• Chromosome
  • Human chromosome 1 specific probe on Human Male Metaphase Slide. (appliedgenetics.com)
  • Although many auto-focusing methods have been developed and tested for a variety of imaging modalities, few investigations have been performed on the selection of an optimal auto-focusing method that is suitable for the pathological metaphase chromosome analysis under a high resolution scanning microscopic system. (hindawi.com)
  • Objective: The purpose of this study is to investigate and identify an optimal auto-focusing method for the pathological metaphase chromosome analysis. (hindawi.com)
  • Methods: In this study, five auto-focusing methods were applied and tested using metaphase chromosome images acquired from bone marrow and blood specimens. (hindawi.com)
  • Results: For the specific condition investigated in this study, the results showed that the Brenner gradient and threshold pixel counting methods were the optimal methods for acquiring high quality metaphase chromosome images from the bone marrow and blood specimens, respectively. (hindawi.com)
  • Then, an interphase or metaphase chromosome preparation is produced. (wikipedia.org)