• We evaluated the rate of switching to second-line antiretroviral therapy (ART), and the impact of delayed switching on immunologic, virologic, and mortality outcomes in the Rakai Health Sciences Program (RHSP) Clinical Cohort Study which started providing ART in 2004 and implemented 6 monthly routine virologic monitoring beginning in 2005. (biomedcentral.com)
  • Immunologic decline after virologic failure was defined as decrease in CD4 count of ≥50 cells/ul and virologic increase was defined as increase of 0.5 log 10 copies/ml. (biomedcentral.com)
  • Competing risk models were used to summarize rates of switching to second-line ART while cox proportional hazard marginal structural models were used to assess the risk of virologic increase or immunologic decline associated with delay to switch first line ART failing patients. (biomedcentral.com)
  • In order to promptly switch treatment and to ensure sustained virologic suppression, viral load (VL) monitoring to identify virologic failure is crucial. (biomedcentral.com)
  • However, data on patient-centered outcomes in ART programs with routine virologic monitoring in developing countries are still limited. (biomedcentral.com)
  • Using data from the Rakai Health Sciences Program (RHSP) Clinical Cohort Study, which monitors HIV care programs, we retrospectively assessed the rate and factors associated with switching from first- to second-line ART among HIV-infected adults with virologic failure 6 months after ART initiation, and evaluated the impact of delayed switching on immunologic, virologic, and mortality outcomes. (biomedcentral.com)
  • Clinical, Virologic, and Immunologic Evaluation of Symptomatic Coronavirus Disease 2019 Rebound Following Nirmatrelvir/Ritonavir Treatment. (bvsalud.org)
  • There are no standard immunologic monitoring methods that will allow comparison of immune based clinical strategies between labs or will even allow accurate assessment of the immunogenicity of a particular approach. (iths.org)
  • Standardization and development of reproducible and clinical grade immunologic assays to determine the magnitude of tumor specific immune responses generated in the context of clinical trials of cancer immunotherapy is an area of research in the TVG. (iths.org)
  • However, all these solutions cannot be currently implemented in the clinical routine because of the lack of effective means for monitoring allograft function and rational based approaches towards selection of the optimal immunosuppressive therapy. (europa.eu)
  • Rectal temperature and clinical illness scores were monitored, and blood and nasal specimens were obtained for determination of clinicopathologic and immunologic variables. (avma.org)
  • Scholars@Duke publication: Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoring. (duke.edu)
  • Rheumatology and Immunology Research is the official journal of the National Clinical Research Center for Dermatologic and Immunologic Diseases of China (NCRC-DID) . (degruyter.com)
  • This guideline is jointly sponsored by the National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), the Chinese Systemic Lupus Erythematosus Treatment and Research Group (CSTAR), and the Chinese Research Committee of Pregnancy and Reproduction in Autoimmune Rheumatic Diseases (CHOPARD). (degruyter.com)
  • In the past, the clinical practice supported by treatment guidelines was generally to monitor both CD4 count and viral load concurrently. (hiv.gov)
  • Analogous studies in a murine syngeneic tumor model using surrogate antibodies demonstrated significant synergy between LAG-3 and PD-1 blockade-combination treatment led to a marked improvement in therapeutic efficacy, increased T-cell proliferation, IFNγ production, and elicited durable immunologic memory upon tumor rechallenge. (aacrjournals.org)
  • Modification of tumor cells for luciferase expression enables non-invasive monitoring of orthotopic tumor growth, and has proven useful for studying glioblastoma response to novel therapeutics. (northwestern.edu)
  • GL261 and GL261.luc cells were then implanted intracranially in C57BL/6 mice, with GL261.luc tumor growth monitored by quantitative bioluminescence imaging, and all mice were followed for survival to compare relative malignancy of tumor cells. (northwestern.edu)
  • Very few studies address the appropriate frequency of viral load monitoring. (hivguidelines.org)
