Matched pair analysis. Medical search. Frequent questions

We used a questionnaire to collect farm data, which were analyzed by matched-pair analysis and multivariate conditional logistic regression. (cdc.gov)

Patients were propensity score-matched (1:1) by sex, age, type and year of transplantation. (smu.ac.za)
We created 1897 propensity score-matched case-control pairs based on preprogram similarities in disease profile, predictive risk score, medical cost, and utilization. (ajmc.com)
Program participation was significantly associated with reduced all-cause inpatient admissions (-21.2%) and lower total medical expenditures (-22.0%) compared with a propensity score-matched cohort of nonparticipants. (ajmc.com)

Matched molecular pair analysis (MMPA) is a method in cheminformatics that compares the properties of two molecules that differ only by a single chemical transformation, such as the substitution of a hydrogen atom by a chlorine one. (wikipedia.org)
Because the structural difference between the two molecules is small, any experimentally observed change in a physical or biological property between the matched molecular pair can more easily be interpreted. (wikipedia.org)
Each molecular pair is associated with a particular transformation. (wikipedia.org)
The MMPs, which were not reproduced by the model, could correspond to experimental errors or deficiency of the model (inappropriate descriptors, too few data, etc.).[citation needed] Analysis of MMPs (matched molecular pair) can be very useful for understanding the mechanism of action. (wikipedia.org)
Matched molecular pair (MMPA) analyses can be classified into two types: supervised and unsupervised MMPA. (wikipedia.org)
Turbocharging Matched Molecular Pair Analysis: Optimizing the Identification and Analysis of Pairs. (medchemica.com)
Using advanced matched molecular pair analysis (MMPA), we combined data from three pharmaceutical companies and generated ADMET rules, avoiding the need to disclose the full chemical structures. (ljmu.ac.uk)
The technical methods and results of Matched Molecular Pair Analysis (MMPA) applied from a small, individual assay scale through large pharma scale, to multiple pharma data sharing scale have been published and reviewed. (slideshare.net)

In supervised MMPA, the chemical transformations are predefined, then the corresponding matched pair compounds are found within the data set and the change in end point computed for each transformation. (wikipedia.org)
Learning Medicinal Chemistry Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) Rules from Cross-Company Matched Molecular Pairs Analysis (MMPA). (ljmu.ac.uk)

Effectiveness of concurrent procedures during high tibial osteotomy for medial compartment osteoarthritis: a systematic review and meta-analysis. (orthogate.org)
1 Since the body of primary literature has increased, conducting systematic reviews and meta-analyses has become a necessity to more accurately and comprehensively present accumulated knowledge to scientific, clinical and general audiences. (bmj.com)
analysis of funnel plots from 37 meta-analyses identified from a hand search of four leading general medicine journals 1993-6 and 38 meta-analyses from the second 1996 issue of the Cochrane Database of Systematic Reviews . (bmj.com)

In 14 (38%) journal meta-analyses and 5 (13%) Cochrane reviews, funnel plot asymmetry indicated that there was bias. (bmj.com)

The meta-analysis finds that CTC reduces delinquent behavior and that the effect of CTC on delinquent behavior varies significantly across communities. (nih.gov)
The use of meta-analysis in randomized matched-pair studies can provide a useful accompaniment to other analytic approaches because it opens the possibility of identifying factors associated with differential effects across units or matched pairs in the context of a randomized control trial. (nih.gov)
We matched each industry-supported meta-analysis with an academic meta-analysis using high-level MeSH terms in PubMed. (ed.gov)
Two individuals independently assessed each meta-analysis. (ed.gov)
Results: We examined 126 meta-analysis publications in 63 matched pairs. (ed.gov)
Conclusions: Academic meta-analysis papers are generally of higher quality than industry-supported ones. (ed.gov)
Effectiveness of multicomponent nonpharmacological delirium interventions: a meta-analysis. (ahrq.gov)
Design Meta-analysis. (bmj.com)
Bias in meta-analysis. (bmj.com)
In the eight pairs of meta-analysis and large trial that were identified (five from cardiovascular medicine, one from diabetic medicine, one from geriatric medicine, one from perinatal medicine) there were four concordant and four discordant pairs. (bmj.com)
1 2 Such reviews are, whenever possible, based on meta-analysis: "a statistical analysis which combines or integrates the results of several independent clinical trials considered by the analyst to be 'combinable. (bmj.com)
5 The appearance of misleading meta-analysis is not surprising considering the existence of publication bias and the many other biases that may be introduced in the process of locating, selecting, and combining studies. (bmj.com)

