PulmonaryInfectionBovisIsolatesNontuberculous mycobacteriaAbstractDiagnosis of tuberculosisStrainsGenomeBacteriaPolymerase chain reH37RvAntigenDetectionCausative agent2018SmegmatisVaccineComplexSputumStrainLatentInfectionsMultidrug resistant tuBovine TuberculosisAfricanumClinicalAvium-intracellularePathogenicHumansObligate aerobeSpoligotypeMolecularFortuitumPathogensTreatment of tuberculosisHigh prevalenceHuman TuberculosisProteinBacterialLaboratoryPrevalenceIntracellularBiologyMycobacterial cultureLineageInfectious diseaseInfectsLungsAlveolarExtrapulmonaryMGIT
Pulmonary16
- https://doi.org/10.1016/j. from 93 cases of pulmonary tuberculosis. (cdc.gov)
- In this context, a cohort study was conducted to assess the prevalence of BL strains among pulmonary tuberculosis (PTB) patients in the Kandy district of Sri Lanka (a popular tourist destination) and its association with patients' sociodemographic and clinical characteristics. (hindawi.com)
- Mycobacterium tuberculosis is transmitted in the form of droplet nuclei exhaled by individuals affected with laryngeal/pulmonary TB. (gideononline.com)
- In the present work, the detection of Mycobacterium tuberculosis by the Polymerase Chain Reaction (PCR) was standardized, and the laboratory diagnosis of pulmonary tuberculosis was evaluated comparing baciloscopy, culture and PCR tests. (scielo.br)
- The study was carried out with 117 sputum samples from different patients suspected of having pulmonary tuberculosis, for whom physicians had ordered a baciloscopy test. (scielo.br)
- Early-morning sputum samples were collected from 170 patients referred to the National Tuberculosis Institute in Sana'a city with suspected pulmonary tuberculosis. (who.int)
- Four types of opportunistic mycobacterial disease of humans have been described: skin lesions (following traumatic inoculation of bacteria), localized lymphadenitis, tuberculosis (TB)-like pulmonary lesions and disseminated disease [5]. (who.int)
- The human microbiota in pulmonary tuberculosis: Not so innocent bystanders. (ac.ir)
- In the United States, pulmonary tuberculosis accounts for most tuberculosis cases. (medscape.com)
- As in pulmonary tuberculosis, antituberculous chemotherapy has become the standard of care for scrofula, and newer diagnostic techniques (eg, fine-needle aspiration) have replaced more invasive methods of tissue harvesting. (medscape.com)
- However, M. tuberculosis prefers tissues with high levels of oxygen , hence, pulmonary tuberculosis has the highest rate. (wikidoc.org)
- Tuberculosis preventive therapy (TPT) offered to children who come into contact with infectious adult pulmonary tuberculosis (TB) cases is an important childhood TB prevention strategy. (who.int)
- We report a rare case of pulmonary tuberculosis (TB) secondary to M. africanum in a man in Brunei Darussalam who had lived and worked in Guinea, West Africa for 6 years more than 20 years ago. (who.int)
- Initial infections that are not contained may cause either progressive local disease (primary progressive pulmonary tuberculosis), or may disseminate hematogenously to seed other organs such as kidney, CNS, or bones, occasionally causing miliary tuberculosis. (medscape.com)
- Primary pulmonary tuberculosis results from initial infection with tubercle bacilli. (medscape.com)
- Pulmonary lesions progress to tuberculous pneumonia, cavitate, and can shed tubercle bacilli into bloodstream and result in miliary tuberculosis. (medscape.com)
Infection22
- No. The Cooperative State-Federal Tuberculosis Eradication Program, including the U.S. Department of Agriculture, state animal health agencies, and U.S. livestock producers, has nearly eliminated M. bovis infection from cattle in the United States. (cdc.gov)
- M. tuberculosis causes TB and is a highly contagious respiratory infection, primarily affecting the lungs. (medicalnewstoday.com)
- One of the most significant developments in the diagnosis of tuberculosis (TB) infection has been the introduction of whole-blood based interferon-γ release assays (IGRAs) [ 1 - 3 ]. (ersjournals.com)
- Isoniazid Therapy for Mycobacterium Tuberculosis Infection in HIV Clinics, Los Angeles, California. (aidshealth.org)
- Different Mycobacterium tuberculosis (M.tb) infection phase-dependent antigens may be differentially recognized in infected and diseased individuals and therefore useful as diagnostic tools for differentiating between M.tb infection states. (biomedcentral.com)
