• weakness
  • In dystrophinopathy, it was reported that 5 % of female DMD carriers reported myalgia and cramps, 17 % experienced mild-to-moderate muscle weakness and 8 % experienced dilated cardiomyopathy, with a mean onset age of approximately 30 years. (clinicaltrials.gov)
  • Subjects meeting all eligibility criteria will undergo a full history and physical examination, including details of age of onset of symptoms, distribution and severity of muscle weakness, muscle function, pulmonary function, and nutritional status. (clinicaltrials.gov)
  • Strategies to minimize or mitigate dyspnea and to boost motivation are imperative for improving adherence to PA, and, in turn, improving fatigue, muscle weakness, PA itself, functional status, disability, and depression in HF patients. (clinicaltrials.gov)
  • The purpose of this pilot/feasibility study is to evaluate a diaphragmatic breathing retraining (DBR) intervention that incorporates informal caregiver coaching to improve the primary outcomes of dyspnea, fatigue, and muscle weakness, and the secondary outcomes of PA, functional status, depression, disability, and depression. (clinicaltrials.gov)
  • Background: In the absence of a curative treatment for Duchenne Muscular Dystrophy (DMD), corticosteroid therapy (prednisone, deflazacort) has been adopted as the standard of care, as it slows the progression of muscle weakness and enables longer retention of functional mobility. (plos.org)
  • Results: A main effect for age was seen in select lower extremity muscle groups (hip flexors, knee extensors and ankle dorsiflexors), standing dimension skills, and all TMTs with significantly greater weakness and loss of motor skill ability seen in the older age group regardless of treatment group. (plos.org)
  • In the long term, patients may exhibit renal failure due to the myoglobinuria, and with age, patients may exhibit progressively increasing weakness and substantial muscle loss. (wikipedia.org)
  • Baseline
  • Specific aims are to a) define the baseline physical activity and fitness levels and prevalence of insulin resistance and dyslipidemia in stable sedentary myasthenic subjects, b) determine whether a 3 month moderate intensity home exercise program is safe and feasible in deconditioned, stable myasthenic subjects and c) whether a 3 month comprehensive home exercise program can enhance fitness, strength, and lung function to improve physical activity and reduce cardiovascular disease risk. (clinicaltrials.gov)
  • Biochemical parameters from collected blood sample Muscle Biopsy will be obtained at baseline and at 12 months. (clinicaltrials.gov)
  • dyspnea
  • Hypotheses are that a) subjects with myasthenia gravis are physically inactive with reduced fitness level and high incidence of obesity and poor cardiovascular disease risk profile, and b) a 3 month multi-modal home exercise program that includes aerobic, resistive, and pulmonary training components will improve physical activity, strength, fitness, dyspnea, body composition and reduce cardiovascular disease risk. (clinicaltrials.gov)
  • Dyspnea and fatigue lead to activity avoidance, subsequent muscle de-conditioning, and further increases of dyspnea at even lower levels of activity. (clinicaltrials.gov)
  • atrophy
  • There is a growing research database which suggests that skeletal muscles, particularly postural muscles of the lower limb, undergo atrophy and structural and metabolic alterations during space flight. (wikipedia.org)
  • Power grip, pinch grip, manual muscle testing or thenar atrophy - which should be assessed as a motor outcome after carpal tunnel decompression? (wikipedia.org)
  • functional
  • Walking speed is a simple, reliable, and valid measure of functional status that is considered a surrogate for the overall quality of gait and motor function, and even short distance walking tests have the ability to measure motor control, strength, balance, and adaptations in the gait pattern. (ahajournals.org)
  • Can Quantitative Muscle Strength and Functional Motor Ability Differentiate the Influence of Age and Corticosteroids in Ambulatory Boys with Duchenne Muscular Dystrophy? (plos.org)
  • Buckon C, Sienko S, Bagley A, Sison-Williamson M, Fowler E, Staudt L, Heberer K, McDonald CM, Sussman M. Can Quantitative Muscle Strength and Functional Motor Ability Differentiate the Influence of Age and Corticosteroids in Ambulatory Boys with Duchenne Muscular Dystrophy? (plos.org)
  • Identifying functional outcomes sensitive to the early, subtle changes in muscle function has confounded clinical trials. (plos.org)
  • In the U.S. human space program, the only in-flight countermeasure to skeletal muscle functional deficits that has been utilized thus far is physical exercise. (wikipedia.org)
  • pulmonary
  • This study will also determine whether a 3 month home exercise program with aerobic, resistive, and pulmonary training can improve physical activity, strength, fitness, lung function and reduce cardiovascular disease risk. (clinicaltrials.gov)
  • loads
  • Unloading of skeletal muscle, both on Earth and during spaceflight, results in remodeling of muscle (atrophic response) as an adaptation to the reduced loads placed upon it. (wikipedia.org)
  • test
  • Practically able to run themselves in many cases, the company's dynamometers can be nearly hands-free, from starting the engine to gathering data, emitting warnings when necessary and shutting the engine down upon completion of the test. (thefreedictionary.com)
  • investigation
  • The investigation will include sceletal muscle degeneration and strength, as well as cardiac status. (clinicaltrials.gov)
  • While none of these ground-based analogs provides a perfect simulation of human microgravity exposure during spaceflight, each is useful for study of particular aspects of muscle unloading as well as for investigation of sensorimotor alterations. (wikipedia.org)
  • walk
  • This type of strength is epitomized by the "Farmer's walk", where the bucket is filled with sand or water, and carried over a long distance. (wikipedia.org)
  • blood
  • Muscle sympathetic nerve activity (MSNA) was directly recorded via microneurography and blood flow by venous occlusion plethysmography. (ahajournals.org)
  • specific
  • Humans in the microgravity environment of space, within our current space vehicles, are exposed to various mission-specific periods of skeletal muscle unloading (unweighting). (wikipedia.org)
  • research
  • Consequently, a more complete understanding of physiologic models for conduct of both fundamental and applied skeletal muscle research. (wikipedia.org)
  • type
  • This has recently been demonstrated by researchers for the recessively inherited limb girdle muscle dystrophy (LGMD) type 2A, where carriers of single mutations can also be symptomatic. (clinicaltrials.gov)
  • The gene for myophosphorylase, PYGM (the muscle-type of the glycogen phosphorylase gene), is located on chromosome 11q13. (wikipedia.org)
  • pull
  • When a teams of horses were hooked to the machine, they would pull and the weights would move according to the strength of the team. (wikipedia.org)
  • A starting load of 1500 pounds is set into the dynamometer, a weight that most teams are expected to be able to pull. (wikipedia.org)
  • evaluation
  • Due to limitations in the number of spaceflights and crewmembers in which novel countermeasures can be tested, future development, evaluation and validation of new countermeasures to the effects of skeletal muscle unloading will likely employ variations of these same basic ground-based models. (wikipedia.org)