• Influence of gender in pathogenesis of trichomoniasis in congenitally athymic (nude) mice. (bmj.com)
  • Tumor material from 91 patients with squamous cell carcinoma of the head and neck was transplanted subcutaneously in athymic nude mice. (amsterdamumc.org)
  • Retinoid-induced suppression of squamous cell differentiation in human oral squamous cell carcinoma xenografts (line 1483) in athymic nude mice. (tamu.edu)
  • Chemical substance induction was utilized to determine the tumorigenicity-enhanced cell range, JC1-2, that may type syngeneic tumors in immunocompetent C57BL/6 mice. (mycareerpeer.com)
  • Unlike nearly all syngeneic mouse tumors, the JC1-2-shaped tumors resembled 'swollen tumors' because of the abundancy of immune system cells in Naringin (Naringoside) the tumor microenvironment. (mycareerpeer.com)
  • All the mice injected with transformed cells developed tumors indicating the tumorigenic potential of TCE. (cdc.gov)
  • Photocarcinogenesis in hairless mice induced tumors harbors more UVA than UVB fingerprint by ultraviolet A tanning devices with or without mutations: A role for UVA in human skin car- subsequent solar-simulated ultraviolet irradia- cinogenesis. (who.int)
  • Moreover, the absence of functioning T cells prevents nude mice from rejecting not only allografts (grafts of tissue from other mice) but also xenografts (grafts of tissue from another species). (wikipedia.org)
  • Growth and iodine metabolism were studied by autoradiography in normal and hyperfunctioning thyroid tissue obtained from cats injected with 125I before surgery, and in xenografts, grown in nude mice, after double-labeling with 131I and [3H]thymidine. (avmi.net)
  • Xenografts of hyperplastic hot tissue in thyroxine-treated nude mice retain their original histologic pattern and continue to accumulate radioiodine intensely. (avmi.net)
  • Administration of sera from donor cats into host mice fails to stimulate the xenografts. (avmi.net)
  • To address this issue, head and neck squamous carcinoma cells (line 1483) were established as xenografts in nude mice. (tamu.edu)
  • To test this, we used systemic VEGF monoclonal antibody (VEGF-MAb) to treat PTC xenografts in nude mice. (uthscsa.edu)
  • Nude female BALB/c mice, 8- to 12-wk old, were injected intraperitoneally or intravenously. (snmjournals.org)
  • A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells. (wikipedia.org)
  • Because they lack a thymus, nude mice cannot generate mature T lymphocytes. (wikipedia.org)
  • Most strains of nude mice are slightly "leaky" and do have a few T cells, especially as they age. (wikipedia.org)
  • In a cage devoid of any enrichment (a fancy term for mouse toys), many strains display unfavorable behavior, including barbering, reduced eating and reduced breeding. (jax.org)
  • The phenotype (main outward appearance) of the mouse is a lack of body hair, which gives it the "nude" nickname. (wikipedia.org)
  • Mice with a targeted deletion in the FOXN1 ("knockout" mice) also show the "nude" phenotype. (wikipedia.org)
  • Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation. (lu.se)
  • Exposing the human nude phenotype. (lu.se)
  • The nude mouse is valuable to research because it can receive many different types of tissue and tumor grafts, as it mounts no rejection response. (wikipedia.org)
  • Mice were inoculated with PC-3 prostate cancer cells followed by a 7-week tumor development. (umd.edu)
  • Tumor development in adult nude mice (Experiment 1) was suppressed whereas in young nude mice (Experiment 2) was promoted by feeding a high selenium diet. (umd.edu)
  • Taken together, there is an opposing role of excessive selenium on tumor xenograft development in adult and young nude mice carrying differential T cell profiles. (umd.edu)
  • A relationship between tumor growth in nude mice and patient prognosis could not be found. (amsterdamumc.org)
  • When transplanting head and neck squamous cell carcinoma in nude mice, it has to be recognized that some tumor characteristics will influence the success of tumor growth. (amsterdamumc.org)
  • Inhibition of YAP or TGF-β breaks this loop and suppresses cancer stemness and proliferation In nude mice, RAD18 promoted subcutaneous transplanted tumor growth and M2-type TAM recruitment. (nature.com)
