• Porcine Model
  • Objectives This study sought to compare dynamic versus single-phase high-pitch computed tomography (CT) acquisitions for the assessment of myocardial perfusion in a porcine model with adjustable degrees of coronary stenosis. (onlinejacc.org)
  • Cardiac
  • Stress equilibrium is imposed in weak form and the resulting force balance equations are coupled to a lumped-parameter model of the circulation, leading to a system of differential-algebraic equations, whose numerical solution yields predictions of LV pressure and volume, together with spatial distributions of stresses and strains throughout the cardiac cycle. (deepdyve.com)
  • In addition to the HRV analysis, model-based assessment also revealed the absence of both arterial baroreflex and respiratory-cardiac coupling augmentations in SCD patients during the cold face stimulus, while in CTL subjects both mechanisms showed tendencies to increase during the test. (usc.edu)
  • Modeling of Cardiac Muscular Thin Films: Pre-stretch, Passive and Active Behavior . (uci.edu)
  • Incorporating inductances in tissue-scale models of cardiac electrophysiology. (unc.edu)
  • It can hardly be argued that cardiac imaging methodologies targeting small-animal models have been crucial for rapidly transitioning therapies from bench to bedside. (onlinejacc.org)
  • Several physiological measures, including weight-adjusted cardiac output, body-length-adjusted aortic velocities and intracardiac shear forces, are similar to those in the closed vertebrate cardiovascular systems, including that of humans. (biologists.org)
  • In rodent (e.g. mouse, rat) cardiovascular research, it also is commonplace to normalize cardiac output to body size (e.g. (biologists.org)
  • The existence of cardiovascular physiological homology between vertebrates and D. melanogaster requires similarities not only in cardiovascular performance but also in cardiac-driven global mass transport dynamics. (biologists.org)
  • The number of vascular beds with clinical disease, diabetes, smoking, low body mass index, history of atrial fibrillation, cardiac failure, and history of cardiovascular event(s) 1 year before baseline examination increased risk of a subsequent cardiovascular event. (acc.org)
  • Datasets
  • Rather than developing yet another similar CVD risk prediction model, in this era of large datasets, future research should focus on externally validating and comparing head-to-head promising CVD risk models that already exist, on tailoring or even combining these models to local settings, and investigating whether these models can be extended by addition of new predictors. (bmj.com)
  • physiology
  • The physiology of the Drosophila melanogaster cardiovascular system remains poorly characterized compared with its vertebrate counterparts. (biologists.org)
  • The rat continues to be extensively used by researchers as a model organism for investigating pharmacology, toxicology, general physiology and the biology and pathophysiology of disease. (wikipedia.org)
  • Plant physiology, Developmental biology, Molecular genetics, Population genetics, Cytology, Molecular biology) The genus Boechera combines some of the experimental tractability and genetic tools developed for its close relative Arabidopsis with a largely undisturbed natural history, making it a promising model system for research at the intersection of genetics, genomics, ecology, and evolution. (wikipedia.org)
  • research
  • From the Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY (J.M.M., Q.M.Z., C.J.L. (ahajournals.org)
  • Previous research has demonstrated genetic, molecular, cellular and tissue function homology between the D. melanogaster and vertebrate cardiovascular systems. (biologists.org)
  • This is a list of model organisms used in scientific research. (wikipedia.org)
  • They are the most commonly used mammalian research model and are used for research in genetics, psychology, medicine and other scientific disciplines. (wikipedia.org)
  • This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. (wikipedia.org)
  • George Alexander Truskey is an American biomedical engineer noted for his research on transport phenomena in biological systems, cardiovascular tissue engineering, and cell adhesion to natural and synthetic surfaces. (wikipedia.org)
  • QRISK
  • We have assessed 3 models for CVD risk using the THIN database: the standard Framingham model, and the more recent ASSIGN and QRISK models. (uea.ac.uk)
  • The latest model, QRISK, was developed using a primary care database and our work has reinforced the current debate over analysis methodology in such studies. (uea.ac.uk)
  • diabetes
  • The individual risk factor weighting is intuitive, but the body mass index of 2 , which increases risk comparable to a cardiovascular event in the past year and diabetes. (acc.org)
  • organism
  • The mouse has since been used extensively as a model organism and is associated with many important biological discoveries of the 20th and 21st Centuries. (wikipedia.org)
  • unclear
  • The usefulness of most of the models remains unclear owing to methodological shortcomings, incomplete presentation, and lack of external validation and model impact studies. (bmj.com)
  • species
  • Therefore, the comparison of normalized measures of cardiovascular performance among different species is a physiologically and metabolically relevant approach for establishing physiological homology. (biologists.org)
  • human
  • Strain records include information about the origin and availability of the strain, associated phenotypes, whether the strain is a model for a human disease, and any information that is available about breeding, behavior, husbandry, etc. (wikipedia.org)
  • study
  • Eligibility criteria for study selection Studies describing the development or external validation of a multivariable model for predicting CVD risk in the general population. (bmj.com)
  • The study involved the application of current CVD risk models to the THIN dataset. (uea.ac.uk)
  • This study establishes and validates a risk model to predict secondary cardiovascular events and cardiovascular death in outpatients with established atherothrombotic disease. (acc.org)
  • This is a well-designed contemporary investigator-initiated population study that assessed risk of future cardiovascular events among patients with one or more vascular disease event types. (acc.org)
  • In a study by Wang, Z. and colleagues, they used engineered rats (insulin-resistant cardiovascular disease models). (wikipedia.org)
  • Lotus japonicus a model legume used to study the symbiosis responsible for nitrogen fixation. (wikipedia.org)
  • aortic
  • Habashi JP, Judge DP, Holm TM et al (2006) Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. (springer.com)
  • Feintuch A, Ruengsakulrach P, Lin A et al (2007) Hemodynamics in the mouse aortic arch as assessed by MRI, ultrasound and numerical modeling. (springer.com)
  • Image-based immersed boundary model of the aortic root. (unc.edu)
  • Immersed boundary-finite element model of fluid-structure interaction in the aortic root. (unc.edu)
  • equations
  • In 2014 she was elected as a fellow of the Society for Industrial and Applied Mathematics "for contributions to the modeling and analysis of partial differential equations motivated by applications in the life sciences. (wikipedia.org)
  • Biology
  • Agronomy, Molecular biology, Genetics) Setaria viridis is an emerging model grass for C4 photosynthesis and related bioenergy grasses. (wikipedia.org)
  • performance
  • Model performance was heterogeneous and measures such as discrimination and calibration were reported for only 65% and 58% of the external validations, respectively. (bmj.com)
  • Quantifying performance in the medusan mechanospace with an actively swimming three-dimensional jellyfish model. (unc.edu)
  • risk
  • The prediction horizon was not specified for 49 models (13%), and for 92 (25%) crucial information was missing to enable the model to be used for individual risk prediction. (bmj.com)
  • Many of the risk factors predisposing people to CVD are known, and there are a number of survival models to identify those who could benefit from preventive treatment. (uea.ac.uk)
  • 95% CI, 0.83-0.99) also were significantly associated with reduced risk of cardiovascular events. (acc.org)
  • Risk of cardiovascular death was similarly estimated with the same set of risk factors. (acc.org)
  • known
  • Participants from the prospective REduction of Atherothrombosis for Continued Health (REACH) Registry provided a global outpatient population with known cardiovascular disease at entry. (acc.org)