Multivariable analysis, adjusted for diabetes mellitus and race/color, showed a greater risk of graft loss for patients using tacrolimus plus mycophenolate compared to patients treated with cyclosporine plus azathioprine. (smu.ac.za)
By multivariable analysis, chemotherapy was associated with a 31% reduction in the survival hazard ratio (95% CI 0.52-0.90, P =0.006). (medpagetoday.com)
A multivariable analysis of tumor size ranging from 2-9 mm showed that an 8-mm cutoff achieved statistical significance ( P for interaction = 0.01). (medpagetoday.com)

A machine learning algorithm is used to finds all possible matched pairs in a data set according to a set of predefined rules. (wikipedia.org)
Objective: The objective of this study is to compare the quality of pharmaceutical-industry-supported meta-analyses with academic meta-analyses and of meta-analyses published before and after companies started to disclose their data. (ed.gov)
Data Sources: We identified industry-supported meta-analyses by searching the Scopus bibliographic database, using author affiliations. (ed.gov)
The first large scale analysis of in vitro absorption, distribution, metabolism, excretion, and toxicity (ADMET) data shared across multiple major pharma has been performed. (ljmu.ac.uk)
Data analysis included 10,065 patients who had a median age of 59 and a median follow-up of 41.8 months. (medpagetoday.com)
second, the estimated m is used for log- F -penalized logistic regression analyses of all variants using data augmentation with standard software. (karger.com)
COVID-profiler: a webserver for the analysis of SARS-CoV-2 sequencing data. (cdc.gov)
We developed a web-based bioinformatic pipeline ('COVID-Profiler') that inputs raw or assembled sequencing data, displays raw alignments for quality control, annotates mutations found and performs phylogenetic analysis. (cdc.gov)
[ 10 ] Other single-center data show match rates as high as 25%, [ 11 ] but this may be the result of a looser definition of 'matched' than prespecified treatment arms. (medscape.com)

By use of MethyLight analysis of faecal DNA from three independent sets of patients, we identified SFRP2 met. (researchgate.net)
Impact of adverse events on prescribing warfarin in patients with atrial fibrillation: matched pair analysis. (ahrq.gov)
Limited influence of blunt aortic injuries on the outcome of polytraumatized patients: a matched pair analysis. (orthogate.org)
After excluding those patients, 1,207 patients were included in the analysis. (researchsquare.com)
[ 2 ] In the announcement, the FDA praised the ability of F1CDx to pair patients with targeted treatment options. (medscape.com)
In the update from NCI match trial as of 12 March 2017, only 495 out of 4703 (10.5%) of patients were paired with therapy. (medscape.com)

Thus, the distribution of increasing and decreasing pairs should be significantly different from the binomial ("no effect") distribution with a particular p-value (usually 0.05). (wikipedia.org)
This investigation indicates that the magnitude of muscle activity and the ratios examined are not significantly different between men and women in a maximal voluntary isometric squat when matched for normalized strength. (jssm.org)
However, age itself was not significantly associated with the occurrence of complications in multivariate analysis. (researchsquare.com)

In conclusion, this Brazilian real-world study, with a long follow-up period using matched analysis for relevant clinical features and the representativeness of the sample, demonstrated improved long-term effectiveness for therapeutic regimens containing cyclosporine plus azathioprine. (smu.ac.za)
Third, match rates, a prerequisite for clinical benefit, remain suboptimal for next-generation sequencing in diverse solid tumors. (medscape.com)

citation needed] Activity cliffs are pairs or groups of compounds that are highly similar in the structures but have large different in potency towards the same target. (wikipedia.org)
In this example we look at R-Group analysis of chemical series to identify key functionalities which influence potency. (optibrium.com)

Similar findings came from a matched-pair analysis. (medpagetoday.com)
A mixed-model analysis confirmed these findings except for anti-S-IgG at 1 month (p =.005) and identified severity score as the most important predictor of antibody response. (lu.se)

Such pairs of compounds are known as matched molecular pairs (MMP). (wikipedia.org)

We estimated the program's impact on all-cause inpatient admissions, emergency department visits, and total medical expenditures (TME) relative to a matched cohort of nonparticipants. (ajmc.com)

Our statistical design and analysis approach seeks to transparently document participant recruitment and allow an assessment of the representativeness of the study to the target population, a key aspect of pragmatic trials. (biomedcentral.com)

Funnel plots, plots of the trials' effect estimates against sample size, may be useful to assess the validity of meta-analyses. (bmj.com)
Sensitivity analyses will assess the impact of potential biases arising from assumptions made by the RDS-2 estimation. (biomedcentral.com)

