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  • nmol
  • At a substrate concentration of 20 μM, propofol hydroxylase activity was significantly lower ( p = .032) in greyhound microsomes (1.7 ± 0.4 nmol/mg/min) compared with beagle microsomes (5.1 ± 1.3 nmol/mg/min) but was not statistically different ( p = .42) compared with mixed-breed microsomes (3.1 ± 1.2 nmol/mg/min). (aspetjournals.org)
  • drug
  • Biotransformation of propofol to 2,6-diisopropyl-1,4-quinol (4-hydroxypropofol) by cytochrome P-450 in the liver is proposed as a critical initial step in the elimination of this drug in dogs. (aspetjournals.org)
  • protein
  • The introduction of the double bond in lathosterol at C-5 to form 7-dehydrocholesterol that is catalyzed by lathosterol-5-dehydrogenase was equally rapid in controls and homozygotes liver microsomes (120 +/- 8 vs 100 +/- 7 pmol/mg protein per min, P = NS). (jci.org)
  • In other words, the test is used to determine if elevated protein levels are due to skeletal damage or liver damage. (wikipedia.org)
  • kidney
  • Use by those with significant kidney problems, liver problems, or who are pregnant is not recommended. (wikipedia.org)
  • CYP2D6
  • CYP2D6 is primarily expressed in the liver. (wikipedia.org)
  • This enzyme also metabolizes several endogenous substances, such as hydroxytryptamines, neurosteroids, and both m-tyramine and p-tyramine which CYP2D6 metabolizes into dopamine in the brain and liver. (wikipedia.org)
  • adrenal
  • The remainder of radioactivity was distributed among all tissues, with the highest relative concentrations occurring in the following tissues (in descending order): fat, ovaries, adrenal, liver, and spleen. (inchem.org)
  • smooth
  • Both subunits are present in the ER membrane in equimolar amounts and co-fractionate in constant stoichiometry when rough and smooth liver microsomes are separated on sucrose gradients. (ucsf.edu)
  • cells
  • While all animal cells are capable of synthesizing glutathione, glutathione synthesis in the liver has been shown to be essential. (wikipedia.org)
  • Such a reaction is probable due to the relatively high concentration of glutathione in cells (up to 7 mM in the liver). (wikipedia.org)
  • small
  • integrals may Close resources from the near-native body or help Additional or live small enjoying. (euroturs.rs)