- The identification of antigens able to differentiate tuberculosis (TB) disease from TB infection would be valuable. (pasteur.fr)
- Thus, CD4 T cell assist performs a vital function in producing protecting CD8 T cell responses towards M. tuberculosis an infection in vitro and in vivo. (tbdb.org)
- In 2017, the Korean authorities launched an unprecedentedly large-scaled latent tuberculosis an infection (LTBI) screening venture which lined greater than one million people in congregate settings. (tbdb.org)
- The test is performed when the doctor suspects tuberculosis or other mycobacterium infection. (medlineplus.gov)
- Cervical tuberculosis is usually a result of an infection in the lymph nodes, known as lymphadenitis. (medscape.com)
- Surgery alone in M tuberculosis infection has had disappointing results and is plagued by a high rate of recurrence and fistulizations. (medscape.com)
- Advanced cavitary disease and the presence of high numbers of M. tuberculosis in expectorated sputum is associated with transmission [ 7 ] but it is not known how early in the infection that patients pose a significant risk of infecting others. (biomedcentral.com)
- It is intended for diagnosing and monitoring of patients related to infection by M. tuberculosis and other Mycobacteria. (mytaq.com)
- To probe the role of the nrp gene in infection, we generated an nrp deletion mutant in M. tuberculosis H37Rv and tested its virulence in immunocompetent (C57BL/6) mice. (elsevierpure.com)
- Mice infected with the mutant strain also survived for twice as long as those infected with wild-type M. tuberculosis and, remarkably, showed subdued pathology, despite similar bacterial loads at later stages of infection. (elsevierpure.com)
- The symptoms in humans are usually restricted to skin and soft tissue destruction in most instances of Mycobacterium marinum infection via small purple lesions that can gradually grow. (aquarium-pond-answers.com)
- Background: Zoonotic tuberculosis is defined as human infection with Mycobacterium bovis. (psu.edu)
- Cholesterol, a four-ringed steroid with an alkyl side chain, is an important growth substrate for Mycobacterium tuberculosis (Mtb) during infection. (ubc.ca)
- This article reviews the dermatologic manifestations of Mycobacterium avium-intracellulare (MAI, or MAC) infection. (medscape.com)
- In the United States, Mycobacterium avium-intracellulare (MAI, or MAC) infection is considered a nonreportable infectious disease. (medscape.com)
- It is important to consider cutaneous infection with Mycobacterium avium-intracellulare (MAI, or MAC) in patients with antibiotic-resistant cellulitis, nonhealing nodules, and ulcers, as well as in patients who are immunosuppressed with evidence of disseminated MAI (DMAI) infection. (medscape.com)
- Data on skin and soft-tissue infection caused by nontuberculous mycobacteria in Taiwan (1997-2008) suggest that MAI is an important pathogen. (medscape.com)
Bovis10
- In 2019, M. tuberculosis was found in a genetically related complex group of Mycobacterium species called Mycobacterium tuberculosis complex that has at least 9 members: M. tuberculosis sensu stricto M. africanum M. canetti M. bovis M. caprae M. microti M. pinnipedii M. mungi M. orygis It requires oxygen to grow, and is nonmotile. (wikipedia.org)
- However, as with M. tuberculosis , not everyone infected with M. bovis becomes sick. (cdc.gov)
- M. bovis is treated similarly to M. tuberculosis . (cdc.gov)
- In fact, healthcare providers might not know that a person has M. bovis instead of M. tuberculosis . (cdc.gov)
- In this context, we are interested in M. tuberculosis and M. bovis transmission between livestock to human. (jcvi.org)
- IGRAs are endowed with great specificity, as the antigens used are almost exclusively expressed by the Mycobacterium tuberculosis (MTB) complex, but not Mycobacterium bovis bacille Calmette-Guerin (BCG) [ 1 - 3 ]. (ersjournals.com)
- The results of isolation and identification using conventional culture method (Lowenstein- Jensen medium) were 22 mycobacterial isolates (75.9%), 20 (68.97%) Mycobacterium bovis and 2 (6.9%) unidentified slow growth. (ajol.info)
- M. tuberculosis is one of the Mycobacterium tuberculosis complex, which also includes bacteria , such as M. bovis and M. africanum. (wikidoc.org)
- Overexpression of Rv0494 in Mycobacterium bovis BCG reduced the basal level expression of kas operon genes, thereby suggesting the repressor nature of this protein in fatty acid synthase II regulation. (microbiologyresearch.org)
