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  • oocyte
  • Section 1 will discuss defects that emerge with age in controlling the fidelity of meiotic oocyte chromosome segregation apparatus, and other molecular machinery. (frontiersin.org)
  • Section 2 will discuss the impact of the molecular environment of the oocyte as a determinant of elevated aneuploidy with age. (frontiersin.org)
  • As the oocyte is a product of female gametogenesis, the maternal contribution to the oocyte and consequently the newly fertilized egg is enormous. (wikipedia.org)
  • During the growth of the oocyte, a variety of maternally transcribed messenger RNAs, or mRNAs, are supplied by maternal cells. (wikipedia.org)
  • The oocyte receives mitochondria from maternal cells, which will go on to control embryonic metabolism and apoptotic events. (wikipedia.org)
  • In mammals, the nucleolus of the oocyte is derived solely from maternal cells. (wikipedia.org)
  • fetal
  • The number one factor is really health," says Kecia Gaither, M.D., maternal fetal medicine specialist and director of perinatal outreach at Montefiore Medical Center in New York City. (fitpregnancy.com)
  • In particular, exposure of the immature fetal immune system to excessive maternal oestrogen has been postulated to be associated with the subsequent development of atopy in the offspring. (bmj.com)
  • Outcomes
  • The seemingly poorer birth outcomes of teenage mothers appear to result largely from their adverse socioeconomic circumstances, not from young maternal age per se. (guttmacher.org)
  • Research has documented that teenage mothers are at high risk for poor birth outcomes: Babies born to teenagers are more likely than those born to women in their 20s to be born early, to weigh less than 2,500 g at birth or to die before age one. (guttmacher.org)
  • Further research suggests that these risks vary by age even among teenage mothers, with those younger than 15 having the worst outcomes. (guttmacher.org)
  • Teenagers are not the only age-group at high risk for poor birth outcomes, but they have received the most public attention. (guttmacher.org)
  • On the other end of the age spectrum, while women who give birth relatively late in their reproductive lives have fewer socioeconomic disadvantages than teenagers, they nonetheless share increased risks for poor birth outcomes. (guttmacher.org)
  • There were no significant differences in mean age of menarche between mothers of children with and without each of the primary outcomes. (bmj.com)
  • Further evidence of an effect of age of menarche on atopic outcomes came from a large epidemiological study in Denmark in which early onset menarche was associated with an increased risk of allergic rhinitis in adult women. (bmj.com)
  • mothers
  • The highest newborn systolic bp was in children of the oldest mothers, and the lowest in the maternal age group 20-24 years ( ⇓ Table). (ahajournals.org)
  • the reviewers found that there was an overall 5 percent increase in childhood type 1 diabetes risk for each five-year increase in the age of the mother (risks ranged from an odds ratio of 0.88 for mothers younger than 20 years to an odds ratio of 1.10 for mothers aged 35 or older). (scoliosis.org)
  • Both black and white mothers in their 30s were significantly more likely to deliver a low-birth-weight baby than women aged 25-29 of the same race. (guttmacher.org)
  • There is a great deal of debate, however, about whether these consequences are due to maternal age per se, or whether they are caused by the adverse economic and social circumstances of teenagers who become mothers. (guttmacher.org)
  • 2017
  • A 2017 review found that while severe health effects are associated with higher paternal age, the total increase in problems caused by paternal age is low. (wikipedia.org)
  • A 2017 review concluded that the vast majority of studies supported a relationship between paternal age and autism and schizophrenia, but that there is less convincing and also inconsistent evidence for associations with other psychiatric illnesses. (wikipedia.org)
  • According to a 2017 review, there is consistent evidence of an increase in incidence of childhood acute lymphoblastic leukemia with paternal age. (wikipedia.org)
  • fertilization
  • According to Henri Leridon, PhD, an epidemiologist with the French Institute of Health and Medical Research, of women trying to get pregnant, without using fertility drugs or in vitro fertilization: At age 30 75% will have a conception ending in a live birth within one year 91% will have a conception ending in a live birth within four years. (wikipedia.org)
  • It is therefore recommended to consider in vitro fertilization after one failed COH/IUI cycle for women aged ≥40 years. (wikipedia.org)
  • Prevalence
  • 7, 8 Xu et al have demonstrated in a Finnish birth cohort that early age of maternal menarche, a surrogate marker for persistently raised levels of oestrogen, was associated with a higher prevalence of atopy among their offspring at the age of 31 years. (bmj.com)
