocks CML cells differentiation and protects these cells from apoptosis. (jcancer.org)
  • Here, we determined the effect of Jiyuan oridonin A (JOA), an ent -kaurene diterpenoid compound, on the differentiation blockade in imatinib-sensitive, particularly, imatinib-resistant CML cells with BCR-ABL-T315I mutation by cell proliferation assay, apoptosis analysis, cell differentiation analysis, cell cycle analysis and colony formation assay. (jcancer.org)
  • Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. (mcw.edu)
  • Trajectory inference revealed that altered gene expression dynamics accompanied cell differentiation, which could explain age-associated changes in hematopoiesis. (cun.es)
  • Using previous findings in healthy cells as a reference, we analyzed scRNA-seq data obtained from patients with myelodysplastic syndrome (MDS) and detected specific alterations of the expression dynamics of genes involved in erythroid differentiation in all patients with MDS such as TRIB2. (cun.es)
  • In summary, we demonstrate that the combination of single cell technologies with computational analysis tools enable the study of a variety of cellular mechanisms involved in complex biological systems such as early hematopoiesis and can be used to dissect perturbed differentiation trajectories associated with perturbations such as aging and malignant transformation. (cun.es)
  • We found that JOA at lower concentration significantly inhibited the proliferation of CML cells expressing mutant BCR-ABL (T315I mutation included) and wild-type BCR-ABL, which was due to that JOA induced the cell differentiation and the cell cycle arrest at G0/G1 phase. (jcancer.org)
  • Mechanistically, the cell differentiation mediated by JOA may be originated from the inhibition of BCR-ABL/c-MYC signaling in CML cells expressing wild-type BCR-ABL and BCR-ABL-T315I. (jcancer.org)
  • JOA displayed the activity of inhibiting the BCR-ABL and promoted differentiation of not only imatinib -sensitive but also imatinib -resistant cells with BCR-ABL mutation, which could become a potent lead compound to overcome the imatinib -resistant induced by inhibitors of BCR-ABL tyrosine kinase in CML therapy. (jcancer.org)
  • BCR-ABL oncogene encodes a BCR-ABL tyrosine kinase (TK), which triggers different downstream targets including c-Myc, STAT5 and CrkL, which participated in the control of cell differentiation, proliferation, migration and other cellular behaviors [ 3 - 5 ]. (jcancer.org)
  • miR-203 drives breast cancer cell differentiation. (medscape.com)
  • M, Peterson C. 2018 Haematopoietic stem suggests that during differentiation a stem cell approaches a stable equili- cells: entropic landscapes of differentiation. (lu.se)
  • Single cells in these populations exhibit different com- stem cell differentiation, Shannon information binations of regulator activity that suggest the presence of multiple theory, entropy configurations of a potential differentiation network as a result of multiple entry points into the committed state. (lu.se)
  • First, we screened 513 natural compounds on primary AML cells and identified a novel diterpene (H4) that preferentially induced differentiation of FLT3 wild-type AMLs, while FLT3-ITD/mutations conferred resistance. (lu.se)
  • By combinatorial screening using H4 and molecules with defined targets, we demonstrated that H4 induces differentiation by the activation of protein kinase C (PKC) signaling pathway, and in line with this, activates PKC phosphorylation and translocation of PKC to the cell membrane. (lu.se)
  • Myeloid-related precursor neoplasms derive from precursor cells that have at least one form of myeloid differentiation. (medscape.com)
  • The presence of the characteristic chromosomal translocation always involving the fibroblast growth factor receptor 1 ( FGFR1 ) gene at chromosome 8p11 in both the myeloid and lymphoid malignancies suggests bilineage differentiation from an affected pluripotent stem cell. (medscape.com)
  • Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. (frontiersin.org)
  • His mentor, Dr. Jeffrey S. Miller, is a world-renowned NK cell immunotherapy expert with vast experience in clinical approaches targeting myeloid leukemias using NK cells. (dtic.mil)
  • Furthermore, the identification of abnormal regulatory mechanisms associated with myeloid malignancies could be exploited for personalized therapeutic approaches in individual patients. (cun.es)
  • ArcherDx has launched the Archer VariantPlex Core Myeloid panel, a next-generation sequencing-based targeted panel that analyzes 37 genes related to myeloid malignancies. (genomeweb.com)
  • Histopathological analyses of CNS tissue from individuals with MS and mice with the murine model experimental autoimmune encephalomyelitis (EAE) have revealed substantial myeloid cell infiltration within inflamed lesions. (listlabs.com)
  • Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
  • Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. (frontiersin.org)
  • In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression. (frontiersin.org)
  • These cells have emerged as an important contributor to tumor progression. (aacrjournals.org)
  • Reports on the accumulation of immune-suppressive myeloid cells associated with tumor progression were published sporadically beginning in the early 1970s ( 1 ). (aacrjournals.org)
  • For those who are ineligible for cisplatin-based regimens or experience progression of disease, in 2016-2017 the United States Food and Drug Administration approved five monoclonal antibodies that achieve immune checkpoint blockade by targeting the programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) pathway. (iospress.com)
  • Leukemia stem cells (LSCs) in acute myeloid leukemia (AML) played important roles in development of leukemia, chemotherapeutic drug resistance, and disease relapse and progression. (researchsquare.com)
  • Additionally, inhibition of activated PC modulated the functional responses of CD11b(+) cells, leading to the expansion and increased activation of MDSCs, which are suppressive to the CD4(+) T cells required for EAE progression, thereby resulting in attenuated EAE. (listlabs.com)
  • However, it remains unknown how T¿RII are regulated in myeloid cells during tumor progression. (nih.gov)
  • Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)
  • In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)
  • Immune cells abundantly infiltrate tumors, creating a complex environment mediated by repetitive cycles of antitumor responses and immune evasion ( 1 ). (frontiersin.org)
  • The observations of the accumulation in spleens and tumors of large numbers of these cells with potent immune-suppressive activity were readily reproducible in most murine tumor models. (aacrjournals.org)
  • Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA. (medscape.com)
  • The tumors generally are made up of spindle-shaped cells and have a high cellularity. (medscape.com)
  • During the 1980s and early 1990s, work from the laboratories of Diana Lopez, Jim Talmadge, M. Rita Young, and Hans Schreiber demonstrated that various types of myeloid cells could inhibit immune function in cancer. (aacrjournals.org)
  • In previous research, the authors demonstrated that the methanol extract of Artemisia vulgaris (AVM) has the ability to inhibit chronic myeloid leukemia (CML) cell proliferation. (spandidos-publications.com)
  • In previous research, the authors demonstrated that the methanol extract of A. vulgaris (AVM) has the ability to inhibit the viability of CML cells ( 10 ). (spandidos-publications.com)
  • Using Lys-Cre mediated myeloid specific Tgfbr2 knockout mice, TGF¿ type II receptor (TbRII) in myeloid cells inhibit tumor metastasis. (nih.gov)
  • Granulocytic myeloid cells include populations of terminally differentiated polymorphonuclear neutrophils, eosinophils, basophils, and mast cells. (aacrjournals.org)
  • Also, these cell populations directly correlated with poor survival [ 2 , 5 ]. (researchsquare.com)
  • RvD1 had minimal direct impact on in vitro myogenesis but directly suppressed myokine production and stimulated macrophage phagocytosis, showing that SPMs can modulate both infiltrating myeloid and resident muscle cell populations. (jci.org)
  • Regional differences in the intrinsic regulation of resident myeloid cell populations may mediate susceptibility to lesion formation. (listlabs.com)
  • Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
  • Vaccination alone or in combination with anti-PD-1/anti-CTLA4 did not elicit tumor regression nor increase CD8 + T cells in the tumor microenvironment (TME), suggesting the presence of immune-suppressive barriers. (nih.gov)
  • Another myeloid population in the tumor microenvironment (TME) are DCs, that originate from different precursors and display various phenotypes, ranging from immunosuppressive monocyte-derived DCs (Mo-DCs) to immunocompetent cDC1 and cDC2 subsets ( 22 ). (frontiersin.org)
  • In breast cancer, MDSCs are recruited mainly by breast cancer cells to form a tumor-favoring microenvironment to suppress the anti-tumor immune response. (oncotarget.com)
  • Patients with cervical cancer have poor dendritic cell functions, have weak cytotoxic lymphocyte responses, and demonstrate an accumulation of myeloid cells in the periphery. (nih.gov)
  • Skin involvement by blastic plasmacytoid dendritic cell neoplasm. (medscape.com)
  • To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
  • Cytokines are essential for the function and maintenance of cells, and altered cytokine levels influence not only leukemic cells, but also the normal HSC within the BM. (haematologica.org)
