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  • Baseline
  • Specific aims are to a) define the baseline physical activity and fitness levels and prevalence of insulin resistance and dyslipidemia in stable sedentary myasthenic subjects, b) determine whether a 3 month moderate intensity home exercise program is safe and feasible in deconditioned, stable myasthenic subjects and c) whether a 3 month comprehensive home exercise program can enhance fitness, strength, and lung function to improve physical activity and reduce cardiovascular disease risk. (clinicaltrials.gov)
  • Biochemical parameters from collected blood sample Muscle Biopsy will be obtained at baseline and at 12 months. (clinicaltrials.gov)
  • weakness
  • In dystrophinopathy, it was reported that 5 % of female DMD carriers reported myalgia and cramps, 17 % experienced mild-to-moderate muscle weakness and 8 % experienced dilated cardiomyopathy, with a mean onset age of approximately 30 years. (clinicaltrials.gov)
  • Subjects meeting all eligibility criteria will undergo a full history and physical examination, including details of age of onset of symptoms, distribution and severity of muscle weakness, muscle function, pulmonary function, and nutritional status. (clinicaltrials.gov)
  • In the long term, patients may exhibit renal failure due to the myoglobinuria, and with age, patients may exhibit progressively increasing weakness and substantial muscle loss. (wikipedia.org)
  • atrophy
  • Power grip, pinch grip, manual muscle testing or thenar atrophy - which should be assessed as a motor outcome after carpal tunnel decompression? (wikipedia.org)
  • gross
  • Lawson and others, evaluating the relative performance of the new-fangled dynamometer and the old-fashioned BAR-90, found that the BAR-90 performed about as well as dynamometers in identifying the real gross polluters. (thefreedictionary.com)
  • With hidden remote sensors designed to spot a gross polluter on the street, testing devices called dynamometers and state-selected referees who will require motorists to fix their cars, the state is seeking to cut pollution by 25 percent. (thefreedictionary.com)
  • Gross muscle function will be measured by the Walton Scale, the Timed Muscle Function Test and the Six-Minute Walk. (clinicaltrials.gov)
  • pulmonary
  • This study will also determine whether a 3 month home exercise program with aerobic, resistive, and pulmonary training can improve physical activity, strength, fitness, lung function and reduce cardiovascular disease risk. (clinicaltrials.gov)
  • Hypotheses are that a) subjects with myasthenia gravis are physically inactive with reduced fitness level and high incidence of obesity and poor cardiovascular disease risk profile, and b) a 3 month multi-modal home exercise program that includes aerobic, resistive, and pulmonary training components will improve physical activity, strength, fitness, dyspnea, body composition and reduce cardiovascular disease risk. (clinicaltrials.gov)
  • provide
  • Smog inspections performed in the state's smoggiest areas now use a treadmill-like devise called a dynamometer - nicknamed ``dynos'' - and provide more accurate readings for levels of HC and CO. (thefreedictionary.com)
  • It is used to diagnose diseases, to evaluate and compare treatments, to document progression of muscle strength, and to provide feedback during the rehabilitation process. (wikipedia.org)
  • The purpose of this testing is diverse, including to diagnose diseases, to evaluate and compare treatments, to document progression of muscle strength, and to provide feedback during the rehabilitation process as a measure indicating the level of hand function. (wikipedia.org)
  • test
  • Practically able to run themselves in many cases, the company's dynamometers can be nearly hands-free, from starting the engine to gathering data, emitting warnings when necessary and shutting the engine down upon completion of the test. (thefreedictionary.com)
  • Purpose
  • PURPOSE: The purpose of the study was to examine the relation between serum 25-hydroxy vitamin D (25(OH)D) levels and muscle strength in 419 healthy men and women over a broad age range (20-76 yr). (biomedsearch.com)
  • blood
  • Muscle sympathetic nerve activity (MSNA) was directly recorded via microneurography and blood flow by venous occlusion plethysmography. (ahajournals.org)
  • Alterations
  • While none of these ground-based analogs provides a perfect simulation of human microgravity exposure during spaceflight, each is useful for study of particular aspects of muscle unloading as well as for investigation of sensorimotor alterations. (wikipedia.org)
  • walk
  • This type of strength is epitomized by the "Farmer's walk", where the bucket is filled with sand or water, and carried over a long distance. (wikipedia.org)
  • type
  • This has recently been demonstrated by researchers for the recessively inherited limb girdle muscle dystrophy (LGMD) type 2A, where carriers of single mutations can also be symptomatic. (clinicaltrials.gov)
  • The gene for myophosphorylase, PYGM (the muscle-type of the glycogen phosphorylase gene), is located on chromosome 11q13. (wikipedia.org)
  • data
  • CONCLUSION: These data suggest that there may be a differential effect of vitamin D on upper and lower body strength. (biomedsearch.com)
  • large
  • In addition, grip- and pinch strength are functionally relevant to measure the combined action of a large number of intrinsic and extrinsic hand muscles as well as the combined action of a number of different joints. (wikipedia.org)
  • The advantage of these dynamometers is that they to do not measure a large number of muscles in combined action, but can measure single actions such as thumb opposition of index finger abduction. (wikipedia.org)
  • pull
  • When a teams of horses were hooked to the machine, they would pull and the weights would move according to the strength of the team. (wikipedia.org)
  • A starting load of 1500 pounds is set into the dynamometer, a weight that most teams are expected to be able to pull. (wikipedia.org)
  • skeletal muscle
