• The minichromosome maintenance proteins were named after a yeast genetics screen for mutants defective in the regulation of DNA replication initiation. (wikipedia.org)
  • A hexameric protein complex of minichromosome maintenance proteins. (bvsalud.org)
  • In particular, ProEx C is an immunohistochemical cocktail containing antibodies direct against topoisomerase IIα (TOP2A) and minichromosome maintenance 2 (MCM2) proteins. (medsci.org)
  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. (nih.gov)
  • Chromosome area maintenance 1 proteins (CRM1 or known as XPO1) can be a member of the importin superfamily of nuclear move receptors (karyopherins). (cancerhugs.com)
  • An essential component of chromosome dynamics is a family of structural maintenance of chromosomes proteins, originally described in budding yeast as stability of minichromosomes (SMC) proteins, which are implicated in chromosome segregation and condensation. (pberghei.eu)
  • Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles. (colorado.edu)
  • During G1 phase, the two head-to-head Mcm2-7 rings serve as the scaffold for the assembly of the bidirectional replication initiation complexes at the replication origin. (wikipedia.org)
  • During S phase, the Mcm2-7 complex forms the catalytic core of the Cdc45-MCM-GINS helicase - the DNA unwinding engine of the replisome. (wikipedia.org)
  • During the G1 phase of the cell cycle, Cdc6 is recruited by ORC to form a launching pad for the loading of two head-to-head Mcm2-7 hexamers, also known as the pre-replication complex (pre-RC). (wikipedia.org)
  • The structure of the ORC-Cdc6-Cdt1-MCM (OCCM) intermediate formed after the loading of the first Cdt1-Mcm2-7 heptamer indicates that the winged helix domain at the C-terminal extensions (CTE) of the Mcm2-7 complex firmly anchor onto the surfaces created by the ORC-Cdc6 ring structure around origin DNA. (wikipedia.org)
  • Global gene expression profiling of mouse medulloblastomas and bioinformatics analyses of microRNA targets suggest that minichromosome maintenance complex component 2 (MCM2) is a likely target gene of miR-31 in suppressing cell growth. (oncotarget.com)
  • We demonstrate that miR-31 inhibits MCM2 expression via its 3'-untranslated region, that knockdown of MCM2 in DAOY cells leads to a degree of growth inhibition comparable to that by miR-31 restoration, and that overexpression of miR-31 reduces the chromatin loading of MCM2 at the point of G1/S transition. (oncotarget.com)
  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. (nih.gov)
  • Site selection for replication origins is carried out by the Origin Recognition Complex (ORC), a six subunit complex (Orc1-6). (wikipedia.org)
  • Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-O. (yeastrc.org)
  • integrator complex subunit 13 [Sourc. (gsea-msigdb.org)
  • system_update_alt데이터시트system_update_alt안전 데이터시트Overview 개요Product Name:Human TIP49A ELISA KitProduct Code:HUFI01923Size:96 AssaysAlias:RUVBL1, TIP49a, Pontin 52, Nuclear matrix protein 238, NMP 238, INO80 complex subunit H, TIP60-associated protein. (assaygenie.kr)
  • The pre-replication complex (pre-RC) assembly or the DNA replication licensing is the first step in DNA replication initiation, characterized by the sequential recruitment of ORCs, Cdc6, Cdt1 and MCMs to the DNA replication origins to form the pre-RC at the end of mitosis ( Bell and Dutta 2002 ). (intechopen.com)
  • Bell SD and Botchan MR (2013) The minichromosome maintenance replicative helicase. (yeastgenome.org)
  • Because the gene page contains a lot of information, it takes on average 3-5 seconds to load. (uth.edu)
  • Here, we examined the genetic basis of Goss's wilt through differential gene expression, standard genome-wide association mapping (GWAS), extreme phenotype (XP) GWAS using highly resistant (R) and highly susceptible (S) lines, and quantitative trait locus (QTL) mapping using 3 bi-parental populations, identifying 11 disease association loci. (nsf.gov)
  • Identifying conserved protein complexes between species by constructing interolog networks. (yeastgenome.org)
  • Drosophila MCM protein complexes. (colorado.edu)
  • Structure of the eukaryotic MCM complex at 3.8 Å. (yeastgenome.org)
  • Higher eukaryotic organisms have two condensin complexes, condensin I and condensin II, whereas many single-celled organisms such as yeast have only one condensin complex. (pberghei.eu)
  • Kleisin Ig (CAP-H), Heat IA (CAP-D2), and Heat IB (CAP-G) form the condensin I complex, whereas Kleisin IIb (CAP-H2), Heat IIA (CAP-D3), and Heat IIB (CAP-G2) form the condensin II complex. (pberghei.eu)
  • Two classes of mcm mutants were identified: Those that affected the stability of all minichromosomes and others that affected the stability of only a subset of the minichromosomes. (wikipedia.org)
