• Roles of hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha, a lipid metabolism enzyme, in Wilms tumor patients. (nih.gov)
  • Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution. (yale.edu)
  • Most identifiable cases involve inherited or spontaneous mutations in the pyruvate dehydrogenase complex (PDC) or in one or more enzymes of the respiratory chain. (bmj.com)
  • Pyruvate may be reduced to lactate in the cytoplasm or may be transported into the mitochondria for anabolic reactions, such as gluconeogenesis and lipogenesis, or for oxidation to acetyl CoA by the pyruvate dehydrogenase (PDH) complex (PDC). (bmj.com)
  • The pyruvate dehydrogenase (PDH) multienzyme complex (PDC). (bmj.com)
  • A component of the multienzyme 2-oxo-acid dehydrogenase complexes. (expasy.org)
  • In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12 and catalyzes oxidation of its dihydrolipoyl groups. (expasy.org)
  • It plays a similar role in the oxoglutarate and 3-methyl-2- oxobutanoate dehydrogenase complexes. (expasy.org)
  • Formation of reactive oxygen species by human and bacterial pyruvate and 2- oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components , FREE RADICAL BIOLOGY AND MEDICINE 89: pp. 642-650. (doktori.hu)
  • Pyruvate dehydrogenase is a multi-enzyme complex responsible for the generation of acetyl CoA from pyruvate for the Krebs cycle. (msdmanuals.com)
  • If you feel you need some extra digestive support after meals, using Solgar® Advanced Multi-Enzyme Complex may help. (johnbellcroyden.co.uk)
  • Solgar® Advanced Multi-Enzyme Complex is a unique blend of naturally derived enzymes and botanicals to help support your digestive system and the absorption of your food. (johnbellcroyden.co.uk)
  • By taking 1-3 capsules of Solgar® Advanced Multi-Enzyme Complex a day, you are helping your body to digest the food you eat and absorb the nutrients you need. (johnbellcroyden.co.uk)
  • Pro Multi Enzyme Complex is a powerful, comprehensive blend of enzymes, herbs, and other targeted nutrients to support digestive function. (charnyhealing.com)
  • This study was conducted to investigate the effect of dietary supplementation of exogenous multi-enzyme complex and feed form on growth performance, slaughter characteristics, nutrient digestibility, phosphorus (P), calcium (Ca), and nitrogen-corrected apparent metabolizable energy (AMEn) utilization in broilers fed corn-soybean meal diets. (integrityresjournals.org)
  • A total of 312 male one day-old broiler chicks (Ross 308) were allocated to 6 dietary treatment groups with 13 replicates (4 birds each) in a 2×3 factorial arrangement of treatments in a randomized design, which includes mash (M) or pellet (P) diets supplemented with three levels of a multi-enzyme complex (0, 125, or 175 mg/kg) for 42 days. (integrityresjournals.org)
  • 0.05) by adding the multi-enzyme complex to the pelleted feeds. (integrityresjournals.org)
  • 0.05) linearly with an increase in the multi-enzyme complex added to both the mash and pelleted feeds. (integrityresjournals.org)
  • ATCase is part of the CAD multi-enzyme complex, part of the pyrimidine biosynthesis pathway, along with carbamoyl phosphate synthetase II and dihydroorotase. (jove.com)
  • Digestive Enzymes Supplement Multi-Enzyme Complex For Bet. (alpspurenutra.com)
  • Multienzyme complex contains several copies of one or several enzymes (polypeptide chains) packed into one assembly. (wikipedia.org)
  • The digestive process is a complex system in which the body breaks down the food that we eat into nutrients with the help of digestive enzymes, which are produced in the pancreas and small intestines. (johnbellcroyden.co.uk)
  • Using Bacillus subtilis YTB4 with high yield of multienzyme complex as original strain, mutation breeding was carried out by He-Ne laser irradiation in this study. (ajol.info)
  • In addition, the hereditary stability test showed that the activities of multienzyme complex were stable and that there was no reverse mutation after 25 generations. (ajol.info)
  • Eukaryotic lipid and fatty acid metabolism remains a critical challenge for studies at the atomic, molecular and cellular scale: In contrast to simple prokaryotic systems, fatty acid metabolism in eukaryotes builds upon large multienzymes, which integrate multiple catalytic activities into giant proteins. (unibas.ch)
  • Molecular pathomechanisms of enhanced reactive oxygen species (ROS) generation and impaired binding to multienzyme complexes were also addressed according to the structural data for the relevant mutations. (rcsb.org)
  • A new chapter in this field will be, in the near future, the discovery of mechanisms and actors underlying the formation of supercomplexes, molecular structures formed by the physical, and possibly functional, interaction of some of the individual respiratory complexes, particularly complex I, III and IV. (cam.ac.uk)
  • Cytochrome c oxidase (complex IV) catalyses the reduction of molecular oxygen to water and ATP synthase (complex V) generates ATP from ADP. (bmj.com)
  • A gene (His-3) was found to encode a protein that functions as a multienzyme complex having three distinct enzymatic activities in the biosynthesis pathway. (wikipedia.org)
  • Quaternary structure Protein complex Macromolecular assembly Biomolecular complex Neuman, Nicole (2016). (wikipedia.org)
  • Development of new or improved instruments, methods, and related software to elucidate 3D structures of macromolecules and macromolecular complexes. (nih.gov)