  • Finally, the inhibitory effect of the combined chidamide and bortezomib treatment on MGC-803 cells was verified in vivo through tumor formation experiments in nude mice. (dovepress.com)
  • The effects of the low-dose chidamide and bortezomib combination reduced the growth on gastric cancer in vivo were investigated by using a subcutaneous tumor mouse model. (dovepress.com)
  • Because of the different tumorigenicities in nude and C57BL/6 mice, the disease fighting capability might play a significant role in inoculated JC1 tumor progression. (mycareerpeer.com)
  • As a total result, a trusted mouse model can be urgently necessary for tumor Naringin (Naringoside) immunology research (14). (mycareerpeer.com)
  • Orthotopic and heterotopic mouse tumor types of JC1-2 cells had been established and even more intense immune system responses had been seen in the microenvironment from the orthotopic model. (mycareerpeer.com)
  • Mice are sensitive creatures, so noises and vibrations that are unnoticeable to humans can greatly affect them. (jax.org)
  • 22, 2023 Even without a central brain, jellyfish can learn from past experiences like humans, mice, and flies, scientists report for the first time. (sciencedaily.com)
  • Of 1,820 rodents dent species, such as hamsters and guinea pigs, can become tested in 1 facility, 382 (21%) mice ( Mus musculus ) had infected and transmit infection to humans ( 1 ). (cdc.gov)
  • Humans be- inNorthAmerica.Contactbywildmicewithcolonymice come infected through close contact with infected rodents, wasthelikelysourceforLCMV,andshipmentsofinfected through transplantation of infected organs, or by vertical mice among facilities spread the infection. (cdc.gov)
  • 1991. Genetic activity of the human carcinogen sulphur mustard towards salmonella and the mouse bone marrow. (cdc.gov)
  • MG-63 cells were pre-treated with 0, 1, or 10 µg/mL caffeic acid, and 6 hours after pre-treatment, MG-63 cells were injected into subcutaneous space of mice to induce osteosarcoma. (inabj.org)
  • For example, C57BL/6J mice are maintained on a 6% fat diet, whereas CAST/EiJ mice ( 000928 ) perform better on a diet containing 10% fat while CC059/TauUncJ ( 025125 ) perform much better on a 4% fat diet than on a 6% diet. (jax.org)
  • Splenocytes had been isolated from C57BL/6 mice and co-cultured with JC1-2 cells to verify the responsiveness Naringin (Naringoside) from the interferon (IFN)- pathway in the JC1-2 cell range. (mycareerpeer.com)
  • NewsNation ) - Researchers at the University of Rochester transferred a longevity gene from naked mole rats to mice, calling it a "groundbreaking endeavor. (wgnradio.com)
  • According to the University of Rochester , naked mole rats have long captured the attention of scientists for their lengthy lifespans and resistance to age-related diseases. (wgnradio.com)
  • The researchers previously learned that HMW-HA is also one mechanism responsible for the unusual resistance naked mole rats have to cancer. (wgnradio.com)
  • spreadsheet (Microsoft Excel, Microsoft, Redmond, WA, Trace-back investigations also identified a distributor (fa- USA) and analyzed by using statistical analysis software cility B) where live rats ( Rattus norvegicus ) and mice ( M. (SAS 9.3, SAS Institute, Cary, NC, USA). (cdc.gov)
  • We know that brown adipose tissue may protect rodents (such as mice and rats) from the cold in winter. (medscape.com)
  • Unresponsiveness of nude mice to skin allografts. (jax.org)
  • Another model was also created by subcutaneously injecting MG-63 cells to the back of mice, and after 48 days, the visible tumour mass was injected intra-tumour with 0 or 10 µg/mL caffeic acid every 7 days for 6 times. (inabj.org)
  • The genetic basis of the nude mouse mutation is a disruption of the FOXN1 gene. (wikipedia.org)
  • Nude mice have a spontaneous deletion in the FOXN1 gene. (wikipedia.org)
  • Before administration, 2 weeks after administration, and 4 weeks after administration, the feces of the model nude mice were taken respectively, subpacked into labeled cryotubes, and stored at −80°C. All samples were sent for gene sequencing after completion. (hindawi.com)
