InhibitorsInhibitorMembrane-bound metalloproteaseMatrixDisintegrinProteinsProteolytic activationZinc dependentCytokinesChelatesNeprilysinEGFRProbesSerineExpressionProteinMutationBiologicalMigrationRoleHumanActivityHighlyApplicationMMPsZinc metalloproteaseDisintegrin and metalloprotease 33Major metalloproteaseEnzymesInhibitionProteolyticExtracellularAminopeptidasesTissueMelanomaGeneApoptosisMembraneSubstratesFamilyDevelopmentStudyWorkImportant
Inhibitors10
- Metalloprotease inhibitors are cellular inhibitors of the Matrix metalloproteinases (MMPs). (wikipedia.org)
- To investigate this question, we used metalloprotease inhibitors to block EGFR ligand release from human mammary epithelial cells. (nih.gov)
- We found that metalloprotease inhibitors reduced cell proliferation in direct proportion to their effect on transforming growth factor alpha release. (nih.gov)
- Metalloprotease inhibitors also reduced growth of EGF-responsive tumorigenic cell lines and were synergistic with the inhibitory effects of antagonistic EGFR antibodies. (nih.gov)
- The effects of metalloprotease inhibitors could be reversed by either adding exogenous EGF or by expressing an artificial gene for EGF that lacked a membrane-anchoring domain. (nih.gov)
- Metalloprotease inhibitors have shown promise in preventing spread of metastatic disease. (nih.gov)
- The X-ray crystal structures of the catalytic domain of human collagenase-3 (MMP-13) and collagenase-1 (MMP-1) with bound inhibitors provides a basis for understanding the selectivity profile of a novel series of matrix metalloprotease (MMP) inhibitors. (rcsb.org)
- The myonecrotic, fibrinogenolytic and subsequent procoagulant activities of malabarin was neutralized by specific metalloprotease inhibitors such as EDTA, EGTA and 1, 10-phenanthroline but not by PMSF a specific serine protease inhibitor. (uni-mysore.ac.in)
- However, in cells incubated with both internalization inhibitors and metalloprotease inhibitors (batimastat, inhibitor of TNFalpha-convertase) or metal chelators (EDTA, phenanthroline), the cleavage was blocked, indicating that metalloproteases cleave the agonist-occupied ET(B) receptor at the cell surface. (mdc-berlin.de)
- For example, tissue matrix metalloproteases can cause the degradation of tissue, as in the development of CWP small profusions, but usually overexpression of matrix metalloproteases is controlled by serum protein inhibitors. (cdc.gov)
Inhibitor1
- Finally, I study the potential role of endodermin, which displays significant homology to ct-2 macroglobulin, as an inhibitor of Tld metalloproteases. (ucl.ac.uk)
Membrane-bound metalloprotease1
- Neprilysin is a circulating and membrane-bound metalloprotease that cleaves peptides. (medscape.com)
Matrix3
- Expression of extracellular matrix proteins and metalloproteases (MMPs) has been implicated in neoplasm recurrence. (jsurgmed.com)
- Based on previous data, the aim of this study was to find a correlation between the immunohistochemical (IHC) expression patterns of a group of matrix modifier proteins, including CD147, Matrix Metalloprotease 2 and 9 (MMP2 and 9, respectively), Epithelial Cadherin (ECAD), and Galectin-3 (GAL3) with World Health Organization (WHO)-defined grade, brain invasion, recurrence, and other clinicopathological features. (jsurgmed.com)
- In this catabolic process, matrix metalloproteases and cytokines also cause degradation of cartilage. (medscape.com)
Disintegrin10
- The metalloprotease-disintegrin ADAM8 is highly expressed in GBM tumor and immune cells and correlates with poor. (uni-marburg.de)
- A Disintegrin And Metalloproteases (ADAMs) include a group of enzymes that are able to cleave membrane-bound proteins. (uu.nl)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat A Disintegrin And Metalloprotease 9 (ADAM9) in Tissue homogenates, cell lysates and other biological fluids. (scalegen.com)
- Description: A sandwich ELISA kit for detection of A Disintegrin And Metalloprotease 9 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)
- Description: Quantitativesandwich ELISA kit for measuring Human A Disintegrin And Metalloprotease 9, ADAM9 in samples from serum, plasma, tissue homogenates, cell culture supernates, asciticfluid. (scalegen.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human A Disintegrin And Metalloprotease 9 (ADAM9) in samples from Tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (agctsequencing.com)
- Description: This Human A Disintegrin And Metalloprotease 9 (ADAM9) ELISA Kit employs a two-site sandwich ELISA to quantitate ADAM9. (agctsequencing.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Human A Disintegrin And Metalloprotease 9 (ADAM9) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (pharmas-eu.org)
- A family of membrane -anchored glycoproteins that contain a disintegrin and metalloprotease domain. (online-medical-dictionary.org)
- Furthermore, D-Pen mainly regulated A disintegrin and metalloprotease 10 (ADAM10) expression via melatonin receptor 1 (MTNR1α) and the downstream PKA/ERK/CREB pathway. (figshare.com)
Proteins1
- This enzyme is part of a family of metalloproteases, which are zinc-containing enzymes that cut apart other proteins. (medlineplus.gov)
