BovineCattleVaccinationHumansStrain of Mycobacterium bovisCausative agentBacillus calmetLepraeAviumAfricanumZoonotic tuberculosisStrainsIntracellularAF2122IsolatesAntigensImmunityAbstractLeprosyInfectionsBacteriaMacrophageEnvironmental mycobacteriaHuman tuberculosisAssayCauses tuberculosisTuberculosis vaccineMacrophagesSpeciesAntigenPerson-to-person transmissComplexCapraePrevalenceDiseaseCytokineVitroBacilliChelonaeTissuesIsolatePulmonary TuberculosisImmuneMelesPatientsProteinCitationDistinct
Bovine15
- Mycobacterium bovis is a slow-growing (16- to 20-hour generation time) aerobic bacterium and the causative agent of tuberculosis in cattle (known as bovine TB). (wikipedia.org)
- A Mexican study found that a high proportion of human TB cases were due to M. bovis in an endemic area of bovine TB (Pérez-Guerrero et al. (scielo.br)
- This term was created for, but is not limited in use to, the submitter's Bovigam Mycobacterium bovis Gamma Interferon Test Kit for Cattle, a blood-based in vitro laboratory test for bovine tuberculosis. (loinc.org)
- Mycobacterium bovis (aka Bovine TB) is a slow growing aerobic bacterium closely related to Mycobacterium tuberculosis and is a significant zoonotic disease concern especially among those who consume raw milk. (loinc.org)
- Mycobacterium bovis belongs to the Mycobacterium tuberculosis complex and is the main pathogen causing bovine tuberculosis. (researchsquare.com)
- Mycobacterium bovis is the causative agent of bovine tuberculosis (BTB), the pathogen responsible for serious economic impact on the livestock sector. (fiocruz.br)
- We report here an update to the reference genome sequence of the bovine tuberculosis bacillus Mycobacterium bovis AF2122/97, generated using an integrative multiomics approach. (pacb.com)
- The specific focus of this thesis was to enable a stronger understanding of the bovine immune response over different periods of M. bovis infection and to apply this new knowledge in evaluating the efficacy of a novel BCG vaccination. (herts.ac.uk)
- Interferon gamma (IFN-γ), tumour necrosis factor alpha (TNF-α), interleukin (IL) 4 and 10 expression were analysed using quantitative (q) PCR in formalin fixed bovine lymph nodes following five, twelve and nineteen weeks of M. bovis infection. (herts.ac.uk)
- Mycobacterium bovis, the causative agent of bovine tuberculosis is known to persist within granulomas, distinct lesions represented by a caseonecrotic core surrounded by epithelioid macrophages, T-lymphocytes, B-lymphocytes, Langhans-type multinucleated giant cells and fibroblasts. (usda.gov)
- Comparative 'omics analyses differentiate Mycobacterium tuberculosis and Mycobacterium bovis and reveal distinct macrophage responses to infection with the human and bovine tubercle bacilli. (ox.ac.uk)
- To explore MTBC host tropism, we present in-depth profiling of the MTBC reference strains M. bovis AF2122/97 and M. tuberculosis H37Rv at both the global transcriptional and the translational level via RNA-sequencing and SWATH MS. Furthermore, a bovine alveolar macrophage infection time course model was used to investigate the shared and divergent host transcriptomic response to infection with M. tuberculosis H37Rv or M. bovis AF2122/97. (ox.ac.uk)
- A divergent transcriptional response was observed between M. tuberculosis H37Rv and M. bovis AF2122/97 infection of bovine alveolar macrophages, in particular cytosolic DNA-sensing pathways at 48 h post-infection, and highlights a distinct engagement of M. bovis with the bovine innate immune system. (ox.ac.uk)
- Mycobacterium bovis is the causative agent of bovine tuberculosis, a disease that is increasing in incidence in United Kingdom cattle herds. (ox.ac.uk)
- Other zoonotic diseases such as rabies, brucellosis and bovine tuberculosis (caused by Mycobacterium bovis ) have been controlled or eliminated in several industrialized countries, but remain endemic in developing regions. (who.int)
Cattle17
- Although information from many M. bovis , and cattle are the major reservoir ( 2 , 3 ). (cdc.gov)
- M. bovis is most commonly found in cattle and other animals such as bison, elk, and deer. (cdc.gov)
- M. bovis transmission from cattle to people was once common in the United States. (cdc.gov)
