• disease models
  • Therapeutic implications include the ability to establish new humanized disease models for understanding mechanisms, conduct high throughput screening for novel biogenic compounds to reverse or prevent the disease phenotype, identify and engineer genetic rescue of causal mutations, and develop patient-specific cellular replacement strategies. (pubmedcentralcanada.ca)
  • However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. (frontiersin.org)
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  • cellular level
  • At the cellular level, dysplastic hippocampal neurons in the MAM model were shown to have reduced potassium current function and expression for the Kv4.2 channel subunit These findings may contribute to the spontaneous seizures and reduced seizure thresholds seen in this model. (wikipedia.org)
  • computational models
  • Now, University of Missouri researchers Ashwin Mohan and Sandeep Pendyam, doctoral students in the Department of Electrical and Computer Engineering , are utilizing computational models to study how the brain's chemicals and synaptic mechanisms, or connections between neurons, react to cocaine addiction and what this could mean for future therapies. (missouri.edu)
  • By using computational models, we're targeting the connection in the brain that latches onto the pleasure center and the parameters that maintain that process. (missouri.edu)
  • Computational science and engineering (CSE) is a relatively new discipline that deals with the development and application of computational models and simulations, often coupled with high-performance computing, to solve complex physical problems arising in engineering analysis and design (computational engineering) as well as natural phenomena (computational science). (wikipedia.org)
  • mice
  • The protocol has been used to test several mutant mice, including dystrophin-deficient mutants, transgenic models of amyotrophic lateral sclerosis and Alzheimer's disease, and a spontaneous mutant with degeneration of the cerebellum. (wikipedia.org)
  • dopaminergic
  • These cells take up DA and NE more efficiently than undifferentiated cells suggesting they could be used either as partial noradrenergic or dopaminergic models. (wichita.edu)
  • They show poor catecholamine uptake characteristics compared to SH-SY5Y cells, however n-butyric acid differentiated MN9D cells show more efficient DA uptake similar to undifferentiated SH-SY5Y, suggesting that they could be used as a reasonable dopaminergic model. (wichita.edu)
  • Unfortunately, by the time the symptoms are evident, the neurological damage is already severe, with a massive loss of dopaminergic neurons in the substantia nigra ( Double, 2012 ). (frontiersin.org)
  • behavioral change
  • Using the computational model, MU researchers found that in an addict's brain excessive glutamate produced in the pleasure center makes the brain's mechanisms unable to regulate themselves and creates permanent damage, making cocaine addiction a disease that is more than just a behavioral change. (missouri.edu)
  • We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. (foyles.co.uk)
  • shift
  • In the opponent-process model, this is the result of a shift over time from fear to pleasure in the fear-pleasure emotion pair. (wikipedia.org)
  • suggests
  • However, the neural organization of language is more complex than the Wernicke-Geschwind model of language suggests. (wikipedia.org)
  • The first model suggests a "critic" which encodes value, and an actor which encodes responses to stimuli based on perceived value. (wikipedia.org)
  • Research
  • The long-term objective of our research is to find out how some rehabilitative drugs work by devising a model of the fundamental workings of an addict's brain," said Mohan, who will attend Washington University in St. Louis for his postdoctoral fellowship. (missouri.edu)
  • NINDS' mission is impartial to the model system employed, but is advanced by the neuroscientific impact of each research project. (nih.gov)
  • Indeed, the NIH BRAIN Initiative supports the use of invertebrate model systems in research to understand neural functions and recognizes that this is an important part of the neuroscience ecosystem. (nih.gov)
  • We've created a model that tests the ability to do sensory integration, which should be extremely useful for pharmaceutical research . (medicalxpress.com)
  • Further research by Goddard on the characteristics of the kindling phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory. (wikipedia.org)
  • neuroscience
  • Neuroscience applicants using invertebrate model systems have successfully competed for NINDS grant funding in peer review in recent years. (nih.gov)
  • development
  • During the past ten years, the development of mouse models of FRDA has allowed better understanding of the pathophysiology of the disease. (curefa.org)
  • In rat models, the specific effect of MAM on neural development depends on the gestational age of the subject. (wikipedia.org)
  • Because of its very natural way of expressing mathematical computations, and its built-in visualization capacities, the proprietary language/environment MATLAB is also widely used, especially for rapid application development and model verification. (wikipedia.org)
  • therapeutic
  • Overall, these data suggest that in hamsters hE16 can ameliorate neurological disease after significant viral replication has occurred, although there is a time window that limits therapeutic efficacy. (biomedsearch.com)
  • Moreover, this model may be utilized to establish diagnostic and therapeutic strategies for fucosidosis. (biologists.org)
  • knowledge
  • Modeling and simulation Algorithms for solving discrete and continuous problems Analysis and visualization of data Mathematical foundations: Numerical and applied linear algebra, initial & boundary value problems, Fourier analysis, optimization Data Science for developing methods and algorithms to handle and extract knowledge from large scientific data With regard to computing, computer programming, algorithms, and parallel computing play a major role in CSE. (wikipedia.org)
  • cases
  • In many cases, neurological disease has a pharmacological treatment which, as in the case of Alzheimer's disease, Parkinson's disease, Epilepsy, and Multiple Sclerosis can reduce the symptoms and slow down the course of the disease but cannot reverse its effects or heal the patient. (frontiersin.org)
  • However
  • Various models have been proposed, however the dominant one is that of temporal difference learning, in which a prediction is made before a reward and afterwards adjustment is made based on a learning factor and reward yield versus expectation leading to a learning curve. (wikipedia.org)
  • mouse model
  • Among the mouse models of FRDA, the liver conditional mouse model pointed to a tumor suppressor activity of frataxin leading to the hypothesis that individuals with FRDA might be predisposed to cancer. (curefa.org)
  • Here we report the generation of a fucosidosis mouse model, in which the gene for lysosomal α-L-fucosidase ( Fuca1 ) was disrupted by gene targeting. (biologists.org)
  • complex
  • When bicamerality as a method of social control was no longer adaptive in complex civilizations, this mental model was replaced by the conscious mode of thought which, Jaynes argued, is grounded in the acquisition of metaphorical language learned by exposure to narrative practice. (wikipedia.org)
  • Another
  • Another common model, MN9D cells, store high levels of DA under normal growth conditions, but do not convert it to NE. (wichita.edu)
  • activity
  • In some MAM animals, video-EEG monitoring has documented the presence of spontaneous electrographic seizure activity In some epilepsy rat models, MAM is administered at the fifteenth gestational day. (wikipedia.org)