Proteolytic activation1
- Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation. (medlineplus.gov)
Zinc dependent2
- Tolloid (Tld) metalloproteases are zinc dependent extra-cellular endopeptidases that have numerous roles during embryonic development. (ucl.ac.uk)
- Angiotensin I Converting Enzyme (ACE-2), also called ACEH (ACE homologue), is a dimeric, zinc-dependent metalloprotease of the ACE family that also includes somatic and germinal ACE (1, 2). (rndsystems.com)
Cytokines1
- Rheumatoid arthritis causes damage mediated by cytokines, chemokines, and metalloproteases. (msdmanuals.com)
Chelates1
- The high affinity of these materials for metalloproteases was attributed to the formation of chelates between the chelating moieties and the metal ions of metalloproteases. (ua.pt)
Neprilysin2
- Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies. (ox.ac.uk)
- Altogether, we observed heterozygous rare loss-of-function and missense mutations in MME encoding the metalloprotease neprilysin in 19 index case subjects diagnosed with axonal polyneuropathies or neurodegenerative conditions involving the peripheral nervous system. (ox.ac.uk)
EGFR1
- Ligands that activate the epidermal growth factor receptor (EGFR) are synthesized as membrane-anchored precursors that appear to be proteolytically released by members of the ADAM family of metalloproteases. (nih.gov)
Probes1
- Thus, these materials were proven to be valuable probes for the selective enrichment and rapid recovery of metalloproteases from human saliva, particularly when dealing with trace amounts of material. (ua.pt)
Serine1
- In this work, a general biochemical characterization in snake venom of serine proteases (SVSP), phospholipases A 2 (PLA 2 ), metalloproteases (SVMP) and hyaluronidases (SVH) of Crotalus aquilus (Ca), Crotalus polystictus (Cp) and Crotalus molossus nigrescens (Cmn) was done. (mdpi.com)
Expression2
- Evidence suggests that metalloprotease expression may affect the biological behavior of odontogenic lesions. (bvsalud.org)
- The pattern of metalloprotease expression in odontogenic lesions was different from the pattern found in other lesions. (bvsalud.org)
Protein1
- This is the first example of a multispanning membrane protein, which is cleaved by a metalloprotease, but retains its functional activity and overall structure. (mdc-berlin.de)
Mutation1
Biological1
- These magnetic particles exhibited high colloidal stability in the biological standard buffers MES, HEPES, TEAB and Tris-HCl, within a significant pH range (pH 5-9) and, due to their magnetic features, enabled a fast separation of the metalloproteases from the medium by simply applying an external magnetic field. (ua.pt)
Migration1
- Peptide-induced keratinocyte migration was mediated by purinergic receptors and metalloproteases. (nature.com)
Role2
- This study was conducted to review the literature about the role of metalloproteases in the development of odontogenic lesions. (bvsalud.org)
- Mechanotransduction requires metalloprotease activity, indicating a pivotal role for proteolytic EGF-family ligand shedding. (elsevierpure.com)
Human1
- New magnetic nanoprobes based on surface-functionalized magnetite particles were synthesized and used to selectively capture metalloproteases from human saliva samples. (ua.pt)
Activity1
- A major myonecrotic zinc containing metalloprotease `malabarin' with thrombin like activity was purified by the combination of gel permeation and anion exchange chromatography from T. malabaricus snake venom. (uni-mysore.ac.in)
Highly1
- The most distinct feature of these particles is their capability to selectively recover metalloproteases even in highly diluted saliva samples. (ua.pt)
Application1
- Metalloprotease was partially purified by ammonium sulfate followed by application on Sephadex G-75 column. (ijsr.net)
MMPs6
- Metalloprotease inhibitors are cellular inhibitors of the Matrix metalloproteinases (MMPs). (wikipedia.org)
- Matrix metalloproteases (MMPs) are involved in a wide range of pathological processes related to a dysfunction of their proteolytic activity. (rug.nl)
- Matrix metalloproteases (MMPs) have been found to be highly expressed in a variety of malignant tumor tissues. (nih.gov)
- Matrix metalloproteases (MMPs) are able to degrade all components in the extracellular matrix and are important tissue-remodeling enzymes and key elements in tumor invasion and metastasis. (asturias.es)
- It has been hypothesized that cysteine cathepsins (CTs) along with matrix metalloproteases (MMPs) may work in conjunction in the proteolysis of mature dentin matrix. (elsevierpure.com)
- IMPLICATION By understanding Matrix Metalloprotease ( MMP ) dysregulation from a pan- cancer perspective, this study sheds light on the diagnostic potentials of MMPs across multiple neoplasms . (bvsalud.org)
Zinc metalloprotease1
- Materials and Methods: In this study the protease gene encoding a zinc-metalloprotease was isolated from the previously isolated red-pigmented Serratia sp. (ijbiotech.com)
Disintegrin and metalloprotease 332
- A disintegrin and metalloprotease 33 ( ADAM33 ) has been identified as a susceptibility gene for asthma and single nucleotide polymorphisms (SNPs) in this gene have been associated with excessive decline of lung function in individuals with asthma. (atsjournals.org)
