• enzymology
  • In enzymology, a hexaprenyldihydroxybenzoate methyltransferase (EC 2.1.1.114) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate Thus, the two substrates of this enzyme are S-adenosyl methionine and 3-hexaprenyl-4,5-dihydroxybenzoate, whereas its two products are S-adenosylhomocysteine and 3-hexaprenyl-4-hydroxy-5-methoxybenzoate. (wikipedia.org)
  • In enzymology, a phenol O-methyltransferase (EC 2.1.1.25) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine + phenol ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + anisole Thus, the two substrates of this enzyme are S-adenosyl methionine and phenol, whereas its two products are S-adenosylhomocysteine and anisole. (wikipedia.org)
  • In enzymology, a polysaccharide O-methyltransferase (EC 2.1.1.18) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine + 1,4-alpha-D-glucooligosaccharide ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units Thus, the two substrates of this enzyme are S-adenosyl methionine and 1,4-alpha-D-glucooligosaccharide, whereas its two products are S-adenosylhomocysteine and oligosaccharide containing 6-methyl-D-glucose units. (wikipedia.org)
  • proteins
  • This entry represents a methyltransferase domain found in proteins which are involved in C1 metabolism in methanogenic archaea and methylotrophic bacteria. (ebi.ac.uk)
  • Aberrant behavior by several proteins in the methyltransferase family is a possible cause of debilitating neurodegenerative disorders like Alzheimer's disease and Parkinson's disease. (sbir.gov)
  • To accelerate the discovery of improved therapies for these diseases, we are developing screening kits to find drug molecules that correct the malfunctioning methyltransferase proteins. (sbir.gov)
  • Structures
  • The thirteen chapters describe in detail the structures, enzyme kinetics and biological roles of the AdoMet-dependent methyltransferases from a wide range of cell types: plant, animal, bacterial and archaeal. (google.com)
  • catalyze
  • MTases can be divided into three different groups on the basis of the chemical reactions they catalyze: m6A - those that generate N6-methyladenine EC 2.1.1.72 m4C - those that generate N4-methylcytosine EC 2.1.1.113 m5C - those that generate C5-methylcytosine EC 2.1.1.37 m6A and m4C methyltransferases are found primarily in prokaryotes. (wikipedia.org)
  • catalytic
  • Universal catalytic domain structure of AdoMet-dependent methyltransferases. (ebi.ac.uk)
  • The structure of HhaI methyltransferase (M.HhaI) has been resolved to 2.5 A: the molecule folds into 2 domains - a larger catalytic domain containing catalytic and cofactor binding sites, and a smaller DNA recognition domain. (wikipedia.org)
  • emphasis
  • This invaluable volume, written by an international group of scientists, presents an overview of the AdoMet-dependent methyltransferases, with special emphasis on structure-function relationships. (google.com)