GeneticAntigensVivoResponsesMechanismsMiceInflammationMicrobiologicalHumansTumor modelsPathwaysLungCytotoxicProgressionInvestigationsFrontiersDevelopmentalMicroenvironmentMurineC57BLBiologicalLiverImplicationsMechanismVitro modelNeuronsIntegrationPatientsPredictiveAspectsPracticeCultivationInfectionResponseTissueFinite elementDataStudiesRespiratoryRiskResearchResultsImmuneAnimal modelsHealthMemoryCancerContext of differentLevel
Genetic10
- Integration of genetic and immunological insights into a model of celiac disease pathogenesis. (bvsalud.org)
- This review integrates insights from immunological studies with results of recent genetic genome-wide association studies into a disease model. (bvsalud.org)
- This paper provides a brief presentation on the genetics of multiple sclerosis susceptibility and on current work that uncovers the cellular effects, immunological and non-immunological, associated with genetic risk variants. (researchgate.net)
- Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model. (rochester.edu)
- A host genetic severity predictor (HGSP) model was developed by combining several state-of-the-art machine learning algorithms (decision tree-based models: Random Forest and XGBoost classifiers). (cdc.gov)
- These models were trained using a genetic Whole Exome Sequencing (WES) dataset and clinical covariates (age and gender) formulated from a 5-fold stratified cross-validation computational strategy to randomly split the dataset to overcome model instability. (cdc.gov)
- Our study validated the HGSP model based on the 18 features (i.e., 16 identified candidate genetic variants and 2 covariates. (cdc.gov)
- An explainable model of host genetic interactions linked to COVID-19 severity. (cdc.gov)
- Genetic and immunological evaluation of children with inborn errors of immunity and severe or critical COVID-19. (cdc.gov)
- Computational models are combined with genetic approaches to identify risk genes for blood- and immunological disorders, as well as regulators of the cell functions. (lu.se)
Antigens1
- Immunological tolerance to developmental sperm antigens is not induced in males, because spermatogenesis begins first in the testis on puberty, much after the establishment of tolerance to self-antigens. (benthamscience.com)
Vivo8
- Neutrophil-depleting antibodies, such as anti-GR1 (RB6-8C5) and anti-Ly6G (1A8), are commonly used to study the in vivo function of neutrophils in murine disease models. (itg.be)
- It furthermore underlines the need for new tools to understand the in vivo role of neutrophils in immunological models. (itg.be)
- Therefore, the aim of our study was to develop a transplantable immunocompetent mouse model of HPV-positive OSCC and characterize it in vitro and in vivo. (biomedcentral.com)
- In addition, tumor models were characterized in vivo in C57Bl/6NCrl mice in terms of their histological properties, tumor growth kinetics, and radiosensitivity. (biomedcentral.com)
- Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
- Co-administration of a clinically relevant dexamethasone dosage with ablative radiotherapy reduces peripheral lymphocytes but does not alter in vivo intratumoral lymphocyte phenotype or inhibit efficacy of radiotherapy in a murine colorectal tumor model. (rochester.edu)
- Our results suggest that cultured cells may recapitulate an early phase of the disease, which is also less obscured with a consequent "immunological" phenotype and in vivo compensatory mechanisms observed in the embryonic brain. (harvard.edu)
- In in vivo mouse models, synthetic dsRNA can be used as a surrogate for ssRNA virus replication. (lu.se)
Responses8
- It should be noted that liver transplantation invokes relatively weak immunological responses. (hindawi.com)
- reported the experimental design of an in utero hepatocellular transplantation model in rats, which is an interesting tool for investigating immune responses in other settings as well. (hindawi.com)
- suggested that peripheral blood CD4+ adenosine triphosphate activity (ATP) assay (ImmuKnow assay) can be useful in monitoring immunological aspects of transplant responses, while Y. Hu et al. (hindawi.com)
- The models can be used to design the dimensions of the surface textures and the operating conditions of the wear tests for generation of the particle population with specified size and shape.Murine air pouch animal tests have been used to test the biological responses induced by UHMWPE particles. (nist.gov)
- The results indicated elongated particles induced stronger immunological responses than round-like particles. (nist.gov)
