• excess
  • Clearance of soluble proteins, waste products, and excess extracellular fluid is accomplished through convective bulk flow of the ISF, facilitated by astrocytic aquaporin 4 (AQP4) water channels. (wikipedia.org)
  • While glymphatic flow was initially believed to be the complete answer to the long-standing question of how the sensitive neural tissue of the CNS functions in the perceived absence of a lymphatic drainage pathway for extracellular proteins, excess fluid, and metabolic waste products, two subsequent articles by Louveau et al. (wikipedia.org)
  • respectively
  • Using in vivo 2-photon microscopy, the authors reported that when cerebral arterial pulsation was either increased or decreased, the rate of paravacular CSF flux in turn increased or decreased, respectively. (wikipedia.org)
  • Mice
  • Analysis of genetically modified mice that lacked the AQP4 gene revealed that the bulk flow-dependent clearance of interstitial solutes decreases by 70% in the absence of AQP4. (wikipedia.org)
  • drug
  • Absorption characteristics (absorption rate constant [Ka] and mean absorption time [MAT]) were assessed after calculation of the cumulative fraction of drug absorbed, amount of bioavailable drug, and percent remaining to be absorbed per unit time using the Loo-Riegelman method. (biomedsearch.com)
  • 1,4-Butanediol is also used as a recreational drug known by some users as "One Comma Four", "Liquid Fantasy", "One Four Bee" or "One Four B-D-O". It exerts effects similar to γ-hydroxybutyrate (GHB), which is a metabolic product of 1,4-butanediol. (wikipedia.org)
  • Since pembrolizumab is cleared from the circulation through non-specific catabolism, no metabolic drug interactions are expected and no studies were done on routes of elimination. (wikipedia.org)
  • Undesirable effects of a drug include: Increased probability of cell mutation (carcinogenic activity) A multitude of simultaneous assorted actions which may be deleterious Interaction (additive, multiplicative, or metabolic) Induced physiological damage, or abnormal chronic conditions The therapeutic window is the amount of a medication between the amount that gives an effect (effective dose) and the amount that gives more adverse effects than desired effects. (wikipedia.org)
  • However, the half-life of the drug noticeably increases in people with creatinine clearance rates equal to or less than 30 mL/minute. (wikipedia.org)
  • changes
  • Melatonin diurnal pattern disruption and metabolic changes due to liver insufficiency can affect the human biologic clock. (jcircadianrhythms.com)
  • 6 - 12 ] Liver diseases are often associated with hormonal disorders, and metabolic changes in cirrhosis can result in circadian rhythm abnormalities. (jcircadianrhythms.com)
  • The effect of gait parameters on energetic cost is a relationship that describes how changes in step length, cadence, step width, and step variability influence the mechanical work and metabolic cost involved in gait. (wikipedia.org)
  • These measured metabolic changes are attributed to variations in step length, step width, and other parameters of gait, which have a direct bearing on COT Metabolic cost is naturally optimized by selection of a nominal gait. (wikipedia.org)
  • parameters
  • Model-independent pharmacokinetic parameters (volume of distribution [Vss] and total clearance [CLt]) were determined for each subject. (biomedsearch.com)
  • The mechanical work and metabolic cost associated with these parameters can be described by the dynamic walking model. (wikipedia.org)
  • clinical
  • For many clinical purposes BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. (wikipedia.org)
  • mechanism
  • The pathway consists of a para-arterial influx route for cerebrospinal fluid (CSF) to enter the brain parenchyma, coupled to a clearance mechanism for the removal of interstitial fluid (ISF) and extracellular solutes from the interstitial compartments of the brain and spinal cord. (wikipedia.org)
  • Effects
  • Dydrogesterone is associated with approximately two-fold significant reduction in the miscarriage rate as compared to standard care in threatened and recurrent miscarriages with minimal side effects. (wikipedia.org)
  • measure
  • 5 In 1975, Gant and colleagues 6 demonstrated that the dehydroisoandrosterone sulfate clearance, as a measure of uteroplacental perfusion, decreased by 18% when short-term use of furosemide was employed in chronic hypertensive patients and returned to baseline once the medication was stopped. (motherisk.org)
  • multiple
  • 72% of the variance between observed and predicted lignocaine clearances could be accounted for by multiple linear regression analysis incorporating indocyanine green half-life and the presence or absence of heart failure. (biomedsearch.com)
  • shown
  • One study has shown the allergic reaction rate to be about 3.0% over 359 courses of therapy. (wikipedia.org)
  • patients
  • 1. Blood clearances of lignocaine and indocyanine green together with indocyanine green half-lives were measured in 17 post-myocardial infarct patients (one patient was studied twice) between 8 h and 36 h after starting intravenous lignocaine infusions for the treatment of cardiac arrhythmias. (biomedsearch.com)