• TIMP
  • We assessed the hypothesis that disparity between MMP-9 and tissue inhibitors of MMP-1 (TIMP-1) is associated with the clinical manifestation and is related to prognostic risk in patients with systolic heart failure. (ahajournals.org)
  • In the present study, to investigate whether transdermal ERT can eliminate oral estrogen's adverse effects, we measured plasma concentrations of MMP and their inhibitors such as tissue inhibitor of MMP (TIMP) in postmenopausal women treated with estrogen orally or transdermally. (ahajournals.org)
  • 7 Because MMP degrades collagen obtained from fibrin caps of human atherosclerotic plaques and their inhibitors such as TIMP-1 block this process, our results indicate that oral ERT may increase the plaque vulnerability. (ahajournals.org)
  • It was with great interest that I read the article by Tuomainen et al 1 recently published in this journal on the association of matrix metalloproteinase (MMP)-8 and tissue inhibitor of MMP-1 (TIMP-1) with cardiovascular diseases. (ahajournals.org)
  • The aim of this paper was to evaluate gender related difference in level of matrix metalloproetinases MMP-2 and tissue inhibitor of matrix metalloproetinases (TIMP-1, TIMP- 2, TIMP-3, TIMP-4) in aqueous humor in patients with pseudoexfoliation syndrome/glaucoma. (ebscohost.com)
  • In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. (wikipedia.org)
  • substrates
  • Classical lock and key inhibitors such as phosphoramidon and bestatin bind tightly by approximating the transition state of the hydrolysis of the peptide, preventing it from acting on other substrates. (wikipedia.org)
  • Following the sIII strand the sequence meets the 'S-shaped double loop' that is of primary importance for the peptide structure and catalytic activity (see further) as it extends to the cleft side "bulge", continuing to the only antiparallel β-strand sIV, which is prime importance for binding peptidic substrates or inhibitors by forming main chain hydrogen bond. (wikipedia.org)
  • tumor
  • We treated the animals with SD-7300, an oral inhibitor of MMP-2, -9, and -13, starting after the initial detection of the primary tumor. (aacrjournals.org)
  • These early events in tumor progression and metastasis involve the breaching of histologic barriers-extracellular matrix (ECM), basement membranes, stroma, and vascular basal laminae-which requires the degradation of their molecular components by enzymes produced by the invasive cells and/or tumor stroma ( 4, 5 ). (aacrjournals.org)
  • In about half the patients with pancreatic ductal adenocarcinoma tested, lumican in the extracellular matrix around the tumor was associated with a reduction in metastatic recurrence after surgery and with a three-fold longer survival than patients without stromal lumican. (wikipedia.org)
  • drugs
  • Protease inhibitors that have been developed and are currently used in clinical practice include: Antiretroviral HIV-1 protease inhibitors - class stem -naviramprenavir atazanavir darunavir fosamprenavir indinavir lopinavir nelfinavir ritonavir saquinavir tipranavir Hepatitis C virus NS3/4A protease inhibitors - class stem -previrasunaprevir boceprevir grazoprevir paritaprevir simeprevir telaprevir Given the specificity of the target of these drugs there is the risk, as in antibiotics, of the development of drug-resistant mutated viruses. (wikipedia.org)
  • Protease inhibitors were the second class of antiretroviral drugs developed. (wikipedia.org)
  • Inhibitors of the proteasome, such as bortezomib are now front-line drugs for the treatment of multiple myeloma. (wikipedia.org)
  • migration
  • because migration of the cells is essential for the formation of the neointima, altered metabolism of the extracellular matrix of the blood vessels must occur. (ahajournals.org)
  • Chronic mucosal inflammation is characterised by an inflammatory cell infiltrate associated with changes in epithelial proliferation and migration, 1 paralleled by intensive remodelling of the subepithelial connective tissue leading to increased turnover of extracellular matrix (ECM) components. (bmj.com)
  • degrade
  • 2 Plasminogen activators convert plasminogen to plasmin, which can degrade several matrix molecules. (ahajournals.org)
  • They are distinguished from other endopeptidases by their dependence on metal ions as cofactors, their ability to degrade extracellular matrix, and their specific evolutionary DNA sequence. (wikipedia.org)
  • patients
  • Despite significant variation in humour protease and protease inhibitors level among patients with different clinical forms of glaucoma and cataract there are not important gender related difference. (ebscohost.com)
  • David Ho - AIDS researcher who pioneered the use of protease inhibitors in treating HIV-infected patients The Proteolysis Map Reverse transcriptase inhibitor Discovery and development of NS5A inhibitors "The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances" (PDF). (wikipedia.org)