- No. The Cooperative State-Federal Tuberculosis Eradication Program, including the U.S. Department of Agriculture, state animal health agencies, and U.S. livestock producers, has nearly eliminated M. bovis infection from cattle in the United States. (cdc.gov)
- Cattle infected with Mycobacterium bovis spoligotype 9 were treated with Isoniazid (INH) from three to 14 weeks post infection, rested for four weeks to allow INH depletion and then challenged with M. bovis spoligotype 35. (aber.ac.uk)
- Mycobacterium bovis, one of several mycobacteria of the M. tuberculosis complex, is a global zoonotic pathogen that primarily infects cattle. (lvhn.org)
- To examine temporal changes in granuloma development, 32 cattle were inoculated with M. bovis. (usda.gov)
- The objective of the investigation was to provide data on how a prior exposure of cattle to Mycobacterium avium, used here as a model of exposure to an environmental mycobacterium, affected the cellular immune response that follows vaccination with Mycobacterium bovis BCG. (ox.ac.uk)
- Here, we analysed how environmental variables could be associated with the Mycobacterium bovis concomitant infection in both cattle and badgers, in an area of south-western France. (hal.science)
- These results suggest that terrain features, badger population structure and food availability may influence the spread of M. bovis infection between badgers and cattle, leading to concomitant infection of both species. (hal.science)
- Notably, while Mycobacterium bovis is highly virulent and pathogenic for cattle, the human pathogen M. tuberculosis is attenuated in cattle. (ox.ac.uk)
- Dendritic cells induce CD4+ and CD8+ T-cell responses to Mycobacterium bovis and M. avium antigens in Bacille Calmette Guérin vaccinated and nonvaccinated cattle. (ox.ac.uk)
- We used autologous dendritic cells (DC) infected with Mycobacterium bovis Bacille Calmette Guérin (BCG) or pulsed with purified protein derivative from M. bovis (PPD-B) or M. avium (PPD-A) to assess responses of CD4+, CD8+ and WC1+ gammadelta TCR+ lymphocytes from BCG vaccinated and nonvaccinated cattle. (ox.ac.uk)
- Mycobacteria-specific CD4+ and CD8+, but not WC1+ gammadelta TCR+, memory T lymphocytes were demonstrated in BCG-vaccinated cattle. (ox.ac.uk)
- The findings suggest that immunity to M. bovis induced by BCG vaccination in cattle may involve CD8+ memory T cells which produce IFN-gamma, as well as CD4+ memory T cells. (ox.ac.uk)
- Flow cytometric detection of gamma interferon can effectively discriminate Mycobacterium bovis BCG-vaccinated cattle from M. bovis-infected cattle. (ox.ac.uk)
- This assay could allow an accurate diagnosis of M. bovis and allow the discrimination of BCG-vaccinated cattle from infected cattle. (ox.ac.uk)
Vaccination6
- Data on gamma interferon (IFN-γ)-secreting CD4 + T cells over time after recent Mycobacterium bovis BCG vaccination were available for 55 humans and 81 macaques. (ox.ac.uk)
- ABSTRACT Previous work with small-animal laboratory models of tuberculosis has shown that vaccination strategies based on heterologous prime-boost protocols using Mycobacterium bovis bacillus Calmette-Guérin (BCG) to prime and modified vaccinia virus Ankara strain (MVA85A) or recombinant attenuated adenoviruses (Ad85A) expressing the mycobacterial antigen Ag85A to boost may increase the protective efficacy of BCG. (ox.ac.uk)
- Exposure to Mycobacterium avium primes the immune system of calves for vaccination with Mycobacterium bovis BCG. (ox.ac.uk)
- A policy involving vaccination would require an accurate diagnosis of M. bovis-infected animals and the potential to distinguish these animals from vaccinates. (ox.ac.uk)
- Papulonecrotic tuberculid-like lesions have also been associated with other mycobacterial infections, including Mycobacterium bovis and Mycobacterium kansasii, and from BCG vaccination. (medscape.com)
- Local Lung Immune Response to Mycobacterium bovis Challenge after BCG and M. bovis Heat-Inactivated Vaccination in European Badger ( Meles meles ). (bvsalud.org)
Humans13
- It is related to Mycobacterium tuberculosis, the bacterium which causes tuberculosis in humans. (wikipedia.org)
- M. bovis can jump the species barrier and cause tuberculosis-like infection in humans and other mammals. (wikipedia.org)
- M. bovis is usually transmitted to humans by consuming raw milk from infected cows, although it can also spread via aerosol droplets. (wikipedia.org)
