• dose
  • When medetomidine was given at 3 and 5 times the recommended dose IV, and 5 and 10 times IM, effects were not intensified but were prolonged. (drugs.com)
  • Dogs
  • The dogs became sedated by medetomidine after a mean (sd) time of 6.7 (5.4) minutes, and their heart rates and respiration rates decreased. (bmj.com)
  • The pharmacological restraint and pain relief provided by medetomidine facilitates handling dogs and aids in the conduct of diagnostic or therapeutic procedures. (drugs.com)
  • Spontaneous muscle contractions (twitching) can be expected in some dogs sedated with medetomidine. (drugs.com)
  • effects
  • PMID 17359455 Belda E, Laredo FG, Escobar M, Soler M, Lucas X, Agut A. Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats. (wikipedia.org)
  • peripheral
  • With medetomidine administration, blood pressure is initially increased due to peripheral vasoconstriction and thereafter drops to normal or slightly below-normal levels. (drugs.com)
  • Effect
  • D. Stenberg, "Physiological Role of Alpha 2-Adrenoceptors in the Regulation of Vigilance and Pain: Effect of Medetomidine," Acta Veterinaria Scandinavica. (scirp.org)