  • There is also a 6 monthly immunologic monitoring and targeted plasma viral load testing is used to confirm immunologic failure. (mediaforfreedom.com)
  • HIV RNA (viral load) and CD4 T lymphocyte cell (CD4) count are the two surrogate markers of antiretroviral therapy (ART) responses and HIV disease progression that have been used for decades to manage and monitor HIV infection. (hiv.gov)
  • Thus, the most important use of the viral load is to monitor the effectiveness of therapy after initiation of ART. (hiv.gov)
  • Clarify the appropriate use of immunologic (CD4 count) monitoring in the care of patients with HIV. (hivguidelines.org)
  • Patients who are monitored at longer intervals should be carefully selected based on length of viral suppression, CD4 count, use of ART for transmission prevention, and adherence to medical care, including visit attendance and retention in care. (hivguidelines.org)
  • Patients receiving topical and systemic aminoglycoside antibiotics: Total serum concentrations should be monitored. (drugs.com)
  • In patients of all ages who are started on antidepressant therapy, monitor closely for worsening and for emergence of suicidal thoughts and behaviors. (rxlist.com)
  • But the first half is those who respond quite well to 5-ASA [aminosalicylate] and don't seem to progress, and then the other half for whom [aminosalicylate] is not enough, and you do need to monitor and see early that these patients are responding. (hcplive.com)
  • Extensive immune monitoring was performed in all patients. (duke.edu)
  • The combination of CKA and DSA monitoring or the performance of transvivo DTH correlated with immune status of the patients. (duke.edu)
  • Addressing this critical need for enhanced reproductive and prenatal care, there is a pressing imperative to establish standardized protocols for peri-gestational monitoring and treatment in SLE patients. (degruyter.com)
  • However, because most patients with HIV in care now receive ART, the rationale for frequent CD4 count monitoring is weaker. (hiv.gov)
  • For further discussion on HIV-2 RNA monitoring in patients with HIV-1/HIV-2 coinfection or HIV-2 mono-infection, see the HIV-2 Infection section. (hiv.gov)
  • The purpose of this protocol is to assess the extent and activity of the disease in patients, conduct immunologic studies of lymphocyte and antigen-presenting cells derived from peripheral blood and tissues, administer and monitor treatments, and study the genetic risk factors for these diseases The immediate aims of these studies are to define the immunologic abnormalities present and to identify genetic susceptibility factors in patients with these diseases. (healthengine.com.au)
  • Results Sixty-six patients were screened and 19 enrolled of whom 14 received at least 3 doses of the vaccine and thus evaluated for the primary immunologic endpoint. (bmj.com)
  • The detection of anti-HBs is indicative of a prior immunologic exposure to the antigen or vaccine. (cdc.gov)
  • and after initiation of ART to assess immunologic response and to establish the need for discontinuation of OI prophylaxis. (hiv.gov)
  • OBJECTIVE: To assess the effect on the function and immunologic status of potential donor livers of the duration of brain death combined with the presence and absence of hemodynamic instability in the donor. (ox.ac.uk)
  • that immunologic reactivity to anthrax antigens, if any, and Germaine Hanquet would very likely demonstrate exposure to B. anthracis . (cdc.gov)
  • Because of the high rate of asymptomatic infection with these viruses, information about the prevalence of these diseases is needed to monitor prevention efforts. (cdc.gov)
  • In general, regular physical activity improves the physiologic, metabolic, and immunologic processes, as well as quality of life of individuals (5). (cdc.gov)
  • Organ function was studied by monitoring standard serum parameters. (ox.ac.uk)
  • In this issue of the Cleveland Clinic Journal of Medicine , Ashcherkin and colleagues 1 review how bone turnover markers (BTMs) can be used to monitor oral bisphosphonate treatment efficacy and patient adherence. (ccjm.org)
  • Monitoring the state of the immune system, therefore, can tell us not only if a patient is currently fighting an infection, but by digging into the institutional memory of the immune system, it can also tell us if someone has ever faced a specific challenge. (hackaday.com)