- Interpretation: M bovis prevalence in humans is an inadequate proxy of zoonotic tuberculosis. (psu.edu)
Isolates9
- 1. Allix-Béguec C, Harmsen D, Weniger T, Supply P, Niemann S. Evaluation and strategy for use of MIRU-VNTRplus, a multifunctional database for online analysis of genotyping data and phylogenetic identification of Mycobacterium tuberculosis complex isolates. (cdc.gov)
- Tuberculosis (TB) is one of the major causes of death related to antimicrobial resistance worldwide because of the spread of Mycobacterium tuberculosis multi- and extensively drug resistant (multi-drug resistant (MDR) and extensively drug-resistant (XDR), respectively) clinical isolates. (frontiersin.org)
- To this aim, in this work an in vitro generation of M. tuberculosis mutants resistant to BDQ was performed starting from two MDR clinical isolates as parental cultures. (frontiersin.org)
- The two M. tuberculosis MDR clinical isolates were firstly characterized by whole genome sequencing, finding the main mutations responsible for their MDR phenotype. (frontiersin.org)
- Of the 120 isolates analysed, 118 (98.3%) were identified as M. tuberculosis complex and 2 (1.7%) were identified as mycobacteria other than M. tuberculosis. (who.int)
- The results showed that those 2 isolates were multi-drug resistant and the DNA sequencing analysis showed that the alignment of nucleic acid of DNA in isolates of mycobacteria other than M. tuberculosis was different from that of M. tuberculosis complex. (who.int)
- 8. Gong Z, Wang G, Zeng J, Stojkoska A, Huang H, Xie J. Differential DNA methylomes of clinical MDR, XDR and XXDR Mycobacterium tuberculosis isolates revealed by using single-molecule real-time sequencing. (ac.ir)
- Isolates identified as MTBC other than M tuberculosis or as inconclusive on PCR were subject to whole-genome sequencing (WGS), and phylogenetically compared with publicly available MTBC sequences from south Asia. (psu.edu)
- Four isolates of cattle origin were dispersed among human sequences within M tuberculosis lineage 1, and the seven M orygis isolates from human MGIT cultures were dispersed among sequences from cattle. (psu.edu)
Nontuberculous mycobacteria2
- In contrast, the MAC consists of several nontuberculous mycobacterial species, known as nontuberculous mycobacteria (NTM). (medicalnewstoday.com)
- 2014). Distinguishing Nontuberculous Mycobacteria from Multidrug-Resistant Mycobacterium tuberculosis, China. (cdc.gov)
Abstract2
- ABSTRACT This study was done to characterize at the species level Mycobacterium spp. (who.int)
- ABSTRACT This research compared the numbers and types of different Mycobacterium species in soil samples taken from 2 areas of Golestan province, Islamic Republic of Iran, 1 with a high prevalence of tuberculosis and 1 with a low prevalence. (who.int)
Diagnosis of tuberculosis4
- These compounds have the potential to be used as antimicrobials or in the diagnosis of tuberculosis. (ejbiotechnology.info)
- The diagnosis of tuberculosis (TB) disease remains a challenge in resource-limited settings. (biomedcentral.com)
- 2. Isaza R, Ketz C. A trunk wash technique for the diagnosis of tuberculosis in elephants. (vin.com)
- Six patients provided apparent false positive breathalyzer results that did not correlate with a diagnosis of tuberculosis. (biomedcentral.com)
Strains6
- Here we report that members of the family, ivermectin, selamectin, and moxidectin, are bactericidal against mycobacterial species, including multidrug-resistant and extensively drug-resistant clinical strains of Mycobacterium tuberculosis. (nih.gov)
- In this context, we undertook a study in Kandy (a popular tourist destination) with the aim of understanding the prevalence, patient characteristics, and treatment outcomes associated with BL strains among tuberculosis patients in Kandy, Sri Lanka. (hindawi.com)
- Furthermore, several M. tuberculosis BDQ resistant mutants were isolated by both MDR strains, harboring mutations in both atpE and Rv0678 genes. (frontiersin.org)
- tuberculosis strains to better understand transmission among persons deprived of liberty (PDL) in Rio Grande do Sul (RS), southern Brazil. (medworm.com)
- A total of 598 M. tuberculosis strains were genotyped, and 37.5% were grouped into 53 clusters. (medworm.com)
- Strategies for its control may be not as effective as it should be, specifically in case of resistant strains of Mycobacterium tuberculosis ( M.tb . (ac.ir)
Genome9