- Actual infections in humans are nowadays rare in developed countries, mainly because pasteurisation kills M. bovis bacteria in infected milk. (wikipedia.org)
- Direct transmission from animals to humans through the air is thought to be rare, but M. bovis can be spread directly from person to person when people with the disease in their lungs cough or sneeze. (cdc.gov)
- 1997) and these outbreaks highlight the risk associated with MDR M. bovis , especially in countries where animals with M. bovis and humans with HIV co-exist. (scielo.br)
- The best estimate of the prevalence of zoonotic TB due to M. bovis in humans in Argentina, Brazil, Chile, Colombia, Costa Rica, Dominican Republic, Ecuador, Peru, Uruguay and Venezuela was published in 2008 (de Kantor et al. (scielo.br)
- 2008). In Chile, Colombia, Costa Rica, the Dominican Republic, Peru and Uruguay, M. bovis was most likely never isolated from humans and only four of these countries reported bacteriologically confirmed cases of M. bovis infection in humans. (scielo.br)
- Mycobacterium bovis is a rare cause of tuberculosis in humans, but should be considered in individuals at risk secondary to medical comorbidities (notably immunocompromise) or occupational exposure. (ox.ac.uk)
- Interpretation: M bovis prevalence in humans is an inadequate proxy of zoonotic tuberculosis. (psu.edu)
- M. bovis and M. caprae, a lesser known member of the MTBC exhibit an exceptionally wide host spectrum in animals and are capable of causing disease in humans. (edu.pe)
- CONCLUSIONS: The cases reported here constitute convincing evidence that M. caprae and M. bovis are causative agents of TB infection in humans in Peru and underscore the importance of species-level MTBC member identification to effectively control and treat zoonotic TB. (edu.pe)
- Members of the Mycobacterium tuberculosis complex (MTBC) are the causative agents of tuberculosis in a range of mammals, including humans. (ox.ac.uk)
Strain of Mycobacterium bovis2
- One hundred years ago, Albert Calmette developed an avirulent strain of Mycobacterium bovis, but there is no evidence that his BCG strain was more immunogenic than wild-type M. bovis. (nih.gov)
- To improve the current vaccine against tuberculosis, a recombinant strain of Mycobacterium bovis bacillus Calmette-Guérin (rBCG) expressing a Mycobacterium tuberculosis vaccine candidate antigen (MPT64) in strong association with the mycobacterial cell wall was developed. (unicatt.it)
Causative agent1
- Thus, failure to identify M. bovis as the causative agent in reported TB cases leads to higher levels of treatment failure and contributes to the transmission of drug-resistant TB. (edu.pe)
Bacillus calmet1
- The only preventive measure available is Mycobacterium bovis Bacillus Calmette-Guerin (BCG), which has fared extremely well in providing protection against childhood TB 3 . (nature.com)
Leprae4
- We hypothesized that exposure to M. bovis through unpasteurized milk might protect against Mycobacterium tuberculosis and Mycobacterium leprae. (nih.gov)
- Exposure to wild-type M. bovis through unpasteurized milk may provide cross-protection against M. tuberculosis and M. leprae and contribute to geographic disparities in BCG efficacy. (nih.gov)
- In contrast, intraneural injection of 10(9) cobalt-irradiated Mycobacterium leprae organisms induces a macrophage granuloma in 5 weeks, similar to that found in lepromatous leprosy patients. (nih.gov)
- There are currently 71 recognized or proposed species of Mycobacterium [1], all of which, except M. tuberculosis complex and M. leprae, are considered as environmental mycobacteria and can usually be isolated from environmental samples including water, soil and dust [2]. (who.int)
Avium4
- One group of calves was inoculated subcutaneously with M. avium followed 12 weeks later by M. bovis-BCG. (ox.ac.uk)
- Calves previously exposed to M. avium responded more rapidly, as assessed in the in vitro assays, to purified protein derivative (PPD) from M. avium (PPD-A) or M. bovis (PPD-B) than did calves inoculated with BCG only, indicating that the exposure to M. avium had primed the immune response in these calves. (ox.ac.uk)
- They suggest that M. avium infection primes the immune system of calves and that the detection of an immune response specific for M. bovis BCG is masked by reactivity to antigens also present in M. avium. (ox.ac.uk)