- Laboratory mice may not be effective models for studying immune responses to disease. (bristol.ac.uk)
- Molecules discovered using this technology were tested in several preclinical tumor models, and showed that targeting CCR8, depleted Tregs specifically in the tumor microenvironment and resulted in strong anti-tumor responses in monotherapy as well as in combination with anti-PD1. (pharmiweb.com)
- Hence, we have compared lung immunological responses of BALB/c, C57Bl/6N and C57Bl/6J mice to synthetic dsRNA. (lu.se)
Mechanisms2
- We will develop and evaluate transgenic mouse, cell culture and in vitro models which, as well as allowing an experimental estimation of the risks of transmission of BSE to humans and a complete assessment of the transmission characteristics and phenotypic range of the human prion diseases, should provide the tools to study the mechanisms and pathways of prion neurodegeneration. (europa.eu)
- Conclusions: The transcriptional profile in brain tissues primarily centered on immunological mechanisms, whereas the profiles from cell cultures showed defects in neuronal activity. (harvard.edu)
Mice6
- In the laboratory, mice can be infected and this is a useful animal model. (wikipedia.org)
- Furthermore, an incomplete anti-Ly6G-dependent neutrophil depletion was obtained in two immune-mediated mouse models, i.e. in malaria-infected C57BL/6 mice and in complete Freund's adjuvant (CFA)-challenged BALB/c mice. (itg.be)
- We inoculated only the nasopharynx of mice to explore the course of infection in a more natural exposure model. (cdc.gov)
- The research, published in Nature Communications, reveals limitations of laboratory mice as immunological models. (bristol.ac.uk)
- In 62 immunological measures, 57 differed between wild and laboratory mice. (bristol.ac.uk)
- The reason is that it is not active in mice, but many immunological studies are carried out on these model organisms. (uni-bonn.de)
Inflammation2
- The AB part is based on existing biological models of inflammation and immunological response as a set of coupled non-linear differential equations. (upf.edu)
- In a retrospective study of patients that underwent cardiac surgery employing cardiopulmonary bypass (CPB), and an animal model of CPB, we revealed hypothermia and inflammation as important players in the etiology of renal injury following CPB. (rug.nl)
Microbiological2
- To address these question, the essay approaches Lu Xun's story via its broader literary context-including a set of contemporary New Youth essays that propose a microbiological model to explain societal reform, suggesting that political reformers are comparable to the immune system's white blood cells. (osu.edu)
- Objective: The aim of this study was to conduct a brief literature review on LAP, and present the clinical, radiographic, microbiological and immunological aspects of this rare form of periodontal disease. (bvsalud.org)
Humans2
- As a result, nutrition affects the incidence, natural progression and therapeutic response of malignant diseases, both in humans and in preclinical animal models. (nature.com)
- For this reason, scientists need to rely on animal models, which works, but showing the relevance in animal models to humans is a challenge. (thermofisher.com)
Tumor models4
- Furthermore, immunofluorescence staining of blood vessels, hypoxic areas, proliferating cells and immune cells was performed to characterize the tumor microenvironment of all three tumor models. (biomedcentral.com)
- Characterization of the resulting MOC1-HPV cell lines and tumor models confirmed stable expression of HPV-16 oncogenes and differences in cell morphology, in vitro migration capacity, and tumor microenvironment characteristics. (biomedcentral.com)
- Although the cell lines did not differ in their intrinsic radiosensitivity, one of the HPV-positive tumor models, MOC1-HPV K1, showed a significantly longer growth delay after irradiation with a single dose of 15 Gy compared to parental MOC1 tumors. (biomedcentral.com)
- Characteristics of the newly developed HPV-positive OSCC tumor models correlate with the transcriptomic profile of MOC1-HPV cell lines. (biomedcentral.com)
Pathways2
- Background: Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. (harvard.edu)
- We observed an over-representation of immunological signaling pathways in embryonic Fmr1KO cortical and hippocampal tissues and over-represented mGluR5-downstream signaling pathways in Fmr1KO cortical and hippocampal primary cultures. (harvard.edu)