- The M. tuberculosis genome was sequenced in 1998. (wikipedia.org)
- the complete genome sequence of Mycobacterium tuberculosis continues to provide an invaluable resource to understand tuberculosis (TB), the leading cause of global infectious disease mortality. (jci.org)
- At the 25-year anniversary of this accomplishment, we describe how insights gleaned from the M. tuberculosis genome have led to vital tools for TB research, epidemiology, and clinical practice. (jci.org)
- Whole-genome sequencing (WGS) of M. tuberculosis and related mycobacteria is now routine, allowing comparisons across time and space. (jci.org)
- The M. tuberculosis genome has ushered in a quarter century of substantial clinical and public health advancements. (jci.org)
- The second half was subjected to a qPCR targeting IS1081 of the M. tuberculosis complex genome. (vin.com)
- Genetic variations in the M. tuberculosis genome lead to important phenotypical changes. (wikidoc.org)
- 1998 ). Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. (microbiologyresearch.org)
- The Mycobacterium tuberculosis genome harbors a nonribosomal peptide synthase gene, nrp, which is part of a gene cluster proposed to be involved in the biosynthesis of isonitrile lipopeptides. (elsevierpure.com)
Bacteria15
- Mycobacterium tuberculosis (M. tb), also known as Koch's bacillus, is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis. (wikipedia.org)
- Compared to other commonly studied bacteria, M. tuberculosis has a remarkably slow growth rate, doubling roughly once per day. (wikipedia.org)
- The slices of the Mycobacterium tuberculosis analyzed under a scanning electron microscope by a Japan-based research group has revealed that bacteria is about 2.71 ± 1.05μm in length with an average diameter of the cell approximately 0.345 ± 0.029 μm. (wikipedia.org)
- Mycobacterium tuberculosis (MTB) and Mycobacterium avium complex (MAC) are two distinct types of bacteria that can cause infections in the lungs and other parts of the body. (medicalnewstoday.com)
- Seven lineages of Mycobacterium tuberculosis (MTB), the bacteria that causes "Tuberculosis" (TB), have been identified till date [ 1 ]. (hindawi.com)
- The most common acid-fast staining method for M. tuberculosis is the Ziehl-Neelsen stain method, in which a bacteria specimen is fixed, stained with carbol-fuchsin dye, and decolorized with an acid-alcohol mixture. (gideononline.com)
- Contact with different species of environmental Mycobacterium can cause acquired immunity to M. tuberculosis or increase the efficacy of BCG vaccine protection (M. vaccae, M. microti), although some species of these bacteria reduce the efficacy of BCG vaccine (M. scrofulaceum) [8,10-13]. (who.int)
- Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. (ac.ir)
- Sputum stain for mycobacteria is a test to check for a type of bacteria that cause tuberculosis and other infections. (medlineplus.gov)
- Computer-generated image of a cluster of rod-shaped drug-resistant Mycobacterium tuberculosis bacteria. (wikidoc.org)
- Fish Tuberculosis is generally caused by Mycobacterium marinum , a bacterium closely related to the human TB (Tuberculosis) bacteria, Mycobacterium tuberculosis , although incidents of Mycobacterium triplex have also been reported with Bettas. (aquarium-pond-answers.com)
- Despite some internet claims, based on my many years of "house calls" and other professional aquarium maintenance work has shown Fish "TB" to be relatively uncommon with the exception of cases where the bacteria has been passed around and the fish' immune system has been compromised, this is especially the case with recently confirmed Mycobacterium triplex . (aquarium-pond-answers.com)
- Generally when the Mycobacterium marinum bacteria infects humans it is a dermatological issue as the bacterium usually enter the skin via small abrasions or cuts when you are performing aquarium maintenance. (aquarium-pond-answers.com)
- The immune response against 85A protects against tuberculosis, as it primes the immune system to target the TB-causing bacteria. (thenakedscientists.com)
- Using a variety of approaches, I elucidated key aspects of cholesterol catabolism in Mtb and other bacteria, particularly with respect to 3aα-H-4α(3'-propanoate)-7aβ-methylhexahydro-1,5-indane-dione (HIP), a metabolite that contains the last two steroid rings (C/D). Chapter 2 demonstrates that the first two steroid rings (A/B) are degraded prior to the side chain in mycobacteria and rhodococci. (ubc.ca)