- Mycobacterium avium Complex (MAC) Infections Many species of mycobacteria exist. (msdmanuals.com)
Africanum2
- M. tuberculosis, Mycobacterium bovis, or Mycobacterium africanum). (cdc.gov)
- Other related bacteria (called mycobacteria), such as Mycobacterium bovis or Mycobacterium africanum , occasionally cause a similar disease. (msdmanuals.com)
Zoonotic tuberculosis1
- Background: Zoonotic tuberculosis is defined as human infection with Mycobacterium bovis. (psu.edu)
Strains5
- First, there have been outbreaks of multidrug-resistant (MDR) M. bovis strains among hospitalised patients with human immunodeficiency virus (HIV) (Samper et al. (scielo.br)
- In addition, the Adolfo Lutz Institute, located in the city of São Paulo, tested approximately 355,000 EPTB cultures using pyruvate-containing medium and isolated only two M. bovis strains from 2001-2005. (scielo.br)
- In order to obtain data on isolated M. bovis strains and assist in the control and eradication program for BTB, a cross sectional descriptive molecular epidemiology study in the Brazilian Midwest was conducted. (fiocruz.br)
- Herein, the 29 patterns found amongst the 37 isolates of M. bovis circulating in the Brazilian Midwest can be due to the animal movement between regions, municipalities and farms, thus causing the spread of various M. bovis strains in herds from Midwest Brazil. (fiocruz.br)
- The emergence of MdR-TB and extensively drug-resistant TB (XdR-TB) has raised special concerns in relation to the international spread of par- ticularly dangerous strains of Mycobacterium tuberculosis . (bvsalud.org)
Intracellular5
- M. bovis is a facultative intracellular parasite. (wikipedia.org)
- Accumulating evidence has demonstrated that the macrophage phenotype switch from M0 to M1 is critical in the clearance of intracellular mycobacteria during Mycobacterium bovis infection. (researchsquare.com)
- Cellular experimental studies confirm that GBP2b was a novel regulatory molecule that promotes M1 macrophage polarization during M. bovis infection and was also an antimicrobial protein that promotes intracellular bacterial clearance. (researchsquare.com)
- Flow cytometry and colony forming unit were used to test the phagocytosis and the survival of intracellular Mycobacterium bovis BCG (BCG), respectively. (elsevierpure.com)
- We tested the hypothesis that the quantification of IFN-gamma-producing lymphocytes by flow cytometric analysis of intracellular IFN-gamma expression would provide a more accurate discrimination of M. bovis-infected animals from BCG vaccinates. (ox.ac.uk)
AF21221
- Updated reference genome sequence and annotation of Mycobacterium bovis AF2122/97. (pacb.com)
Isolates6
- A dynamic nomenclature proposal for isolates as M. bovis by whole-genome sequencing. (cdc.gov)
- Of these samples, 174 isolates simultaneously grew on Löwenstein-Jensen (LJ) and Stonebrink (SB)-containing media and presented phenotypic and molecular profiles of Mycobacterium tuberculosis , whereas 12 had molecular profiles of M. tuberculosis based on the DNA analysis of formalin-fixed paraffin wax-embedded tissue samples (paraffin blocks). (scielo.br)
- One patient produced two sputum isolates, the first of which simultaneously grew on LJ and SB media and presented phenotypic and molecular profiles of M. tuberculosis , and the second of which only grew on SB media and presented phenotypic profiles of Mycobacterium bovis . (scielo.br)
- Moreover, we found a low prevalence (1.6%) of M. bovis among these isolates, which suggests that local health service procedures likely underestimate its real frequency and that it deserves more attention from public health officials. (scielo.br)
- Through spoligotyping and 24-loci MIRU-VNTR methods, 37 clinical isolates of M. bovis circulating in the region were analyzed, 10 isolated from the state of Mato Grosso, 12 from the state of Mato Grosso do Sul and 15 from the state of Goiás. (fiocruz.br)
- When associating the results of both techniques, the isolates were grouped in five clusters and 24 unique M. bovis profiles. (fiocruz.br)
Antigens1
- Tuberculosis in elephants: antibody responses to defined antigens of Mycobacterium tuberculosis , potential for early diagnosis, and monitoring of treatment. (vin.com)
