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  • inhibition
  • (mdpi.com)
  • Since angiogenesis appears to represent a vital step in the pathogenesis of herpetic stromal keratitis, these results indicate that targeting MMP-9 for inhibition should prove useful for the therapy of herpetic stromal keratitis. (jci.org)
  • used organotypic cultures to demonstrate increased release and activity of MMP-9 after stimulation with neurotoxic kainate and reduced neuronal cell death following MMP-9 inhibition. (jneurosci.org)
  • cleaves
  • Previous studies have also demonstrated that enterokinase, a membrane-bound serine protease, cleaves proMMP-9 at Lys 65 -Ser 66 [ 13 ] and that trypsin-2 activates proMMP-9 at very low molar ratios, 1 : 1000. (hindawi.com)
  • protein
  • Low-density lipoprotein receptor-related protein (LRP-1) is an endocytic receptor for diverse proteins, including matrix metalloproteinase-9 (MMP-9), and a cell-signaling receptor. (jneurosci.org)
  • MMP-9-induced cell signaling and migration were blocked by inhibiting MMP-9-binding to LRP-1 with receptor-associated protein (RAP) or by LRP-1 gene silencing. (jneurosci.org)
  • Furthermore, a novel glutathione- S -transferase fusion protein (MMP-9-PEX), which includes only the hemopexin domain of MMP-9, replicated the activities of intact MMP-9, activating Schwann cell signaling and migration by an LRP-1-dependent pathway. (jneurosci.org)
  • 31 coronary atherosclerotic plaque specimens were studied by immunohistochemistry, polymerase chain reaction (PCR), and reverse transcription PCR for the presence of C pneumoniae antigen and genomic DNA, and of MMP-9 protein and transcripts. (bmj.com)
  • proteins
  • Cell migration involves the integrated function of cell-signaling factors, integrins, proteins that regulate dynamic actin assembly, and proteinases that model extracellular matrix (ECM) ( Lauffenberger and Horwitz, 1996 ). (jneurosci.org)
  • contributes
  • Remarkably, MMP-9 deficiency also corrected non-neural features of Fmr1 deficiency-specifically macroorchidism-indicating that MMP-9 dysregulation contributes to FXS-associated abnormalities outside the CNS. (jneurosci.org)
  • Remarkably, MMP-9 deficiency also prevented macroorchidism in dbl ko mice, suggesting that MMP-9 dysregulation also contributes to FXS-associated abnormalities outside the CNS. (jneurosci.org)
  • Disruption
  • Genetic disruption of Mmp-9 rescued key aspects of Fmr1 deficiency, including dendritic spine abnormalities, abnormal mGluR5-dependent LTD, as well as aberrant behaviors in open field and social novelty tests. (jneurosci.org)
  • progression
  • Marked suppression of kindled seizure progression in response to repeated PTZ treatment was observed in MMP-9 (−/−) mice compared with wild-type mice, an observation that was accompanied by decreased hippocampal levels of mature brain-derived neurotrophic factor. (jneurosci.org)
  • These findings suggest that MMP-9 is involved in the progression of behavioral phenotypes in kindled mice because of conversion of pro-BDNF to mature BDNF in the hippocampus. (jneurosci.org)
  • Cell Migration
  • MMP-9 also promotes Schwann cell migration. (jneurosci.org)
  • The effects of MMP-9 on Schwann cell migration also were inhibited by blocking the cell-signaling response. (jneurosci.org)
  • in these cells, MMP-9-PEX had no further effect, indicating that ERK1/2 activation is sufficient to explain the effects of MMP-9-PEX on Schwann cell migration. (jneurosci.org)
  • These results establish LRP-1 as a cell-signaling receptor for MMP-9, which may be significant in regulating Schwann cell migration and physiology in PNS injury. (jneurosci.org)
  • demonstrate
  • Using single quantum dot tracking, we demonstrate that MMP-9 enzymatic activity increases NR1-NMDAR surface trafficking but has no influence on AMPA receptor mobility. (jneurosci.org)
  • Our results demonstrate that MMP-9, while undetectable in normal eyes, is produced in the cornea in response to HSV infection. (jci.org)
  • interaction
  • An antibody targeting the hemopexin domain of MMP-9, which mediates the interaction with LRP-1, blocked MMP-9-induced cell signaling and migration. (jneurosci.org)
  • role
  • Contrary to earlier models, recent studies show that MMP-9 plays a protective role in oral cancers. (hindawi.com)
  • Therefore, the role of MMP-9 is complicated and may fluctuate throughout the different types and stages of oral cancers. (hindawi.com)
  • Recent data strongly implicate a role for matrix metalloproteinase-9 (MMP-9) in the development of vascular damage in stroke. (ahajournals.org)
  • To evaluate the role of MMP-9 in behavioral and morphological deficits associated with loss of FMRP, we produced double ko (dbl ko) mice that are deficient for both Mmp-9 and Fmr1 . (jneurosci.org)
  • Here, we investigated the role of MMP-9 in the development of pentylenetetrazole (PTZ)-induced kindled seizure in mice. (jneurosci.org)
  • mechanisms
  • There are other identified activation mechanisms for MMP-9: oxidation by reactive oxygen species, S-nitrosylation, and allosteric activation, which occurs when proMMP-9 is bound to either a gelatin or type IV collagen [ 21 - 23 ]. (hindawi.com)
  • These findings establish that MMP-9 is critical to the mechanisms responsible for neural and non-neural aspects of the FXS phenotype. (jneurosci.org)
  • inhibitory
  • However, it remains unclear whether the benefits of minocycline are due to its inhibitory effects on MMP-9 or its antibiotic properties. (jneurosci.org)
  • The matrix degrading inhibitory capacity was the same for both NSPE and PSPE, despite their different polyphenolic profiles. (mdpi.com)
  • serum
  • Changes of serum sICAM-1 and MMP-9 induced by rIFN β -1b treatment in relapsing-remitting MS," Neurology , vol. 53, no. 7, pp. 1402-1408, 1999. (hindawi.com)
  • Serum MMP-9 and TIMP-1 levels are related to MRI activity in relapsing multiple sclerosis," Neurology , vol. 53, no. 7, pp. 1397-1401, 1999. (hindawi.com)
  • Marker
  • MMP-9 colocalized with the neuronal marker NeuN and the glial marker GFAP in the dentate gyrus of the kindled mouse hippocampus. (jneurosci.org)
  • cells
  • Cells transfected with siRNA against MMP-9 following RSV infection had lower viral titers. (mdpi.com)
  • MMP-9-PEX failed to activate cell signaling in uninjured nerves, consistent with the observation that Schwann cells express LRP-1 at significant levels only after nerve injury. (jneurosci.org)
  • Signaling through this integrin is necessary for melanoma cell viability and growth in a collagen matrix and can potentially rescue the cells from apoptosis. (wikipedia.org)
  • 0.001
  • Immunohistochemical analysis identified a strong association between the presence of C pneumoniae antigen and production of MMP-9 in coronary atherosclerotic plaques (p = 0.001). (bmj.com)