Matched-pair analysis of endovascular versus open surgical repair of a" by Nicolas Diehm, Athanassious Tsoukas et al. (baptisthealth.net)
Analyses of individual industries, occupations and chemical (ever versus never exposed) showed slightly elevated odds ratios. (cdc.gov)

The similarity score, S , between two peak lists is calculated as Σ s ij , where s ij is the peak match score between peak i in first list and peak j in second list. (lu.se)
M' ). The matches are chosen to maximize the similarity score by using the Needlemann and Wunsch algorithm. (lu.se)

In the present paper, we suggest that meta-analyses within the context of matched-pair designs can provide useful insight into intervention effects. (nih.gov)
Context: Meta-analyses are regularly used to inform healthcare decisions. (ed.gov)

Changes in outcomes 6 months post program were measured using difference-in-differences analyses. (ajmc.com)

We illustrate the advantages to this analytic strategy by examining the effectiveness of the Communities That Care (CTC) prevention system on 8th-grade delinquent behavior in a randomized matched-pair trial. (nih.gov)

Subjects were paired and assigned to a creatine or placebo group with a double-blind research design. (nih.gov)
A type of analysis in which subjects in a study group and a comparison group are made comparable with respect to extraneous factors by individually pairing study subjects with the comparison group subjects (e.g., age-matched controls). (bvsalud.org)

SOTRs (n = 65) were matched with controls (n = 65) for COVID-19 disease severity, age, and sex in order of priority. (lu.se)
The association between the cumulative exposure score and case/control status was examined by calculation of odds ratios for matched pair analyses using all controls, only sibling controls and only friend controls and a frequency matched pair, as well as unmatched cases and controls. (cdc.gov)
PARTICIPANTS: For each eye using Alleye, we matched 2-4 controls not using home-monitoring based on age, gender, number of previous intravitreal injections (IVI), best corrected visual acuity (BCVA) (Early Treatment Diabetic Retinopathy Study letters), central macular thickness (CRT) and time point of enrolment, using the Mahalanobis distance matching algorithm. (bvsalud.org)
Cases were defaulters to TB treatment and were matched by age and sex to non-defaulters (controls). (who.int)

We estimate the intervention effect within each of the matched-pair communities, aggregate the effect sizes across matched pairs to derive an overall intervention effect, and test for heterogeneity in the effect of CTC on delinquency across matched pairs of communities. (nih.gov)
Kaplan-Meier analysis was used to estimate the cumulative probabilities of survival. (smu.ac.za)
Primary analysis will use the 'RDS-2' method to estimate cluster summaries and will adapt Hayes and Moulton's '2-step' method to adjust effect estimates for individual-level confounders and further adjust for cluster baseline prevalence. (biomedcentral.com)

Primary tumors of 25 UCCs and 20 SCCs were selected showing exclusively aneuploid DNA patterns and matching DNA stemlines. (uni-luebeck.de)
In contrast, an analysis of tumors 8-10 mm favored use of chemotherapy (HR 0.53, 95% CI 0.36-0.78). (medpagetoday.com)

To evaluate risk factors for infection with highly pathogenic avian influenza A virus (H5N1) in backyard chickens in Bangladesh, we conducted a matched case-control study. (cdc.gov)
The Human Factors Analysis Classification System (HFACS) applied to health care. (ahrq.gov)

This results in much larger numbers of matched pairs and unique transformations, which are typically filtered during the process to identify those transformations that correspond to statistically significant changes in the targeted property with a reasonable number of matched pairs. (wikipedia.org)
We examined whether a simple test of asymmetry of funnel plots predicts discordance of results when meta-analyses are compared to large trials, and we assessed the prevalence of bias in published meta-analyses. (bmj.com)
A simple analysis of funnel plots provides a useful test for the likely presence of bias in meta-analyses, but as the capacity to detect bias will be limited when meta-analyses are based on a limited number of small trials the results from such analyses should be treated with considerable caution. (bmj.com)
By matching households across the surveys, we are able to examine both the regressivity of the household tobacco burden, and any change in that regressivity, and since tobacco taxes have been a consistent component of tobacco prices, our results also relate to the regressivity of tobacco taxes. (who.int)

Industry-supported meta-analyses less often demonstrated adequate methods for locating studies and assessing their quality (odds ratio 0.44, 95% confidence interval 0.21 to 0.92), for analysing the included studies (0.52, 0.25 to 1.06), for undertaking meta-analyses (0.82, 0.40 to 1.68) and in reaching sound conclusions (0.62, 0.30 to 1.28). (ed.gov)