Immunity1
- Contact with different species of environmental Mycobacterium can cause acquired immunity to M. tuberculosis or increase the efficacy of BCG vaccine protection (M. vaccae, M. microti), although some species of these bacteria reduce the efficacy of BCG vaccine (M. scrofulaceum) [8,10-13]. (who.int)
Abstract2
- ENGLISH ABSTRACT: SCCHg en SCCmec elemente is, maar verdere filogenetiese ondersoeke moet uitgevoer word, om insig te gee oor die oorsprong en verspreiding van hierdie nuwe element. (sun.ac.za)
- ABSTRACT This research compared the numbers and types of different Mycobacterium species in soil samples taken from 2 areas of Golestan province, Islamic Republic of Iran, 1 with a high prevalence of tuberculosis and 1 with a low prevalence. (who.int)
Leprosy1
- National data were obtained from United Nations agencies and international organizations about milk production per capita (1980-1999) as a proxy for exposure to wild-type M. bovis, TB (2000-2019) and leprosy (2005-2019) incidence, HIV prevalence (2000-2019), human development index (2010), global hunger index (2010), neonatal BCG coverage (1980-1999), urbanization (2000) and temperature (1990-2020). (nih.gov)
Infections3
- Not all M. bovis infections progress to TB disease, so there might be no symptoms at all. (cdc.gov)
- This study showed that the available diagnostic tests are in many instances lacking the necessary specificity for proper diagnosis of M. bovis infections in captive lions. (sun.ac.za)
- Infections Caused by Bacteria Related to Tuberculosis (TB) Many species of mycobacteria exist. (msdmanuals.com)
Bacteria5
- citation needed] Mycobacterium tuberculosis group bacteria are 1.0-4.0 µm long by 0.2-0.3 µm wide in tissues. (wikipedia.org)
- Tuberculosis is a chronic contagious infection caused by the airborne bacteria Mycobacterium tuberculosis . (msdmanuals.com)
- Tuberculosis (TB) in Newborns Tuberculosis is a contagious infection caused by the bacteria Mycobacterium tuberculosis . (msdmanuals.com)
- Tuberculosis is caused by bacteria called Mycobacterium tuberculosis . (msdmanuals.com)
- These bacteria plus Mycobacterium tuberculosis and some others are called the mycobacterium tuberculosis complex. (msdmanuals.com)
Macrophage1
- The molecular mechanisms involved in macrophage polarization in M. bovis infection remain unclear. (researchsquare.com)
Environmental mycobacteria2
- The results are consistent with a model in which prior exposure to environmental mycobacteria does not necessarily inhibit the immune response to the vaccine strain, BCG. (ox.ac.uk)
- The different environmental mycobacteria are very similar and for many years were mistakenly assumed to be M. tuberculosis in patients [1,2]. (who.int)
Human tuberculosis2
- However, in areas of the developing world where pasteurisation is not routine, M. bovis is a relatively common cause of human tuberculosis. (wikipedia.org)
- Although most cases of human tuberculosis (TB) are caused by Mycobacterium tuberculosis , there are rising concerns over infection with Mycobacterium bovis . (scielo.br)
Assay2
- The aim of this study was to identify and develop a cell-mediated immunological cytokine-release assay that could distinguish between Mycobacterium bovis -infected and uninfected cheetahs using commercially available feline cytokine ELISA and domestic cat ( Felis catus ) recombinant proteins. (bioone.org)
- A preliminary cheetah specific cutoff value (11 pg/ml) for detecting M. bovis infection using the Mabtech Cat IFN-γ release assay was calculated using a M. bovis uninfected cheetah cohort. (bioone.org)
Causes tuberculosis1
- The species Mycobacterium tuberculosis is the one that causes tuberculosis. (msdmanuals.com)
Tuberculosis vaccine1
- Reference genome and comparative genome analysis for the WHO reference strain for Mycobacterium bovis BCG Danish, the present tuberculosis vaccine. (pacb.com)
Macrophages2
- In this study, the entire gene expression profiles of M1 bone marrow-derived macrophages (BMDMs) induced by interferon-gamma and lipopolysaccharide, M2 BMDMs induced by interleukin (IL) - 4 and IL-13, M0 BMDMs, and M0 BMDMs after 6 h of infection with M. bovis were subjected to bioinformatics analysis. (researchsquare.com)
