Mice mutant strains. Medical search. Frequent questions

Genomic blots from inbred strains carrying 22 loss, gain-loss, and gain mutations on the BALB/c and C57BL/6 backgrounds were hybridized with probes homologous to the long terminal repeat (LTR) and envelope (env) regions of MMTV. (elsevierpure.com)
However, genomic blots of one gain mutant, B6.C-KH-84, exhibited restriction fragments which were not exhibited by either of the parental strains, C57BL/6 or BALB/c. (elsevierpure.com)
C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. (mmpc.org)
C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. (mmpc.org)
identified a single genetic locus (Ahl) that could explain the early presbycusis observed in the inbred C57BL/6J mouse strain. (cdc.gov)
In the congenic C57BL/6J strain, the Ahl locus has been replaced by the wild-type locus from the inbred CBA/CaJ strain (strain B6.CBA). (cdc.gov)
This presentation will compare ABR results in the two congenic strains as well as compare the present data with the previous inbred C57BL/6J and CBA/CaJ data. (cdc.gov)
The efficacy of such htcPep was assessed in C57BL/6 mice injected with syngeneic melanoma B16F10 or lung TC1 tumor cell lines, in combination with metronomic chemotherapy and immune checkpoint inhibitors. (bvsalud.org)

Mice bearing mutant genes which are phenotypically expressed in the animals. (ucdenver.edu)
These included lists and maps of mouse genes and mutants, information on inbred strains, and brief reports of useful results that did not merit a full paper. (wikipedia.org)
On behalf of the Committee for Standardised Genetic Nomenclature for Mice, nomenclature rules for naming mouse genes and mouse strains were published. (wikipedia.org)
The new maps ranged from a Mouse Chromosome Atlas that showed man-mouse homologies and correspondence between the genetic and G-band maps and replaced the previous linkage map, to maps of man-mouse homologies, cancer-related genes, the Genetic Imprinting map (http://mousebook.org), the chromosome aberration map, and a probe/clone map. (wikipedia.org)
The first issue of the year was a "Maps" issue, the second issue was a "Genes" issue, the third issue was "Inbred Strains" and the fourth issue was a DNA probes and Restriction fragment length polymorphism issue. (wikipedia.org)
In a new study, McIver's laboratory and researchers at the University of Maryland School of Medicine identified two genes important for invasive group A Streptococcus infections in mice. (scienceblog.com)
To identify functional categories overrepresented in the differentially expressed genes, we used integrated gene-network analysis, gene ontology enrichment and mouse phenotype ontology analysis. (biomedcentral.com)
RNA sequencing revealed the upregulation of inflammasome pathway-related genes, keratinocyte stress marker genes, and keratinocyte differentiation marker genes in the Nlrp1b KI mice after UVB irradiation. (frontiersin.org)
Genetically altered (GA) mice are used extensively to study the function and regulation of genes and their role in human development and disease. (nc3rs.org.uk)
Bulk and scRNAseq of mutant kidneys revealed differential expression of several hundred genes, but not genes previously implicated in inherited cystic kidney disease. (asn-online.org)
In homozygous mutants, there was marked differential expression of genes involved in the unfolded protein response, c-Myc sigaling, and fatty acid oxidation. (asn-online.org)
In the early 1980s, researchers began genetically manipulating mice by inserting genes from other species (including humans) during the earliest stages of embryonic cell division. (mentalfloss.com)
Scientists also began turning off specific genes during early development, creating 'knockout mice. (mentalfloss.com)
These results, combined with transcriptome profiling (this GEO submission: RNA-Seg of whole thymus from wt and the two ZnF mutants), reveal that different subsets of fingers within multi-finger transcription factors can regulate distinct target genes and biological functions, and they demonstrate that selective mutagenesis can facilitate efforts to elucidate the functions and mechanisms of action of this prevalent class of factors. (nih.gov)
After years of obscurity, strains of mice with mutations in particular genes are thrust to the fore of autism research. (the-scientist.com)
The first study on the mice came out in 2000, when researchers knew practically nothing about genes linked to autism. (the-scientist.com)
Two other genes, CHD8 and ANK2 , were also thrust to the forefront of autism research-and as with SCN2A , mice lacking these genes had been generated years before for unrelated studies . (the-scientist.com)
In 1996, researchers had made mice with mutations in TCF4 , which regulates the expression of other genes and plays a key role in immune cell development . (the-scientist.com)
Searching for these mice can sometimes be tricky because the genes are christened with new names as time goes on. (the-scientist.com)
Researchers identify a handful of genes that help bacteria in the mouse gut adapt to dietary changes. (the-scientist.com)
Researchers at Washington University School of Medicine in St. Louis, Missouri, have now identified some of the genes bacteria residing in the mouse gut use to adapt to changes in diet, according to a study published today (October 1) in Science . (the-scientist.com)
AceView: gene:him-8, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. (nih.gov)
Analysis of these mice with HLHS allowed us to identify for the first time two genes interacting in combination to cause HLHS," said Cecilia Lo, Ph.D., professor at Pitt's School of Medicine who also holds the F. Sargent Cheever Chair in Developmental Biology. (upmc.com)
Further analysis of these mutant mice indicated the genetic origins of HLHS likely involve many interacting genes. (upmc.com)
In one mouse strain, they discovered that mutations in two genes, named Sap130 and Pcdha9, were required for HLHS. (upmc.com)
Using CRISPR-Cas9 gene editing in mice, the researchers confirmed that mutations in these two genes can cause HLHS. (upmc.com)