Lung5
- In vitro model to mimic the lung epithelial barrier for nano-toxicology studies. (cdc.gov)
- An experimental model was developed using an immortalized human lung epithelial cell line [Calu-3 cells (HTB- 55), ATCC, Manassas, VA] and Transwell inserts (Costar 6.5 mm polyester membrane with 3.0 um pores). (cdc.gov)
- Immunization with human acellular pertussis vaccine, which prevents severe lung infections in the conventional pneumonic infection model, had little effect on nasopharyngeal colonization. (cdc.gov)
- In pertussis models that emerged from this approach, large numbers of pathogen are introduced deep in the respiratory tract of animals, resembling extreme human infections in their severity and virulence but with more lung involvement than is generally clinically observed. (cdc.gov)
- They are susceptible to respiratory infections due to reduced lung function, increased oxygen consumption, and alteration in immunological function due to pregnancy. (who.int)
Cytotoxic1
- The models suggest that an efficient cytotoxic T lymphocyte (CTL) memory response is required to control the virus. (nih.gov)
Progression3
- Coupled Immunological and Biomechanical Model of Emphysema Progression. (upf.edu)
- In this work we present a multi-scale model of both aspects, coupling Finite Element (FE) and Agent Based (AB) techniques that we would like to use to predict the onset and progression of emphysema in patients. (upf.edu)
- These data provide an immunological mechanism to explain HLA-related risk of progression to AIDS and emphasize the central role of viral evolution in the pathogenesis of HIV. (unige.ch)
Investigations1
- Immunological investigations. (rochester.edu)
Frontiers2
- What is the Frontiers peer review model? (frontiersin.org)
- Frontiers operates a single-blind model during the review process. (frontiersin.org)
Developmental1
- To study the developmental trajectory and to relate mouse model data to human data, we used an expression map of human development to plot murine differentially expressed genes in KO/WT cultures and brain. (harvard.edu)
Microenvironment2
- Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer. (rochester.edu)
- Correction: Expression of hormone receptors is associated with specific immunological profiles of the breast cancer microenvironment. (medscape.com)
Murine3
- CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models. (rochester.edu)
- Development of an Orthotopic Murine Model of Rectal Cancer in Conjunction With Targeted Short-Course Radiation Therapy. (rochester.edu)
- Here, we study transcriptomes obtained in situ in the intact brain tissues of a murine model of FXS to see how they reflect the in vitro state. (harvard.edu)
C57BL1
- Of particular note, the highlighted differences in the inflammatory response of C57Bl/6J and C57Bl/6N substrains underscore the value of strain selection in mouse models of respiratory viral infections. (lu.se)
Biological3
- We devise a strategy to couple the discrete biological model at the molecular /cellular level and the biomechanical finite element simulations at the tissue level. (upf.edu)
- With this technique, we have been able to generate UHMWPE wear particles with different size and shape within phagocytosable and non-phagocytosbale ranges for biological response studies.A mathematical model to predict the dimensions of generated UHMWPE particles has been developed. (nist.gov)
- These results point to us having to be much more cautious in extrapolating from the lab to the wild, but laboratory mouse models will continue to be hugely important in biological and biomedical research. (bristol.ac.uk)
Liver1
- A multicompartment geometric model of the liver in relation to regional induction of cytochrome P450s. (cdc.gov)
Implications1
- This "quantitative and time-sequence dependent" model has several implications for prevention, diagnosis, and therapy of COVID-19. (preprints.org)
Mechanism1
- Immunological data provide an explanatory mechanism for this relationship. (unige.ch)
Vitro model1
- The Transwell Calu-3 model represents a potential rapid assessment in vitro model to test the effects of nano-material exposure on cell tight junction integrity. (cdc.gov)
Neurons1
- Moreover, cultured neurons lack the close coupling with glia that might be responsible for the immunological phenotype in the intact brain. (harvard.edu)
Integration1
- In this study it was investigated whether and to what extent semantic data models and their methods for data modeling are useful for adequate representation and integration of immunological and clinical data. (thieme-connect.de)