- Forty-eight candidate genes associated with M. bovis infection and involved in M1 polarized macrophages were screened. (researchsquare.com)
Species4
- Furthermore the recent diversification of farming enterprise to include a wide range of animal species has necessitated the consideration of members of the Mycobacterium Tuberculosis Complex (MTBC) with the potential for zoonotic transmission. (edu.pe)
- The most common species isolated were Mycobacterium fortuitum, M. flavescens and M. chelonae. (who.int)
- The other mycobacteria species that cause disease are discussed here. (msdmanuals.com)
- Our objective in this research was to These facultative pathogens can cause compare the number and types of different infection, especially among immunosup- species of Mycobacterium in the soil from pressed or immunodeficient patients [ 4 ]. (who.int)
Antigen1
- 0.100 above that of the avian result OD [LOINC 82387-2] and nil antigen result OD [LOINC 82509-1], indicates the presence of M. bovis infection. (loinc.org)
Person-to-person transmiss3
- Second, evidence for person-to-person transmission of M. bovis has been demonstrated (Evans et al. (scielo.br)
- Possible Airborne Person-to-Person Transmission of Mycobacterium bovis" by Bryan F Buss, Alison Keyser-Metobo et al. (lvhn.org)
- Possible Airborne Person-to-Person Transmission of Mycobacterium bovis - Nebraska 2014-2015. (lvhn.org)
Complex3
- We analyzed 98 Mycobacterium tuberculosis complex platform to enhance SARS-CoV-2 testing capacity. (cdc.gov)
- The aim of this study was to obtain estimates of the human prevalence of animal-associated members of the Mycobacterium tuberculosis complex (MTBC) at a large referral hospital in India. (psu.edu)
- Disease caused by Mycobacterium tuberculosis complex (i.e. (cdc.gov)
Caprae3
- 1.4% in connection with overall TB in- M. bovis or M. caprae . (cdc.gov)
- A case report of transmission and disease caused by Mycobacterium caprae and Mycobacterium bovis in Lima, Peru. (edu.pe)
- CASE PRESENTATION: Reported here are the clinical presentations, investigations and treatment histories of two patients identified from a population level genotyping study in Lima, Peru that were at the time of treatment thought to be M. tuberculosis patients but in retrospect were spectated using whole genome sequencing as M. caprae and M. Bovis. (edu.pe)
Prevalence1
- The frequencies of environmental Mycobacterium in the low-prevalence area were much higher than in the high-prevalence area, perhaps due to different environmental factors. (who.int)
Disease7
- is another mycobacterium that can cause TB disease in people. (cdc.gov)
- In people, M. bovis causes TB disease that can affect the lungs, lymph nodes, and other parts of the body. (cdc.gov)
- M. bovis causes a relatively small proportion, less than 2%, of the total number of cases of TB disease in the United States. (cdc.gov)
- The pasteurization process, which destroys disease-causing organisms in milk by rapidly heating and then cooling the milk, eliminates M. bovis from milk products. (cdc.gov)
- M. bovis is usually resistant to one of the antibiotics, pyrazinamide, typically used to treat TB disease. (cdc.gov)
- However, these studies mostly focused on tumors and other disease studies rather than on diseases caused by M. bovis . (researchsquare.com)
- Protection was determined by measuring development of disease as an end point after M. bovis challenge. (ox.ac.uk)
Cytokine1
- Time Course Study: Knowledge of time dependent cytokine expression following M. bovis infection would aid vaccine development by revealing potential correlates of protection. (herts.ac.uk)
Vitro1
- A respiratory type of nitrate reductase (NarGHJI), which was induced during dormancy, could reflect the viability of dormant bacilli of Mycobacterium bovis BCG in microplate adopted model of in vitro dormancy. (houstonmethodist.org)
Bacilli1
- Khan, A & Sarkar, D 2008, ' A simple whole cell based high throughput screening protocol using Mycobacterium bovis BCG for inhibitors against dormant and active tubercle bacilli ', Journal of Microbiological Methods , vol. 73, no. 1, pp. 62-68. (houstonmethodist.org)
Chelonae1
- Les espèces les plus couramment isolées étaient Mycobacterium fortuitum, M. flavescens et M. chelonae. (who.int)
Tissues1
- In vivo validation results showed significant expression of GBP2b in the tissues of M. bovis -infected mice. (researchsquare.com)