The potential association between integration or deletion of mouse mammary tumor virus (MMTV) retroviral sequences and the appearance of non-H-2 histocompatibility (H) antigen mutations was investigated. (elsevierpure.com)
Blue squares indicate phenotypes directly attributed to mutations/alleles in this strain. (jax.org)
Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. (mmpc.org)
For example, he said, "you could imagine the same procedure applied to variety of mice with genetic mutations. (the-scientist.com)
Our study has been made possible by leveraging findings from a large-scale analysis in mice to recover mutations causing congenital heart defects. (upmc.com)
Lo and her team used fetal ultrasound imaging to screen mice with experimentally induced mutations, looking for structural heart defects. (upmc.com)
By comparing the genome of mice with the HLHS heart defects to the genome of normal mice, Lo and her team identified several hundred mutations in the HLHS mutant strains. (upmc.com)

An ENU mutagenesis library was screened for renal phenotypes and mutant mouse strains were established via backcrossing. (asn-online.org)
Each mutant strain exhibited a specific subset of the phenotypes observed with Ikaros null mice. (nih.gov)
We will determine whether this approach can induce ALS phenotypes in the wild type mice and/or modulate the disease phenotypes and pathology in the mutant ALS transgenic mice. (neurodegenerationresearch.eu)

2006. Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. . (oregonstate.edu)
A human blood chimeric mouse could serve to harmonize in vitro P. falciparum cultivation and in vivo studies carried out in rodent animal models. (frontiersin.org)
If successful, this experiment will establish a new mouse model for ALS and a new method that is faster than the conventional gene knockout approach for construction of mouse models for ALS and for studying mutant gene interactions in vivo. (neurodegenerationresearch.eu)
persister cells are clinically relevant, and antimicrobial therapy selects for high-persister strains in vivo. (medscape.com)

