MAPKPathwayInhibitionStress-activated protein kinaseSerineP38deltaExtracellularPhosphorylationSynonymsMAPK13Phorbol-12-myriPathways2022InhibitorMAPKsReceptorsGenesIsoformsGeneRecombinant ProteinCytokinesInhibitDownstreamMediatesReceptorMRNAExpressionBiochemicalTranscriptionMiceApoptosisSuperfamilyCellsActivityPeptideClosely relatedEnzymeHumanMetabolismInteractionsChemicalsTargets
MAPK22
- Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene. (wikipedia.org)
- Mechanistically, HD-13 activated mitogen-activated protein kinase (MAPK) and nuclear factor kB (NF- κ B) signals. (hindawi.com)
- In conclusion, HD-13 may activate MAPK and NF- κ B pathways via accelerating TLR9 expression, thereby accelerating the inflammatory response in the progression of swine pneumonia. (hindawi.com)
- It has been reported that various hosts recognize lipopolysaccharides in the cell membrane structure through TLR9 and activate downstream mitogen-activated protein kinase (MAPK) and nuclear transcription factor- κ B (NF- κ B) pathways mediated by MyD88 to promote the MAPK protein phosphorylation, and NF- κ B enters the nucleus, further releasing cellular inflammatory factors [ 12 ]. (hindawi.com)
- The opioid receptor activation regulates a variety of intracellular signaling, including the mitogen-activated protein kinase (MAPK) pathway. (iasp-pain.org)
- We found that apigenin could inhibit PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), which was involved in the down-regulation of the expression of matrix metalloproteinase-9 (MMP-9) at mRNA levels. (spandidos-publications.com)
- G protein-coupled receptors can activate Erk MAPK pathways through a variety of mechanisms, including stimulation of Src, phosphoinositide-3 kinase (PI-3-K), protein kinase C (PKC), or the epidermal growth factor (EGF) receptor tyrosine kinase. (aspetjournals.org)
- In isolated strips of rat aorta, the MAPK/Erk kinase inhibitor U0126 (50 μM), Src inhibitor PP1 (0.5 μM), PKC inhibitors calphostin C (1 μM) and chelerythrine (10 μM), and the PI-3-K inhibitor LY294002 (1-20 μM) reduced 5-HT-induced contraction. (aspetjournals.org)
- Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
- Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
- This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)
- Erk3, also known as MAPK6 or p97 MAPK, is almost 50% identical to Erk1/2 at the kinase domain located in its amino-terminal region. (creativebiomart.net)
- leads to modifications in mitogen turned on proteins kinase (MAPK) signaling pathways as the 106-126 peptide activates development aspect related signaling pathways including vascular endothelial development aspect (VEGF) signaling as well as the phosphoinositide-3 kinase (PI3K) pathway. (fabretp.org)
- Two of the phosphotyrosine-containing proteins, migrating in SDS-polyacrylamide gels of approximately 43 and 45 kDa, corresponded in mobility to phosphorylated species of the 42- and 44-kDa mitogen-activated protein kinase (MAPK) isoforms. (nih.gov)
- Chromatography of soluble fractions from these cells on Mono Q columns revealed early and late eluting peaks of myelin basic protein kinase activity, which contained the 42- and 44-kDa MAPK isoforms, respectively. (nih.gov)
- Further studies into the mechanisms by which MAPK was activated by 20:4(n-6) strongly suggested the involvement of protein kinase C (PKC). (nih.gov)
- Not only did incubation of WB cells with 20:4(n-6) result in the translocation of PKC alpha, delta, and epsilon to a particulate fraction, it was found that the fatty acid failed to activate MAPK in cells pretreated for 26 h with phorbol 12-myristate 13-acetate, which depleted WB cells of PKC alpha, delta and epsilon. (nih.gov)
- Here, we show that mice lacking the mitogen-activated protein kinase (MAPK) p38delta display improved glucose tolerance due to enhanced insulin secretion from pancreatic beta cells. (ox.ac.uk)
- These results suggest that MAAs accelerate wound repair by activating the FAK-MAPK signaling pathways. (elsevierpure.com)
- Lingonberry extract blocked UVB-induced phosphorylation of the mitogen-activated protein kinase (MAPK) signaling members ERK1, ERK2, p38, and MEK1/2 but not JNK. (cdc.gov)
