• tyrosine kinase
  • 6,7 Before the commencement of circulation at 24 hours hpf, dorsal aorta expresses arterial endothelial markers, such as Ephrin-B2a, Notch5, and Gridlock, whereas the posterior cardinal vein expresses venous endothelial markers, such as EphB4 and Flt4 (fms-related tyrosine kinase 4). (ahajournals.org)
  • Spread-1 is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. (wikipedia.org)
  • pathway
  • In the case of protein-folding diseases such as Huntington's disease (HD), however, induction of the heat shock response pathway would prove beneficial. (wikipedia.org)
  • inhibition
  • Cellular efficacy studies were accomplished and revealed several of the designed inhibitor analogs demonstrated near complete inhibition of MEK1 and PI3K kinase activity by western blot analysis in A549 lung adenocarcinoma and D54 glioma cell lines at concentrations as low as 5 μM. (aacrjournals.org)
  • Pharmacological inhibition of ERK1/2 restores GSK3β activity and protein synthesis levels in a model of tuberous sclerosis. (wikipedia.org)
  • The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. (wikipedia.org)
  • PI3K
  • Initial biological results are presented from a series of novel small molecule kinase inhibitors specifically designed to simultaneously target both MEK1 and PI3K. (aacrjournals.org)
  • endothelial
  • 3 In addition to mediating tumor-stromal interaction in a paracrine loop, 4 HGF/SF can induce vascular endothelial growth factor (VEGF) 5 and promote angiogenesis. (ahajournals.org)
  • 3,4 In zebrafish, endothelial progenitor cells, called angioblasts, first become evident in 2 parallel stripes of lateral plate mesoderm by 12 to 14 hours postfertilization (hpf) ( Figure 1 ). (ahajournals.org)
  • This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. (wikipedia.org)
  • superfamily
  • It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of ligands. (wikipedia.org)
  • DHRS7B is a member of the short chain dehydrogenase/reductase (SDR) superfamily and possesses characteristic features of an SDR within the protein sequence. (wikipedia.org)
  • substrate
  • Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. (wikipedia.org)
  • tumor
  • The apoptosis inhibitor-5 (API5), anti-apoptosis protein, is considered a key molecule in the tumor progression and malignant phenotype of tumor cells. (nih.gov)
  • API5 protein expression was exclusively identified in the nucleus of tumor cells while the expression of pERK1/2 was detected in the cytoplasmic and nuclear of the tumor cells (Figure 3A). (nih.gov)
  • ERK2
  • Quantitative sandwich enzyme immunoassay (EIA) systems, that can distinguish between active-form subtypes of mitogen-activated protein kinases (p44 and p42 MAP kinase, also called ERK1 and ERK2), were developed employing subtype-specific antibodies as a solid phase and an antibody specific for the phosphorylated region of MAP kinases as the detector. (biomedsearch.com)
  • Both ERK1 and ERK2 were activated immediately after stimulation, and the activity reached a maximum at 5-10 min. (biomedsearch.com)
  • MKP-3 also binds to ERK2 regardless of whether it is phosphorylated or not. (wikipedia.org)
  • receptor
  • Hepatocyte growth factor/scatter factor (HGF/SF) is a mesenchymally derived signal that acts through the c- met receptor as a morphogen and mitogen for epithelial cells 1 and hepatocytes 2 and is implicated in both developmental and adult processes. (ahajournals.org)
  • This protein is a ligand for the EGF receptor. (wikipedia.org)
  • It is the sole known ligand for death receptor 3, and it can also be recognized by decoy receptor 3. (wikipedia.org)
  • This cytokine is a ligand for receptor TNFRSF25 (death receptor 3) and TNFRSF6B (decoy receptor 3). (wikipedia.org)
  • Humans
  • In humans, DHRS7B has been shown to physically interact with other proteins such as Mediator complex subunit 19 (MED19) and Brain and reproductive expressed-modulator protein (BRE). (wikipedia.org)
  • Constitutive
  • Substitution of a valine for a glutamic acid in the transmembrane domain can result in the constitutive dimerisation of this protein in the absence of a ligand. (wikipedia.org)
  • genes
  • HSF1 transactivates genes for many cytoprotective proteins involved in heat shock, DNA damage repair, and metabolism. (wikipedia.org)
  • The genes activated by HSF1 under heat shock conditions have been recently shown to differ from those activated in malignant cancer cells, and this cancer-specific HSF1 panel of genes has indicated poor prognosis in breast cancer. (wikipedia.org)
  • Cells
  • Distinct structural forms of type I collagen modulate cell cycle regulatory proteins in mesangial cells. (biomedsearch.com)
  • The HSR plays a protective role by ensuring proper folding and distribution of proteins within cells. (wikipedia.org)
  • The ability of cancer cells to use HSF1 in a unique manner gives this protein significant clinical implications for therapies and prognoses. (wikipedia.org)
  • High expression of MEKK3 in most of these ovarian cancer cells supposedly activate IKK kinase activity, which lead to increased levels of active NFκB. (wikipedia.org)
  • nuclear
  • In a first step, DCL1, aided by cofactors including the C2H2-zinc finger protein SERRATE (SE), the nuclear cap-binding complex (CBC), the double-stranded RNA-binding protein HYPONASTIC LEAVES1 (HYL1), and the HYL1 phosphatase C-TERMINAL DOMAIN PHOSPHATASE-LIKE1 (CPL1), removes the two single-stranded RNA tails of the pri-miRNAs to form a largely double-stranded miRNA precursor (premiRNA) ( 2 ⇓ ⇓ - 5 ). (pnas.org)
  • The structure for the small protein Betacellulin that is shown was determined by two-dimensional nuclear magnetic resonance spectroscopy. (wikipedia.org)
  • signal
  • Component of a protein kinase signal transduction cascade. (nih.gov)
  • Here, we investigated API5 expression in cervical cancer, its clinical significance, and its relationship with phosphorylated extracellular signal-regulated kinase 1 and 2 (pERK1/2) in development and progression of cervical cancer. (nih.gov)
  • Human
  • Moreover, as these EIA systems can be applied not only to rat MAP kinases but also to human, mouse and rabbit MAP kinases, they are potentially very useful for a range of investigations. (biomedsearch.com)
  • residues
  • These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. (wikipedia.org)
  • There is one predicted transmembrane domain in the protein sequence, a large neutrally charged region spanning residues 18-38. (wikipedia.org)