  • RvD1 suppressed inflammatory cytokine expression, enhanced polymorphonuclear cell clearance, modulated the local muscle stem cell response, and polarized intramuscular macrophages to a more proregenerative subset. (jci.org)
  • These patients had a markedly decreased cytokine production and expressed low levels of T cell receptor CD3ζ chain. (aacrjournals.org)
  • Mechanically, miRs 130a and 145 overexpression in Gr1+CD11b+myeloid cells decreased Th2 cytokine production, and increased IFNg producing CD8+ cytotoxic lymphocytes. (nih.gov)
  • During blast crisis of chronic myelogenous leukemia (CML), abnormal granulocyte macrophage progenitors (GMP) with nuclear beta-catenin acquire self-renewal potential and may function as leukemic stem cells (Jamieson et al. (ca.gov)
  • These results provide further evidence that BCR-ABL-transformed GMP with abnormal beta-catenin activity can function as leukemic stem cells. (ca.gov)
  • Leveraging a transgenic mouse model of HPV-derived cancers, K14HPV16/H2b, we demonstrated that a potent nanoparticle-based E7 vaccine, but not a conventional "liquid" vaccine, induced E7 tumor antigen-specific CD8 + T cells in cervical tumor-bearing mice. (nih.gov)
  • Here, we illustrated that myeloid cells in K14HPV16/H2b mice possess potent immunosuppressive activity toward antigen-presenting cells and CD8 + T cells, dampening antitumor immunity. (nih.gov)
  • MDSCs from anti-PC mice exhibited increased expression of T cell suppressive factors and effectively inhibited T cell proliferation. (listlabs.com)
  • MDSCs differ from other myeloid cell types in that they have immunosuppressive activities, as opposed to immune-stimulatory properties. (wikipedia.org)
  • Similar to other myeloid cells, MDSCs interact with immune cell types such as T cells, dendritic cells, macrophages and natural killer cells to regulate their functions. (wikipedia.org)
  • Tumor cell lines overexpress colony-stimulating factors (G-CSF and GM-CSF) and IL6, which promote development of MDSCs that have immune suppressive function in vivo. (wikipedia.org)
  • In addition, by releasing S100A8 and S100A9, advanced PDAC lesions cause an expansion of highly immunosuppressive CD33 + CD14 + HLA-DR - monocytic MDSCs expressing low levels of cytotoxic T lymphocyte antigen 4 (CTLA4) on the cell surface. (nih.gov)
  • In addition, MDSCs can react directly with breast cancer cells. (oncotarget.com)
  • In this paper, we describe several ways to recruit MDSCs in breast cancer, including breast cancer cell-derived cytokines and chemokines. (oncotarget.com)
  • MDSCs act on T cells and NK cells to suppress the body's immunity, and via IL-6 trans-signaling, promote breast cancer directly. (oncotarget.com)
  • It is now known that new blood vessels originate from preexisting vessels by activation, proliferation and migration of endothelial cells through a process named "angiogenesis" [ 4 ]. (hindawi.com)
  • Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
  • Although arginase activity has been described in cancer patients, it is thought to originate from tumor cells metabolizing arginine to ornithine needed to sustain rapid cell proliferation. (aacrjournals.org)
  • 13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)
  • In summary, we identify myostatin propeptide as a novel positive regulator of primitive CML cells and corresponding normal hematopoietic cells. (haematologica.org)
  • Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)
  • Chronic myeloid leukemia (CML) is a clonal expansion of the progenitor hematopoietic stem cells arising from the existence of the fusion BCR-ABL oncogene, that represents 15%-20% of the newly diagnosed cases of leukemia patients [ 1 - 2 ]. (jcancer.org)
  • Amongst hematopoietic cells, also macrophages express the MR but, unlike kidney or colon, they do not co-express the enzyme 11β-hydroxysteroid dehydrogenase type II (11β-HSDII). (uni-goettingen.de)
  • Introduction: In the United States, autologous hematopoietic cell transplantation (autoHCT) has fallen out of favor over chemotherapy consolidation for non-high-risk acute myeloid leukemia (AML) when allogeneic hematopoietic cell transplantation (alloHCT) is unfeasible, which is common in racial minorities because of donor registry under-representation and socioeconomic challenges. (elsevierpure.com)
  • The responding samples to H4, displayed increased expression of myeloid markers, a clear decrease in the nuclear-cytoplasmic ratio and the potential of re-activation of the monocytic transcriptional program reducing leukemia propagation in vivo. (lu.se)
  • Cell separation studies showed that the increased arginase activity was limited to a specific subset of CD11b+, CD14−, CD15+ cells with a polymorphonuclear granulocyte morphology and markers, instead of macrophages or dendritic cells described in mouse models. (aacrjournals.org)
