• humans
  • The purpose of this study is to see if an investigational vaccine can make antibodies (proteins found in blood) in humans that will influence the course of an AIDS-like disease in monkeys. (clinicaltrials.gov)
  • These diseases in monkeys mirror what happens in humans, and the study results are cause for hope that the antibody, named m102.4, ultimately may be developed into a possible treatment for people who become infected with these viruses. (equinetrader.co.nz)
  • Hendra virus emerged in 1994 in Australia and primarily affects horses, which can spread the disease to humans. (equinetrader.co.nz)
  • Macaques develop age-associated cognitive/memory impairments as well as brain abnormalities (particularly senile plaques) similar to those occurring in the brains of older humans and individuals with Alzheimer's disease (AD). (springer.com)
  • Wildlife managers in Florida say they want to remove roaming monkeys from the state in light of a new study published on Wednesday, which finds some of the animals are excreting a virus that can be dangerous to humans. (nexusnewsfeed.com)
  • The CDC said there is always concern about the threat that diseases like herpes B virus pose to people, especially in settings where there is frequent interaction between animals and humans where scratches or bites can occur. (nexusnewsfeed.com)
  • In humans, herpes B causes a devastating brain disease that the CDC says is deadly about 70 percent of the time - especially without treatment. (clicklancashire.com)
  • While there are no official statistics on monkey attacks on humans in the park, a state-sponsored study in the 1990s found 31 monkey-human incidents, with 23 resulting in human injury between 1977 and 1984. (clicklancashire.com)
  • Monkeypox infection is zoonotic disease - that is, a disease that is transmitted from animals to humans and vice versa. (afrimash.com)
  • The species chosen will usually meet a determined taxonomic equivalency to humans, so as to react to disease or its treatment in a way that resembles human physiology as needed. (wikipedia.org)
  • Although biological activity in a model organism does not ensure an effect in humans, many drugs, treatments and cures for human diseases are developed in part with the guidance of animal models. (wikipedia.org)
  • Homologous animals have the same causes, symptoms and treatment options as would humans who have the same disease. (wikipedia.org)
  • He went on to develop an antitoxin against diphtheria in animals and then in humans, which resulted in the modern methods of immunization and largely ended diphtheria as a threatening disease. (wikipedia.org)
  • Most cases of humans contracting the disease from infected animals are in developing nations. (wikipedia.org)
  • Conversely, when humans are zoonotically infected with B virus, patients can present with severe central nervous system disease, resulting in permanent neurological dysfunction or death. (wikipedia.org)
  • Ebola
  • A new Ebola virus study resulting from a widespread scientific collaboration has shown promising preliminary results, preventing disease in infected nonhuman primates using monoclonal antibodies. (medicalxpress.com)
  • MVD is a viral hemorrhagic fever (VHF), and the clinical symptoms are indistinguishable from Ebola virus disease (EVD). (wikipedia.org)
  • citation needed] Contrary to Ebola virus disease (EVD), which has been associated with heavy rains after long periods of dry weather, triggering factors for spillover of marburgviruses into the human population have not yet been described. (wikipedia.org)
  • herpes B vir
  • Herpes B virus was first identified in 1932 following the death of Dr. William Brebner, a young physician who was bitten by a monkey while researching the virus that causes poliomyelitis. (wikipedia.org)
  • bodily
  • Scientists studying a growing population of rhesus macaques in Silver Springs state park say that rather than just carrying herpes B, which is common in the species, some of the monkeys have the virus in their saliva and other bodily fluids, posing a potential risk of spreading the disease. (nexusnewsfeed.com)
  • Still, he said, while the research confirms the presence of the virus in the monkeys' bodily secretions, more work needs to be done to establish how much virus there is, and how easily transferable it is. (nexusnewsfeed.com)
  • lethal
  • In this week's online edition of the Proceedings of the National Academy of Sciences ( PNAS ), the research team describes a proof-of-concept for using a "cocktail" of monoclonal antibodies , or mAbs, to prevent lethal disease in rhesus macaques. (medicalxpress.com)
  • The NIAID-supported study, which appears online in Science Translational Medicine, involved infecting 14 African green monkeys with a lethal dose of Hendra virus. (equinetrader.co.nz)
  • brains
  • To test the safety and effectiveness of DA neurons made from human iPS cells, Tetsuhiro Kikuchi, a neurosurgeon working in the Takahashi lab, transplanted the cells into the brains of monkeys. (laboratoryequipment.com)