The team at University of Leeds led by Dr Virginia Pensabene has developed a novel and reliable microfluidic device that improves the developmental competence of in vitro -derived mouse embryos to allow the use of non-surgical embryo transfer (NSET) in the generation of transgenic mice. (nc3rs.org.uk)
In October 2021, we held a webinar highlighting the IVF micro microfluidic device, developed to address the EASE Challenge, which enables non-surgical embryo transfer for generating transgenic mice. (nc3rs.org.uk)
The team at University of Leeds led by Dr Virginia Pensabene has developed a novel and reliable microfluidic device that improves the developmental competence of in vitro -derived mouse embryos and their implantation potential, enabling the use of non-surgical embryo transfer (NSET) in the generation of transgenic mice. (nc3rs.org.uk)
The result was 'transgenic mice. (mentalfloss.com)
mutant HIM-8 fails to suppress mutant egl-13 on a free transgenic array, and also fails to suppress native mutant egl-13 if transgenic excess copies of the egl-13 promoter are present. (nih.gov)
Currently this is done by intercrossing different mutant transgenic mouse strains. (neurodegenerationresearch.eu)
However, this process is slow because of the low yield of double or triple transgenic mice and the multigenerational crosses that are necessary to bring different transgenic lines to the same genetic background. (neurodegenerationresearch.eu)
To solve these problems, we propose a rAAV-intrathecal gene delivery approach for construction of transgenic mouse models for ALS. (neurodegenerationresearch.eu)
We will inject the rAAV into several mouse strains including the normal wild type and mutant transgenic mice that develop ALS phenotype. (neurodegenerationresearch.eu)

While heterozygous mice exhibited a renal-restricted phenotype inherited in an autosomal dominant fashion, homozygous mutants exhibited perinatal lethality due to vascular anomalies and hypoxia. (asn-online.org)
In heterozygous mutants, a similar but attenuated transcript signature was seen in differentiated nephron progenitors and mature epithelial clusters. (asn-online.org)
On the genetic background of the inbred strain C3H heterozygous mutant mice showed a pathological increase of the plasma urea concentration. (uni-muenchen.de)
For those examinations heterozygous mutant mice were mated to C3H mice and the offspring were divided in the two groups of mutant and wildtype littermates according to the concentration of plasma urea. (uni-muenchen.de)

In 1998 Mouse Genome, the official journal of the International Committee for Standardized Genetic Nomenclature for Mice, merged with Mammalian Genome the official journal of the International Mammalian Genome Society. (wikipedia.org)
Finally, Little made a crucial decision that would change medical and genetic research forever: He compiled a catalog of the inbred strains he'd created and used for his own research, and he offered to sell it to other institutions. (mentalfloss.com)
Introduction of several mouse strains with genetic immune deficiencies has greatly benefited the development of a small laboratory animal model ( 7 - 15 ) to study the asexual blood stage infection of P. falciparum . (frontiersin.org)
Genetic analysis revealed that a specific part of the H. pylori gene, called the T-repeat region, varied in length from strain to strain. (news-medical.net)
Slight differences in the genetic sequence of H. pylori can sometimes give certain strains advantages over others that allow it to grow better,' says lead author of the study Ryo Kinoshita-Daitoku. (news-medical.net)
We were interested in the genetic and molecular reasons behind why particular strains are more pathogenic and can live in the stomach for decades, leading to cancer development. (news-medical.net)

Jensen and collaborators showed that strains from different genotypes can infect the same host repeatedly 14 . (nature.com)
This would be expected based on the fact that the congenic CBA.B6 mice genotypes included the mutant Ahl locus. (cdc.gov)
Adult females of all genotypes were blood-fed on a single human subject during mutant generation, for behavioral assays, and calcium imaging. (elifesciences.org)

BALB/c mice were infected intraperitoneally with 0.1 mL of the diluted bacterial suspension. (cdc.gov)

Toxoplasma strains in South America are more genetically diverse than those in North America and Europe. (nature.com)
In 2015, approximately 50% of the animals used for scientific procedures in the UK were for the creation and breeding of genetically modified animals, the majority of which are mice (Home Office, 2015). (nc3rs.org.uk)
To address these questions, the researchers infected gerbils and mice with wild type (normal) H. pylori for 8 weeks, then extracted and genetically characterized the mutant strains that appeared. (news-medical.net)

