• NTM are also referred to as atypical mycobacteria, mycobacteria other than tuberculosis (MOTT), or environmental mycobacteria. (cdc.gov)
  • Hamsch C, Hartschuh W, Enk A, Flux K. A Chinese tattoo paint as a vector of atypical mycobacteria-outbreak in 7 patients in Germany. (medscape.com)
  • Mycobacterium avium-intracellulare infection (MAI) is an atypical mycobacterial infection, i.e. one with nontuberculous mycobacteria or NTM, caused by Mycobacterium avium complex (MAC), which is made of two Mycobacterium species, M. avium and M. intracellulare. (wikipedia.org)
  • Further, this case showed that the clinical symptoms of NTM infection are atypical and highly occult, especially for extrapulmonary NTM infections, which are difficult to diagnose. (degruyter.com)
  • To exclude atypical infection, we performed skin biopsy for pathology exam, as well as fungal and mycobacterial culture. (biomedcentral.com)
  • The literature is complicated by the fact that the term "atypical acid-fast organisms" covers a considerable variety of mycobacteria. (jamanetwork.com)
  • Adult pulmonary infection with atypical acid-fast organisms has been described with increasing frequency. (jamanetwork.com)
  • The atypical mycobacterium Mycobacterium chelonae grows rapidly and is a normal commensal organism in water and soil. (medscirev.com)
  • Mycobacterium marinum is an atypical Mycobacterium species found in cold or warm, fresh or salted water. (medscape.com)
  • M marinum is water-borne atypical Mycobacterium species that commonly infects fish and amphibians. (medscape.com)
  • The infected tapir was a 20-yr-old female wild caught animal that died in 1995 with culture confirmed Mycobacterium bovis infection. (vin.com)
  • These results suggest that MAPIA and RT tests have potential utility for rapid detection of M. bovis infection in Malayan tapir. (vin.com)
  • Accumulating evidence has demonstrated that the macrophage phenotype switch from M0 to M1 is critical in the clearance of intracellular mycobacteria during Mycobacterium bovis infection. (researchsquare.com)
  • Forty-eight candidate genes associated with M. bovis infection and involved in M1 polarized macrophages were screened. (researchsquare.com)
  • Cellular experimental studies confirm that GBP2b was a novel regulatory molecule that promotes M1 macrophage polarization during M. bovis infection and was also an antimicrobial protein that promotes intracellular bacterial clearance. (researchsquare.com)
  • Therefore, elucidating the different mechanisms of host defense against M. bovis infection is important. (researchsquare.com)
  • The molecular mechanisms involved in macrophage polarization in M. bovis infection remain unclear. (researchsquare.com)
  • The effects of a Mycobacterium bovis infection on the metabolic and reproductive systems of African lions (Panthera leo) in the Kruger National Park. (sun.ac.za)
  • A preliminary cheetah specific cutoff value (11 pg/ml) for detecting M. bovis infection using the Mabtech Cat IFN-γ release assay was calculated using a M. bovis uninfected cheetah cohort. (bioone.org)
  • Mycobacterium marinum is a nontuberculous mycobacterium capable of causing skin and soft tissue infections. (cdlib.org)
  • The Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) are investigating reports that a device used to heat and cool the blood during surgery has been linked to a rare bacterial infection caused by Mycobacterium chimaera , a type of bacteria known as nontuberculous mycobacterium (NTM). (cooperhealth.org)
  • ENGLISH ABSTRACT: SCCHg en SCCmec elemente is, maar verdere filogenetiese ondersoeke moet uitgevoer word, om insig te gee oor die oorsprong en verspreiding van hierdie nuwe element. (sun.ac.za)
  • abstract = "A patient presenting with recurrent ventriculoperitoneal shunt infection was found to have Mycobacterium abscessus growing from cerebrospinal fluid (CSF), which remained persistently positive. (northwestern.edu)
  • ABSTRACT This research compared the numbers and types of different Mycobacterium species in soil samples taken from 2 areas of Golestan province, Islamic Republic of Iran, 1 with a high prevalence of tuberculosis and 1 with a low prevalence. (who.int)
  • ABSTRACT This study was done to characterize at the species level Mycobacterium spp. (who.int)
  • Nontuberculous mycobacteria (NTM) are mycobacteria other than M. tuberculosis (the cause of tuberculosis) and M. leprae (the cause of leprosy). (cdc.gov)
  • Its preference for lower temperatures, similar to that of Mycobacterium leprae and Mycobacterium marinum, has been associated with a predilection for clinical infections to be located over the extremities. (medscape.com)