  • This study, which can be read in Nature Communications , shows that dopamine neurons derived from MHC-matched monkey iPS cells stimulate far less neuroinflammation when transplanted into monkey brains than did dopamine neurons derived from MHC-unmatched monkey iPS cells. (engineeringevil.com)
  • Bahmanyar S, Higgins GA, Goldgaber D, Lewis DA, Morrison JH, Wilson MC, Shankar SK, Gajdusek DC (1987) Localization of amyloid β-protein messenger RNA in brains from patients with Alzheimer's disease. (springer.com)
  • Florida
  • A rhesus macaques monkey along the Silver river in Silver Springs, Florida. (nexusnewsfeed.com)
  • Without management action, the presence and continued expansion of non-native rhesus macaques in Florida can result in serious human health and safety risks including human injury and transmission of disease," Thomas Eason, assistant executive director of the Florida Fish and Wildlife Conservation Commission, said in a statement. (nexusnewsfeed.com)
  • Thomas Eason, assistant executive director of the Florida Fish and Wildlife Conservation Commission , said in a statement that without the organization the specter of sustainable and extended enlargement of non-resident rhesus macaques in Florida can lead to consequential human health and safety probability involving human damage or transferal of disease. (clicklancashire.com)
  • transmit
  • Animals with rabies suffer deterioration of the brain and tend to behave bizarrely and often aggressively, increasing the chances that they will bite another animal or a person and transmit the disease. (wikipedia.org)
  • India
  • The fruit bats, which are resistant to the diseases, are found primarily in Australia but have been found as far west as Africa, north to India and Pakistan, and east to the Philippines. (equinetrader.co.nz)
  • The disease was first reported from Kyasanur Forest of Karnataka in India in March 1957. (wikipedia.org)
  • It was determined that the Harper strain of smallpox kills monkeys slowly while the India strain kills them quickly. (wikipedia.org)
  • therapies
  • The investigators are now studying the onset of the disease and its behavioral and cognitive effects, with the goal of using the monkey model to better understand disease mechanisms and to design therapies. (medgadget.com)
  • The findings suggest HLA matching for iPS cell therapies will improve outcomes in patients with neurodegenerative diseases. (engineeringevil.com)
  • macaques
  • National Institutes of Health (NIH) researchers have developed an animal model of human hantavirus pulmonary syndrome (HPS) in rhesus macaques , an advance that may lead to treatments, vaccines and improved methods of diagnosing the disease. (wordpress.com)
  • human
  • The multiple sclerosis (MS) community has a surprising and important new animal model, the Japanese macaque monkey, which could provide a tantalizing new clue to the etiology of the human disease. (lww.com)
  • It also raises the possibility that a related virus could potentially be playing a role in human disease," said Dr. Tyler, the Reuler-Lewin Family Professor and chair of neurology at the University of Colorado-Denver. (lww.com)
  • DR. DENNIS BOURDETTE: "We now have a new class of viruses that can cause an MS-like disease in non-human primates, and this will give us the molecular tools to look in MS tissue and MS blood samples to see if there is a similar virus involved in the disease. (lww.com)
  • For this reason, monkeys will be used to evaluate the role of specific human antibodies. (clinicaltrials.gov)
  • This is because human social factors ultimately create the conditions that allow zoonotic diseases to be transmitted from animal reservoirs and to spread. (stanford.edu)
  • We will study social networks to understand how social resources structure key activities relevant to human-primate contact and zoonotic transmission risk, and we will explore knowledge, beliefs, and perceptions of human-primate contact and disease transmission for a broad sample of the population. (stanford.edu)
  • Human amyloidosis, Alzheimer disease and related disorders. (springer.com)
  • Goedert M (1987) Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease. (springer.com)
  • Model organisms are in vivo models and are widely used to research human disease when human experimentation would be unfeasible or unethical. (wikipedia.org)
  • page needed] In researching human disease, model organisms allow for better understanding the disease process without the added risk of harming an actual human. (wikipedia.org)
  • Predictive models are similar to a particular human disease in only a couple of aspects, but are useful in isolating and making predictions about mechanisms of a set of disease features. (wikipedia.org)
  • It has contributed most of the basic knowledge in fields such as human physiology and biochemistry, and has played significant roles in fields such as neuroscience and infectious disease. (wikipedia.org)