Patients4
- 19 Pawelec G, Schlag H, Schwuléra U, Lenz E, Schneider E, Schaudt K, Bühring HJ, Ehninger G. Immunological monitoring of cancer patients during a phase I/II clinical trail of natural interleukin 2. (thieme-connect.de)
- Our study revealed the prognostic value of PRGs in PAAD and created a reliable model for predicting the prognosis of PAAD patients. (hindawi.com)
- CCR8 has been validated to be a tumor-infiltrating Treg-specific marker in solid tumors in both patients and animal models, making it the preferred target for therapeutic depletion of Tregs in cancer. (pharmiweb.com)
- The primary immune cells from these patients enabled the Bonn researchers to validate the results from the CRISPR-Cas9 model cell lines very well," says Prof. Dr. Jutta Gärtner, Director of the Department of Pediatrics and Adolescent Medicine at the University Medical Center Göttingen, who first described this disease and provided the Bonn researchers with immune cells from these rare patients. (uni-bonn.de)
Predictive3
- These analyses will be used to identify ecological variables associated with VS disease occupancy and spread in the western U.S. and to develop predictive models for disease spread. (usda.gov)
- A collaboration with USDA-APHIS will established to determine the phylogeopraphic characteristics of VSV strains causing outbreaks in the U.S. This information will be used to create predictive models for VSV occurrence. (usda.gov)
- Despite these challenges, use of AI, predictive modeling, and other computations as well as bioinformatics tools are powerful solutions to help analyze the collected data, in her opinion. (thermofisher.com)
Aspects2
- This experimental approach can measure aspects of the infection processes not observed in the conventional pneumonic infection model. (cdc.gov)
- We examine each of the connections that compose the triangle of nutrition, immunological and inflammatory reactions and cancer while focusing on the mechanistic aspects of these relationships. (nature.com)
Practice2
- Support models of care that provide maximum level of continuity of care are "midwifery continuity of care, case management, as well as models of cares provided by midwife navigator, general practitioner (GP), private practice midwives, also cultural support models of care such as supports by healthcare workers or a community organization" (7,8). (who.int)
- Models of care in low risk cases is limited to midwifery care only, however, in high risk cases is could be provided by GPs, obstetricians or obstetricians and midwifery Group Practice, if available(7,8). (who.int)
Cultivation1
- Leprosy : cultivation of the etiologic agent, immunology, animal models, proceedings of the Workshop on Future Problems in the Microbiology of M. Leprae [held in Baltimore, Maryland], 12-15 October 1976. (who.int)
Infection7
- We use mathematical models to study the relationship between HIV and the immune system during the natural course of infection and in the context of different antiviral treatment regimes. (nih.gov)
- We propose here the first model, explaining how the outcome of first, crucial 10-15 days after infection, hangs on the balance between the cumulative dose of viral exposure and the efficacy of the local innate immune response (natural IgA and IgM antibodies, MBL). (preprints.org)
- Our infection model revealed that B. pertussis can efficiently colonize the mouse nasopharynx, grow and spread within and between respiratory organs, evade robust host immunity, and persist for months. (cdc.gov)
- Most of our knowledge of B. pertussis has been learned from animal models of pneumonic infection that were developed during an era guided by Koch's postulates ( 8 - 19 ). (cdc.gov)
- As valuable as conventional high-dose models have been, the bolus introduction of many bacteria deep into the lungs bypasses many key steps in the highly infectious catarrhal stage of pertussis, the prolonged period of early infection involving milder nonspecific upper respiratory tract symptoms. (cdc.gov)
- They use a variety of molecular, genetics, and immunological research instruments which help with their research in areas such as, but not limited to, patient cohorts, animal models, and in vitro infection. (thermofisher.com)
- Immunological response of the golden hamster during infection with Leishmania donovani / Chaltu Gifawesen. (who.int)
Response1