  • 1 The BCR-ABL1 fusion protein is a constitutively active tyrosine kinase and triggers a cascade of aberrant downstream signaling pathways leading to clonal outgrowth of CML cells and subsequent disease manifestation. (haematologica.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • In this study we investigated i) the role of CD157 in drug response, and ii) explored the intracellular pathways underlying the functional properties of CD157 in AML cells. (unito.it)
  • Altogether, the myeloid compartment in the TME is heterogenous and varies across tumor types, individuals and tumor stage ( 23 ). (frontiersin.org)
  • Expression of BCR-ABL in these cells reproducibly stimulated myeloid expansion in culture and generated leukemia-initiating cells specifically in the GMP compartment. (ca.gov)
  • 1% of peripheral blood mononuclear cells. (databasefootball.com)
  • Peripheral blood mononuclear cells from 123 patients with metastatic renal cell carcinoma, prior to treatment, were found to have a significantly increased arginase activity. (aacrjournals.org)
  • Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
  • OBJECTIVES: I. Determine whether mixed or full donor chimerism can be safely established in older patients with acute myeloid leukemia (AML) treated with nonmyeloablative conditioning comprised of low dose total body irradiation, followed by allogeneic peripheral blood stem cell transplantation, followed by unrelated donor lymphocyte infusion (DLI). (knowcancer.com)
  • In conclusion, CD45RA contributes to more accurate LSC detection and is recommended for inclusion in stem cell tracking panels. (eur.nl)
  • Acute myeloid leukemia (AML) is generally regarded as a stem cell disease, and it originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity [ 1 , 2 ]. (researchsquare.com)
  • Myelosuppressive drugs (eg, hydroxyurea ), stem cell transplantation, and interferon alfa are also sometimes used. (msdmanuals.com)
  • and myeloid cells are seen in stem cell leukemia/lymphoma (SCLL), which is also known as 8p11 myeloproliferative syndrome (EMS). (medscape.com)
  • Stem cell leukemia/lymphoma (SCLL), which is also known as the 8p11 myeloproliferative syndrome (EMS), is characterized in its typical form by the occurrence, either simultaneously or sequentially, of a bcr/abl-negative myeloproliferative disorder and a lymphoma, usually a precursor T-cell lymphoblastic lymphoma. (medscape.com)
  • The main functional characteristic of these cells is their potent ability to suppress various types of immune responses. (aacrjournals.org)
  • Recently, ten-eleven translocation 2 (TET2), an epigenetic modifier that can suppress pro-inflammatory functions in myeloid cells, was identified as a susceptibility locus for MS. TET2 uniquely oxidizes methylcytosine to 5 hydroxymethylcytosine (5hmC) and facilitates the active demethylation pathway. (listlabs.com)
  • At the opening AACR 2023 plenary session, Ralph DeNardo celebrated the successes of the current, mostly T-cell-based approaches, but also encouraged his colleagues to think more broadly about the antitumor immunity. (bioworld.com)
  • These results established immunosuppressive myeloid cells in lymphoid organs as an HPV + cancer-induced means of circumventing tumor immunity that will require targeted abrogation to enable the induction of efficacious antitumor immune responses. (nih.gov)
  • Hence, myeloid cells play a dual role in cancer as they can initiate antitumor responses and communicate with cells of the adaptive immune system, but also promote local inflammation leading to chronic cancer-associated inflammation ( 5 , 6 ). (frontiersin.org)
  • The innate immune response by myeloid cells occurs as a succession of events starting at signaling through cytosolic or surface PRRs, followed by effector responses including the release of cytokines, reactive oxygen species (ROS), reactive nitrogen species (RNS), antibacterial peptides and degranulation ( Figure 1 ). (frontiersin.org)
  • None of the iMC from the different tumor models suppressed CTL responses in adoptive cell transfer experiments, unless GM-CSF was provided in vivo. (mdc-berlin.de)
  • Understanding the factors that regulate CNS myeloid cell responses could lead to innovative therapeutic strategies for MS treatment. (listlabs.com)
  • The presented data support a role of TAM receptors, and disputes a role of TET2, in controlling myeloid cell responses during EAE. (listlabs.com)
  • Dendritic cells (DCs) serve as professional antigen-presenting cells (APC) bridging innate and adaptive immunity , playing an essential role in triggering specific cellular and humoral responses against tumor and infectious antigens . (bvsalud.org)
  • BCR-ABL-transformed GMP as myeloid leukemic stem cells. (ca.gov)
