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  • receptor-dependent
  • These findings demonstrate that cardiomyocyte-specific mineralocorticoid receptor-dependent signaling contributes to electromechanical vulnerability in acute ischemia-reperfusion via a mechanism involving Ca 2+ /calmodulin protein kinase II activation in association with upstream alteration in expression regulation of the sodium hydrogen exchanger-1. (ahajournals.org)
  • eplerenone
  • We questioned whether the selective mineralocorticoid receptor blocker eplerenone improves resistance artery remodeling in hypertensive patients versus the β-blocker atenolol. (ahajournals.org)
  • In the present study we tested the hypothesis that remodeling of resistance arteries from mild-to-moderate hypertensive patients could be improved by the selective mineralocorticoid receptor blocker eplerenone compared with the β-blocker atenolol at equal levels of BP control. (ahajournals.org)
  • genes
  • Binds to mineralocorticoid response elements (MRE) and transactivates target genes. (abcam.com)
  • So far no mineralocorticoid-response element has been identified in promoters and most genes induced by MR are also induced by GR. Control of miRNA expression by MR would offer an additional level of regulation which has not been investigated until today. (forschung-sachsen-anhalt.de)