To address the question of specificity for the allele encoding the Na V 1.4-R669H variant as a cause of HypoPP and to produce a model system in which to characterize functional defects of the mutant channel and susceptibility to paralysis, we generated knockin mice carrying the ortholog of the gene encoding the Na V 1.4-R669H variant (referred to herein as R669H mice). (jci.org)
Also, C. albicans mutant strains that have defects in glycan assembly at the cell surface are significantly less virulent in mouse infection models. (bl.uk)
From this screen, they recovered eight different mouse strains with structural and functional heart defects indicative of HLHS. (upmc.com)
Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. (infrafrontier.eu)

In 1990 Mouse News Letter changed its name to Mouse Genome which merged with the journal Mammalian Genome in 1998. (wikipedia.org)
In February 1990 Mouse News Letter changed its name to Mouse Genome. (wikipedia.org)
Starting in 1991 Mouse Genome was published four times a year as one volume with four issues. (wikipedia.org)
The merged journal kept the name Mammalian Genome and includes the words "Incorporating Mouse Genome" on its front cover. (wikipedia.org)
Colombo, MP, Melvold, RW & Wettstein, PJ 1987, ' Inheritance of a mutant histocompatibility gene and a new mammary tumor virus genome in the B6.KH-84 mouse strain ', Immunogenetics , vol. 26, no. 1-2, pp. 99-104. (elsevierpure.com)
Wettstein, Peter J. / Inheritance of a mutant histocompatibility gene and a new mammary tumor virus genome in the B6.KH-84 mouse strain . (elsevierpure.com)
Using modern methods and the published mouse genome sequence, UW researchers were able to identify the mutation at a gene called ZFP145, which produces the protein PLZF. (sciencedaily.com)

These mice provided some of the first evidence that susceptibility to cancer can be inherited, just like hair color. (mentalfloss.com)
Susceptibility to noise -induced hearing loss in two congenic mouse strains. (cdc.gov)
Although a defect in the chemokine receptor CX3CR1 increases susceptibility of mice and humans to systemic candidiasis, it does not in mucosal candidosis. (medscape.com)

Six female BALB/c mice were used as a sample population for each isolate. (cdc.gov)
The previously reported pathogenic mutation in NLRP1 in humans, and the missense mutation we inserted into the BALB/c mice in this study. (frontiersin.org)

Neuropathogenicity of mutant strains of mouse hepatitis virus, 1A and 2C, from DBT cells persistently infected with JHM strain. (utmb.edu)
Role of mouse hepatitis virus (MHV) receptor murine CEACAM1 in the resistance of mice to MHV infection: studies of mice with chimeric mCEACAM1a and mCEACAM1b. (jax.org)

Fatty acid availability was increased in cardiomyocyte-specific CLOCK mutant (CCM) and wild-type (WT) littermate mice for 9weeks in time-of-day-independent (streptozotocin (STZ) induced diabetes) and dependent (high fat diet meal feeding) manners. (nih.gov)
Cerebellar and hippocampal tissue samples from three En2 -/- and wild type (WT) littermate mice were assessed for differential gene expression using microarray hybridization followed by RankProd analysis. (biomedcentral.com)

After CHD8 topped the list of autism candidates in 2014, at least five teams rushed to create and characterize their own mutant strains. (the-scientist.com)

Thus, the development of an effective toxoplasmosis vaccine is critical for limiting the infection of various Toxoplasma strains. (nature.com)
A) Virulence potential determination of KP0714 and pVir-KP0714-curing mutant (PC-KP0714) in a mouse infection model. (cdc.gov)
Therefore, humanized mice capable of harboring the human malaria infection are urgently needed to understand the parasite biology. (frontiersin.org)
Evidence that intrauterine infection was caused by the RB51 vaccine strain, and not by field strains of B. abortus or by S19, included immunohistochemical staining specific for RB51 (negative for S19), RB51-specific titer of greater than 1:10,000 on experimental dot-blot assay measuring antibody to RB51, and RB51-specific DNA sequences identified by polymerase chain reaction (PCR). (cdc.gov)