  • Leprosy is an infectious disease caused by Mycobacterium leprae and is endemic in many developing countries. (kit.nl)
  • Mycobacterium leprae Infection in Ticks and Tick-Derived Cells. (bvsalud.org)
  • The majority of patients presenting with zoonotic strains of Mycobacterium leprae note extensive outdoor activity but only rarely report any history of direct contact with wild armadillos . (bvsalud.org)
  • Mycobacterium leprae DNA was detected in multiple tick life cycle stages . (bvsalud.org)
  • Tick -derived cells were able to maintain viable M. leprae over the 49-day course of infection and M. leprae remained infectious within tick cells for at least 300 days. (bvsalud.org)
  • Mycobacterium avium complex (MAC), also called Mycobacterium avium-intracellulare complex, is a microbial complex of three Mycobacterium species (i.e. (wikipedia.org)
  • Results suggest infection is widespread in Spain, affecting 6 domestic and wild animal species. (cdc.gov)
  • 1.800-1.999 for species level for mycobacteria). (biomedcentral.com)
  • Treatment of pulmonary infections caused by M. abscessus remains extremely difficult, as this species is resistant to most classes of antibiotics, including macrolides, aminoglycosides, rifamycins, tetracyclines, and β-lactams. (torvergata.it)
  • The most common species isolated were Mycobacterium fortuitum, M. flavescens and M. chelonae. (who.int)
  • Contact with different species of environmental Mycobacterium can cause acquired immunity to M. tuberculosis or increase the efficacy of BCG vaccine protection (M. vaccae, M. microti), although some species of these bacteria reduce the efficacy of BCG vaccine (M. scrofulaceum) [8,10-13]. (who.int)
  • Many species of mycobacteria exist. (msdmanuals.com)
  • The other mycobacteria species that cause disease are discussed here. (msdmanuals.com)
  • At least 150 fish and frog species, aquatic mammals (eg, dolphins), eels, oysters, African toads, and royal pythons are known to acquire natural M marinum infection. (medscape.com)
  • Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS. (bvsalud.org)
  • There is dearth of data on the prevalence of latent tuberculosis infection among patients with type 2 diabetes. (ersjournals.com)
  • Latent tuberculosis infection in DM patients was associated with degree of glyceamic control and smoking, p value was less than 0.05 each.Predictors of a positive test on QuantiFERON on linear regression include levels of glycosylated hemoglobin and total cholesterol, p value was less than 0.05 each. (ersjournals.com)
  • The prevalence of latent tuberculosis infection is high among type 2 diabetic patients. (ersjournals.com)
  • INTRODUCTION: Interferon-γ (IFN-γ) inducible protein 10kD (IP-10) and IFN-γ release assays (IGRAs) are immunodiagnostic tests aiming to identify the presence of specific cellular immune responses, interpreted as markers for latent infection with Mycobacterium tuberculosis. (ku.dk)
  • In 2017, the Korean authorities launched an unprecedentedly large-scaled latent tuberculosis an infection (LTBI) screening venture which lined greater than one million people in congregate settings. (tbdb.org)
  • According to the World Health Organization (WHO), TB is responsible for about 1.6 million TB deaths and 10 million (5.8 million men, 3.2 million women, and 1.0 million children) new cases have been detected in 2017 and more than a third of the world population is hosting Mycobacterium tuberculosis , the causative pathogen of TB, in its latent form ( 1 , 2 ). (frontiersin.org)
  • In HIV-infected persons, the virus promotes progression of active TB if there is latent or recently-acquired Mycobacterium tuberculosis infections. (who.int)
  • Fifteen-year clinical experience with Mycobacterium haemophilum at the Mayo Clinic: A case series. (medscape.com)
  • M. avium and M. haemophilum infections in children form a distinct clinical entity, not associated with abnormalities of the immune system. (wikipedia.org)
  • One case report described primary MAI infection resulting in a clinical picture resembling lupus vulgaris. (medscape.com)
  • We collected clinical information on 17 patients seen at a New York City hospital who had repeatedly positive cultures for Mycobacterium tuberculosis. (nih.gov)
  • Clinical infections occurred in five male German cases over 50 years of age (range 53-80). (eurosurveillance.org)
  • Sixty-three cases of Mycobacterium marinum infection: Clinical features, treatment and antibiotic susceptibility of causative isolates. (scialert.net)
