• rats
  • Cyclic AMP caused Ca²⁺ release provided that palmitoyl CoA or palmitoylcarnitine were substrates and that the mitochondria prepared from fed rats were used within 1 hr after isolation. (edu.au)
  • It was also noted in this study that the mitochondria isolated from starved rats had a lower NADH/NAD⁺ ratio and released their Ca²⁺ earlier than the mitochondria from fed rats. (edu.au)
  • mechanism
  • However, the pathogenetic mechanism of iron in determining the liver injury has not been experimentally proven 2 . (springer.com)
  • concentration
  • The presence of varying concentration of external Mg²⁺ did not inhibit or increase Ca²⁺ uptake by the mitochondria, however, the extra Mg²⁺ accumulated prolonged Ca²⁺ retention in the mitochondria. (edu.au)
  • During Ca²⁺ release induced by palmitoyl CoA, PEP or glucose plus hexokinase, the total ATP concentration (i.e. that in the medium plus mitochondria) decreased, while the total AMP increased. (edu.au)
  • During prolonged Ca²⁺ retention in the mitochondria, a high concentration of total ATP and a low concentration of total AMP was observed. (edu.au)
  • However, the concentration of the pigment in hepatic mitochondria isolated from starving animals was less than half that in normal mitochondria. (biochemj.org)
  • Clofibrate-treated animals did not show a decreased concentration of cytochrome c in hepatic mitochondria. (biochemj.org)
  • fatty
  • This led to high levels of fatty acyl-CoA being present in the liver, which shows that a diseased liver cannot regulate the amount of fatty acyl-CoA that is present versus a normal, healthy liver. (wikipedia.org)
  • reduction
  • Mitochondria isolated from starving animals, though deficient in cytochrome c, did not show any decrease in succinate dehydrogenase activity or in the rate of substrate-dependent reduction of potassium ferricyanide or attendant phosphorylation. (biochemj.org)
  • normal
  • Swollen mitochondria (∼1.5 µ in diameter), which have been stripped of their outer membranes, are largely devoid of matrix and normal matrix granules and are referred to as "ghosts. (rupress.org)
  • 1982). "Adenosine triphosphate-adenosine-5'-monophosphate phosphotransferase from normal human liver mitochondria. (wikipedia.org)
  • Disease
  • Liver and Biliary Disease", R. Wright, G. H. Millward-Sandier, K. G. M. M. Alberti and S. Korran, eds. (springer.com)
  • Diabetes is the most common cause of liver disease in the U.S., specifically from type 2 diabetes. (wikipedia.org)
  • However
  • However, EGCG at high doses was reported to cause liver injury. (hindawi.com)
  • The rate of phosphorylation is reduced, however, to about 25% of that measured in freshly isolated mitochondria and accounts for lowered P:O ratios using succinate as substrate (P:O ranges from 0.4 to 0.9). (rupress.org)
  • injury
  • Free Radicals in Liver Injury", G. Poli, K. H. Cheeseman, M. U. Dianzani and T. F. Slater, eds. (springer.com)
  • Studies
  • Studies have shown that in rat's that are fed high fat diets, palmitoyl-CoA hydrolase activity in the liver increased. (wikipedia.org)
  • Studies have been done to show that, while there is not direct correlation between palmitoyl-CoA hydrolase and diabetes, streptozotocin-induced diabetes significantly decreased rat liver palmitoyl-CoA hydrolase. (wikipedia.org)
  • high
  • High resolution mass spectrometric analysis confirmed expected diet-driven increases in docosahexaenoic acid (DHA, 22:6, n-3) and eicosapentaenoic acid (EPA, 20:5, n-3) in sera, liver and nonsynaptosomal brain mitochondria. (hindawi.com)
  • effect
  • These data furthermore allow us to define a specific series of follow-up experiments to test related hypotheses about the effect of n-3 PUFAs on brain mitochondria. (hindawi.com)
  • properties
  • 1. Glycine decarboxylase and glycine-bicarbonate exchange activities were detected in extracts of Rhodopseudomonas spheroides and in rat liver mitochondria and their properties were studied. (biochemj.org)