A mutant with cystic kidneys was identified. (asn-online.org)
The histopathological investigation of the kidneys did not reveal any alterations, which could to explain the pathological increase of the plasma urea concentration in the mutant mice. (uni-muenchen.de)
However urea secretion via the kidneys was impaired, since the mutants showed significantly lower urine urea levels compared to the wildtype mice. (uni-muenchen.de)

And we tested that theory by using transposons to make thousands of different individual mutants that we used to infect a subcutaneous environment in mice. (scienceblog.com)

Today, it's estimated that 95 percent of the world's lab mice are descended from mice born in the Jackson Laboratory. (mentalfloss.com)
Green, a well-known mouse geneticist who died several years ago, had several embryos from the 35th generation of the mice frozen at the Jackson Laboratory in Maine, the world's largest mutant mouse resource center. (sciencedaily.com)

In this study, we observed that the knockout of calcium-dependent protein kinase 3 (CDPK3) in the type II ME49 strain greatly attenuated virulence in mice and significantly reduced cyst formation. (nature.com)
When this RNA was completely absent, the amounts of several bacterial pathogenic factors significantly increased and the strain showed stronger colonization within the rodent stomach. (news-medical.net)
After 6 weeks the mutant mice grew more slowly leading to a significantly lower body weight compared to the wildtype littermates. (uni-muenchen.de)
Regarding the relative organ weights the mutant mice showed significantly higher values for the spleen and the brain. (uni-muenchen.de)
The mutant mice had significantly higher plasma concentrations of urea and total protein as well as a higher activity of the alkaline phosphatase. (uni-muenchen.de)

Twenty-one mutants were identical in restriction patterns to the respective background strains with all tested restriction enzymes and both probes. (elsevierpure.com)
So he began to dream of mice strains that were identical and docile, 'like newly minted coins. (mentalfloss.com)

(C) Differences between the three mouse NLRP1 paralogs. (frontiersin.org)
Generally, pre-exposure the B6.CBA congenics started out with more sensitive ABR thresholds than the CBA.B6s (strain differences were statistically significant at all frequencies pre-exposure. (cdc.gov)
or each of these agents, carcinogenicity in rats and/or mice, els, differences in exposure con- there was sufficient evidence of car- for example for the liver (aflatoxins, ditions between studies in animals cinogenicity from studies in rats and/ trichloroethylene [TCE], and vinyl and in humans, or limitations in Part 1 · Chapter 1. (who.int)

Previously, we found that Lactobacillus rhamnosus CNCM I-3690 can protect intestinal barrier functions in mice inflammation model. (nature.com)

It is back and the worse news is that a mutant strain has been detected of the H5N1 Highly Pathogenic Avian Influenza Virus. (pravda.ru)
This does not mean, however, that a human version of H5N1 would have the same highly pathogenic characteristics of the strain which is essentially Avian or Bird Flu. (pravda.ru)

This story really resonates for me as I have a nearly pathological hatred of mice, having battled them in the past (and having killed a few myself). (smithmag.net)

In the postpandemic period, 2009 H1N1 virus strains now are considered to be the predominant seasonal influenza A (H1N1) virus strains. (cdc.gov)

However, this is difficult to model in mice because loss of one TBK1 allele in mice does not cause an overt phenotype but a complete knockout of this gene causes embryonic lethality. (neurodegenerationresearch.eu)

No notable phenotype was detected in a high throughput screen of homozyogus mutant null mice. (jax.org)

Mouse over the ending of each transcript gives tissues from which the supporting cDNAs were extracted. (nih.gov)