  • Clinical presentation and therapy of Mycobacterium marinum infection as seen in 12 cases. (scialert.net)
  • Clinical use of engineered bacteriophages for the treatment of disseminated mycobacterial infection. (nature.com)
  • In a real-world scenario, using a dataset of 50 paired clinical isolates from a study of patients with either reinfections or relapses, we found that QuantTB could detect mixed infections and reinfections at rates concordant with a manually curated approach. (9lib.org)
  • This article reviews the dermatologic manifestations of Mycobacterium avium-intracellulare (MAI, or MAC) infection. (medscape.com)
  • See also Mycobacterium Avium-Intracellulare . (medscape.com)
  • In the United States, Mycobacterium avium-intracellulare (MAI, or MAC) infection is considered a nonreportable infectious disease. (medscape.com)
  • It is important to consider cutaneous infection with Mycobacterium avium-intracellulare (MAI, or MAC) in patients with antibiotic-resistant cellulitis, nonhealing nodules, and ulcers, as well as in patients who are immunosuppressed with evidence of disseminated MAI (DMAI) infection. (medscape.com)
  • The lungs are most commonly infected, and most lung infections are caused by a group known as Mycobacterium avium complex (MAC), which includes Mycobacterium avium and Mycobacterium intracellulare . (msdmanuals.com)
  • The M. avium complex (including M. avium and M. intracellulare ) is most often associated with pulmonary infection. (who.int)
  • 1,3 Be sure to ask for histopathological and microbiological analysis of the biopsy specimen, and make the pathologist aware that mycobacterial infection is in the differential diagnosis. (contemporarypediatrics.com)
  • Our study provides evidence that, similar to the effect in solid tumors, vascular normalization during mycobacterial infection increases the T cell:neutrophil ratio in lesions which may be correlates of protective immunity. (duke.edu)
  • We observed the proteins internalization within macrophages and their capacity to eradicate the intracellular mycobacterial infection at a low micro-molar range. (frontiersin.org)
  • It is important to keep in mind that other outbreaks of nontuberculous mycobacteria have been associated with tattoo parlors, and in follow-up to this investigation, other outbreaks in other tattoo parlors in other states identified a variety of nontuberculous mycobacteria, including M fortuitum, M chelonae , and M abscessus . (medscape.com)
  • Les espèces les plus couramment isolées étaient Mycobacterium fortuitum, M. flavescens et M. chelonae. (who.int)
  • M. fortuitum has been associated with pulmonary infection but more often affects the skin, soft tissue or bones. (who.int)
  • The epidemiology is driven by infections in caprids, although the organism has emerged in cattle. (cdc.gov)
  • This report describes the molecular epidemiology of M. caprae infection in Spain compared with other countries. (cdc.gov)
  • 6 Victorian Infectious Diseases Reference Laboratory Epidemiology Unit at The Peter Doherty Institute for Infection & Immunity, The University of Melbourne and Royal Melbourne Hospital, Parkville, Victoria, Australia. (nih.gov)
  • Received research grant from: Association for Professionals in Infection Control and Epidemiology, Inc. (medscape.com)
  • Association for Professionals in Infection Control and Epidemiology, Inc. (medscape.com)
  • Environmental mycobacteria of soil in mazenderan provience. (scialert.net)
  • Environmental mycobacteria in area of high and low tuberculosis prevalence in the Islamic Republic of Iran. (scialert.net)
  • The different environmental mycobacteria are very similar and for many years were mistakenly assumed to be M. tuberculosis in patients [1,2]. (who.int)
  • In this context, there is an urgent need for the development of an alternative therapeutic strategy that aims at improving the current management of patients affected by chronic M. abscessus infections. (torvergata.it)
  • For additional information on cutaneous M marinum infection, see the Medscape Reference article Dermatologic Manifestations of Mycobacterium Marinum Infection of the Skin. (medscape.com)
  • Mycobacterium caprae is a pathogen that can infect animals and humans. (cdc.gov)
  • Data on skin and soft-tissue infection caused by nontuberculous mycobacteria in Taiwan (1997-2008) suggest that MAI is an important pathogen. (medscape.com)
  • Mycobacterium farcinogenes - senegalense group infection should be considered as a potential pathogen of skin infection in immunocompetent patients. (biomedcentral.com)