- The term RASopathies includes disorders with mutations in the genes that code for the proteins of the RAS/MAPK pathway, such as neurofibromatosis type 1, Noonan syndrome, Legius syndrome, LEOPARD syndrome, Costello syndrome, and cardiofaciocutaneous syndrome. (medscape.com)
- The IL-1Ra-producing bone marrow cells increase the number of IL-1Ra-producing microglia, reduce the availability of IL-1β, and modulate mitogen-activated protein kinase (MAPK) signaling in the ischemic cortex. (lu.se)
Pathway14
- MK-8776 ERK1/2) pathway and phosphatidylinositide 3-kinases (PI3K) pathway [1C4]. (phytid.org)
- In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
- The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
- Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. (the-scientist.com)
- Also, other proteins which involved in the same pathway with MAPK4 were listed below. (creativebiomart.net)
- Pathway evaluation of kinome data The kinome data was put through pathway analysis to determine which cellular pathways/processes are activated beneath the different treatment conditions. (fabretp.org)
- p38 MAP kinase is a key component of the signaling pathway that regulates the body's production of inflammatory mediators, including TNFα and IL-1 beta. (drugbank.com)
- Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. (drugbank.com)
- An elevation of the intracellular calcium level, which is mediated by N-methyl-D-aspartate receptors and L-type Ca2+ channels both, activates the mitogen-activated protein (MAP) kinase signaling pathway involved in synaptic modification. (asahq.org)
- Because the effects of local anesthetics on cellular signal transduction in neuronal cells are not well-known, the authors investigated whether they affect the MAP kinase signaling pathway using PC12 cells. (asahq.org)
- Although probable targets of these local anesthetics might be L-type Ca2+ channels or components between Ca2+ and Ras in MAP kinase pathway, the possibility that they directly affect MAP kinase still remains. (asahq.org)
- The suppression of MAP kinase pathway may thus be a potential target site for the actions of dibucaine and tetracaine, including the modification of the synaptic functions. (asahq.org)
- Multiple signal transduction pathways are affected downstream from EDNRA/B. In the case of interaction of EDNs with EDNRA, a pertussis toxin-insensitive G protein becomes activated and promotes stimulation of phospholipase C, resulting in the transactivation of the mitogen-activated protein kinase pathway [ 13 ]. (biomedcentral.com)
- BRAF is a component of the mitogen-activated protein (MAP) kinase signaling pathway, which is a complex cascade of protein kinases that relays mitogenic signals from the cell surface to the cell nucleus. (medscape.com)
Inhibition5
- Alternatively, pharmacologic approach to inhibition of the proteins activity is normally economical, less frustrating and not at all hard compared to hereditary manipulation. (phytid.org)
- RESEARCH DESIGN AND METHODS- To examine whether hypothalamic protein kinase C (PKC) mediates the ability of central nervous system lipids to activate K ATP channels and regulate glucose production in normal rodents, we first activated hypothalamic PKC in the absence or presence of K ATP channel inhibition. (diabetesjournals.org)
- Pretreatment of JB6 P(+) mouse epidermal cells with lingonberry extracts produced a dose-dependent inhibition on the activation of activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) induced by either 12-O-tetradecanoylphorbol-13-acetate (TPA) or ultraviolet-B (UVB). (cdc.gov)
- Inhibition of Ca2+-activated Cl- channels (CaCCs)-mediated Cl- secretion significantly reduced fluid secretion in rotaviral diarrhea. (bvsalud.org)
- Mostajeran M, Wetterling F, W Blixt F, Edvinsson L, Ansar S. Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging. (lu.se)
Stress-activated protein kinase2
- The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1. (cornell.edu)
- Mitogen- and stress-activated protein kinase 1 (MSK1) is a growth-factor-stimulated serine/threonine kinase that is involved in gene transcription regulation and proinflammatory cytokine stimulation. (cornell.edu)
Serine1
- Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. (idrblab.net)
P38delta1
Extracellular4
- 5-Hydroxytryptamine (5-HT) activates the extracellular signal-regulated kinase (Erk) mitogen-activated protein kinases (MAPKs) in the vasculature, resulting in contraction. (aspetjournals.org)