  • symptoms of the disease
  • Also, the Bayelsa State Government has started an aggressive public enlightenment campaign to advise clinicians and the public on the symptoms of the disease and the steps required to manage the cases and to prevent further spread. (afrimash.com)
  • The symptoms of the disease include a high fever with frontal headaches, followed by haemorrhagic symptoms, such as bleeding from the nasal cavity, throat, and gums, as well as gastrointestinal bleeding. (wikipedia.org)
  • successfully
  • In May 2010, shortly after the NIH study in monkeys successfully concluded, Australian health officials requested m102.4 for emergency use in a woman and her 12-year-old daughter. (equinetrader.co.nz)
  • 1986
  • It was first observed in the monkey colony at the Oregon National Primate Research Center in Beaverton, OR, in 1986, and has developed spontaneously in one to four monkeys per year since then, affecting a total of 56 animals. (lww.com)
  • Cork LC, Sternberger NH, Sternberger LA, Casanova MF, Strubie RG, Price DL (1986) Phosphorylated neurofilament antigens in neurofibrillary tangles in Alzheimer's disease. (springer.com)
  • treatments
  • Twelve of the monkeys then received two treatments with m102.4, one either at 10, 24, or 72 hours after being infected, and another 48 hours later. (equinetrader.co.nz)
  • research
  • Japanese macaque monkeys infected with a newly identified virus develop a progressive disease characterized by paresis in one or more limbs, ataxia, or ocular motor paresis - providing a potential new animal model for multiple sclerosis research. (lww.com)
  • The Emory research team developed this transgenic monkey model by introducing altered forms of the Huntington gene into monkey eggs using a viral vector. (medgadget.com)
  • In 2009, we documented three simian retroviruses co-circulating in a metapopulation of wild red colobus monkeys (Procolobus rufomitratus) in Kibale National Park, Uganda, where we have conducted research for over two decades. (stanford.edu)
  • Dan is clearly one of the leading young disease ecologists working today and his understanding of the field and willingness to do the sometimes unglamorous grunt work of ecology in pursuit of important research questions continually impresses me. (stanford.edu)
  • formerly
  • This article is a list of diseases of Erythranthe (formerly Mimulus), Monkey-Flower (Erythranthe × hybridus) as reported by the American Phytopathological Society. (wikipedia.org)
  • treatment
  • The disease has no specific medicine for treatment, but when intensive supportive care is provided most patients recover fully. (afrimash.com)
  • made
  • Several studies have shown the transplantation of DA neurons made from fetal cells can mitigate the disease. (laboratoryequipment.com)
  • What really made the whole project come together was the fortuitous office-pairing of Dan with Marcel Salathé , another post-doc with whom I have collaborated extensively on questions of social networks and infectious disease . (stanford.edu)
  • Their contacts with the public, including last summer when the monkeys chased a family, have made them somewhat notorious critters and have caused two partial park closures since 2016. (nexusnewsfeed.com)
  • Monkeys living in Silver Springs made headlines past year, when they chased and hissed at a family visiting the popular public park. (clicklancashire.com)
  • transmission
  • This is a cross-cutting program that "supports the development of predictive models and the discovery of principles governing the transmission dynamics of infectious disease agents" (from the EID home page ). (stanford.edu)
  • The vector for disease transmission is Haemaphysalis spinigera, a forest tick. (wikipedia.org)
  • animals
  • The disease, called Japanese Macaque encephalitis (JME), affects male and female animals equally, with no seasonal pattern in development. (lww.com)
  • A "Monkey Cabinet" is designed at USAMRIID and CDC for use in the possible investigation of the question of whether animals can be infected with smallpox. (wikipedia.org)
  • risk
  • Frequent hand washing, and avoiding people with sore throats can help reduce the risk of flesh-eating disease, according to the National Necrotizing Fasciitis Foundation. (survivalmonkey.com)
  • Frequent hand washing, and avoiding people with sore throats can help reduce the risk of flesh-eating disease. (survivalmonkey.com)
  • persist
  • they often persist as latent infections in a host without causing disease, but may produce tumors in a host of a different species, or in individuals with ineffective immune systems. (wikipedia.org)
  • work
  • In the 1960s David Hubel and Torsten Wiesel demonstrated the macro columnar organization of visual areas in cats and monkeys, and provided physiological evidence for the critical period for the development of disparity sensitivity in vision (i.e.: the main cue for depth perception), and were awarded a Nobel Prize for their work. (wikipedia.org)