  • These results offer the conceptual basis for a novel therapeutic regimen based on antibiotic and bioactive liposomes, used as a combined host- and pathogen-directed therapeutic strategy, aimed at the control of M. abscessus infection, and of related immunopathogenic responses, for which therapeutic options are still limited. (torvergata.it)
  • IMPORTANCE Mycobacterium abscessus is an opportunistic pathogen intrinsically resistant to many antibiotics, frequently linked to chronic pulmonary infections, and representing a relevant cause of morbidity and mortality, especially in immunocompromised patients, such as those affected by cystic fibrosis. (torvergata.it)
  • This may be related to the higher incidence of HIV infection in males. (medscape.com)
  • CDC data also suggest that the incidence of MAI infection may be decreasing as a result of highly active antiretroviral therapy and antimicrobial prophylaxis. (medscape.com)
  • The incidence of nontuberculous mycobacterial (NTM) infection has been increasing globally. (degruyter.com)
  • Multicenter study of incidence of Mycobacterium marium in humans in Spain. (scialert.net)
  • However, the relative incidence of the environmental Mycobacterium spp. (who.int)
  • The international incidence and prevalence of M marinum infection are unknown owing to a lack of surveillance. (medscape.com)
  • One French study found the incidence of M marinum infection to be 0.04 per 100,000 inhabitants per year. (medscape.com)
  • Little data are available on the prevalence of NTM infections in TB high-burden countries, but the incidence can nevertheless be substantial. (who.int)
  • Invasive infections with Mycobacterium chimaera were reported in patients with previous open chest surgery and exposure to contaminated heater-cooler units (HCUs). (eurosurveillance.org)
  • Disseminated M marinum infection and more invasive skin infections have been reported in significantly immunosuppressed individuals. (medscape.com)
  • No fish tank granuloma was proved in human, but 11 (9.73%) strains of Mycobacteria were isolated from Caviar fishes, that only 2 strains (1.76%) belong to M. marinum . (scialert.net)
  • Infections caused by Mycobacterium abscessus group strains are usually resistant to multiple antimicrobials and challenging to treat worldwide. (montclair.edu)
  • citation needed] Since the six patients in their retrospective case series were older females, Reich and Johnson proposed that patients without a vigorous cough may develop right middle lobe or left lingular infection with MAC. (wikipedia.org)
  • Retrospective study of Mycobacterium marinum skin infection. (scialert.net)
  • Primary cutaneous MAI infection generally occurs in hosts who are immunocompetent after traumatic introduction into the soft tissue. (medscape.com)
  • Includes ultrasound and MRI images of patient with skin and soft tissue NTM infection (Supplementary Figure 1), antimicrobial susceptibility testing of NTM isolated and included in this study (Supplementary Table 1), photos of patient with skin and soft tissue NTM infection and the wound healing process of this typical patient's three lesions. (mendeley.com)
  • M marinum infection occurs following skin and soft-tissue injuries that are exposed to an aquatic environment or marine animals. (medscape.com)
  • M marinum infection commonly develops as a complication of skin and soft-tissue injuries exposed to aquatic equipment such as fish lines and fishhooks, among others. (medscape.com)
  • One chart review series of 47 children with cervical adenitis revealed a median age of 3 years at the time of MAI infection diagnosis. (medscape.com)
  • Further, it has been reported that early NTM infection diagnosis and treatment can considerably improve patient prognosis. (degruyter.com)
  • A thorough history with an emphasis on possible routes of exposure is key to the diagnosis of M marinum infection. (contemporarypediatrics.com)
  • Tuberculosis in elephants: antibody responses to defined antigens of Mycobacterium tuberculosis , potential for early diagnosis, and monitoring of treatment. (vin.com)
  • This study showed that the available diagnostic tests are in many instances lacking the necessary specificity for proper diagnosis of M. bovis infections in captive lions. (sun.ac.za)
  • As a result, diagnosis of these infections can be missed or delayed, sometimes for years, making these infections more difficult to treat. (cooperhealth.org)
  • Background: Mixed infections ofMycobacterium tuberculosis and antibiotic heteroresistance continue to complicate tuberculosis (TB) diagnosis and treatment. (9lib.org)