Polymerase chain re5
- The most frequently used diagnostic methods for tuberculosis are the tuberculin skin test, acid-fast stain, culture, and polymerase chain reaction. (wikipedia.org)
- The aim of this study was to collect prospectively tissue from patients with sarcoidosis in whom tuberculosis had been excluded, and to use polymerase chain reaction (PCR) to search for DNA sequences specific for MTb. (bmj.com)
- In addition, the opportunity to compare and potentially validate a direct real-time polymerase chain reaction (qPCR) method to detect Mycobacterium tuberculosis (Mtb) DNA in TW samples with standard mycobacterial culture methods for TW samples was undertaken. (vin.com)
- The high sensitivity of amplification by polymerase chain reaction requires the specimen to be processed in an environment in which contamination of the specimen by Mycobacterium tuberculosis DNA is unlikely. (testcatalog.org)
- It comprises less than 10% berculosis was confirmed at the time by of all perianal diseases and 0.7% of all polymerase chain reaction to amplify poly- tuberculosis cases [ 1 ]. (who.int)
H37Rv1
- The most potent antimycobacterial demonstrated a minimum inhibitory concentration (MIC99) of 9.6 μM against Mycobacterium tuberculosis H37Rv. (uwc.ac.za)
Antigen3
- Mycobacterium tuberculosis (MTb) has long been a likely contender as the inciting antigen in sarcoidosis, although Koch's postulates have never been fulfilled. (bmj.com)
- The 38 kDa protein is a serious antigen of mycobacterium tuberculosis and has been broadly utilized in TB serodiagnosis, on account of its extremely sensitivity and specificity. (tbdb.org)
- We describe a novel device that utilizes immunosensor and bio-optical technology to detect M. tuberculosis antigen (Ag85B) in cough and demonstrate its use under field conditions during a pilot study in an area of high TB incidence. (biomedcentral.com)
Detection8
- Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. (cdc.gov)
- Simultaneous drug resistance detection and genotyping of Mycobacterium tuberculosis using a low-density hydrogel microarray. (cdc.gov)
- We isolated 315 fungal types, which represented 85 morphologies, from different parts of P. aduncum L. The bioassays were performed on 82 culture filtrates and 6 plant extracts and resulted in the detection of 1 culture filtrate that stimulated the growth of M. tuberculosis and 15 that inhibited microbial growth. (ejbiotechnology.info)
- The mean time for detection of Mycobacteria was 17.8 ± 0.9 days and 46.5 ± 0.4 days for BACTEC MGIT 960 TM system and Lowenstein-Jensen medium, respectively while the contamination rate with BACTEC MGIT 960 TM system was 6.9% and 10.3% in Lowenstein-Jensen medium. (ajol.info)
- We used lymphoproliferation, ELISpot IFN-gamma, cytokine production assays and detection of specific human antibodies against recombinant M. tuberculosis proteins. (pasteur.fr)
- This test is not intended for the detection of latent tuberculosis and must not be used as a substitute for tests intended for detection of latent tuberculosis such as the tuberculin skin test or an interferon gamma release assay. (testcatalog.org)
- Description: This kit is anenzyme-linked immunosorbent assay for qualitative detection of IgG antibodies to Mycobacterium tuberculosis in human serum or plasma. (mytaq.com)
- Description: The Mycobacterium tuberculosis IgG antibody ELISA kit has been designed for the detection andthe quantitative determination of specific IgG antibodies against Mycobacterium tuberculosis in serum and plasma. (mytaq.com)
Causative agent2
- Mycobacterium tuberculosis (M. tuberculosis) is the causative agent of tuberculosis (TB) , a global health concern and leading cause of death. (medicalnewstoday.com)
- Mycobacterium tuberculosis , the causative agent is spread from person to person via infected aerosols created by patients with respiratory forms of the disease. (biomedcentral.com)
20183
- According to the World Health Organization (WHO) report, in 2018, tuberculosis (TB), caused by Mycobacterium tuberculosis , was one of the major causes of death related to antimicrobial resistance ( World Health Organization [WHO], 2019a ). (frontiersin.org)
- tuberculosis isolated from PDL, stored at the Central Laboratory of RS, in the period from 2013 to 2018. (medworm.com)