  • A program that focuses on the scientific relationship of physiological function to the structure and actions of macromolecules and supramolecular assemblies such as multienzyme complexes, membranes, and viruses. (ed.gov)
  • Combining experimental structural studies with functional analysis, we elucidate fundamental principles of multienzyme architecture & regulation and the role of protein assemblies for spatial organization of metabolism. (unibas.ch)
  • In addition, NlpI seems to contribute both to PG elongation and division biosynthetic complexes based on its localization and genetic interactions. (uu.nl)
  • Our results indicate that peptidoglycan regulators and adaptors are part of PG biosynthetic multi-enzyme complexes, regulating and potentially coordinating the spatiotemporal action of PG synthases and hydrolases. (uu.nl)
  • The accumulation of FtsY-ribosome complexes induces the formation of intracellular membranes needed for their quantitative accommodation. (rupress.org)
  • An intracellular ribonucleolytic protein complex that participates in POSTRANSCRIPTIONAL RNA PROCESSING and RNA DEGRADATION. (bvsalud.org)
  • Reducing equivalents (NADH, FADH 2 ) are generated by reactions catalysed by the PDC and the tricarboxylic acid cycle and donate electrons (e - ) that enter the respiratory chain at NADH ubiquinone oxidoreductase (complex I) or at succinate ubiquinone oxidoreductase (complex II). (bmj.com)
  • The mTOR kinase exerts its functions in two functionally and structurally distinct complexes, mTORC1 & 2. (unibas.ch)
  • Multienzyme complex carries out a single or a series of biochemical reactions taking place in the cells. (wikipedia.org)
  • A multienzyme complex that functions in the histidine biosynthesis pathway has been studied at the biochemical and genetic level in the fungus Neurospora crassa. (wikipedia.org)
  • Mutations in a large number of these assembly factors are responsible for mitochondrial disorders, in most cases of infantile onset, typically characterized by biochemical defects of single specific complexes. (cam.ac.uk)
  • Consistent with such a role, we reconstitute PG multi-enzyme complexes containing NlpI, the PG synthesis regulator LpoA, its cognate bifunctional synthase, PBP1A, and different endopeptidases. (uu.nl)
  • Our structural studies have revealed the intricate interlinking, coupling and crosstalk between domains that result in emergent properties beyond the functionality of their isolated building blocks and shed light on the evolution of this family of multienzymes (Maier et al. (unibas.ch)
  • The structural biogenesis and functional proficiency of the multiheteromeric complexes forming the mitochondrial oxidative phosphorylation system require the concerted action of a number of chaperones and other assembly factors, most of which are specific for each complex. (cam.ac.uk)
  • In fact, pathogenic mutations in complex-specific assembly factors outnumber, in many cases, the repertoire of mutations found in structural subunits of specific complexes. (cam.ac.uk)
  • It has been reported that the use of multi-enzyme complexes can significantly promote the overall degradation efficiency of substrates(Huang et al. (researchsquare.com)
  • A genetic analysis of mutants defective in the N. crassa histidine pathway indicated that the individual activities of the multienzyme complex occur in discrete regions of the His-3 genetic map. (wikipedia.org)
  • This finding suggested that each of the activities of the multienzyme complex are encoded separately from each other, but within the same gene. (wikipedia.org)
  • Some His-3 mutants were also found that lacked all three activities simultaneously, suggesting that some mutations can cause loss of function of the whole multienzyme complex. (wikipedia.org)
  • In summary, we present here for the first time a comprehensive study that links three-dimensional structures of disease-causing hE3 variants to residual hLADH activities, altered capacities for ROS generation, compromised affinities for multienzyme complexes and eventually clinical symptoms. (rcsb.org)
  • Here we show that in cells depleted of the SRP protein, Ffh or the translocon component SecE, the ribosomal targeting pathway is blocked downstream and unprecedented, membrane-bound FtsY-ribosomal complexes are captured. (rupress.org)
  • The two complexes share the defining core mTOR protein but employ characteristic subunits, Raptor for mTORC1 and Rictor for mTORC2, for capturing input signals controlling and localization, as well as for recognizing specific targets for phosphorylation. (unibas.ch)
  • The wide use of next generation sequencing has led and will allow to identify additional components of the assembly machinery of individual complexes, mutations of which are responsible for human disorders. (cam.ac.uk)
  • NlpI binds to different classes of hydrolases and can specifically form complexes with various PG endopeptidases. (uu.nl)
  • The resulting hydroxyethyl-TPP complex reacts with oxidised lipoamide (LipS 2 ), the prosthetic group of dihydrolipoamide transacetylase (E 2 ), to form acetyl lipoamide. (bmj.com)
  • In the late 1980s Alfred L. Goldberg , professor of cell biology at Harvard Medical School, and Martin C. Rechsteiner , professor of biochemistry at the University of Utah, addressed this question when they discovered proteasomes--large, multienzyme complexes that play a key role in protein breakdown. (the-scientist.com)
  • This enzyme is commercially available alone or in multi-enzyme complexes for use in pre-processing of ingredients/diets or supplementation of diets during feed production. (nofima.no)