  • The pathological hallmark of this disease is an accumulation of glycogen and autophagic vacuoles in cardiac and skeletal muscle that, along with the myopathy, is also present in LAMP-2-deficient mice. (biomedcentral.com)
  • Humans in the microgravity environment of space, within our current space vehicles, are exposed to various mission-specific periods of skeletal muscle unloading (unweighting). (wikipedia.org)
  • Unloading of skeletal muscle, both on Earth and during spaceflight, results in remodeling of muscle (atrophic response) as an adaptation to the reduced loads placed upon it. (wikipedia.org)
  • In addition, there are cardiopulmonary and vascular changes, including a significant decrease in red blood cell mass, that affect skeletal muscle function. (wikipedia.org)
  • In the U.S. human space program, the only in-flight countermeasure to skeletal muscle functional deficits that has been utilized thus far is physical exercise. (wikipedia.org)
  • Collective knowledge gained from these mission has aided in the evolution of exercise hardware and protocols in attempts to refine the approach to prevention of spaceflight-induced muscle atrophy and the concomitant deficits in skeletal muscle function. (wikipedia.org)
  • Access to human crewmembers during both short- and long-duration mission for the study of skeletal muscle adaptation to microgravity and the efficacy of countermeasures has been, and continues to be, limited. (wikipedia.org)
  • Consequently, a more complete understanding of physiologic models for conduct of both fundamental and applied skeletal muscle research. (wikipedia.org)
  • Due to limitations in the number of spaceflights and crewmembers in which novel countermeasures can be tested, future development, evaluation and validation of new countermeasures to the effects of skeletal muscle unloading will likely employ variations of these same basic ground-based models. (wikipedia.org)
  • Myoglobinuria may result from the breakdown of skeletal muscle known as rhabdomyolysis, a condition in which muscle cells breakdown, sending their contents into the bloodstream. (wikipedia.org)
  • thumb
  • MagPro X100 and a figure-of-8 coil centered over the motor cortex (M1).MEP - will be made 10 stimuli with an intensity of 120% of motor threshold (MT). SP- is determined from the maximum force of adduction of right thumb measured with a dynamometer. (clinicaltrials.gov)
  • The advantage of these dynamometers is that they to do not measure a large number of muscles in combined action, but can measure single actions such as thumb opposition of index finger abduction. (wikipedia.org)
  • joints
  • P1 Flexibility- The range of movement possible at joints The sit and reach test is a common measure of flexibility, and it specifically measures the flexibility of the lower back and hamstring muscles. (studymode.com)
  • Point Relief ColdSpot offers temporary relief of minor aches and pains of muscles and joints associated with simple. (ptunited.com)
  • In addition, grip- and pinch strength are functionally relevant to measure the combined action of a large number of intrinsic and extrinsic hand muscles as well as the combined action of a number of different joints. (wikipedia.org)
  • lower
  • The purpose of this study was to investigate the role of adiposity (i.e. body fat percentage, BF%) on lower extremity kinematics, muscle force requirements and their individual contributions to the acceleration of the center of mass (COM) during walking. (forceandmotion.org)
  • physical
  • Cardiovascular Fitness - Cardiovascular fitness (also known as cardiorespiratory fitness) is the ability of the heart, lungs and vascular system to deliver oxygen-rich blood to working muscles during sustained physical activity. (studymode.com)
  • structural
  • 5 . Body Composition Body Composition is the three basic structural componets that make up the body: Far, Muscle and bone. (studymode.com)
  • ability
  • For most organisms, signals of weapon size appear to be accurate or reliable predictors of strength or fighting ability (e.g. (biologists.org)
  • test
  • Muscle torque was a test of knee extensor and flexor muscle strength using a special device called a dynamometer. (grapevinept.com)
  • Measurement of outcomes by parameters of pain threshold: Threshold Tolerance Test Algometry Pressure: the tolerance threshold pressure is measured by pressure algometer digital, with an area of 1 cm2 in area with muscle trigger point that triggers more pain. (clinicaltrials.gov)
  • exercise
  • In both trials the control group received a progressive muscle relaxation intervention aiming at investigating the pure physiological exercise effect isolated from psychosocial effects. (biomedcentral.com)
  • However, the relationships between in-flight exercise, muscle changes and performance are not well understood. (wikipedia.org)
  • mass
  • 5. Body Composition - Body composition is the amount of fat in the body compared to the amount of lean mass (muscle, bones etc. (studymode.com)
  • changes
  • It can be the result of neural factors (eg, spasticity after stroke), systemic conditions (eg, diabetes mellitus), or peripheral changes in the mechanical properties of the muscles and joint capsule caused by adhesive capsulitis or arthrofibrosis. (biomedsearch.com)
  • study
  • While none of these ground-based analogs provides a perfect simulation of human microgravity exposure during spaceflight, each is useful for study of particular aspects of muscle unloading as well as for investigation of sensorimotor alterations. (wikipedia.org)
  • Long
  • This type of strength is epitomized by the "Farmer's walk", where the bucket is filled with sand or water, and carried over a long distance. (wikipedia.org)
  • studies
  • Previous studies have shown that males of the Australian freshwater crayfish ( Cherax dispar ) routinely use unreliable signals of strength whereas females use reliable signals of weapon strength. (biologists.org)
  • pull
  • When a teams of horses were hooked to the machine, they would pull and the weights would move according to the strength of the team. (wikipedia.org)
  • A starting load of 1500 pounds is set into the dynamometer, a weight that most teams are expected to be able to pull. (wikipedia.org)