  • Biologists at the university introduced a specific gene responsible for enhanced cellular repair and protection into mice, which they say may be a step toward unlocking the secrets of aging and potentially extending human lifespan. (wgnradio.com)
  • The gene is responsible for making high molecular weight hyaluronic acid (HMW-HA), improving the health of the mice and leading to an approximate 4.4% increase in median lifespan. (wgnradio.com)
  • A gene therapy technique that can halt the progression of a condition resembling multiple sclerosis (MS) in mice has. (thenakedscientists.com)
  • 1998). ment in hairless mice. (who.int)
  • He claimed that his laboratory cancer mice had had remarkable positive effects from being kept in a Faraday cage, so he built human-size versions, where one could sit inside. (wikipedia.org)
  • Studies reported that caffeic acid might promote apoptosis in MG-63 osteosarcoma cells, however, the effect of caffeic acid treatment in preventing tumour mass formation has not been well elucidated, especially in MG-63 cells-induced nude mice in vivo . (inabj.org)
  • Results of caffeic acid pre-treatment and caffeic acid treatment in tumour mass of mice show that caffeic acid is able to inhibit the MG-63 cells formation. (inabj.org)
  • Called Nude Mice, these striking creatures are a result of spontaneous inbreeding, natural genetic freak shows if you will. (ubc.ca)
  • Chemicals released by gut microbes slow down the ageing process in worms, flies and even mice, scientists announced. (thenakedscientists.com)
  • Nude mice were first discovered in 1962 by Dr. Norman R. Grist at Ruchill Hospital's Brownlee virology laboratory in Glasgow. (wikipedia.org)
  • The same is true of laboratory mice. (jax.org)
  • Skinny pig Earmouse The Nude Mouse in Experimental and Clinical Research (Vol.1). (wikipedia.org)
  • Giovanella, B.C.(eds) Academic Press, 1978, ISBN 0-12-261860-2 The Nude Mouse in Experimental and Clinical Research (Vol.2). (wikipedia.org)
  • Between cage changes, daily cage and water level checks, and experimental procedures, mice undergo a lot of disruptions to their everyday lives. (jax.org)
  • It is carried by 31(32%)hadIgMand/orIgGtoLCMV,andasepticmen- the common house mouse ( Mus musculus), but other ro- ingitis was diagnosed in 4 employees. (cdc.gov)
  • The rationale of this study was to determine the myelotoxicity in nude mice of the α-emitter 211 At conjugated to monoclonal antibodies (mAbs) and to compare the effect with an electron emitter, 99m Tc, and external irradiation from a 60 Co source, for estimation of the relative biological effectiveness (RBE). (snmjournals.org)
  • After xenograft, dietary selenium status does not affect levels of CD4 and CD8 T cells in adult nude mice in Experiment 1, while high selenium resulted in significant decrease in CD4 T cells in young nude mice in Experiment 2. (umd.edu)
  • In pre-treated MG-63 cells-induced mice, volumes of the mass decreased in reverse with the dose of caffeic acid given. (inabj.org)
  • Further, nude mice were injected with TCE-transformed cells. (cdc.gov)
  • Intriguingly, nude mice-bearing ATO-sensitive cells derived xenograft tumours are more sensitive to ATO. (lu.se)
  • Homozygous NU/J nude mice were fed selenium-deficient, torula yeast basal diet alone or supplemented with 0.15 or 1 mg Se/kg for 8 months in Experiment 1 and for 11 weeks in Experiment 2. (umd.edu)
  • To observe the effects of Asini Corii Colla, turtle carapace glue, and other drugs on the intestinal flora of nude mice with uterine fibroids model, so as to provide evidence for the clinical application of drugs. (hindawi.com)
  • Then, the model nude mice were fed ejiao, turtle carapace glue, and other corresponding drugs. (hindawi.com)
  • Therefore, on the basis of previous experiments, this study conducted biodiversity sequencing through 16SrRNA to observe the structural changes of intestinal flora of the nude mice with uterine fibroids model under the action of donkey-hide gelatin, turtle shell glue, and other traditional Chinese medicines, providing strong evidence for traditional Chinese medicine to regulate the intestinal microecology of nude mice with uterine fibroids. (hindawi.com)
