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  • dose
  • When medetomidine was given at 3 and 5 times the recommended dose IV, and 5 and 10 times IM, effects were not intensified but were prolonged. (drugs.com)
  • dogs
  • Effect of Medetomidine on Electroencephalography and Use of a Quantitative Electroencephalograph for Evaluating Sedation Levels in Dogs," Journal of Veterinary Medicine Series A, Vol. 48, No. 9, 2001, pp. 525-535. (scirp.org)
  • The dogs became sedated by medetomidine after a mean (sd) time of 6.7 (5.4) minutes, and their heart rates and respiration rates decreased. (bmj.com)
  • The pharmacological restraint and pain relief provided by medetomidine facilitates handling dogs and aids in the conduct of diagnostic or therapeutic procedures. (drugs.com)
  • Spontaneous muscle contractions (twitching) can be expected in some dogs sedated with medetomidine. (drugs.com)
  • peripheral
  • With medetomidine administration, blood pressure is initially increased due to peripheral vasoconstriction and thereafter drops to normal or slightly below-normal levels. (drugs.com)
  • effect
  • D. Stenberg, "Physiological Role of Alpha 2-Adrenoceptors in the Regulation of Vigilance and Pain: Effect of Medetomidine," Acta Veterinaria Scandinavica. (scirp.org)