  • To diagnosis widespread MAC infection, doctors usually try to grow (culture) the bacteria from a sample of blood or from tissue taken from the bone marrow, the liver, or an infected lymph node. (msdmanuals.com)
  • Mixed infections as well as false-positive TB diagnosis cannot be ruled out. (who.int)
  • This infection causes respiratory illness in birds, pigs, and humans, especially in immunocompromised people. (wikipedia.org)
  • 1 NTM can be found in the environment, including water and soil, which is the suspected source of occasional infection of humans. (who.int)
  • This study pertains to development of a suitable in vitro model using murine macrophages and Mycobacterium bovis BCG to study proteins expressed during macrophage-myco bacterium interactions. (scirp.org)
  • Peritoneal macrophages from BALB/c mice were infected with M. bovis BCG and intracellular replication was assessed by { 3 H} thymidine uptake assay which was maximal when macrophage to mycobacterium ratio was 1:10. (scirp.org)
  • Seven proteins found to be upregulated during macrophage-mycobacterium interaction were identified by MALDI-TOF. (scirp.org)
  • It has been well documented that intraphagosomal survival and growth of mycobacteria in macrophage is associated with changes in their gene expression and protein composition upon engulfment [2-4]. (scirp.org)
  • In this work, we have tested the human canonical members of the RNase family using a spot-culture growth inhibition assay based mycobacteria-infected macrophage model for evaluating their anti-tubercular properties. (frontiersin.org)
  • Primary cutaneous MAI infection is rare, with 12 cases reported in the literature prior to 1997. (medscape.com)
  • although most case reports of primary cutaneous MAI infection have been in individuals aged 2-10 years, adult cases have also been described. (medscape.com)
  • [ 1 ] Although the prevalence of MAI infection has increased following the epidemic of acquired immunodeficiency syndrome (AIDS), MAI infection remains a rare cause of skin disease. (medscape.com)
  • The results suggest that risk-based culling can reduce prevalence compared with no control, but cannot eliminate the infection. (uu.nl)
  • The frequencies of environmental Mycobacterium in the low-prevalence area were much higher than in the high-prevalence area, perhaps due to different environmental factors. (who.int)
  • The neglected tropical disease Buruli ulcer (BU) is an infection of subcutaneous tissue with Mycobacterium ulcerans There is no effective vaccine. (nih.gov)
  • M haemophilum can cause localized or disseminated infection, usually in individuals with an underlying immunomodulatory condition such as HIV/AIDS, organ transplant recipients, and patients with autoimmune disorders undergoing immunomodulation. (medscape.com)
  • However, Jerome Reich and Richard Johnson describe a series of six patients with MAC infection of the right middle lobe or lingula who did not have any predisposing lung disorders. (wikipedia.org)
  • In the last few years, the FDA has focused on increasing awareness of Nontuberculous Mycobacteria (NTM) infections associated with heater-cooler devices and the subsequent risks to patients in health care facilities. (qlaboratories.com)
  • In this study, we assessed the diagnostic potential of 118 different M.tb infection phase-dependent antigens in TB patients and household contacts (HHCs) in a high-burden setting. (biomedcentral.com)
  • Furthermore, the dependence of most of these tests on sputum implies that they are not suitable for patients with difficulties in providing good quality sputum samples such as children, extrapulmonary TB cases, or in cases where the sputum itself is negative (for example, many patients with HIV- Mycobacterium tuberculosis (M.tb) co-infections). (biomedcentral.com)
  • Cooper University Health Care is notifying patients who have had open-heart surgery about a potential infection risk related to this surgery. (cooperhealth.org)
  • For patients who have had one of these surgeries, the chances of getting this infection are very low. (cooperhealth.org)
  • Of the more than 3000 patients who have had open heart surgery during the relevant time period at Cooper, we are not aware of any patients who have developed this infection. (cooperhealth.org)
  • In hospitals where at least one infection has been identified, the risk of infection was between about 1 in 100 and 1 in 1,000 patients. (cooperhealth.org)
  • The risk that patients will develop an infection following exposure to a contaminated heater-cooler unit is very low. (cooperhealth.org)
