• succinate
  • The rate of phosphorylation is reduced, however, to about 25% of that measured in freshly isolated mitochondria and accounts for lowered P:O ratios using succinate as substrate (P:O ranges from 0.4 to 0.9). (rupress.org)
  • Mitochondria isolated from starving animals, though deficient in cytochrome c, did not show any decrease in succinate dehydrogenase activity or in the rate of substrate-dependent reduction of potassium ferricyanide or attendant phosphorylation. (biochemj.org)
  • concentration
  • The presence of varying concentration of external Mg²⁺ did not inhibit or increase Ca²⁺ uptake by the mitochondria, however, the extra Mg²⁺ accumulated prolonged Ca²⁺ retention in the mitochondria. (edu.au)
  • During Ca²⁺ release induced by palmitoyl CoA, PEP or glucose plus hexokinase, the total ATP concentration (i.e. that in the medium plus mitochondria) decreased, while the total AMP increased. (edu.au)
  • During prolonged Ca²⁺ retention in the mitochondria, a high concentration of total ATP and a low concentration of total AMP was observed. (edu.au)
  • However, the concentration of the pigment in hepatic mitochondria isolated from starving animals was less than half that in normal mitochondria. (biochemj.org)
  • Clofibrate-treated animals did not show a decreased concentration of cytochrome c in hepatic mitochondria. (biochemj.org)
  • fatty
  • This led to high levels of fatty acyl-CoA being present in the liver, which shows that a diseased liver cannot regulate the amount of fatty acyl-CoA that is present versus a normal, healthy liver. (wikipedia.org)
  • normal
  • Swollen mitochondria (∼1.5 µ in diameter), which have been stripped of their outer membranes, are largely devoid of matrix and normal matrix granules and are referred to as "ghosts. (rupress.org)
  • 1982). "Adenosine triphosphate-adenosine-5'-monophosphate phosphotransferase from normal human liver mitochondria. (wikipedia.org)
  • Studies
  • Studies have shown that in rat's that are fed high fat diets, palmitoyl-CoA hydrolase activity in the liver increased. (wikipedia.org)
  • Studies have been done to show that, while there is not direct correlation between palmitoyl-CoA hydrolase and diabetes, streptozotocin-induced diabetes significantly decreased rat liver palmitoyl-CoA hydrolase. (wikipedia.org)
  • content
  • The effect of the local anaesthetic, butacaine, on adenine nucleotide binding and translocation in rat liver mitochondria partially depleted of their adenine nucleotide content was investigated. (biochemj.org)
  • high
  • High resolution mass spectrometric analysis confirmed expected diet-driven increases in docosahexaenoic acid (DHA, 22:6, n-3) and eicosapentaenoic acid (EPA, 20:5, n-3) in sera, liver and nonsynaptosomal brain mitochondria. (hindawi.com)
  • cause
  • Diabetes is the most common cause of liver disease in the U.S., specifically from type 2 diabetes. (wikipedia.org)
  • effect
  • These data furthermore allow us to define a specific series of follow-up experiments to test related hypotheses about the effect of n-3 PUFAs on brain mitochondria. (hindawi.com)
  • properties
  • 1. Glycine decarboxylase and glycine-bicarbonate exchange activities were detected in extracts of Rhodopseudomonas spheroides and in rat liver mitochondria and their properties were studied. (biochemj.org)