  • Three-quarters, two-thirds probably need some type of a biologic, immunologic therapy from the start. (hcplive.com)
  • With increasing pressure on clinicians to normalize anticoagulation therapy, continuous monitoring of coagulation factors has become a primary protocol, thus driving the market for coagulation. (micromarketmonitor.com)
  • Additional and/or more frequent monitoring should be done to ensure receipt of an effective dose while avoiding unnecessary toxicities. (drugs.com)
  • Studies do not indicate the appropriate interval for viral suppression monitoring for ongoing transmission prevention. (hivguidelines.org)
  • Monitor for worsening and emergence of suicidal thoughts and behaviors ( 5.1 ). (nih.gov)
  • To determine immunologic reactivity to Bacillus anthrax antigens, we conducted serologic testing of workers in a The Study factory that performed scouring of wool and goat hair. (cdc.gov)
  • Effects of brain death and hemodynamic status on function and immunologic activation of the potential donor liver in the rat. (ox.ac.uk)
  • At the time I wrote the first article, I could find no indication of an immunologic test for COVID-19 (more specifically, a test for SARS-Cov-2, the virus that causes COVID-19). (hackaday.com)
  • A heart rate monitor by Polar (Polar Electro Inc, Lake Success, New York) was also provided by the WHNRC for assessment because information on its use in children may guide future child health studies. (cdc.gov)
  • This study represents a proof of principle and supports the application of 18F-FEAU PET-CT imaging for monitoring the distribution of intravenously administered sr39HSV1-tk gene-transduced CTLs in humans. (nih.gov)
  • During March through August 2012, children participated in a 4-week study of 3 accelerometer models and a heart rate monitor. (cdc.gov)
  • Until more definitive data are available, the decision to lengthen monitoring intervals for HIV RNA levels should be individualized. (hivguidelines.org)
  • Careful monitoring of lithium levels is recommended when Atacand and lithium are used concomitantly. (medicinenet.com)
  • Cancer Immune Monitoring and Analysis Centers and Cancer Immunologic Data Commons (CIMAC-CIDC) Network (Reissue RFA/Coop. (nih.gov)
  • Through this limited competition Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites applications to continue support for the Cancer Immune Monitoring and Analysis Centers Cancer Immunologic Data Center (CIMAC-CIDC) Network. (nih.gov)
  • We evaluated whether immunologic parameters prior to treatment interruption are predictive of time to rebound in individuals interrupting ART in a highly monitored setting. (natap.org)
  • ACTG 5345 evaluated whether immunologic parameters prior to treatment interruption can predict time to rebound in individuals interrupting ART in a highly monitored setting. (actgnetwork.org)
  • Monitoring and Diagnostic Laboratory a position she held until stepping down in July 2010. (selectbiosciences.com)
  • NIAID is interested in studying immunologic events during the period preceding an autoimmune disease diagnosis as well as the events that precede a flare or progression. (nih.gov)
  • Accurate biomarkers offer the prospect for earlier diagnosis, improved precision of application of expensive and toxic therapies on the optimal patient populations, monitoring disease progression and therapeutic benefits as well as accelerating drug development and discovery. (biomedcentral.com)
  • Martin Hoenigl, the current President of the European Confederation of Medical Mycology (ECMM) and Assistant Professor at the University of California, San Diego, explains us the role of cytokines in the diagnosis and treatment monitoring of invasive mold infections. (ecmm.info)
  • 4. Standards to monitor longitudinal assay performance . (nih.gov)
  • Through the Request for Information (RFI): Inviting Comments and Suggestions on the Identification of Key Events in Autoimmune Diseases , NIAID seeks comments from the scientific community about state-of-the-art sampling and analysis techniques to identify key immunologic events underlying the onset, flare, remission, and progression of autoimmune diseases. (nih.gov)
  • We performed immunologic marker analyses of lymphocytes in a subgroup of 85 children. (nih.gov)