  • Also, the other way around, there is a lower prevalence of poor responders among young women compared to those of advancing age, with 50% of women aged 43- 44 years being poor responders. (wikipedia.org)
  • fetus
  • The screening test carries a much lower risk to the fetus, however, and in conjunction with the age-related risk of the patient it is useful to help determine the need for more invasive tests. (wikipedia.org)
  • health assessment
  • California Department of Public Health, Maternal, Child and Adolescent Health (MCAH) Program, & University of California, San Francisco, Center on Social Disparities in Health, Maternal and Infant Health Assessment (MIHA) Survey (Mar. 2018). (kidsdata.org)
  • oocytes
  • It was proposed that, in order to avoid damage to the DNA genome of the oocytes, the metabolism contributing to the synthesis of much of the oocyte's constituents was shifted to other maternal cells that then transferred these constituents to oocytes. (wikipedia.org)
  • adverse
  • Advanced maternal age is associated with adverse reproductive effects such as increased risk of infertility, and that the children have chromosomal abnormalities. (wikipedia.org)
  • NSCH uses a set of family, economic, and community adversity indicators to ask parents about current adverse experiences to which their children (ages 0 to 17) have been exposed. (kidsdata.org)
  • syndrome
  • In fact, the risk of Downs' syndrome in women over 35 is less than 1%, although that risk does increase to nearly 4% by age 40. (organicfacts.net)
  • It used to be that the risk of a woman at age 35 having a baby with Down syndrome equaled the risk of her suffering a miscarriage during amniocentesis. (fitpregnancy.com)
  • It appears that a paternal-age effect might exist with respect to Down syndrome, but is very small in comparison to the maternal-age effect. (wikipedia.org)
  • mutation
  • We built two sets of nested logistic regression models to detect an increased odds of the de novo germline mutation classification related to older parental age compared to sporadic and familial Rb classifications. (springer.com)
  • fertility
  • Unsurprisingly, high first-birth ages and high rates of birth postponement are associated with the arrival of low, and lowest-low fertility. (wikipedia.org)
  • A woman's fertility peaks lasts during the twenties and first half of thirties, after which it starts to decline, with advanced maternal age causing an increased risk of female infertility. (wikipedia.org)
  • Fertility does begin to decrease with age, but not as dramatically as people seem to think. (organicfacts.net)
  • As we get closer to 40, the ticking becomes louder and by 45, it can be deafening," says Sheryl Ross, M.D., ob-gyn and women's health expert at Providence Saint John's Health Center in Santa Monica, Calif. "Fertility decreases by as much as 95 percent in women between 40 and 45 years of age. (fitpregnancy.com)
  • When she was starting her residency, one of the first lectures the residents got was about how fertility declines sharply after age 30. (mothersinmedicine.com)
  • miscarriage
  • But now, using the guidance of ultrasound, the risk of miscarriage during an amnio is somewhere around 1 in 500, making that "magic age" obsolete. (fitpregnancy.com)
  • Advanced maternal age begins at 35 years of age because a woman's risk of having a child with a chromosomal difference at 35 is equal to the risk of having a miscarriage via an amniocentesis (both risks are equal to 1 in 200). (wikibooks.org)
  • Several studies have reported that advanced paternal age is associated with an increased risk of miscarriage. (wikipedia.org)
  • reproductive age
  • Having children later was not exceptional in the past, when families were larger and women often continued bearing children until the end of their reproductive age. (wikipedia.org)
  • pregnant
  • This change in terminology more accurately reflects the state of being pregnant in your mid-30s, as most people don't consider 35 years of age to be "geriatric" by any means. (organicfacts.net)
  • As you age, whether or not you're pregnant, you have a better chance of developing high blood pressure. (organicfacts.net)
  • Traditionally, women aged 35 and over who become pregnant are referred to as AMA, or advanced maternal age. (fitpregnancy.com)
  • A study was undertaken to examine the association between early onset menarche in pregnant women and asthma and atopic status of their children at 7 years of age. (bmj.com)
  • The risk of severe malaria by Plasmodium falciparum is three times as high in pregnant women, with a median maternal mortality of 40% reported in studies in the Asia-Pacific region. (wikipedia.org)
  • birth
  • Asia, Japan and the United States are all seeing average age at first birth on the rise, and increasingly the process is spreading to countries in the developing world like China, Turkey and Iran. (wikipedia.org)