- Conventional pertussis animal models deliver hundreds of thousands of Bordetella pertussis bacteria deep into the lungs, rapidly inducing severe pneumonic pathology and a robust immune response. (cdc.gov)
Tissue1
- This immunological model, however, is haunted by the necessary possibility that the immune system may mistakenly begin attacking the body's own healthy tissue. (osu.edu)
Finite element1
- In 2002, he started a PhD on spine computational biomechanics at the Universitat Politècnica de Catalunya , Barcelona (UPC), Spain, focussing on theoretical approximations in finite element modelling. (upf.edu)
Data11
- In the first part of this review, we re-interpret these data and strive to dispel the misconception that an acute bout of exercise is detrimental to immunological health. (frontiersin.org)
- Based on the semantic data model RIWT we propose the design of a database system, report on its realization, and discuss this approach. (thieme-connect.de)
- Using a semantic data model, the quality of data increased considerably. (thieme-connect.de)
- 5 Peckham J, Maryanski F. Semantic data models. (thieme-connect.de)
- 7 Chen PP. The Entity-Relationship Model - toward a unified view of Data. (thieme-connect.de)
- SIM: A database system based on the semantic data model. (thieme-connect.de)
- 12 Haux R, Gerneth F. Non-Standard data models for statistical data analysis. (thieme-connect.de)
- 13 Haux R, Winter A. Universal relation assumptions in a modified RM/T data model. (thieme-connect.de)
- A relational model of data for large shared data banks. (thieme-connect.de)
- 16 Mann G, Haux R. Database scheme design for clinical studies based on a semantic data model. (thieme-connect.de)
- 2.A. Develop means to detect and characterize emergent VSV strains and use these data to generate models that predict future outbreaks. (usda.gov)
Studies2
- However, since HPV can only infect human cells, there are only a few immunocompetent mouse models available that enable immunological studies. (biomedcentral.com)
- In conclusion, we developed and characterized a novel immunocompetent mouse model of HPV-positive OSCC that exhibits increased radiosensitivity and enables studies of immune-based treatment approaches in HPV-positive OSCC. (biomedcentral.com)
Respiratory1
- Translational mouse models are a valuable tool for medical research, including research on respiratory viral infections. (lu.se)
Risk3
- A risk score model was created after each patient's risk score was calculated. (hindawi.com)
- Maternity systems need a process to triage women to the most appropriate models of care based on low risk and high-risk criterion. (who.int)
- Studying the association between longitudinal mammographic density measurements and breast cancer risk: a joint modelling approach. (medscape.com)
Research1
- The Armadillo as an experimental model in biomedical research : proceedings of a workshop held at the Pan American Center for Research and Training in Leprosy and Tropical Diseases, Caracas, Venezuela, 23-27 May 1977. (who.int)
Results2
Immune1
- Finally, in the third part of this review, we highlight that regular physical activity and frequent exercise might limit or delay aging of the immune system, providing further evidence that exercise is beneficial for immunological health. (frontiersin.org)
Animal models1
- Animal models in parasitology : a symposium held at the Royal Zoological Society, Regents Park, London, in March 1981 / edited by Dawn G. Owen. (who.int)
Health1
- The university offers degree programs in Human Medicine and Psychology and are tailored to the requirements of the Bologna model, opening the door to new, cutting-edge health professions. (fwf.ac.at)
Memory1
- The treatments led to the establishment of immunological memory. (pharmiweb.com)
Cancer1
- SCR-6852, an oral and highly brain-penetrating estrogen receptor degrader (SERD), effectively shrinks tumors both in intracranial and subcutaneous ER + breast cancer models. (medscape.com)
Context of different1
- The United Nations Population Fund (UNFPA) emphasized the development of a sustainable ANC service delivery model according to the context of different countries, which defines how services will be organized to deliver a core ANC package. (who.int)
Level1
- At a metaphorical level, this possibility of immunological collapse serves as a reminder that political reform is similarly grounded on a process of reading and recognition, and consequently contains the necessary possibility that reformers may mistakenly attack "healthy" elements of society itself. (osu.edu)