- The expression of c-Fos induced by potassium chloride was also suppressed by dibucaine, tetracaine (concentrations that inhibited 50% of the activity of positive control [IC50s] were 16.2+/-0.2 and 73.2+/-0.7 microM, respectively), and PD 98059, a mitogen-activated/extracellular receptor-regulated kinase inhibitor. (asahq.org)
- It has recently been reported that mitogen-activated protein (MAP) kinase (also known as extracellular signal reactive kinase [Erk]) might play an important role in linking membrane depolarization to gene expression in the postsynaptic neurons. (asahq.org)
- We found that SH, M-Gly, and P334 have significant effects on the wound healing process in human keratinocytes and these effects were mediated by activation of focal adhesion kinases (FAK), extracellular signal-regulated kinases (ERK), and c-Jun N-terminal kinases (JNK). (elsevierpure.com)
Phosphorylation4
- Here, we biochemically demonstrated that the systemic crotalphine activates ERK1/2 and JNK and decreases the phosphorylation of p38 in the lumbar spinal cord. (iasp-pain.org)
- Both the phosphorylation of MAP kinase and the induction of c-Fos were detected by immunoblotting. (asahq.org)
- CaM Kinase Makes LTP or LTD Depending on Phosphorylation State Hyun Jae Pi, Nikolai Otmakhov, David Lemelin, Paul De Koninck, and John Lisman (see pages 8704C8709) Calcium entering through NMDA receptors activates calcium/calmodulin-dependent kinase II (CaMKII). (healthyconnectionsinc.com)
- Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. (nih.gov)
Synonyms1
- For alternate protein names/synonyms, use the Search box above or contact us directly at [email protected] and we'll compile a customized list of product options for you. (mayflowerbio.com)
MAPK131
- MAPK13 belongs to the MAP kinase family. (prospecbio.com)
Phorbol-12-myri1
- We found that apigenin markedly inhibits the phorbol-12-myristate-13-acetate (PMA)-induced increase in MMP-9 expression and activity in several cancer cell lines. (spandidos-publications.com)
Pathways1
20222
- Nature Communications 2022, 13: 3140. (yalemedicine.org)
- 13: 962480, 2022. (bvsalud.org)
Inhibitor4
- There is also decreased mRNA and proteins great quantity from the transcription element, early development response 1 (Egr1) in inhibitor-treated granulosa cells. (phytid.org)
- The EGF receptor tyrosine kinase inhibitor AG1478 (0.25-1 μM) was without effect. (aspetjournals.org)
- Coadministration of hypothalamic PKC-δ inhibitor rottlerin with OAG prevented the ability of OAG to activate PKC-δ and lower glucose production. (diabetesjournals.org)
- A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfiler TM service. (guidetomalariapharmacology.org)
MAPKs1
- Using primary cultures of sensory neurons, it was demonstrated that crotalphine increases the level of activated ERK1/2 and JNK-MAPKs and this increase is dependent on the activation of protein kinase Cζ (PKCζ). (iasp-pain.org)
Receptors3
- A Toll-like receptor (TLR) is a transmembrane protein encoded by the Toll gene, which is one of cell transmembrane receptors and pathogen pattern recognition receptors (PRRs) in the innate immune system [ 9 ]. (hindawi.com)
- 5 MAP kinase has been shown to be activated by calcium influx through both N -methyl-D-aspartate (NMDA) receptors and L-type Ca 2+ channels. (asahq.org)
- NPY stimulates a class of G-protein-coupled receptors named as Y receptors [7], including six subtypes, i.e. (cmerp.net)
Genes1
- This abrogated expression of the decidual marker genes, insulin like growth factor binding protein 1 ( IGFBP1 ) and prolactin ( PRL ), and prevented adoption of decidual cell morphology. (bioone.org)
Isoforms1
- 2008). "Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection with human immunodeficiency virus type I." J. Gen. Virol. (wikipedia.org)
Gene9
- The protein encoded by this gene is a member of the MAP kinase family. (wikipedia.org)
- Toll is a gene in fruit fly and toll-like proteins which was discovered in animals and also was named as TLRs. (hindawi.com)
- The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
- Proteins are alphabetically sorted first by the recommended Protein Name (UniProt) followed by the corresponding gene name. (mayflowerbio.com)