  • They form into a protein complex that has helicase activity and is involved in a variety of DNA-related functions including replication elongation, RNA transcription, chromatin remodeling, and genome stability. (bvsalud.org)
  • Functional control of Eco1 through the MCM complex in sister chromatid cohesion. (yeastgenome.org)
  • The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. (nih.gov)
  • Interactions of the human MCM-BP protein with MCM complex components and Dbf4. (yeastgenome.org)
  • Background Chromosome Area Maintenance 1 (CRM1) is a nuclear exporter and its inhibitor has anti-tumor activity in different cancers. (cancerhugs.com)
  • Hsp70 family ATPase, constituent of the import motor component of the Translocase of the Inner Mitoc. (yeastrc.org)
  • The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication. (wikipedia.org)
  • NK cells are a component of the innate immune system identified in animals as serving an essential role in antiviral immunity. (jci.org)
  • Mechanistically, the complex consisting of YAP and transcription factors promotes the expression of genes involved in DNA replication, cell cycle regulation, chromosomal segregation, but also in the control of cellular stemness. (biomedcentral.com)
  • The six SMCs can be classified as subunits of condensin (SMC2 and SMC4, required for chromosomal condensation), cohesin (SMC1 and SMC3, required for chromosomal segregation), and the SMC5-SMC6 complex (involved in DNA repair and homologous recombination. (pberghei.eu)
  • 1-3 Studying the mechanisms of lactose digestion and intolerance has provided insights not only into dietary causes of functional intestinal symptoms but also into human evolution and nutrition, culture and lifestyle ( box 1 ). (bmj.com)
  • The functional regulation of cells is a complex and dynamic process. (nature.com)
  • Description: A sandwich ELISA kit for detection of Complement Component 2 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (myelisakit.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Complement Component 2 (C2) in samples from serum, plasma or other biological fluids. (myelisakit.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Complement Component 2 (C2) in serum, plasma and other biological fluids. (myelisakit.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Complement Component 2 (C2) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (myelisakit.com)
  • Data from ITS rDNA and the genes coding for translation elongation factor 1-α and DNA replication licensing factor mini-chromosome maintenance complex 7 support the distinctness of Mycoblastus s. str. (cambridge.org)
  • 3. State Key Laboratory of Oncology in South China & Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China. (thno.org)
  • Cdt1p, through its interaction with Mcm6p, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex. (yeastgenome.org)
  • These reports suggest a critical role for the minichromosome maintenance helicase complex in NK cells and NK cell-mediated host defense. (jci.org)
  • We also found moderate evidence for the detection of thermal component in eight GRBs. (nsf.gov)
  • In this work, we present a comprehensive analysis of ten very short GRBs detected by Fermi Gamma-Ray Burst Monitor to search for the thermal component. (nsf.gov)
  • the process that governs the early embryonic patterning of the Drosophila body plan is now the best understood example of a complex cascade of transcriptional regulation during development [ 14 , 15 ]. (biomedcentral.com)
  • Although most meningiomas are benign, 15-35% represents atypical or anaplastic forms 3 . (nature.com)
  • Cancers will recur in 30-80% of cases, with a progression to muscle invasive disease of 1-45% within 5 year [ 2 , 3 ]. (medsci.org)
  • For example, maintaining proper dietary habits is an important component of promoting disease prevention. (frontiersin.org)
  • However, when the disease progresses to castration-resistant prostate cancer (CRPC), there are limited treatments for those patients and lead to dissatisfied outcomes [ 2 , 3 ]. (thno.org)
  • Because only 15.5% of the patients with AM harbour BRAF mutation, most patients with AM cannot benefit from targeted therapy [3]. (parpreceptor.com)
  • Although such a thermal component contributes a small proportion of the global prompt gamma-ray emission, the modified thermal-radiation mechanism could enhance the proportion significantly, such as in subphotospheric dissipation. (nsf.gov)
  • Medulloblastoma is a highly malignant tumor of the cerebellum and the most common brain tumor in children [ 3 ]. (oncotarget.com)
  • Our analysis indicates that Goss's wilt resistance is highly complex and major resistance genes are not commonly present. (nsf.gov)