Lovastatin, USP is a cholesterol lowering agent isolated from a strain of Aspergillus terreus. (nih.gov)
Title : Pulmonary immune responses to Aspergillus fumigatus in an immunocompetent mouse model of repeated exposures Personal Author(s) : Buskirk, Amanda D.;Templeton, Steven P.;Nayak, Ajay P.;Hettick, Justin M.;Law, Brandon F.;Green, Brett J.;Beezhold, Donald H. (cdc.gov)

He discovered, for instance, that you can breed strains of mice with bodies that readily accept transplanted cancer tumors. (mentalfloss.com)

These data demonstrated that ME49Δ cdpk3 inoculation induced effective cellular and humoral immune responses against acute and chronic Toxoplasma infections with various strains and was a potential candidate to develop a vaccine against toxoplasmosis. (nature.com)
The National Animal Disease Center, U.S. Department of Agriculture (USDA), identified the B. abortus isolate from the calf as the RB51 vaccine strain. (cdc.gov)
Before 1996, vaccine was made by using the S19 strain. (cdc.gov)

The skin inflammation and hyperkeratosis from UVB irradiation in the Nlrp1b KI mice were inhibited by both intraperitoneal and subcutaneous administration of anti-IL-1β antibodies before UVB irradiation. (frontiersin.org)

Maher tracked down the mice in the literature and found them at The Jackson Laboratory in Bar Harbor, Maine. (the-scientist.com)
The UW researchers contacted The Jackson Laboratory for the embryos, and staff there brought the strain back to life after the 30-year freeze. (sciencedaily.com)

The similarity in brain pathology between the Mahogunin mutant mice and that seen in prion diseases suggested to us that there might be a connection," Dr. Hegde said. (nih.gov)

Thanks to the close relationships established with their hosts, some probiotic strains can provide additional benefits: for example, they can mediate either immune responses or barrier functions 10 . (nature.com)
huRBC-reconstituted immunodeficient mice received infectious challenge with attenuated P. falciparum C9 parasite mutants (C9-M), complemented (C9-C), and wild type (NF54) progenitors to study the role of immune effectors in the clearance of the parasite from mouse circulation. (frontiersin.org)
Further, the presence of mutant parasites in deep-seated tissues suggests the escape of parasites from the host's immune responses and thus extended the survival of the parasite. (frontiersin.org)
Collectively, our data suggest that huRBCs reconstituted NSG mice infected with attenuated P . falciparum is a valuable tool to explore the role of C9 mutation in the growth and survival of parasite mutants and their response to the host's immune responses. (frontiersin.org)
The reduction in the residual innate immune effectors (mainly cells of monocytes and macrophages lineage) and co-administration of huRBCs supplied with decomplemented human serum through an intravenous route led to the development of a reproducible humanized mouse. (frontiersin.org)

She then colonized germ-free mice with the mutant strains and 11 other bacterial strains common in the gut to create simplified microbiota. (the-scientist.com)

The absence of Parkin does not promote dopamine or mitochondrial dysfunction in PolgA mitochondrial mutator mice. (neurotree.org)

However, Mr. Lubroth stated recently on UN Radio that "There is no indication that the new virus strain will behave differently than the previous one or that it is more dangerous to humans. (pravda.ru)
This report describes occupational exposure to animals infected with the RB51 strain and emphasizes the need for surveillance of unintentional exposure of humans to RB51 to assess outcomes of such exposures. (cdc.gov)
Relevant of mutagenicity and clastogenici- angiosarcomas of the liver, which carcinogens discussed in this chap- ty, including the induction of sister are rare tumours, were identified in ter do not include pharmaceutical chromatid exchange (SCE), chro- humans, rats, and mice exposed to drugs classified in Group 1, which mosomal aberrations (CA), and mi- vinyl chloride. (who.int)

Sometimes, the traits that Little and his team found most useful were the ones that produced the least healthy mice. (mentalfloss.com)