  • Recent advances in delineating the functional complexity of both CD4 + and CD8 + T cells should prompt a re-evaluation of strategies currently used to monitor vaccine-specific immune responses. (medscape.com)
  • Recent studies indicate that autoimmune disease patients can perform minimally invasive self-sampling that is sufficient to describe relevant immune pathways in active autoimmune disease, which raises the possibility that this approach in an at-risk cohort might be a viable approach to elucidating immunologic events in the preclinical period. (nih.gov)
  • She is a recognized expert in immune monitoring of patients with cancer. (selectbiosciences.com)
  • Therapeutic drug monitoring is recommended for all patients ( 2.5 , 5.17 ). (nih.gov)
  • Monitoring, Immunologic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • The feasibility of, potential approaches to, and impact of studies of autoimmune disease patient cohorts to define immunologic events that drive flares and remissions. (nih.gov)
  • Total and disease-specific mortality and incidence of various diseases and symptoms were monitored for safety. (nih.gov)
  • The utility, feasibility, and potential approaches to establishing a cohort of subjects at risk of developing autoimmune diseases and obtaining longitudinal samples from this cohort to identify immunologic events that drive disease onset in a productive, cost-effective, and minimally invasive manner. (nih.gov)
  • The secondary objectives are to determine whether HCQ treatment 1) lessens lupus disease activity as measured by standard scoring indices, 2) improves patient-reported outcomes, 3) prevents accumulation of immunologic abnormalities including autoantibodies and cytokines, and 4) has an acceptable toxicity profile. (nih.gov)
  • Doctors can monitor whether a patient's body is rejecting the organ using different methods, depending on the organ. (nih.gov)
  • Patients at low- to moderate-immunologic risk: Use initially with cyclosporine (CsA) and corticosteroids. (nih.gov)
  • Patients at high-immunologic risk: Use in combination with CsA and corticosteroids for the first 12 months following transplantation ( 1.1 ). (nih.gov)
  • This study will investigate HIV infection and associated conditions by monitoring infected patients. (nih.gov)
  • 3) To characterize the immunologic profile of HCQ in ILE-treated patients. (nih.gov)
  • Given that the patients remain on the study for a total of 92 days to monitor their response to PH-10, Provectus anticipates that the originally projected completion date of December 2015 will be the actual date of completion for this 30 patient trial. (biospace.com)
  • Despite the availability of sophisticated virological and immunologic techniques, there is plenty of room for novel diagnostics. (nanowerk.com)
  • This graph shows the total number of publications written about "Monitoring, Immunologic" by people in UAMS Profiles by year, and whether "Monitoring, Immunologic" was a major or minor topic of these publications. (uams.edu)
  • Below are the most recent publications written about "Monitoring, Immunologic" by people in Profiles over the past ten years. (uams.edu)
  • People living with an immunologic disorder are encouraged to maintain a healthy weight, avoid smoking, limit stress and exercise regularly. (nationaljewish.org)
  • Across our company we are committed to ethical artificial intelligence (AI) principles, which include shaping policy, ensuring appropriate data and AI use and avoiding and monitoring for bias in our data sets and insights. (jnj.com)
  • In addition, use of freezers for sample storage that are monitored for temperature stability and that have 24 hours-a-day alarm response eliminates concerns that samples might undergo freeze-thaw cycles or be otherwise compromised by temperature changes during storage. (biomedcentral.com)
  • Recommendations for use and monitoring in this patient population will be developed. (nih.gov)
  • Immunologic effectors are derived from large pools of human plasma and comprise 4 subclasses of antibodies, approximating the distribution of human serum. (medscape.com)
  • Immunologic disorders cover a broad category of conditions that includes food allergy, asthma and immunodeficiency. (nationaljewish.org)
  • They monitor, screen, and troubleshoot analyzers featuring the latest technology available. (lexmed.com)