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  • TIMP
  • We assessed the hypothesis that disparity between MMP-9 and tissue inhibitors of MMP-1 (TIMP-1) is associated with the clinical manifestation and is related to prognostic risk in patients with systolic heart failure. (ahajournals.org)
  • In the present study, to investigate whether transdermal ERT can eliminate oral estrogen's adverse effects, we measured plasma concentrations of MMP and their inhibitors such as tissue inhibitor of MMP (TIMP) in postmenopausal women treated with estrogen orally or transdermally. (ahajournals.org)
  • 7 Because MMP degrades collagen obtained from fibrin caps of human atherosclerotic plaques and their inhibitors such as TIMP-1 block this process, our results indicate that oral ERT may increase the plaque vulnerability. (ahajournals.org)
  • It was with great interest that I read the article by Tuomainen et al 1 recently published in this journal on the association of matrix metalloproteinase (MMP)-8 and tissue inhibitor of MMP-1 (TIMP-1) with cardiovascular diseases. (ahajournals.org)
  • The aim of this paper was to evaluate gender related difference in level of matrix metalloproetinases MMP-2 and tissue inhibitor of matrix metalloproetinases (TIMP-1, TIMP- 2, TIMP-3, TIMP-4) in aqueous humor in patients with pseudoexfoliation syndrome/glaucoma. (ebscohost.com)
  • In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. (wikipedia.org)
  • substrates
  • Classical lock and key inhibitors such as phosphoramidon and bestatin bind tightly by approximating the transition state of the hydrolysis of the peptide, preventing it from acting on other substrates. (wikipedia.org)
  • Following the sIII strand the sequence meets the 'S-shaped double loop' that is of primary importance for the peptide structure and catalytic activity (see further) as it extends to the cleft side "bulge", continuing to the only antiparallel β-strand sIV, which is prime importance for binding peptidic substrates or inhibitors by forming main chain hydrogen bond. (wikipedia.org)
  • enzyme
  • Inhibitors that favor few or individual members of the MMP family often take advantage of interactions outside the enzyme active site. (mdpi.com)
  • This group of inhibitors contain a hydroxamate (-CONHOH) group that binds the zinc atom in the active site of the MMP enzyme. (wikipedia.org)
  • The inhibitor binds to the zinc at the active center of the enzyme, thereby blocking its activity. (wikipedia.org)
  • Matrix metalloproteinase-1 (MMP-1) also known as interstitial collagenase and fibroblast collagenase is an enzyme that in humans is encoded by the MMP1 gene. (wikipedia.org)
  • Reverse zymography copolymerizes both the substrate and the enzyme with the acrylamide, and is useful for the demonstration of enzyme inhibitor activity. (wikipedia.org)
  • Matrix metalloproteinase-12 (MMP-12) also known as macrophage metalloelastase (MME) or macrophage elastase (ME) is an enzyme that in humans is encoded by the MMP12 gene. (wikipedia.org)
  • hydroxamic acid
  • This is the first demonstration that imidazole and thiazole carboxylic acid-based compounds are more efficacious MMP-2 inhibitor than their hydroxamic acid derivatives. (frontiersin.org)
  • Ilomastat is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. (wikipedia.org)
  • degradation
  • These zinc-containing endopeptidases consist of subsets of enzymes, and they are involved in the degradation of the extracellular matrix (ECM) that forms the connective material between cells and around tissues. (biomedsearch.com)
  • These early events in tumor progression and metastasis involve the breaching of histologic barriers-extracellular matrix (ECM), basement membranes, stroma, and vascular basal laminae-which requires the degradation of their molecular components by enzymes produced by the invasive cells and/or tumor stroma ( 4, 5 ). (aacrjournals.org)
  • tumor
  • We treated the animals with SD-7300, an oral inhibitor of MMP-2, -9, and -13, starting after the initial detection of the primary tumor. (aacrjournals.org)
  • In about half the patients with pancreatic ductal adenocarcinoma tested, lumican in the extracellular matrix around the tumor was associated with a reduction in metastatic recurrence after surgery and with a three-fold longer survival than patients without stromal lumican. (wikipedia.org)
  • Proteolysis
  • These results show that, while metalloproteinase activity is widepread throughout the RPE-choroid, drusen are cold spots for proteolysis. (arvojournals.org)
  • David Ho - AIDS researcher who pioneered the use of protease inhibitors in treating HIV-infected patients The Proteolysis Map Reverse transcriptase inhibitor Discovery and development of NS5A inhibitors "The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances" (PDF). (wikipedia.org)
  • drugs
  • Protease inhibitors that have been developed and are currently used in clinical practice include: Antiretroviral HIV-1 protease inhibitors - class stem -naviramprenavir atazanavir darunavir fosamprenavir indinavir lopinavir nelfinavir ritonavir saquinavir tipranavir Hepatitis C virus NS3/4A protease inhibitors - class stem -previrasunaprevir boceprevir grazoprevir paritaprevir simeprevir telaprevir Given the specificity of the target of these drugs there is the risk, as in antibiotics, of the development of drug-resistant mutated viruses. (wikipedia.org)
  • Protease inhibitors were the second class of antiretroviral drugs developed. (wikipedia.org)
  • Inhibitors of the proteasome, such as bortezomib are now front-line drugs for the treatment of multiple myeloma. (wikipedia.org)