Researchers quickly realized the value of using standardized mice strains, and the money began pouring in. (mentalfloss.com)
He had sent some of his mice to other researchers, and some ended up with a team in Houston, Texas. (the-scientist.com)
While the SCN2A mice dwelled in obscurity, researchers had made significant strides in understanding the genetics of autism. (the-scientist.com)
Although researchers had been working with the mice for years, they had not noticed any unusual behaviors because they mostly studied mice lacking both copies of a gene. (the-scientist.com)
Back in the 70s, researchers were able to position the luxoid mutation on mouse chromosome 9. (sciencedaily.com)

Sequence type 11 carbapenem-resistant hypervirulent K. pneumoniae strain CR-HvKP4 was used as a hypervirulence control. (cdc.gov)
Macrophages from this strain are resistant to the effects of anthrax lethal toxin. (mmpc.org)
Need a mouse that's resistant to anthrax but will get drunk easily? (mentalfloss.com)
ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)
Our preliminary study using 2D isolates were recovered from liq- new cases throughout the world cu- gel electrophoresis in drug sensitive/ uid nitrogen, and sub-cultured in taneous leishmaniasis (CL) remains resistant strains of L. tropica showed RPMI1640 medium (Gibco/BRL) a serious public health problem in that some proteins were differentially supplemented with 10% fetal bovine numerous countries [1,2]. (who.int)

Phenotypic and genotypic characterization of the ENU-induced mutant mouse line HST001 for use in nephrological research A dominant mutation was established in the line HST001 within the Munich ENU mouse mutagenesis project. (uni-muenchen.de)

The phenotypic characterization of the mutant line included the measurement of body and organ weights, food intake and a broad spectrum of clinical chemical and hematological parameters as well as histological investigations of inner organs. (uni-muenchen.de)

RB51 is a live, attenuated strain that was licensed conditionally by the Veterinary Services, Animal and Plant Health Inspection Service, USDA, on February 23, 1996, for vaccination of cattle in the United States. (cdc.gov)

At the functional level, time-of-day-dependent high fat meal feeding tended to influence cardiac function to a greater extent in WT versus CCM mice. (nih.gov)

KATIE CAREY FOR SPECTRUM N early 20 years ago, a new strain of mice debuted in a California laboratory. (the-scientist.com)
Moreover, several studies from Dr. Hegde's group and others showed that when too much of a cell's PrP is exposed to the cytoplasm in laboratory mice, they develop brain deterioration. (nih.gov)
The discovery was made by applying the latest laboratory methods to a strain of mice restored from embryos frozen since the early 70s. (sciencedaily.com)

We generated Nlrp1b (the mouse homologue of human NLRP1 ) gain-of-function knock-in ( Nlrp1b KI) mice with UVB irradiation-induced autoinflammatory skin lesions. (frontiersin.org)
Figure 1 Homology in domain structures and amino acid sequences between human and mouse NLRP1 and the present knock-in mutation. (frontiersin.org)
(A) Domain structures of human NLRP1 and mouse NLRP1B. (frontiersin.org)
(B) Similar and conserved amino acid sequences between human NLRP1 and mouse NLRP1B. (frontiersin.org)
Controlled reactive professional phagocytic leukocytes in immunodeficient mice allowed for sizeable human blood chimerism and injected huRBCs acted as bona fide host cells for P. falciparum . (frontiersin.org)
This NSG mouse, depleted with γ-chain of the IL-2 receptor, has been shown to better tolerate a variety of human transplanted cells ( 17 - 24 ). (frontiersin.org)
Additionally, they were curious how these fluctuations would allow some strains to colonize the human stomach more efficiently than others. (news-medical.net)
Animal experimentation: For routine strain maintenance, animals were blood-fed on live mice or human subjects. (elifesciences.org)
Mice were treated with cisplatin, and human cancer cells were exposed to inflammatory cytokines, to confirm increased PD-L1 and major histocompatibility complex (MHC) I expression by tumor cells or dendritic cells. (bvsalud.org)

