• Baseline
  • Specific aims are to a) define the baseline physical activity and fitness levels and prevalence of insulin resistance and dyslipidemia in stable sedentary myasthenic subjects, b) determine whether a 3 month moderate intensity home exercise program is safe and feasible in deconditioned, stable myasthenic subjects and c) whether a 3 month comprehensive home exercise program can enhance fitness, strength, and lung function to improve physical activity and reduce cardiovascular disease risk. (clinicaltrials.gov)
  • Biochemical parameters from collected blood sample Muscle Biopsy will be obtained at baseline and at 12 months. (clinicaltrials.gov)
  • weakness
  • In dystrophinopathy, it was reported that 5 % of female DMD carriers reported myalgia and cramps, 17 % experienced mild-to-moderate muscle weakness and 8 % experienced dilated cardiomyopathy, with a mean onset age of approximately 30 years. (clinicaltrials.gov)
  • Subjects meeting all eligibility criteria will undergo a full history and physical examination, including details of age of onset of symptoms, distribution and severity of muscle weakness, muscle function, pulmonary function, and nutritional status. (clinicaltrials.gov)
  • Strategies to minimize or mitigate dyspnea and to boost motivation are imperative for improving adherence to PA, and, in turn, improving fatigue, muscle weakness, PA itself, functional status, disability, and depression in HF patients. (clinicaltrials.gov)
  • The purpose of this pilot/feasibility study is to evaluate a diaphragmatic breathing retraining (DBR) intervention that incorporates informal caregiver coaching to improve the primary outcomes of dyspnea, fatigue, and muscle weakness, and the secondary outcomes of PA, functional status, depression, disability, and depression. (clinicaltrials.gov)
  • In the long term, patients may exhibit renal failure due to the myoglobinuria, and with age, patients may exhibit progressively increasing weakness and substantial muscle loss. (wikipedia.org)
  • dyspnea
  • Hypotheses are that a) subjects with myasthenia gravis are physically inactive with reduced fitness level and high incidence of obesity and poor cardiovascular disease risk profile, and b) a 3 month multi-modal home exercise program that includes aerobic, resistive, and pulmonary training components will improve physical activity, strength, fitness, dyspnea, body composition and reduce cardiovascular disease risk. (clinicaltrials.gov)
  • Dyspnea and fatigue lead to activity avoidance, subsequent muscle de-conditioning, and further increases of dyspnea at even lower levels of activity. (clinicaltrials.gov)
  • pulmonary
  • This study will also determine whether a 3 month home exercise program with aerobic, resistive, and pulmonary training can improve physical activity, strength, fitness, lung function and reduce cardiovascular disease risk. (clinicaltrials.gov)
  • measure
  • In addition, grip- and pinch strength are functionally relevant to measure the combined action of a large number of intrinsic and extrinsic hand muscles as well as the combined action of a number of different joints. (wikipedia.org)
  • The advantage of these dynamometers is that they to do not measure a large number of muscles in combined action, but can measure single actions such as thumb opposition of index finger abduction. (wikipedia.org)
  • The purpose of this testing is diverse, including to diagnose diseases, to evaluate and compare treatments, to document progression of muscle strength, and to provide feedback during the rehabilitation process as a measure indicating the level of hand function. (wikipedia.org)
  • provide
  • Smog inspections performed in the state's smoggiest areas now use a treadmill-like devise called a dynamometer - nicknamed ``dynos'' - and provide more accurate readings for levels of HC and CO. (thefreedictionary.com)
  • It is used to diagnose diseases, to evaluate and compare treatments, to document progression of muscle strength, and to provide feedback during the rehabilitation process. (wikipedia.org)
  • test
  • Practically able to run themselves in many cases, the company's dynamometers can be nearly hands-free, from starting the engine to gathering data, emitting warnings when necessary and shutting the engine down upon completion of the test. (thefreedictionary.com)
  • blood
  • Muscle sympathetic nerve activity (MSNA) was directly recorded via microneurography and blood flow by venous occlusion plethysmography. (ahajournals.org)
  • Purpose
  • PURPOSE: The purpose of the study was to examine the relation between serum 25-hydroxy vitamin D (25(OH)D) levels and muscle strength in 419 healthy men and women over a broad age range (20-76 yr). (biomedsearch.com)
  • investigation
  • The investigation will include sceletal muscle degeneration and strength, as well as cardiac status. (clinicaltrials.gov)
  • While none of these ground-based analogs provides a perfect simulation of human microgravity exposure during spaceflight, each is useful for study of particular aspects of muscle unloading as well as for investigation of sensorimotor alterations. (wikipedia.org)
  • walk
  • This type of strength is epitomized by the "Farmer's walk", where the bucket is filled with sand or water, and carried over a long distance. (wikipedia.org)
  • data
  • CONCLUSION: These data suggest that there may be a differential effect of vitamin D on upper and lower body strength. (biomedsearch.com)
  • type
  • This has recently been demonstrated by researchers for the recessively inherited limb girdle muscle dystrophy (LGMD) type 2A, where carriers of single mutations can also be symptomatic. (clinicaltrials.gov)
  • The gene for myophosphorylase, PYGM (the muscle-type of the glycogen phosphorylase gene), is located on chromosome 11q13. (wikipedia.org)
  • pull
  • When a teams of horses were hooked to the machine, they would pull and the weights would move according to the strength of the team. (wikipedia.org)
  • A starting load of 1500 pounds is set into the dynamometer, a weight that most teams are expected to be able to pull. (wikipedia.org)
  • evaluation
  • Due to limitations in the number of spaceflights and crewmembers in which novel countermeasures can be tested, future development, evaluation and validation of new countermeasures to the effects of skeletal muscle unloading will likely employ variations of these same basic ground-based models. (wikipedia.org)
  • study
  • Access to human crewmembers during both short- and long-duration mission for the study of skeletal muscle adaptation to microgravity and the efficacy of countermeasures has been, and continues to be, limited. (wikipedia.org)