  • What is so radical about this recent transformation is that it is the age at which women give birth to their first child which is becoming comparatively high, leaving an ever more constricted window of biological opportunity for second and subsequent children, should they be desired. (wikipedia.org)
  • At age 35 66% will have a conception ending in a live birth within one year 84% will have a conception ending in a live birth within four years. (wikipedia.org)
  • The effects of maternal age on low birth weight, newborns' hospital costs and infant mortality were estimated based on individual 1989 and 1990 vital statistics records from New Jersey that were linked with uniform billing hospital discharge records. (guttmacher.org)
  • Among blacks, however, 15-19-year-olds faced significantly lower risks of delivering low-birth-weight babies than did black women aged 25-29. (guttmacher.org)
  • The research on the relationship between maternal age and birth outcome has left important gaps, however. (guttmacher.org)
  • It is true that the risks outlined above will increase with age but, as mentioned, there are still plenty of women who give birth to healthy, normal children once they cross the age of 40. (organicfacts.net)
  • In my spare time, I scan through census bureau economic data, and some of the analysis I've done has me convinced that if any of these IQ researchers actually took the time to adjust test scores for the birth age of the mother, this debate would look entirely different. (andrewsullivan.com)
  • There is a strong correlation, across all races, between IQ and birth-age of mother. (andrewsullivan.com)
  • MIHA surveys postpartum women (15 years and older) who delivered a live birth about their own childhood hardships prior to age 14. (kidsdata.org)
  • As maternal age increases, risks of birth defects increase. (wikibooks.org)
  • In ovarian hyperstimulation combined with IUI, women aged 38-39 years appear to have reasonable success during the first two cycles, with an overall live birth rate of 6.1% per cycle. (wikipedia.org)
  • However, for women aged ≥40 years, the overall live birth rate is 2.0% per cycle, and there appears to be no benefit after a single cycle of COH/IUI. (wikipedia.org)
  • childhood
  • Many childhood diseases are associated with advanced maternal age. (scoliosis.org)
  • No consistent association was found between maternal age at menarche and asthma, eczema, hay fever or atopy in their children during early childhood. (bmj.com)
  • It is estimated that genes contribute about 20-40% of the variance in intelligence in childhood and about 80% in old age. (wikipedia.org)
  • While the critical period for the visual cortex ends in early childhood, other cortical areas and abilities have a critical period that lasts up through maturity (age 16), the same time frame for the development of fluid intelligence. (wikipedia.org)
  • cohort
  • To further our understanding of the association of parental age and risk of de novo germline RB1 mutations, we evaluated the effect of parental age in a cohort of Rb survivors in the United States. (springer.com)
  • infant
  • MIHA is a collaborative effort of the Maternal, Child and Adolescent Health Division and the Women, Infant and Children Division of the California Department of Public Health and the Center on Social Disparities in Health at the University of California, San Francisco. (kidsdata.org)
  • Results Women of advanced age had slightly higher scores of psychological distress over the period than the reference group, also after controlling for obstetric and infant variables. (wiley.com)
  • Type 1 Diabet
  • High paternal age has been suggested as a risk factor for type 1 diabetes, but research findings are inconsistent and a clear association has not been established. (wikipedia.org)
  • Associations
  • Logistic regression analyses based on generalised estimation equations were used to investigate associations between advanced maternal age and psychological distress. (wiley.com)
  • years of age
  • Historically, there has been great interest in the field of intelligence research to determine environmental influences on the development of cognitive functioning, in particular, fluid intelligence, as defined by its stabilization at 16 years of age. (wikipedia.org)
  • errors
  • Egg infertility is a predisposition to miscarriages, infertility, and trisomic pregnancies caused by increased frequency of chromosome segregation errors in the eggs of women of advanced maternal age (AMA). (frontiersin.org)
  • autism
  • Older paternal and maternal age is associated with having a child with autism, according to a study from the University of Texas Health Science Center in Houston. (wfnt.com)
  • Some studies examining autism spectrum disorder (ASD) and advanced paternal age have demonstrated an association between the two, although there also appears to be an increase with maternal age. (wikipedia.org)
  • data
  • Census data also strongly suggests that blacks, who have kids around the same age as white or Asians, do just as well economically. (andrewsullivan.com)
