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  • biopsy
  • Muscle weakness is a prominent feature in DMD and BMDand common MR and biopsy findings include fatty infiltration and inflammation of muscular tissue. (lumc.nl)
  • Centers
  • This work was supported by grants from the National Institutes of Health (NIH), a Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers grant, and a Robert A. Welch Foundation grant. (eurekalert.org)
  • functional
  • Among the numerous pathogenetic concepts the hypothesis of a structural or/and functional defect of the muscular plasma membrane is still the most attractive. (springer.com)
  • drug
  • The muscular dystrophy community is particularly well organized and has lobbied the agency for years to approve the drug, including getting members of Congress to write letters to the agency. (sfgate.com)
  • tissue
  • Fatty infiltration and edema/inflammation of muscular tissue are clearly visible using MRI and will be assessed quantitatively. (lumc.nl)
  • The experiments utilizing laminin-111 as a source of therapy for Duchenne muscular dystrophy suggest that it has protective qualities in addition to its association with muscle tissue. (wikipedia.org)
  • fascination
  • In opposition to his father's wishes that he become a sailor, and driven by a fascination with science, Duchenne enrolled at the University of Douai where he received his Baccalauréat at the age of 19. (wikipedia.org)
  • wheelchair
  • Since inception, fundraising campaigns Funds2Orgs have worked on include "Feet for Francis" sponsored by the Archdiocese of Baltimore, "Million Pair Initiative" organized by cancer nonprofit The Half Fund, and "Shoe Me The Love", a fundraiser to purchase a wheelchair accessible van for a man afflicted with Duchenne muscular dystrophy. (wikipedia.org)
  • found
  • The American neurologist Dr. Joseph Collins (1866-1950) wrote that Duchenne found neurology, "a sprawling infant of unknown parentage which he succored to a lusty youth. (wikipedia.org)
  • known
  • Originally known as the Muscular Dystrophy Associations of America, it was renamed to its present name in the 1970s. (wikipedia.org)
  • He is counted as one of the developers of electro-physiology and electro-therapeutics, and he also showed that smiles resulting from true happiness not only utilize the muscles of the mouth but also those of the eyes: such "genuine" smiles are known as Duchenne smiles in his honor. (wikipedia.org)
  • personal
  • The organization was founded in 1950 by a group with personal connections to muscular dystrophy. (wikipedia.org)
  • This resulted in a lengthy period of personal difficulties for Duchenne with her family and in a prolonged estrangement from his son (who later followed Duchenne into medical practice) and they were only reunited towards the end of his life. (wikipedia.org)
  • Research
  • Guillaume-Benjamin-Amand Duchenne (de Boulogne) (September 17, 1806 in Boulogne-sur-Mer - September 15, 1875 in Paris) was a French neurologist who revived Galvani's research and greatly advanced the science of electrophysiology. (wikipedia.org)
  • After a brief and unhappy second marriage, Duchenne returned to Paris in 1842 in order to continue his medical research. (wikipedia.org)
  • results
  • Nicox S.A. (NYSE Euronext Paris: COX) recently announced promising pre-clinical results on naproxcinod, a CINOD (Cyclooxygenase-Inhibiting Nitric Oxide-Donating) anti-inflammatory candidate, in models of muscular dystrophies. (federchimica.it)