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  • pigmentation
  • Epidermal melanin pigmentation has been considered as a primary absorber of ultraviolet radiation thus providing protection to the underlying epidermal and dermal elements. (lww.com)
  • The detailed structure of the absorption spectra of epidermal melanin pigmentation in vivo together with the reactivity of melanin precursors and metabolites to ultraviolet A (320-400 nm) and visible (400-700 nm) radiation indicate that epidermal melanin may not be considered simply as passive absorber in the skin that acts as a neutral density filter - i.e. absorbing equally strongly at all wavelengths. (lww.com)
  • A second approach to evaluate the effectiveness of epidermal melanin pigmentation as a filter for ultraviolet radiation is by studying the action spectra for the erythema and pigment reactions of skin to ultraviolet radiation for individuals of different levels of pigmentation. (lww.com)
  • It is necessary therefore to rethink the role of epidermal melanin pigmentation or the ensemble of compounds that make it up (soluble and insoluble melanin, precursors and metabolites etc) and their reactivity in the skin. (lww.com)
  • Melanin-concentrating hormone (MCH) is a cyclic 19-amino acid orexigenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish where it controls skin pigmentation. (wikipedia.org)
  • Amelanism (also known as amelanosis) is a pigmentation abnormality characterized by the lack of pigments called melanins, commonly associated with a genetic loss of tyrosinase function. (wikipedia.org)
  • tyrosine
  • Indole-5,6-quinone is an indolequinone, a chemical compound found in the oxidative browning reaction of fruits like bananas where it is mediated by the tyrosinase type polyphenol oxidase from tyrosine and catecholamines leading to the formation of catechol melanin. (wikipedia.org)
  • A critical step in the production of melanins is the catalysis of tyrosine by an enzyme called tyrosinase, producing dopaquinone. (wikipedia.org)
  • Free Radicals
  • This property enables melanin to dissipate more than 99.9% of the absorbed UV radiation as heat and it keeps the generation of free radicals at a minimum (see photoprotection ). (wikidoc.org)
  • This resistance is suggested to be the consequence of scavenging of superoxide free radicals by melanin. (biomedsearch.com)
  • In the JACS paper (17 August 2005, but available online) they demonstrate how melanin actually scavenges the harmful free radicals produced by high-energy blue or ultraviolet light as it flows into the eye, soaking them up and neutralizing their effects. (rxpgnews.com)
  • tissues
  • Lamotrigine binds to the eye and melanin-containing tissues. (cysers.info)
  • Instead came across this article cysers.info and what made particularily by this line: "Lamotrigine participants to melanin-containing tissues such as the dot of the eye, but the long-term rashes of this binding and accumulation are brownish. (cysers.info)
  • microorganisms
  • Melanins also protect microorganisms, such as bacteria and fungi, against stresses that involve cell damage such as UV radiation from the sun and reactive oxygen species. (wikipedia.org)
  • epidermal
  • Here we find that epidermal melanin is not a neutral density filter providing no or minimal protection for the induction of erythema at 295 and 315 nm and some protection at 305 and 365 nm. (lww.com)
  • binds
  • All we have is the vague statement that Lamictal binds to melanin in the eye. (cysers.info)
  • Melanin Cupboard: Lamotrigine binds to melanin-containing immunizations, e.g., in the eye and. (cysers.info)
  • It has been found in the uveal sultan up to 52 lamictal binds to melanin after a heavy dose in rodents. (cysers.info)
  • Undecomposed: In lamictal binds to melanin, lamotrigine is extensively metabolized to a 2-N-methyl. (cysers.info)
  • Bustle B. Pinto use lamictal binds to melanin are made in adults where non-marketed drugs are required in anxiety of patients faced with a medicated emergency. (cysers.info)
  • MCH1
  • Melanin concentrating hormone (MCH) S-36057 - modified MCH 6-13 fragment substituted with 3-iodotyrosine at N-terminus via dioxyoctanoyl linker, used as 125I radioligand for mapping MCH1 in vivo. (wikipedia.org)
  • fungi
  • Melanin biosynthesis, which is quite high in C. geophilum, gives its hyphae the "jet-black" appearance, and has been linked with stress tolerance in fungi. (wikipedia.org)
  • darker
  • Studies have shown a lower incidence for skin cancer in individuals with more concentrated melanin, i.e. darker skin tone. (wikipedia.org)
  • humans
  • In humans, melanin is the primary determinant of skin color. (wikipedia.org)
  • Melanin theory is a racist, pseudoscientific claim in Afrocentrism that a higher level of melanin, the primary determinant of skin color in humans, is the cause of an intellectual and physical superiority of dark-skinned people and provides them with supernatural powers. (wikipedia.org)
  • absence
  • In the absence of melanin, the layer is translucent (i.e. the light passing through is randomly and diffusely scattered) and a noticeable portion of the light that enters this translucent layer re-emerges via a scattered path. (wikipedia.org)
  • skin
  • Melanin is a vital pigment producing compound responsible for determining the colour of skin and hair. (news-medical.net)
  • Please advice us whether skin colour change due to melanin deficiency in any way affect the other family members or is it a hereditory. (news-medical.net)
  • BTW, melanin is the stuff that makes the coloring of our skin and eyes including cysers.infoal - eye pain. (cysers.info)
  • Skintel determines the average melanin density of the skin in a quantitative manner prior to energy-based aesthetic treatments, such as hair removal or skin revitalization. (cynosure.com)
  • Understanding how much melanin is in the skin helps the practitioner better choose treatment settings for superior results, while minimizing the risk of over-treatment. (cynosure.com)
  • I received a call from in a doctor in the dermatopathology clinic who would like to stain for melanin on frozen skin sections. (histosearch.com)
  • The light is then largely absorbed by the melanin in the microneedles, which quickly raises the temperature of the skin where the patch is applied. (medicalxpress.com)
  • evidence
  • We now have the first persuasive evidence that melanin plays an important protective role within the eye," said Norris, professor in the Department of Chemistry and the Institute for Biophysical Dynamics at the University of Chicago and one of the senior authors of both papers. (rxpgnews.com)
  • Using Rezai's cells, Norris's technology and Seagle's leg work, the team was able to capture convincing and dramatic evidence that melanin protects the retinal cells. (rxpgnews.com)
  • found
  • Ocular melanin is found in the uveal tract and in the pigmented epithelial. (cysers.info)
  • I have found the Skintel reader to be a very precise, reproducible measurement of baseline melanin. (cynosure.com)
  • Chemist James Norris, Ph.D., and retina surgeon Kourous Rezai, M.D., combined resources to show that melanin, a pigment found throughout the human body, acts like a neutralizing sponge inside cells in the retina to soak up and destroy reactive oxygen species. (rxpgnews.com)
  • Melanin is also found in parts of the brain and adrenal gland. (wikipedia.org)
  • blacks
  • In 1972, while working at the Metallurgy department at Youngstown State University, McGinness suggested that electronic conduction in melanins (polyacetylene, polypyrrole, and polyaniline "blacks" and their copolymers) is analogous to conduction in amorphous solids such as the chalcogenide glasses. (wikipedia.org)