- It has recently been suggested that MAP kinase plays a role in coupling the synaptic excitation to gene expression in the nucleus of postsynaptic neurons. (asahq.org)
- SIGNALS initiated by neurotransmitter release are transferred to the nuclei of the postsynaptic cells to activate specific programs of gene expression, thus influencing synaptic functions. (asahq.org)
- Gene ID: 6300, updated on 13-Mar-2020. (rycraftlaw.com)
- LEOPARD syndrome, also known as Noonan syndrome with multiple lentigines, is a rare autosomal dominant disorder most often caused by missense mutations in the PTPN11 gene, which encodes the protein tyrosine phosphatase SHP2. (medscape.com)
- [ 4 ] Molecular studies have proven that LEOPARD syndrome and Noonan syndrome are allelic disorders caused by different missense mutations in PTPN11, a gene encoding the protein tyrosine phosphatase SHP-2 located at band 12q24.1. (medscape.com)
Recombinant Protein1
- A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase Hotspot SM platform. (guidetomalariapharmacology.org)
Cytokines2
- This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. (wikipedia.org)
- TLRs activate viral responses by recognizing pathogenic microorganisms such as viruses, bacteria, and mycoplasmas to release inflammatory cytokines [ 10 ]. (hindawi.com)
Inhibit3
- Furthermore, using pharmacologic technique you can inhibit proteins activity activity transiently at an accurate physiological stage. (phytid.org)
- Dibucaine and tetracaine at clinical concentrations were found to inhibit the activation of MAP kinase and the expression of c-Fos mediated by L-type Ca2+ channels in PC12 cells. (asahq.org)
- We have mapped brimapitide to JNK3, as this appears to be the isozyme used in [ 3 ], but it is likely to inhibit kinase activity of all JNK enzymes. (guidetomalariapharmacology.org)
Downstream1
- The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of epidermal growth factor receptor during decidualization. (bioone.org)
Mediates1
- PKCζ-Mitogen-Activated Protein Kinase Signaling Mediates Crotalphine-Induced Antinociception. (iasp-pain.org)
Receptor1
- Resveratrol also down-regulated the increased expressions of vascular endothelial growth factor (VEGF) and kinase insert domain receptor (KDR, or VEGF receptor-2) induced by high glucose. (springer.com)
MRNA2
- The mRNA expression of MMP-2 and MMP-9 was determined by reverse transcription-polymerase chain reaction, and the protein expression of MMP-2 and MMP-9 by gelatin zymography analysis and qualified by the gel electrophoresis image analysis in different HA concentrations. (molvis.org)
- We investigated the effects of different level of HA concentrations on mRNA and protein expressions of MMP-2 and MMP-9 in cultured trabecular meshwork cells using reverse transcription-polymerase chain reaction (RT-PCR) method and gelatin zymography analysis. (molvis.org)
Expression4
- HD-13 activated the inflammatory response via accelerating TLR9 expression. (hindawi.com)
- Expression analysis of mutant XY gonads at the same stage also reveals a dramatic reduction in Sox9 and, crucially, Sry at the transcript and protein levels. (plos.org)
- A tissue microarray was used to study EDN3 protein expression in breast carcinoma (n = 150) and normal breast epithelium (n = 44). (biomedcentral.com)
- Malnutrition, both protein-energy mal- aimed to assess the use of CD95 expression nutrition (PEM) and micronutrient defi- as a marker for following up these patients ciencies, continues to be a major health during their nutritional rehabilitation and burden in developing countries. (who.int)
Biochemical2
- MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. (wikipedia.org)
- MAP kinases perform as an incorporation point for various biochemical signals. (prospecbio.com)
Transcription2
- Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase. (wikipedia.org)
- MAP kinases take part in an extensive range of cellular courses like differentiation, development, transcription regulation and proliferation. (prospecbio.com)
Mice1
- 2010 ). Results from cav-1 (caveolin-1, the key structural protein of caveolae)-deficient mice indicated that cav-1 in endothelium is essential in the translocation of LDL-derived cholesterol into the vessel wall and in the development of atherosclerosis, and this result was further confirmed in apoE-/- mice (Fernandez-Hernando et al. (springer.com)