  • Antibiotics put patients at risk for allergic reactions and a potentially deadly diarrheal infection caused by the bacteria Clostridium difficile. (cooperhealth.org)
  • Antibiotic use is also a key driver of antibiotic resistance, which can put patients at risk for antibiotic-resistant infections later. (cooperhealth.org)
  • Mycobacterium abscessus is the etiological agent of severe pulmonary infections in vulnerable patients, such as those with cystic fibrosis (CF), where it represents a relevant cause of morbidity and mortality. (torvergata.it)
  • Conclusion: QuantTB can determine infection multiplicity, identify hetero-resistance patterns, enable differentiation between relapse and re-infection, and clarify transmission events across seemingly unrelated patients- even in low-coverage (1×) samples. (9lib.org)
  • These facultative pathogens can cause infection, especially among immunosuppressed or immunodeficient patients [4]. (who.int)
  • Mycobacterium marinum skin infection successfully treated with levofloxacin. (qxmd.com)
  • A 15-year-old patient with cystic fibrosis with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. (nature.com)
  • M marinum infection, often called swimming pool granuloma, is rarely associated with exposure to swimming pools because of advances in chlorination. (contemporarypediatrics.com)
  • Mycobacterium marinum is the etiologic agent of fish tank granuloma in human. (scialert.net)
  • Determination of the fish tank granuloma in Fishermen and Mycobacterium marinum infection in Caviar fishes in Ashorade, in south east Caspian Sea were our objectives. (scialert.net)
  • Using the zebrafish-Mycobacterium marinum infection model, we demonstrate that vascular normalization by inhibition of vascular endothelial protein tyrosine phosphatase (VE-PTP) decreases granuloma hypoxia, the opposite effect of hypoxia-inducing antiangiogenic therapy. (duke.edu)
  • The infection usually presents as a localized granuloma but can evolve into an ascending lymphangitis that resembles sporotrichosis or can spread to deeper tissues. (medscape.com)
  • M marinum infection was once called swimming pool granuloma, but that term is now rather obsolete because of the widespread use of chlorination in swimming pools. (medscape.com)
  • Sputum stain for mycobacteria is a test to check for a type of bacteria that cause tuberculosis and other infections. (medlineplus.gov)
  • Water reservoirs may be the source of M haemophilum infections. (medscape.com)
  • Thus, CD4 T cell assist performs a vital function in producing protecting CD8 T cell responses towards M. tuberculosis an infection in vitro and in vivo. (tbdb.org)
  • The results indicate that the present in vitro infection model was able to support the growth of M. bovis BCG in murine macrophages and is an ideal model to determine the pattern of functions of gene expression during the interaction of mycobacterium with macrophages. (scirp.org)
  • Resurgence of mycobacterial diseases particularly tuberculosis has caused a renewed interest to unravel the strategies employed by mycobacteria for intracellular survival. (scirp.org)
  • Several reports have demonstrated that the use of different cell lines and culture conditions can significantly influence the protein patterns and intracellular survival of mycobacteria [9,10]. (scirp.org)
  • Infection and Immunity , 73 (10), 6299-6310. (itg.be)
  • Nowadays these bacteria are believed to have an important role in infections, allergies, immunity to other pulmonary infections and the efficacy of bacille Calmette-Guerin (BCG) vaccination [3]. (who.int)
  • Tuberculosis and nontuberculosis mycobacterial infections / David Schlossberg. (who.int)
  • Sommerstein R , Rüegg C , Kohler P , Bloemberg G , Kuster SP , Sax H . Transmission of Mycobacterium chimaera from heater-cooler units during cardiac surgery despite an ultraclean air ventilation system. (eurosurveillance.org)
  • The FDA reports that there were 32 reports of infections associated with heater-cooler devices or bacterial heater-cooler device contamination between 2010 and 2015, but 25 of those cases came in 2015, so the occurrence is steeply increasing. (qlaboratories.com)
  • There is also no evidence that giving antibiotics just prior or during surgery with a potentially contaminated heater-cooler device will prevent infection. (cooperhealth.org)
  • Overall, our data anticipate a biological role for human antimicrobial RNases in host response to mycobacterial infections and set the basis for the design of novel anti-tubercular drugs. (frontiersin.org)
  • Although anyone can get an NTM infection, NTM are opportunistic pathogens placing some groups at increased risk, including those with underlying lung disease or depressed immune systems. (cdc.gov)