  • A pro-inflammatory environment is thought to provide a selective advantage for the leukemic stem cells (LSC). (haematologica.org)
  • Under nontumor conditions, these cells provide the first line of protection against pathogens. (hindawi.com)
  • Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
  • Configuration of immunoglobulin and T cell receptor beta and gamma genes in acute myeloid leukaemia: pitfalls in the analysis of 40 cases. (bmj.com)
  • Together, iMC expand independent of the type of anti-tumor response and are not immune-suppressive in a cell-autonomous fashion. (mdc-berlin.de)
  • Our data highlighted a link between HPV-induced cancers, systemic amplification of myeloid cells, and the detrimental effects of myeloid cells on CD8 + T-cell activation and recruitment into the TME. (nih.gov)
  • Intravenous and intranasal pathogenicity tests produced systemic disease with vascular endothelial cell tropism in chickens. (cdc.gov)
  • Therefore, targeting these cells may represent an attractive therapeutic opportunity. (aacrjournals.org)
  • In addition, this cell population might be a novel therapeutic target for AML. (researchsquare.com)
  • Dendritic Cells as a Therapeutic Strategy in Acute Myeloid Leukemia: Vaccines. (bvsalud.org)
  • Consequently, various DC-based antitumor therapeutic strategies have been developed, particularly vaccines , and have been intensively investigated specifically in the context of acute myeloid leukemia (AML). (bvsalud.org)
  • Pathogen clearance is mediated by mechanisms such as phagocytosis, respiratory burst with the production of ROS and RNS and release of bacteriostatic peptides, but also through the cell-extrinsic initiation of inflammation via the release of proinflammatory cytokines and chemokines ( 24 ). (frontiersin.org)
  • Out of the 313 unique human cytokines evaluated, 11 were found to expand cell numbers ≥2-fold in a 7-day culture. (haematologica.org)
  • Figure 1 Survival of acute myeloid leukemia patients (without palliative) according to 1% CD34+CD38- cut-off. (wjgnet.com)
  • OUTLINE: Conditioning: Patients undergo low dose total body irradiation followed by infusion of allogeneic peripheral blood stem cells (PBSC) on day 0. (knowcancer.com)
  • CD45RA is expressed on leukaemic cells in the majority of AML patients. (eur.nl)
  • Additionally, the high levels of the CD45 dim CD34 + CD38 - CD133 + cells in AML patients were an independently significant poor risk factor for overall survival and event free survivals. (researchsquare.com)
  • For examples, Rhenen et al showed that a high percentage of CD34 + CD38 - stem cells at diagnosis significantly correlated with a high minimal residual disease frequency and subsequently to relapse especially after the third course of chemotherapy in AML patients. (researchsquare.com)
  • Une étude a été menée dans des unités de soins intensifs en chirurgie pour adultes de l'hôpital universitaire de Zagazig, (Égypte) auprès de 25 patients atteints de septicémie, de 27 patients atteints d'une septicémie sévère et de 28 témoins. (who.int)
  • Aging and myeloid malignant transformation are characterized by changes in the composition and regulation of HSPCs. (cun.es)
  • Mammalian cells require oxygen and nutrients for their survival and are therefore located within 100 to 200 m of blood vessels, the diffusion limit of oxygen. (hindawi.com)
  • Results Ligation of CD157 by SY11B5 mAb elicited a time- and dose-dependent pro-survival effect, compared to the isotype-matched control mAb, both in fresh AML blasts and cell lines. (unito.it)
  • Previous studies showed that myeloid specific transforming growth factor beta (TGF¿) signaling is essential for tumor metastasis. (nih.gov)
  • In addition, it is also important to exclude other, more specific AML categories (ie, AML with myelodysplasia-related changes, therapy-related myeloid neoplasm, AML with germline predisposition, myeloid proliferations related to Down syndrome) before classifying a condition as AML NOS. (medscape.com)
  • Subsequent studies described a VEGFR2 and AC133 expressing subpopulation of these CD34 positive circulating cells that could form endothelial colonies in vitro [ 14 , 15 ]. (hindawi.com)
  • Flow cytometry can discriminate CD34+CD38- LSC and normal haematopoietic stem cells (HSC) by using aberrant expression of markers and scatter properties. (eur.nl)
  • Therefore, our results suggest that CD45 dim CD34 + CD38 - CD133 + cells in AML might have the potential of leukemia stem cells. (researchsquare.com)
  • Myeloid cells contribute to pathogenesis by producing cytotoxic factors and presenting antigen to encephalitogenic T cells. (listlabs.com)
  • Collectively, these findings contribute to our understanding of the regulation of myeloid cells in neuroinflammation. (listlabs.com)