• The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. (wikipedia.org)
  • The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. (wikipedia.org)
  • The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. (wikipedia.org)
  • In particular, ProEx C is an immunohistochemical cocktail containing antibodies direct against topoisomerase IIα (TOP2A) and minichromosome maintenance 2 (MCM2) proteins. (medsci.org)
  • A hexameric protein complex of minichromosome maintenance proteins. (bvsalud.org)
  • Chromosome area maintenance 1 proteins (CRM1 or known as XPO1) can be a member of the importin superfamily of nuclear move receptors (karyopherins). (cancerhugs.com)
  • An essential component of chromosome dynamics is a family of structural maintenance of chromosomes proteins, originally described in budding yeast as stability of minichromosomes (SMC) proteins, which are implicated in chromosome segregation and condensation. (pberghei.eu)
  • Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. (innatedb.com)
  • CCDC154 interacts with Minichromosome Maintenance Complex Component 2 (MCM2) protein and promotes malignant phenotype via MCM2.We validated the expression level and survival prediction value of CCDC154 in clinical samples, and analyzed its co-expression of MCM2, Ki-67 and p53. (bvsalud.org)
  • Global gene expression profiling of mouse medulloblastomas and bioinformatics analyses of microRNA targets suggest that minichromosome maintenance complex component 2 (MCM2) is a likely target gene of miR-31 in suppressing cell growth. (oncotarget.com)
  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. (nih.gov)
  • This phenotype is reminiscent of hypomorphic mutations in MCM4, which encodes a component of the minichromosome maintenance (MCM) helicase complex that is functionally linked to Pol-α during the DNA replication process. (jci.org)
  • Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-O. (yeastrc.org)
  • integrator complex subunit 13 [Sourc. (gsea-msigdb.org)
  • system_update_alt데이터시트system_update_alt안전 데이터시트Overview 개요Product Name:Human TIP49A ELISA KitProduct Code:HUFI01923Size:96 AssaysAlias:RUVBL1, TIP49a, Pontin 52, Nuclear matrix protein 238, NMP 238, INO80 complex subunit H, TIP60-associated protein. (assaygenie.kr)
  • Orthologous to human MCM8 (minichromosome maintenance 8 homologous recombination repair factor). (nih.gov)
  • The six SMCs can be classified as subunits of condensin (SMC2 and SMC4, required for chromosomal condensation), cohesin (SMC1 and SMC3, required for chromosomal segregation), and the SMC5-SMC6 complex (involved in DNA repair and homologous recombination. (pberghei.eu)
  • Bell SD and Botchan MR (2013) The minichromosome maintenance replicative helicase. (yeastgenome.org)
  • The pre-replication complex (pre-RC) assembly or the DNA replication licensing is the first step in DNA replication initiation, characterized by the sequential recruitment of ORCs, Cdc6, Cdt1 and MCMs to the DNA replication origins to form the pre-RC at the end of mitosis ( Bell and Dutta 2002 ). (intechopen.com)
  • Structure of the eukaryotic MCM complex at 3.8 Å. (yeastgenome.org)
  • Higher eukaryotic organisms have two condensin complexes, condensin I and condensin II, whereas many single-celled organisms such as yeast have only one condensin complex. (pberghei.eu)
  • In vivo interaction of human MCM heterohexameric complexes with chromatin. (wikipedia.org)
  • Cdt1p, through its interaction with Mcm6p, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex. (yeastgenome.org)
  • They form into a protein complex that has helicase activity and is involved in a variety of DNA-related functions including replication elongation, RNA transcription, chromatin remodeling, and genome stability. (bvsalud.org)
  • The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. (nih.gov)
  • Kleisin Ig (CAP-H), Heat IA (CAP-D2), and Heat IB (CAP-G) form the condensin I complex, whereas Kleisin IIb (CAP-H2), Heat IIA (CAP-D3), and Heat IIB (CAP-G2) form the condensin II complex. (pberghei.eu)
  • Ensembl chr 4:121,346,434. (mcw.edu)
  • Background Chromosome Area Maintenance 1 (CRM1) is a nuclear exporter and its inhibitor has anti-tumor activity in different cancers. (cancerhugs.com)
  • Identifying conserved protein complexes between species by constructing interolog networks. (yeastgenome.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Complement Component 2 (C2) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (myelisakit.com)
  • Interactions of the human MCM-BP protein with MCM complex components and Dbf4. (yeastgenome.org)
  • Functional control of Eco1 through the MCM complex in sister chromatid cohesion. (yeastgenome.org)
  • The functional regulation of cells is a complex and dynamic process. (nature.com)
  • Description: A sandwich ELISA kit for detection of Complement Component 2 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (myelisakit.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Complement Component 2 (C2) in samples from serum, plasma or other biological fluids. (myelisakit.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Complement Component 2 (C2) in serum, plasma and other biological fluids. (myelisakit.com)
  • Mechanistically, the complex consisting of YAP and transcription factors promotes the expression of genes involved in DNA replication, cell cycle regulation, chromosomal segregation, but also in the control of cellular stemness. (biomedcentral.com)
  • β-galactosyl-1,4 glucose) is the main source of carbohydrate in human milk and that of other mammals, except for sea lions and walruses which produce low volume, viscous and fatty lactose-free milk. (bmj.com)
  • Components and Strategies Cell lines and reagents The human being NSCLC cell lines A549, L1650, L1975, L2228, and HCC827 had been attained from American Type Lifestyle Collection (ATCC, Manassas, Veterans administration, USA). (cancerhugs.com)
  • Altogether, our study provides mechanistic connections between Pol-α and the MCM complex and demonstrates their relevance in NK cell function. (jci.org)
  • These protein consist of growth government bodies and suppressors of cell apoptosis, nuclear localization of which can be needed for their correct function [4]. (cancerhugs.com)
  • Data from ITS rDNA and the genes coding for translation elongation factor 1-α and DNA replication licensing factor mini-chromosome maintenance complex 7 support the distinctness of Mycoblastus s. str. (cambridge.org)
  • Hsp70 family ATPase, constituent of the import motor component of the Translocase of the Inner Mitoc. (yeastrc.org)
  • Recent mouse model studies have identified two populations of cells, namely the granule neuron progenitors in the external germinal layer and the multipluripotent neural stem cells likely from the dorsal brain stem [ 4 ], as the cellular origin of medulloblastoma. (oncotarget.com)
  • Simplicity of potato growing and ease of industrial production of pure potato starch makes it a necessary component and starting compound in food and chemical industries and determines valuability of an exhaustive study of all aspects of manufacturing and commercial application of potato starch is necessary. (peerj.com)
  • SMC2 and SMC4 form the core structure for both condensin I and condensin II in higher eukaryotes and interact with three additional non-SMC components: one kleisin and two Heat protein subunits. (pberghei.eu)
  • the process that governs the early embryonic patterning of the Drosophila body plan is now the best understood example of a complex cascade of transcriptional regulation during development [ 14 , 15 ]. (biomedcentral.com)