- Methods: We did a molecular epidemiological surveillance study of 940 positive mycobacteria growth indicator tube (MGIT) cultures, collected from patients visiting the outpatient department at Christian Medical College (Vellore, India) with suspected tuberculosis between Oct 1, 2018, and March 31, 2019. (psu.edu)
Smegmatis3
- Here we report the first structure of a full-length CoaBC, from the model organism Mycobacterium smegmatis , describe how it is organised as a dodecamer and regulated by CoA thioesters. (nature.com)
- PBPA from Mycobacterium tuberculosis is a class B-like penicillin-binding protein (PBP) that is not essential for cell growth in M. tuberculosis, but is important for proper cell division in Mycobacterium smegmatis. (rcsb.org)
- Furthermore, heterologous expression of M. tb PpiA and PpiB in Mycobacterium smegmatis increased bacterial survival in THP-1 cells as compared to those transformed with the vector control . (bvsalud.org)
Vaccine2
- A new study has shown that a breakthrough vaccine against tuberculosis may be more effective when given alone, rather than alongside other vaccines. (thenakedscientists.com)
- 2011. 'Immunogenicity of the Tuberculosis Vaccine MVA85A Is Reduced by Coadministration with EPI Vacci. (thenakedscientists.com)
Complex11
- We analyzed 98 Mycobacterium tuberculosis complex platform to enhance SARS-CoV-2 testing capacity. (cdc.gov)
- tuberculosis complex based on colony phenotype. (cdc.gov)
- Profiles of expression of the antimicrobial activities of LVFX, KRM-1648 (KRM), and CAM against M. tuberculosis (MTB) and M. avium complex (MAC) residing in MONO-MAC-6 human macrophage like cells (MM6-M phi s) and A-549 human type II alveolar pneumocyte cells (A-549 cells) were determined. (nih.gov)
- For PCR, DNA was amplified with a specific pair of primers to the M. tuberculosis complex, with a resulting product of 123 bp from the insertion element IS6110. (scielo.br)
- Among six samples with positive results in culture, one was identified by PCR-RFLP as belonging to the M. tuberculosis complex and one was identified as a non-tuberculosis mycobacteria. (scielo.br)
- There are currently 71 recognized or proposed species of Mycobacterium [1], all of which, except M. tuberculosis complex and M. leprae, are considered as environmental mycobacteria and can usually be isolated from environmental samples including water, soil and dust [2]. (who.int)
- This study was aimed to evaluate the recent technique (BACTEC MGIT 960 TM system) for screening of Mycobacterium tuberculosis complex among cattle in Egypt. (ajol.info)
- Reports of the clinical efficacy of clarithromycin in patients with acquired immunodeficiency syndrome (AIDS) and Mycobacterium avium-intracellulare (MAI) complex have prompted its use in NTM lymphadenitis. (medscape.com)
- Mycobacterium tuberculosis belongs to the Mycobacterium tuberculosis complex. (wikidoc.org)
- The aim of this study was to obtain estimates of the human prevalence of animal-associated members of the Mycobacterium tuberculosis complex (MTBC) at a large referral hospital in India. (psu.edu)
- Sputum culture grew Mycobacterium avium complex. (medscape.com)
Sputum1
- Furthermore, the dependence of most of these tests on sputum implies that they are not suitable for patients with difficulties in providing good quality sputum samples such as children, extrapulmonary TB cases, or in cases where the sputum itself is negative (for example, many patients with HIV- Mycobacterium tuberculosis (M.tb) co-infections). (biomedcentral.com)
Strain1
- A) Section of the variable- number tandem-repeat-based dendrogram of the Latin-American-Mediterranean family of Mycobacterium tuberculosis RD-Rio strain with enlarged branch including SIT20 strain from Kazakhstan. (cdc.gov)
Latent3
- Latent TB represents the condition where the body's immune system restricts the growth of M . tuberculosis bacterium, making the individual appear asymptomatic [10]. (gideononline.com)
- Infections initially contained by host defenses (latent tuberculosis) may, at a later time, in the face of immunosuppression, reactivate to cause either progressive local disease or disseminate. (medscape.com)
- Reactivation of latent M tuberculosis is seen in the subapical posterior lung segments and is likely due to high pO2 concentration and limited lymphatic drainage. (medscape.com)
Infections1
- Today, approximately 95% of mycobacterial cervical infections in adults are caused by Mycobacterium tuberculosis, and the remainder are caused by atypical mycobacterium, or nontuberculous mycobacterium (NTM). (medscape.com)
Multidrug resistant tu1
