• Laboratory
  • The facile and inexpensive clustered regularly interspaced short palindromic repeats (CRISPR) method has now superseded traditional means of genome modification such that virtually any laboratory can quickly assemble reagents for developing new mouse models for cardiovascular research. (ahajournals.org)
  • myocardial infarction
  • In particular, porcine models have been particularly valuable in assessing myocardial infarction and congestive heart failure, as they reflect the human disease state and can be modified to address different research goals. (mpiresearch.com)
  • The new algorithms are called the Reynolds Risk Score and the clinically simplified model for non-diab etic women includes age, systolic blood pressure, current smoking, total and HDL cholesterol, high sensitivity C-reactive protein (CRP) and parental history of myocardial infarction before age 60. (bio-medicine.org)
  • Imaging
  • It can hardly be argued that cardiac imaging methodologies targeting small-animal models have been crucial for rapidly transitioning therapies from bench to bedside. (onlinejacc.org)
  • The adaptation of ultrasound for imaging murine hearts, for example, has allowed characterization of the developing and adult rodent heart, making it an essential tool for the study of developmental biology and cardiovascular disease. (onlinejacc.org)
  • Hence, we present the first study aimed to directly compare this novel imaging modality with both conventional echocardiography and conductance catheter (CC) measurement techniques using an established murine model of ischemic heart disease. (onlinejacc.org)
  • High-frequency ultrasound enables high-resolution in vivo imaging of small-animal models typically used in scientific research and the preclinical stage of the drug development process. (wikipedia.org)
  • clinical
  • This thesis provides a detailed overview of a system dynamics model that focuses on the accident and emergency department and the clinical pathways of cardiovascular patients at Haukeland University hospital. (uib.no)
  • To this end, a successful simulation model has been created that permits a detailed observation of clinical pathways for cardiovascular patients. (uib.no)
  • Substantial heterogeneity in predictor and outcome definitions was observed between models, and important clinical and methodological information were often missing. (bmj.com)
  • Incorporating these larger animal models earlier into preclinical development plans can contribute to better translation and clinical outcomes. (mpiresearch.com)
  • Noise and flow artifacts in the medical images and clinical measurements lead to geometric models that contain some uncertainty. (utaustinportugal.org)
  • We developed, validated and demonstrated highly improved accuracy of two clinical algorithms for global cardiovascular risk prediction that reclassified 40 percent to 50 percent of women at intermediate risk into higher- or lower-risk categories," the authors write. (bio-medicine.org)
  • Datasets
  • Rather than developing yet another similar CVD risk prediction model, in this era of large datasets, future research should focus on externally validating and comparing head-to-head promising CVD risk models that already exist, on tailoring or even combining these models to local settings, and investigating whether these models can be extended by addition of new predictors. (bmj.com)
  • mice
  • Peter's areas of expertise within Technical Information Services include JAX┬« Services, genotyping, complex breeding schemes, diversity outbred mice, and models of cardiovascular disease. (jax.org)
  • This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. (wikipedia.org)
  • system
  • The simulation model illustrates accident and emergency processes and patient attributes in a disaggregated system. (uib.no)
  • In addition to System Dynamics, other modeling concepts facilitated the modeling process. (uib.no)
  • The use of objects to represent attributes and AED processes make this model a unique take on System Dynamics. (uib.no)
  • Similarities in the major organ systems, the vascular system, gastrointestinal tract morphology, as well as similarities in pharmacokinetics make the swine a better model system for studying cardiovascular disease. (mpiresearch.com)
  • Stress equilibrium is imposed in weak form and the resulting force balance equations are coupled to a lumped-parameter model of the circulation, leading to a system of differential-algebraic equations, whose numerical solution yields predictions of LV pressure and volume, together with spatial distributions of stresses and strains throughout the cardiac cycle. (deepdyve.com)
  • A model of the arterial system was created using a saphenous vein cardiopulmonary bypass system. (journals.co.za)
  • SIMCARD is an interdisciplinary project that develops, analyzes, and simulates mathematical models of the cardiovascular system. (utaustinportugal.org)