  • NSCH data were collected by the U.S. Census Bureau on behalf of the Maternal and Child Health Bureau of the Department of Health and Human Services. (kidsdata.org)
  • eggs
  • They are born will all the eggs they will have in their life and these eggs mature with age. (wikibooks.org)
  • older
  • Advanced maternal age, in a broad sense, is the instance of a woman being of an older age at a stage of reproduction, although there are various definitions of specific age and stage of reproduction. (wikipedia.org)
  • In present generations it is more common to have children at an older age. (wikipedia.org)
  • Other recent studies that analyzed the effects of young maternal age tended to compare teenagers to women in their 20s only, and either ignored older women or grouped them all together. (guttmacher.org)
  • The FGFR genes may be particularly prone to a paternal age effect due to selfish spermatogonial selection, whereby the influence of spermatogonial mutations in older men is enhanced because cells with certain mutations have a selective advantage over other cells (see § DNA mutations). (wikipedia.org)
  • study
  • An Australian study determined that AIS in this country is associated with advanced maternal age (an environmental factor) as it is in the United Kingdom. (scoliosis.org)
  • found
  • Evidently at least 2 different studies found that advanced maternal age (environment) was a risk factor. (scoliosis.org)
  • The social class of the patients was found to have a distribution different from the general population, and it is suggested that this is related to the patient's maternal age. (bmj.com)
  • A review 2005 found a U-shaped relationship between paternal age and low intelligence quotients (IQs). (wikipedia.org)
  • behavior
  • For those with closely aligned persona and personal preferences, moderate changes in perception, priorities, and behavior may not necessarily be negative and can be associated with a productive realignment of resources and behavior congruent with age. (encyclopedia.com)
  • Oxytocin is further released during labour when the fetus stimulates the cervix and vagina, and it is believed that it plays a major role in the bonding of a mother to her infant and in the establishment of maternal behavior. (wikipedia.org)
  • adopt
  • The practice of raising up a younger son in this way was common in the case of a wealthy heiress who married an already wealthy husband, and frequently the younger son beneficiary was required to adopt the maternal surname and armorials. (wikipedia.org)
  • younger
  • Although he was briefly engaged to Lady Hester Stanhope, he died unmarried and without legitimate issue at Red Rice, Hampshire in 1842, aged sixty-eight, and his title passed to his younger brother, Richard. (wikipedia.org)
  • death
  • Their age at the moment of death has been determined in both cases on the basis of multi-feature analysis of changes occurring in formation of particular morphologic features of skeleton and teeth. (blogspot.com)
  • He held the seat until his death at the age of 46 in 1882. (wikipedia.org)
  • family
  • She came from a musically gifted family, her maternal aunt Giuseppina Grassini (1773-1850) being a favourite opera singer both on the continent and in London. (wikipedia.org)
  • weeks
  • After 13 weeks of gestation, the fetal age may be estimated using the biparietal diameter (the transverse diameter of the head, across the two parietal bones), the head circumference, the length of the femur, the crown-heel length (head to heel), and other fetal parameters. (wikipedia.org)
  • patients
  • 28 Case series have reported that 5в12 Spironolactoe patients with RVO are under age 45.Spironollactone, M. 1 1.Mesia, K. Yokoyama) indigenous to Japan. (luxbar-starway.ru)
  • love
  • The Immaculate Heart of Mary is a devotional name used to refer to the interior life of the Blessed Virgin Mary, her joys and sorrows, her virtues and hidden perfections, and, above all, her virginal love for God the Father, her maternal love for her son Jesus, and her compassionate love for all people. (wikipedia.org)
  • time
  • His father and maternal grandfather were MPs for Wells at the same time. (wikipedia.org)
  • At the age of four, sometime in 1959, the young Crown Prince received the offerings of good wishes and respects by the public, monks, and officials for the first time in Tashichho Dzong. (wikipedia.org)
  • population
  • Over half ( 52%) of the Latino population falls in the childbearing ages of 15 to 44, compared with only 41 percent of the non- Latino residents of the state. (ncdcr.gov)
  • women
  • The overall birth rate per 1,000 for Latina mothers ages 15- 44 in North Carolina in 2007 was 167.5, compared with a rate of 62.2 for non- Latina women. (ncdcr.gov)
  • among
  • Recruited at the age of 15, she established herself among the top three most recognizable and in-demand models of the late 1980s and the 1990s, and was one of six models of her generation declared supermodels by the fashion industry. (wikipedia.org)