Isolate2
- One patient provided a bronchial lavage isolate, which simultaneously grew on LJ and SB media and presented phenotypic and molecular profiles of M. tuberculosis , but had molecular profiles of M. bovis from paraffin block DNA analysis, and one sample had molecular profiles of M. tuberculosis and M. bovis identified from two distinct paraffin blocks. (scielo.br)
- Among the 24-loci MIRU-VNTR evaluated, two, ETR-A and QUB 11b loci, showed high discriminatory ability (h = ≥ 0.50), while MIRU 16, MIRU 27, ETR-B, ETR-C, Mtub21 and QUB 26 loci showed moderate ability (h = 0.33 or h = 0.49) and were the most effective in evaluating the genotypic similarities among the clinical M. bovis isolate samples. (fiocruz.br)
Pulmonary Tuberculosis1
- In April 2014, a man in Nebraska who was born in Mexico was determined to have extensive pulmonary tuberculosis (TB) caused by M. bovis after experiencing approximately 3 months of cough and fever. (lvhn.org)
Immune6
- The rest of this thesis investigates the possible effects that M. bovis might have on lions' energy metabolism, immune/inflammatory response, and reproductive endocrinology. (sun.ac.za)
- Regardless of the difficulties with diagnosis of TB in the lions used for current study, it was possible to show that the lions in the KNP (exposed to M. bovis) compared to captive (unexposed) lions were experiencing an immune/inflammatory response, differences were observed for energy metabolism biomarkers, and wild male lions had reduced testosterone production. (sun.ac.za)
- However, the development of an effective bTB vaccine has been continually hindered by the lack of knowledge on the immune response following Mycobacterium bovis (M. bovis) infection. (herts.ac.uk)
- The results from this study therefore confirm the importance of the cell mediated immune profile in response to M. bovis infection as well as the integral role of IFN-γ in both protection and pathology. (herts.ac.uk)
- The work presented here therefore provides a basis for the identification of host innate immune mechanisms subverted by virulent host-adapted mycobacteria to promote their survival during the early stages of infection. (ox.ac.uk)
- Another reason for the medical importance of environmental Mycobacterium is the potential impact on the immune response. (who.int)
Meles2
- Efficacy of heat-inactivated Mycobacterium bovis vaccine delivered to European badgers ( Meles meles ) through edible bait. (bvsalud.org)
- Protective Effect of Oral BCG and Inactivated Mycobacterium bovis Vaccines in European Badgers ( Meles meles ) Experimentally Infected With M. bovis . (bvsalud.org)
Patients3
- In this cross-sectional study, mycobacteria specimens from 189 tuberculosis (TB) patients living in an urban area in Brazil were characterised from 2008-2010 using phenotypic and molecular speciation methods ( pncA gene and oxyR pseudogene analysis). (scielo.br)
- 2008) and another Mexican study identified, through microbiological methods, the presence of mycobacteria in sputum samples of human TB patients with chronic respiratory problems. (scielo.br)
- Methods: We did a molecular epidemiological surveillance study of 940 positive mycobacteria growth indicator tube (MGIT) cultures, collected from patients visiting the outpatient department at Christian Medical College (Vellore, India) with suspected tuberculosis between Oct 1, 2018, and March 31, 2019. (psu.edu)
Protein1
- Significant numbers of IFN-gamma-expressing CD4+ T cells were detected following culture of heparinized blood from M. bovis-infected animals, but not from BCG vaccinates, with purified protein derived from M. bovis (PPD-B) or live mycobacteria. (ox.ac.uk)
Citation2
- citation needed] M. bovis is similar in structure and metabolism to M. tuberculosis. (wikipedia.org)
- citation needed] During the first half of the 20th century, M. bovis is estimated to have been responsible for more losses among farm animals than all other infectious diseases combined. (wikipedia.org)
Distinct1
- The spoligotyping analysis identified 10 distinct M. bovis profiles (SB0121 n = 14, SB0295 n = 6, SB0140 n = 6, SB0881 n = 3, SB1144 n = 2, SB1145 n = 2, SB0134 n = 1, SB1050 n = 1, SB1055 n = 1, SB1136 n = 1) grouped in six clusters and four orphan patterns. (fiocruz.br)