  • Plant physiology, Developmental biology, Molecular genetics, Population genetics, Cytology, Molecular biology) The genus Boechera combines some of the experimental tractability and genetic tools developed for its close relative Arabidopsis with a largely undisturbed natural history, making it a promising model system for research at the intersection of genetics, genomics, ecology, and evolution. (wikipedia.org)
  • The Cardiovascular System, specifically the body's ability to transport oxygen. (wikipedia.org)
  • QRISK
  • We have assessed 3 models for CVD risk using the THIN database: the standard Framingham model, and the more recent ASSIGN and QRISK models. (uea.ac.uk)
  • The latest model, QRISK, was developed using a primary care database and our work has reinforced the current debate over analysis methodology in such studies. (uea.ac.uk)
  • research
  • From the Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY (J.M.M., Q.M.Z., C.J.L. (ahajournals.org)
  • This is a list of model organisms used in scientific research. (wikipedia.org)
  • They are the most commonly used mammalian research model and are used for research in genetics, psychology, medicine and other scientific disciplines. (wikipedia.org)
  • George Alexander Truskey is an American biomedical engineer noted for his research on transport phenomena in biological systems, cardiovascular tissue engineering, and cell adhesion to natural and synthetic surfaces. (wikipedia.org)
  • phenotypes
  • Strain records include information about the origin and availability of the strain, associated phenotypes, whether the strain is a model for a human disease, and any information that is available about breeding, behavior, husbandry, etc. (wikipedia.org)
  • organism
  • The mouse has since been used extensively as a model organism and is associated with many important biological discoveries of the 20th and 21st Centuries. (wikipedia.org)
  • systematic
  • The patient-oriented modeling approach has proven useful, as it has enabled a systematic observation on the emergence of various cardiovascular pathways based on patient attributes incorporated in the model. (uib.no)
  • incident
  • Conclusions There is an excess of models predicting incident CVD in the general population. (bmj.com)
  • simulation
  • High resolution model created in 3ds max 2014 rendered with vray materials and particle flow simulation of the blood cells. (turbosquid.com)
  • preclinical
  • Of course, no single model perfectly duplicates the complexity of human disease, and adding studies to a preclinical development strategy requires consideration of timelines, cost, infrastructure, and the requirement for specialized technical personnel. (mpiresearch.com)
  • heart
  • The Portuguese Heart Foundation funded a PhD scholarship to undertake the work on developing a CVD model for Portugal. (europa.eu)
  • This lumped pulsatile cardiovascular model consists of eight compartments of the body that include pumping heart, the systemic circulation, and the pulmonary circulation. (koreascience.or.kr)
  • The pumping heart is modeled by the time-dependent linear curves of compliances in the heart. (koreascience.or.kr)
  • aortic
  • Habashi JP, Judge DP, Holm TM et al (2006) Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. (springer.com)
  • Feintuch A, Ruengsakulrach P, Lin A et al (2007) Hemodynamics in the mouse aortic arch as assessed by MRI, ultrasound and numerical modeling. (springer.com)
  • Image-based immersed boundary model of the aortic root. (unc.edu)
  • Immersed boundary-finite element model of fluid-structure interaction in the aortic root. (unc.edu)
  • equations
  • In 2014 she was elected as a fellow of the Society for Industrial and Applied Mathematics "for contributions to the modeling and analysis of partial differential equations motivated by applications in the life sciences. (wikipedia.org)
  • study
  • Eligibility criteria for study selection Studies describing the development or external validation of a multivariable model for predicting CVD risk in the general population. (bmj.com)
  • The study involved the application of current CVD risk models to the THIN dataset. (uea.ac.uk)
  • Lotus japonicus a model legume used to study the symbiosis responsible for nitrogen fixation. (wikipedia.org)
  • Biology
  • Agronomy, Molecular biology, Genetics) Setaria viridis is an emerging model grass for C4 photosynthesis and related bioenergy grasses. (wikipedia.org)
  • development
  • Results 9965 references were screened, of which 212 articles were included in the review, describing the development of 363 prediction models and 473 external validations. (bmj.com)
  • This project aimed to strengthen the links between participating European countries to explain changes in cardiovascular disease (CVD) in their own countries and compare policy options through the development of powerful computer-based models such as IMPACT, RIVM CDM DYNAMO and Prevent. (europa.eu)
  • Europe
  • The courses covered key themes including: (i) an introduction to CVD epidemiology, (ii) an introduction to models for CVD in Europe and elsewhere and (iii) practical sessions on these models. (europa.eu)