- Multidrug-resistant tuberculosis (MDR) continues to pose a threat to public health. (mdpi.com)
Bovine Tuberculosis3
- Bovine tuberculosis remains a disease of economic and public health importance in developing countries. (ajol.info)
- Although globally, India has the largest number of human tuberculosis cases and the largest cattle population, in which bovine tuberculosis is endemic, the burden of zoonotic tuberculosis is unknown. (psu.edu)
- The identification of M tuberculosis in cattle also reinforces the need for One Health investigations in countries with endemic bovine tuberculosis. (psu.edu)
Africanum1
- Mycobacterium africanum is endemic to West Africa and is rare outside this region. (who.int)
Clinical5
- Patients were enrolled in the study if they fulfilled previously accepted clinical diagnostic criteria, 15 had evidence of non-caseating granulomas on biopsy specimens, a negative Mantoux test, and negative MTb cultures with no prior history of tuberculosis. (bmj.com)
- To fight MDR and XDR tuberculosis, three new antitubercular drugs, bedaquiline (BDQ), delamanid, and pretomanid were approved for use in clinical setting. (frontiersin.org)
- Shete PB, Cattamanchi A, Yoon C. Tuberculosis: clinical manifestations and diagnosis. (medlineplus.gov)
- We recommend studies be undertaken to determine the diagnostic sensitivity and specificity of the device when compared to microbiological and clinical indicators of tuberculosis disease. (biomedcentral.com)
- For clinical aspects of the disease, see Tuberculosis . (wikidoc.org)
Avium-intracellulare1
- See also Mycobacterium Avium-Intracellulare . (medscape.com)
Pathogenic1
- Orthologous clusters are found in other slow-growing pathogenic mycobacteria and actinomycetes. (elsevierpure.com)
Humans3
- Humans are the only known reservoirs of M. tuberculosis. (wikipedia.org)
- Cellular and humoral immune responses to Erp (Exported repetitive protein)-a recently identified M. tuberculosis protein-have not yet been investigated in humans and may contribute to this aim. (pasteur.fr)
- The recovery of M orygis from humans highlights the need to use a broadened definition, including MTBC subspecies such as M orygis, to investigate zoonotic tuberculosis. (psu.edu)
Obligate aerobe2
- Mycobacterium tuberculosis is an obligate aerobe, non-spore-forming, slender rod. (medscape.com)
- M. tuberculosis is an obligate aerobe , non-encapsulated , non-motile , acid-fast bacillus . (wikidoc.org)
Spoligotype3
- Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family. (cdc.gov)
- Human IgG antibody Laboratories manufactures the mycobacterium tuberculosis spoligotype spacers reagents distributed by Genprice. (mytaq.com)
- The Mycobacterium Tuberculosis Spoligotype Spacers reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (mytaq.com)
Molecular2
- SITVITWEB--a publicly available international multimarker database for studying Mycobacterium tuberculosis genetic diversity and molecular epidemiology. (cdc.gov)
- Molecular typing of Mycobacterium spp. (who.int)
Fortuitum3
- An antigenic analysis of the mycobacteria, Mycobacterium fortuitum, Myco. (eurekamag.com)
- The most common species isolated were Mycobacterium fortuitum, M. flavescens and M. chelonae. (who.int)
- Les espèces les plus couramment isolées étaient Mycobacterium fortuitum, M. flavescens et M. chelonae. (who.int)
Pathogens2
- Coenzyme A (CoA) is a fundamental co-factor for all life, involved in numerous metabolic pathways and cellular processes, and its biosynthetic pathway has raised substantial interest as a drug target against multiple pathogens including Mycobacterium tuberculosis . (nature.com)
- One very important application of this work is investigating how pathogens like Mycobacterium tuberculosis (Mtb) respond to antibiotics, as this helps inform how Mtb develops antimicrobial resistance or drug resistance. (seattlechildrens.org)
Treatment of tuberculosis2
- Preliminary report of side effects associated with drugs used in the treatment of tuberculosis in elephants. (vin.com)
- Mycobacterium tuberculosis has developed extensive resistance to numerous antimycobacterial agents used in the treatment of tuberculosis. (uwc.ac.za)
High prevalence1
- The frequencies of environmental Mycobacterium in the low-prevalence area were much higher than in the high-prevalence area, perhaps due to different environmental factors. (who.int)
Human Tuberculosis1