Use of meta-analytic strategies to test intervention effects is an important complement to traditional design-based analyses of intervention effects in randomized control trials. (nih.gov)
DESIGN: Matched-pair analysis. (bvsalud.org)

To do this, we will calculate RDS-diagnostic statistics for each cluster at each time point and compare these statistics within matched pairs and time points. (biomedcentral.com)

Concerns have been expressed about the quality of meta-analyses and, in particular, about those supported by the pharmaceutical industry. (ed.gov)
Study Selection: We included meta-analyses of randomized trials assessing the efficacy or safety of any pharmaceutical intervention in humans, published in 2002-2004 or 2008-2009. (ed.gov)

A 1:2 pair- matched case-control study was carried out in the TB control units in Fez. (who.int)

In all cases discordance was due to meta-analyses showing larger effects. (bmj.com)

MAIN OUTCOME MEASURES: Improvement of ≥5 letters, number of injection visits and treatment retention after correcting for differences in baseline characteristics with multivariate analyses. (bvsalud.org)

For the analysis, we make use of two South African Income and Expenditure Surveys (2005/06 and 2010/11) that span a series of such tax increases and have been matched across the years, yielding 7806 matched pairs of tobacco consuming households and 4909 matched pairs of cigarette consuming households. (who.int)
secondary-analysis-overview-v1.pdf ( 72.6 KB ) - added by Nicklas Nordborg 10 years ago . (lu.se)

The liberal distance is calculated as d = 1 - S /min( N , N' ). Intuitively, this distance measure corresponds to the fraction of peaks in the smaller peak list having no match in the larger peak list. (lu.se)

One of up to seven trained oral health recorders is paired with a dentist to form a dental examination team. (cdc.gov)

The closest pair is found and merged to a new cluster. (lu.se)

We used principal components analysis to identify program features associated with reduced inpatient admissions, classified cases according to intervention fidelity, and measured postprogram changes in TME for each subgroup. (ajmc.com)

The aim was to investigate the influence of age and gender on quality of life (QoL), complaints, and the presence and nature of self-reported diseases in persons aged 75 and older with cancer (n = 150), compared to a matched group without cancer (n = 138). (lu.se)

1. Use quotes to search for an exact match of a phrase. (ahrq.gov)

gmail.comjavascript: wrote: Hi Henrik, after managing to install and run correctly aroma package, I ran the Paired total copy number analysis CRMAv2 (It's the first time, so I strictly followed the vignette). (mail-archive.com)

Matched molecular pairs (MMPs) are widely used in medicinal chemistry to study changes in compound properties which includes biological activity, toxicity, environmental hazards and much more, which are associated with well-defined structural modifications. (wikipedia.org)
MMP based analysis is an attractive method for computational analysis because they can be algorithmically generated and they make it possible to associate defined structural modifications at the level of compound pairs with chemical property changes, including biological activity. (wikipedia.org)
The matching is com- plicated by the fact that there are protein modifications and the sequence databases store the unmodified sequences. (lu.se)
To resolve this, the researcher typi- cally defines a small set of modifications for inclusion in the matching process. (lu.se)
Mass [10] together with information on modifications induced by sample prepa- ration procedures for mass spectrometric analysis, but mass changes are only given as integer values. (lu.se)

A comparative analysis of incident reporting lag times in academic medical centres in Japan and the USA. (ahrq.gov)

The primary analysis included 182,122 matched pairs. (cdc.gov)
Primary analysis is the base calling performed by the Illumina software during the sequencing. (lu.se)

This is largely due to less detailed reporting in industry-supported meta-analyses and a tendency for them to take the included studies at face value, probably arising from the implicit assumption that these studies already have high methodological standards to meet licensing requirements. (ed.gov)

Multivariate conditional logistic regression1

Propensity score-matched3

Molecular pair8

MMPA2

Systematic3

Cochrane1

Meta-Analysis12

Multivariable analysis3

Data9

Patients6

Significantly3

Clinical2

Potency2

Findings2

Compounds1

Cohort1

Approach1

Assess2

Versus2

Similarity2

Context2

Outcomes1

Effectiveness1

Subjects2

Controls4

Estimate3

Tumors2

Factors2

Results4

Conclusions1

Design2

Time points1

Pharmaceutical2

Case-contr1

Effects1

Differences1

Years2

Larger1

Form1

Found1

Identify1

Presence1

Search1

Total1

Modifications5

Academic1

Primary analysis2

Studies1