  • Two beats one: osteosarcoma therapy with light-activated and chemo-releasing keratin nanoformulation in a preclinical mouse model. (inabj.org)
  • Furthermore, more intense immune system responses had been seen in the orthotopic mouse model than in the heterotopic model. (mycareerpeer.com)
  • In thousands of biology labs around the globe, these lab mice quietly do their part in the pursuit of science and medicine. (ubc.ca)
  • Making sure that your touchy breeders are not located near a door or sink where there may be heavy traffic or loud noises, and reminding caretakers to work gently, slowly, and quietly when handling the mice can markedly improve breeding performance. (jax.org)
  • Not only that, but if you picked up a newspaper, you'd see this picture of poor naked Uncle Orv with a huge human ear on his back, and you'd be totally thinking that he could hear out of this thing. (ubc.ca)
  • Suppression by incadronate of invasion and growth of A-375 human melanoma in mandible in nude mice. (bvsalud.org)
  • Once growth was established, all variables studied had no influence on the probability of growth in the subsequent mouse passages. (amsterdamumc.org)
  • Two different growing patterns of sphenoid wing meningioma have been described: meningioma en masse, forming a nodular space-occupying lesion, and meningioma en plaque, which is flat and demonstrates a carpet-like growth pattern. (medscape.com)
  • Not all mice are created equal, and the food on which one strain thrives may not be the best for another. (jax.org)
  • For these reasons, nude mice are less popular in research today. (wikipedia.org)
  • the decrease in the relative abundance of Firmicutes and the increase in the relative abundance of Bacteroidetes were important structural changes of intestinal flora in nude mice at 4 weeks after administration. (hindawi.com)
  • In controlled, germ free environments and with antibiotic treatments found in many laboratories that routinely use nude mice, they can live almost as long as normal mice (18 months to two years). (wikipedia.org)
  • Currently, an organism idenitified as 'mouse' will be found under the name 'Mus sp. (nih.gov)
  • In addition, knockout mice with more complete defects in the immune system have been constructed (e.g. (wikipedia.org)
  • Since nude females have underdeveloped mammary glands and are unable to effectively nurse their young, nude males are bred with heterozygous females. (wikipedia.org)
  • The nomenclature for the nude mouse has changed several times since their discovery. (wikipedia.org)
  • Changing cages more frequently than 1-2 times per week can agitate the mice, and if you are also frequently opening the cage to check on the well-being of the mice, they may exhibit reduced breeding performance. (jax.org)
  • It took us 10 years from the discovery of HMW-HA in the naked mole rat to showing that HMW-HA improves health in mice," said Vera Gorbunova, the Doris Johns Cherry professor of biology and medicine at Rochester. (wgnradio.com)
  • In partnership with Outside's Gaia GPS app , the granola brand is encouraging nude hikers to review trails for nude-friendliness using a discrete emoji code system to evade those who oppose naked hiking. (backpacker.com)
  • The fox features a pair of pesky mice seeming to have a conversation as they stand on a pumpkin stem in a autumn pumpkin patch. (ecrater.com)
  • Mice were treated daily with 30 mg/kg 9-cis retinoic acid, 20 mg/kg all-trans-retinoic acid, or 60 mg/kg 13-cis retinoic acid by p.o. gavage on a schedule of 5 days/week over 4 weeks. (tamu.edu)
  • We're currently migrating Naked Security to the Sophos News platform to provide all our blogs in one place. (sophos.com)
  • In tonight's episode we got to see how fsociety's Mobley and Trenton met for the first time - in a coffee house, playing a cat-and-mouse game, though the mouse might not have realized he was one. (sophos.com)
  • Nothing we love better at the Mouse House than a warm bowl of nourishing soup! (thehungrymouse.com)
  • The life span of nude mice is normally 6 months to a year. (wikipedia.org)