- Description: Enzyme-linked immunosorbent assay kit for quantification of Human tuberculosis (TB) antibody ( IgG) in samples from serum, plasma, tissue homogenates and other biological fluids. (mytaq.com)
Protein3
- The biosynthesis of CoA is performed in five steps, with the second and third steps being catalysed in the vast majority of prokaryotes, including M. tuberculosis , by a single bifunctional protein, CoaBC. (nature.com)
- This is the first report, to the best of our knowledge, of a GntR/FadR family protein acting as a fatty acid-responsive transcriptional regulator in M. tuberculosis , suggesting a possible role for this protein in mycolic acid biosynthesis. (microbiologyresearch.org)
- The so-called 'Modified Vaccinia virus Ankara', or MVA, was then manipulated genetically to express a protein found on Mycobacterium tubercolosis , called 85A. (thenakedscientists.com)
Bacterial2
- In contrast, the MAC consists of several related bacterial species, including Mycobacterium avium ( M. avium ) and Mycobacterium intracellulare ( M.intracellulare ), which are widespread in the environment. (medicalnewstoday.com)
- M tuberculosis is a nonmotile, aerobic, intracellular bacterial pathogen measuring. (medscape.com)
Laboratory1
- M. tuberculosis can be grown in the laboratory. (wikipedia.org)
Prevalence1
- Statistics indicate an increase in the prevalence and isolation of cervical lymphadenitis caused by NTM, far outnumbering tuberculosis as the cause of chronic cervical adenitis in children. (medscape.com)
Intracellular3
- Mycobacterium tuberculosis ( M. tuberculosis ), a non-motile, obligately aerobic, intracellular bacterium known to cause Tuberculosis (TB), was discovered by Robert Koch in 1882 [1]. (gideononline.com)
- Insufficient intracellular accumulation of active moieties allows for selective survival of mycobacteria with drug resistance mutations and accordingly promotes the development of microbial drug resistance. (uwc.ac.za)
- Mycobacterium tuberculosis Peptidyl-Prolyl Isomerases Are Immunogenic, Alter Cytokine Profile and Aid in Intracellular Survival. (bvsalud.org)
Biology1
- Biology and bacteriology of mycobacteria / by Abolhassan Zia Zarifi. (who.int)
Mycobacterial culture2
- Routine mycobacterial culture of trunk wash (TW) samples yielded Mycobacteria tuberculosis organisms from a 45-yr-old female Asian elephant, Elephas maximus . (vin.com)
- If your facility is unable to perform mycobacterial culture, order CTB / Mycobacteria and Nocardia Culture, Varies concurrently with this test. (testcatalog.org)
Lineage1
- Is International Travel an Emerging Issue on Transmission of Beijing Lineage Mycobacterium tuberculosis? (hindawi.com)
Infectious disease3
- Tuberculosis (TB) is the most prevalent and deadly infectious disease worldwide and remains a global epidemic. (nature.com)
- Tuberculosis is the oldest documented infectious disease. (medscape.com)
- Tuberculosis is a highly infectious disease that is spread from person to person by infected aerosols emitted by patients with respiratory forms of the disease. (biomedcentral.com)
Infects1
- Tuberculosis (TB) an infectious illness brought on by Mycobacterium tuberculosis (Mtb), infects the lungs' alveolar surfaces by the aerosol droplets. (tbdb.org)
Lungs1
- When in the lungs, M. tuberculosis is phagocytosed by alveolar macrophages, but they are unable to kill and digest the bacterium. (wikipedia.org)
Alveolar1
- [ 1 ] The granulomas of tuberculosis (see the first image below) are necrotizing and non-necrotizing, with involvement of lung parenchyma leading to peribronchial, perivascular, interstitial and alveolar granulomas and occasionally leading to exudative tuberculous granulomatous pneumonia (see the second image below). (medscape.com)
Extrapulmonary4
- Extrapulmonary tuberculosis, such as scrofula, is observed most often in individuals who are immunocompromised. (medscape.com)
- Involvement of the perianal region in tu- men from the anal ulcer was positive for berculosis is a rare extrapulmonary form acid-fast bacilli and Mycobacterium tub of this disease. (who.int)
- from Madagascar, 14% of 64 patients with Abdominal sonography showed mul- extrapulmonary tuberculosis had tubercular tiple lymphadenopathies in the para-aor- anal fistula [ 3 ]. (who.int)
- Although extrapulmonary tuberculosis splenomegaly was seen as well. (who.int)
MGIT1
- The BACTEC MGIT 960 TM system was used for recovery of Mycobacteria and compared with conventional culture method (Lowenstein-Jensen medium). (ajol.info)