The above characteristics of Toxoplasma strains pose great challenges to the control of toxoplasmosis. (nature.com)

The late entry into the S/M phase coincides with the timing for the peak expression of PF13_0027, suggesting that the deficiency in the mutant cycle can be correlated with the gene expression pattern ( 26 ). (frontiersin.org)

Yet, the amount of this molecule produced in the bacteria is variable among strains. (news-medical.net)

Gray triangles = other expression annotations only (e.g. absence of expression or data from mutants). (jax.org)

Mouse News Letter (MNL) was a bulletin of mouse genetics information published from 1949 to 1998. (wikipedia.org)
Mouse News Letter now exists as a company, Mouse News Letter Ltd, which promotes the science of Genetics and provides funds to enable younger scientists to attend Genetics Conferences. (wikipedia.org)
To survey the history of the Mouse News Letter is to see the history of mouse genetics unfold. (wikipedia.org)
At the Eighth International Genetics Congress in 1948 eminent geneticists Douglas Falconer, R.A.Fisher, Salome Gluecksohn-Waelsch, Hans Grüneberg and Paula Hertwig agreed that investigators working on mouse genetics and development needed a regular information bulletin. (wikipedia.org)
During the 1990s it became clear with the exponential increase in knowledge that the long-term future of mouse genetics information was an electronic one. (wikipedia.org)

Mice vaccinated with ME49Δ cdpk3 were efficiently protected against the tachyzoites of a variety of wild-type strains, including type I RH, type II ME49, Chinese 1 WH3 and Chinese 1 WH6, as well as the cysts of wild-type strains ME49 and WH6. (nature.com)
The δ subunit mRNA was present at wild-type levels in the mutant granule cells, indicating a post-translational loss of the δ subunit. (jneurosci.org)
Finally, SpaFED pili are clearly important effectors since an L. rhamnosus ΔspaF mutant failed to provide the same benefits as the wild type strain. (nature.com)
In the congenic CBA/CaJ strain the wild-type locus has been replaced by the mutant Ahl locus (strain CBA.B6). (cdc.gov)

To unravel recurrent ASD-related neuropathological mechanisms, we took advantage of the En2 -/- mouse model and performed transcriptome profiling on cerebellar and hippocampal adult tissues. (biomedcentral.com)

We found that the H. pylori strains with low HPnc4160 levels were more infectious. (news-medical.net)
Groups of both strains were exposed to various levels of broadband noise between 98 and 118 dB for one hour. (cdc.gov)
The mutants showed increasing plasma urea levels whereas the levels decreased in the controls. (uni-muenchen.de)
At the age of 24 weeks the mutants showed levels, which were two-fold higher than those of the controls. (uni-muenchen.de)

On-chip mouse embryo culture: evaluation of effects of uterine cells-conditioned media on embryo development and gene expression. (nc3rs.org.uk)
Mouse embryo assay to evaluate polydimethylsiloxane embryo-toxicity. (nc3rs.org.uk)
A team led by Dr Virginia Pensabene from the University of Leeds has been awarded £95,883 to deliver the project: Design, Fabrication and Testing of a Mouse Embryo Culture Chip. (nc3rs.org.uk)

Anatomy24

Organisms35

Diseases13

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes90

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Health Care5

C57BL8

Genes26

Mutations7

Phenotypes3

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Defects4

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Characterize1

Infection4

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Identical2

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Predominant1

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Transcript1

Aspergillus2

Tumors1

Vaccine3

Subcutaneous1

Jackson Laboratory2

Pathology1

Immune5

Microbiota1

Mitochondrial1

Humans3

Healthy mice1

Researchers5

Resistant5

Mutagenesis1

Characterization1

19961

Functional1

Laboratory3

Human9

Characteristics1

Deficiency1

Bacteria1

Data1

Genetics5

Type4

Transcriptome1

Levels4

Embryo3