Apoptosis1
- Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. (idrblab.net)
Superfamily2
- Belongs to the protein kinase superfamily. (creativebiomart.net)
- In TE7 cells, these TGF-β1-induced changes were reversed by 100 ng/mL of bone morphogenetic protein 7 (BMP7), another member of the TGF-β1 superfamily. (aacrjournals.org)
Cells6
- Transient activation of AMP-activated protein kinase at G1/S phase transition is required for control of S phase in NIH3T3 cells. (nih.gov)
- The cells were stimulated with either 50 mM KCl or 1 microM ionomycin, and activated MAP kinase was thus immunoprecipitated. (asahq.org)
- Pretreatment of the cells with 1 mM (ethylenedioxy)-diethyl-enedinitrilotetraacetic acid or 5 micron nifedipine blocked the MAP kinase activation induced by 50 mM KCl, whereas pretreatment with 2 microM omega-conotoxin GIVA did not. (asahq.org)
- We now report that incubation of WB cells with 20:4(n-6) resulted in the appearance of several tyrosine-phosphorylated cytosolic proteins. (nih.gov)
- Overexpression of the single C-terminal kinase domain in JB6 cells resulted in tumor-promoter-induced neoplastic transformation in a manner similar to that induced by the full-length MSK1 protein. (cornell.edu)
- Although LC activated the cystic fibrosis transmembrane regulator in epithelial cells, its effect was not apparent in colonic epithelium. (bvsalud.org)
Activity4
- and protein kinase activity. (nih.gov)
- KC706 is a novel anti-inflammatory drug that works by inhibiting the activity of p38 MAP kinase. (drugbank.com)
- In the C-terminal kinase domain of MSK1, the C-terminal alphaL-helix is located in the surface groove, but forms no hydrogen bonds with the substrate-binding loop or nearby helices, and does not interfere with the protein's autophosphorylation activity. (cornell.edu)
- Antioxidant activity in lingonberries (Vaccinium vitis-idaea L.) and its inhibitory effect on activator protein-1, nuclear factor-kappa B, and mitogen-activated protein kinases activation. (cdc.gov)
Peptide1
- Thus, the principle of protein or peptide haptenation could be used in in vitro assays to predict the sensitization potential of a new chemical entity. (cdc.gov)
Closely related1
- The overall results suggest that the C-terminal kinase domain of MSK1 is regulated by a novel alphaL-helix-independent mechanism, suggesting that a diverse mechanism of autoinhibition and activation might be adopted by members of a closely related protein kinase family. (cornell.edu)
Enzyme1
- In this work, we have revealed that early viral protein UBCv1, the only known conjugating enzyme encoded by a virus, modulates innate immune and inflammatory signaling. (mdpi.com)
Human5
- Orthologous to human MAPK1 (mitogen-activated protein kinase 1). (nih.gov)
- Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. (idrblab.net)
- A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs ( Brief Bioinform, 21: 649-662, 2020 ). (idrblab.net)
- Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database. (idrblab.net)
- A screen of 72 inhibitors against 456 human kinases. (guidetomalariapharmacology.org)
Metabolism1
- As stated, insulin is a potent hormone involved in protein, fat and carbohydrate metabolism. (peoplesrx.com)
Interactions1
- The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target's druggability. (idrblab.net)
Chemicals2
- In affected indivi- chemicals possessing the ability to react with duals, it has a serious impact on their quality of proteins, and hence these methods do not esti- life. (cdc.gov)
- The basis of hapten- molecular mechanisms of the sensitization pro- protein binding work is the hypothesis that upon cess will result in novel opportunities for the skin absorption, only protein-reactive chemicals development of alternative methods for assessing (or those that can be metabolically or chemically skin sensitization hazard and relative potency of converted to protein-reactive species) are able to chemicals. (cdc.gov)
Targets1
- At a population level, P. falciparum apical membrane antigen-1 (AMA1) and merozoite surface protein-1 19kD (PfMSP1) IgG decreased during the first 12 months of life before reaching a nadir, whereas IgGs to other targets only declined for the first 4 months of life. (cdc.gov)