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  • mice
  • In RSV infected wild-type (WT) mice, MMP-9, airway resistance and viral load peaked at day 2 post infection, and remained elevated on days 4 and 7. (mdpi.com)
  • On days 2 and 4 post inoculation, the RSV burden was lower in the MMP-9 KO mice compared to WT controls. (mdpi.com)
  • Reduction of MMP-9 (via siRNA knockdown, and in MMP-9 KO mice) resulted in decreased viral replication. (mdpi.com)
  • Furthermore, we demonstrate that the overexpression of miR-132 in the cultured hippocampal neurons from Fmr1 KO mice that have increased synaptic MMP-9 level provokes enlargement of the dendritic spine heads, a process previously implicated in enhanced synaptic plasticity. (springer.com)
  • Here we provide conclusive evidence that matrix metalloproteinase-9 (MMP-9) is necessary to the development of FXS-associated defects in Fmr1 ko mice. (jneurosci.org)
  • Further, MMP-9 deficiency suppressed elevations of Akt, mammalian target of rapamycin, and eukaryotic translation initiation factor 4E phosphorylation seen in Fmr1 ko mice, which are also associated with other autistic spectrum disorders. (jneurosci.org)
  • To evaluate the role of MMP-9 in behavioral and morphological deficits associated with loss of FMRP, we produced double ko (dbl ko) mice that are deficient for both Mmp-9 and Fmr1 . (jneurosci.org)
  • Remarkably, MMP-9 deficiency also prevented macroorchidism in dbl ko mice, suggesting that MMP-9 dysregulation also contributes to FXS-associated abnormalities outside the CNS. (jneurosci.org)
  • Using a MMP9 deficient mouse model, it was seen that MMP9 coordinated epithelial wound repair and deficient mice were unable to remove the fibrinogen matrix during wound healing. (wikipedia.org)

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  • cleaves
  • Previous studies have also demonstrated that enterokinase, a membrane-bound serine protease, cleaves proMMP-9 at Lys 65 -Ser 66 [ 13 ] and that trypsin-2 activates proMMP-9 at very low molar ratios, 1 : 1000. (hindawi.com)
  • mechanisms
  • There are other identified activation mechanisms for MMP-9: oxidation by reactive oxygen species, S-nitrosylation, and allosteric activation, which occurs when proMMP-9 is bound to either a gelatin or type IV collagen [ 21 - 23 ]. (hindawi.com)
  • These findings establish that MMP-9 is critical to the mechanisms responsible for neural and non-neural aspects of the FXS phenotype. (jneurosci.org)
  • airway
  • This review mainly focuses upon the pivotal role of MMP-9 in airway remodeling, and also upon major cellular source of MMP-9 in asthma such as eosinophils, neutrophils, epithelial cells and alveolar macrophages. (eurekaselect.com)
  • synapses
  • Acting in concert with other dendritically synthesized proteins, locally secreted MMP-9 may contribute to the structural and functional plasticity of the activated synapses. (jneurosci.org)
  • MMP-9 is present at the excitatory synapses in the CeA with its activity greatly enhanced after the appetitive training. (jneurosci.org)
  • Disruption
  • Genetic disruption of Mmp-9 rescued key aspects of Fmr1 deficiency, including dendritic spine abnormalities, abnormal mGluR5-dependent LTD, as well as aberrant behaviors in open field and social novelty tests. (jneurosci.org)
  • neurons
  • Third, glutamate stimulation of cultured hippocampal neurons evoked a rapid (in minutes) increase in MMP-9 activity, as measured by cleavage of its native substrate, β-dystroglycan. (jneurosci.org)
  • immunohistochemistry
  • The presence of metastatic cells in the slices of lymph nodes was evaluated by immunohistochemistry using antibodies for CK19 and MMP-9. (mdpi.com)
  • role
  • Several lines of evidence suggest a critical role for MMP-9 in synaptic changes associated with learning and memory. (jneurosci.org)
  • Contrary to earlier models, recent studies show that MMP-9 plays a protective role in oral cancers. (hindawi.com)
  • Therefore, the role of MMP-9 is complicated and may fluctuate throughout the different types and stages of oral cancers. (hindawi.com)
  • To investigate the role of matrix metalloproteinase-9 (MMP-9) in the pre-ovulatory follicular fluid and culture media during in vitro fertilisation (IVF) cycle and to develop the zymographic pre-diagnosis marker for successful implantation and pregnancy in human IVF. (ingentaconnect.com)
  • Recent data strongly implicate a role for matrix metalloproteinase-9 (MMP-9) in the development of vascular damage in stroke. (ahajournals.org)
  • significantly higher
  • MMP-9 activity was significantly higher in the pregnant group than in the non-pregnant group ( P (ingentaconnect.com)
  • The concentrations of pro-and active-MMP-9 in the wound fluid obtained at presentation were significantly higher and those of TIMP-1 and TGF-β1 significantly lower in ulcers that subsequently failed to heal than in ulcers that healed within 12 weeks ( Table 1 ). (diabetesjournals.org)
  • processes
  • These findings describe a new target pathway for MMP-9 action in key physiological and pathological brain processes. (jneurosci.org)
  • demonstrate
  • Our results demonstrate that MMP-9, while undetectable in normal eyes, is produced in the cornea in response to HSV infection. (jci.org)
  • fluids
  • RESEARCH DESIGN AND METHODS -The ulcers were cleansed to remove exudates, and wound fluids were collected for analysis of MMP-2 and -9, TIMP-1, and TGF-ß1. (diabetesjournals.org)
  • cells
  • Cells transfected with siRNA against MMP-9 following RSV infection had lower viral titers. (mdpi.com)
  • Signaling through this integrin is necessary for melanoma cell viability and growth in a collagen matrix and can potentially rescue the cells from apoptosis. (wikipedia.org)
  • wound
  • Measurements of MMP-9, TIMP-1, and TGF-ß in wound fluid may help to identify ulcers at risk of poor healing. (diabetesjournals.org)
  • Therefore, the aim of this study was to measure MMP-9, MMP-2, TIMP-1, and TGF-β1 in wound fluid obtained from diabetic foot ulcers and to examine their relationships with wound healing. (diabetesjournals.org)
  • Multiple regression analysis was used to determine the relationships between WHR 4 weeks , age, duration of diabetes and ulceration, wound fluid pro-and active-MMP-9 and -2, TIMP-1, and TGF-β1. (diabetesjournals.org)
  • Family
  • Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. (wikipedia.org)
  • This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. (wikipedia.org)
  • levels
  • 289. Pijet B., Stefaniuk M., Kostrzewska-Ksiezyk A., Tsilibary P-E., Tzinia A., Kaczmarek L. Elevation of MMP-9 levels promotes epileptogenesis after traumatic brain injury. (gov.pl)
  • development
  • There is growing evidence that tubular injury is a major feature in the development of renal dysfunction in type 2 diabetes ( 1 - 9 ). (diabetesjournals.org)
  • patients
  • Average concentrations of metalloproteinases, TIMP, and proteoglycan fragments in joint fluid were significantly elevated in patients from all disease groups as compared with volunteers with healthy knees (reference group). (lu.se)
  • study
  • 21 Participants were recruited from age-sex registers of general practices in Norfolk as part of a 9-country collaborative study (EPIC) designed to investigate dietary and other determinants of cancer. (ahajournals.org)