  • Pulmonary infection is much less common and may follow skin disease. (medscape.com)
  • This coincidence concords with the fact that DMAI infection often occurs in association with HIV disease. (medscape.com)
  • A review of 8 cases of cutaneous MAI infection occurring secondary to disseminated disease found a median patient age of 22.2 years, with a range of 2-28 years. (medscape.com)
  • This, combined with underlying health problems such as heart disease can make these infections difficult to treat. (cooperhealth.org)
  • Mycobacteria and human disease / John M. Grange. (who.int)
  • Johne's disease (JD) is a chronic enteric disease in cattle caused by Mycobacterium avian subsp. (uu.nl)
  • I'm interested in how bacteria cause disease and look to technology to produce novel tools to study and ultimately prevent infection. (nature.com)
  • However, most exposures do not cause infection, and many infections do not cause disease. (msdmanuals.com)
  • Immunocompromised cases (e.g. human immunodeficiency virus [HIV] positive cases) are susceptible to NTM infection, particularly disseminated M. avium disease. (who.int)
  • Although antibiotics can be life-saving drugs, there is no antibiotic treatment available to ward off this specific infection and antibiotics are also not without risk themselves. (cooperhealth.org)
  • M marinum infection responds slowly to appropriate antibiotic therapy. (medscape.com)
  • This study suggests that an effective BU vaccine must induce localized, tissue-specific immune profiles with controlled inflammatory responses at the site of infection. (nih.gov)
  • IFN-γ responses to TB rpfs show promise as TB diagnostic candidates and should be evaluated further for discrimination between M.tb infection states. (biomedcentral.com)
  • Whether or not CD4 T cells act as "helper" cells to advertise optimum CD8 T cell responses throughout Mycobacterium tuberculosis is unknown. (tbdb.org)
  • The role of HIF s in the regulation of CD4 T cell responses during infection with M. tuberculosis isn't well understood. (immunopaedia.org.za)
  • HIF-1 is required for tuberculosis infection and the poor responses of Vhl-deficient T cells. (immunopaedia.org.za)
  • Tuberculosis (TB) an infectious illness brought on by Mycobacterium tuberculosis (Mtb), infects the lungs' alveolar surfaces by the aerosol droplets. (tbdb.org)
  • The authors show that mice lacking VHL in T cells (Vhl cKO) are highly susceptible to infection with M. tuberculosis, which is associated with a low accumulation of mycobacteria-specific T cells in the lungs that display reduced proliferation, altered differentiation and enhanced expression of inhibitory receptors. (immunopaedia.org.za)
  • MAC infections of the lungs usually develop slowly. (msdmanuals.com)
  • However, traditional methods for detecting pathogenic microorganisms are associated with several limitations, and optimal treatment regimens for several NTM infections have not yet been established. (degruyter.com)
  • Multiplication of the mycobacteria inside the macrophages was ascertained using thymidine uptake assay. (scirp.org)
  • The aim of this study was to identify and develop a cell-mediated immunological cytokine-release assay that could distinguish between Mycobacterium bovis -infected and uninfected cheetahs using commercially available feline cytokine ELISA and domestic cat ( Felis catus ) recombinant proteins. (bioone.org)
  • Different Mycobacterium tuberculosis (M.tb) infection phase-dependent antigens may be differentially recognized in infected and diseased individuals and therefore useful as diagnostic tools for differentiating between M.tb infection states. (biomedcentral.com)
  • Here, we report the case of a 22-year-old woman with renal and lymph node Mycobacterium xenopi infection. (degruyter.com)
  • The combination therapy used showed efficacy and thus could serve as a reference treatment for kidney and lymph node M. xenopi infection. (degruyter.com)
  • MAC infection of the lymph nodes may develop in children, typically those aged 1 to 5 years. (msdmanuals.com)
  • To diagnose the infection, doctors remove and test an affected lymph node. (msdmanuals.com)
  • While most reported cases do not have a clearly identified source, infection in adults has been associated with tattoo parlors and acupuncture needles. (medscape.com)
  • To determine the proportion of non-tuberculous mycobacteria (NTM) in samples of pulmonary tuberculosis (TB) cases from Papua New Guinea who were diagnosed using acid-fast microscopy. (who.int)