- A disintegrin and metalloprotease 33 ( ADAM33 ) has been identified as an asthma susceptibility gene ( 1 ). (atsjournals.org)
Major metalloprotease2
- Characterizations of extracellular proteases from various strains of S. marcescens indicate that most strains produce a very similar major metalloprotease. (ijbiotech.com)
- Finally, our data suggest that L. major metalloproteases are involved in the direct cleavage and degradation of CXCL1, and a synthetic peptide spanning the CXCL1 cleavage site can be used to inhibit L. major metalloprotease activity. (nih.gov)
Enzymes3
- According to importance and the diversity of metalloproteases, these zinc-dependent enzymes are important targets for biomedical applications (10). (ijbiotech.com)
- Serratia marcescens is a Gram-negative bacterium of the family Enterobacteriaceae that secretes a variety of degradative enzymes, such as proteases (serine and thiol proteases, and metalloproteases), lipases, chitinases, hemolysin, and nucleases (11,12). (ijbiotech.com)
- This enzyme is part of a family of metalloproteases, which are zinc-containing enzymes that cut apart other proteins. (nih.gov)
Inhibition2
- 2015 Inhibition mechanisms of membrane metalloprotease by an exosite swiveling conformational antibody. (absoluteantibody.com)
- Zymography and inhibition assays showed that metalloprotease is the major secreted protease of Serratia sp. (ijbiotech.com)
Proteolytic2
- Conclusions: Since the metalloprotease of this strain has strong proteolytic properties and good stability, it would be a suitable candidate to be used as an effective drug in the medicine and pharmaceutical industries. (ijbiotech.com)
- Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation. (nih.gov)
Extracellular2
- Purification and Characterization of 50 kDa Extracellular Metalloprotease from Serratia sp. (ijbiotech.com)
- Objectives: In the present study, purification and characterization of extracellular metalloprotease from Serratia sp. (ijbiotech.com)
Aminopeptidases1
- The cocktail contains a broad specificity of inhibitory properties including serine, cysteine, aspartic and metalloproteases, and aminopeptidases. (sigmaaldrich.com)
Tissue2
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human A Disintegrin And Metalloprotease 9 (ADAM9) in samples from Tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (agctsequencing.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human A Disintegrin And Metalloprotease 9 (ADAM9) in Tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (agctsequencing.com)
Melanoma1
- 1. Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4. (nih.gov)
Gene1
- A pan-cancer perspective of matrix metalloproteases (MMP) gene expression profile and their diagnostic/prognostic potential. (bvsalud.org)
Apoptosis1
- Biomechanics drive histological wall remodeling of neoaortic root: A mathematical model to study the expression levels of ki 67, metalloprotease, and apoptosis transition. (chirurgie-cardiaque-pitie.fr)
Membrane3
- Recombinant monoclonal antibody to Membrane type 1 metalloprotease. (absoluteantibody.com)
- Immunofluorescence staining of fixed HeLa cells with anti-membrane type 1 metalloprotease antibody LEM-2/15 (Ab00364) Immunofluorescence analysis of paraformaldehyde fixed HeLa cells on Shi-fix™ coverslips, permeabilized with 0.15% Triton and stained with the chimeric mouse IgG1 version of LEM-2/15 (Ab00364-1.1) at 10 µg/ml for 1h followed by Alexa Fluor® 488 secondary antibody (2 µg/ml), showing nuclear membrane staining. (absoluteantibody.com)
- Metalloprotease-disintegrins are a family of membrane-anchored glycoproteins that have been implicated in diverse cellular processes, including fertilization and myoblast fusion, release of TNFalpha from the plasma membrane, and neurogenesis. (xenbase.org)
Substrates1
- cuticle suggests that the metalloproteases and the cuticle substrates involved in exsheathment of parasitic nematodes are conserved in free-living nematodes. (gla.ac.uk)
Family1
- Results: The nucleotide sequence demonstrated that deduced amino acid sequence has a higher identity with those of metalloprotease from serralysin family. (ijbiotech.com)
Development2
- A disintegrin and metalloprotease 12 (ADAM12) has been associated with tumor development and progression. (mdpi.com)
- This study was conducted to review the literature about the role of metalloproteases in the development of odontogenic lesions. (bvsalud.org)
Study1
- In conclusion, our study has identified an immune evasion strategy employed by L. major to evade innate immune responses in mice, likely reservoirs in the endemic areas, and further highlights that targeting these L. major metalloproteases may be important in controlling infection within the reservoir population and transmittance of the disease. (nih.gov)
Work1
- Previous work suggested that a metalloprotease, Vvp, may be a virulence factor of Vibrio vulnificus, which causes severe wound infection and septicemia in humans. (nih.gov)
Important1
- This metalloprotease (serrapeptidase, serrapeptase) is an important pharmaceutical agent. (ijbiotech.com)