• leukemia
  • The backbone of AML treatment for the last 30 years has been the combination of daunorubicin and cytosine arabinoside (Ara-C). The BCR/ABL tyrosine kinase Imatinib mesylate (IM) is the mainstay of treatment for CML but does not eliminate primitive leukemia stem and progenitor cells. (cmchaematology.org)
  • Residual leukemia cells are a potential source of relapse, and there is considerable interest in identifying additional therapeutic targets to selectively induce apoptosis in leukemic stem and progenitor cells. (cmchaematology.org)
  • tissue
  • Mast cell sarcoma with tissue eosinophilia arising in the ascending colon. (nih.gov)
  • Plasm" means the substance that makes up something living, like what makes up a cell or a tissue. (mastattack.org)
  • therefore, the presence of mast cells is determined exclusively by means of tissue biopsy (e.g. skin or bone marrow) and not by blood sample. (mastocytosis.eu)
  • The main cellular component of this tissue is the adipocyte, or fat cell. (wikipedia.org)
  • Although mast cells were once thought to be tissue resident basophils, it has been shown that the two cells develop from different hematopoietic lineages and thus cannot be the same cells. (wikipedia.org)
  • These granules also led him to the incorrect belief that they existed to nourish the surrounding tissue, so he named them Mastzellen (from German Mast, meaning 'fattening', as of animals). (wikipedia.org)
  • Basophils leave the bone marrow already mature, whereas the mast cell circulates in an immature form, only maturing once in a tissue site. (wikipedia.org)
  • Feline acne Feline eosinophilic granuloma Flea allergy dermatitis Hyperthyroidism Miliary dermatitis (feline eczema) Mange Nutritional skin disorders Bladder cancer Bone cancer Intestinal cancer Liver cancer Lymphoma in animals Mammary tumor Mast cell tumor Nose cancer Skin cancer Soft tissue sarcoma Stomach cancer Anal sacs impaction Cerebellar hypoplasia is a disorder found in cats and dogs in which the cerebellum is not completely mature at birth. (wikipedia.org)
  • The tumor is classified as a soft tissue sarcoma. (wikipedia.org)
  • Immunohistochemistry (IHC) involves the process of selectively imaging antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues. (wikipedia.org)
  • Preparation of the sample is critical to maintain cell morphology, tissue architecture and the antigenicity of target epitopes. (wikipedia.org)
  • Monoclonal antibodies are made by injecting the animal and then taking a specific sample of immune tissue, isolating a parent cell, and using the resulting immortalized line to create antibodies. (wikipedia.org)
  • Although there is no dense collagen network in adipose tissue, groups of adipose cells are kept together by collagen fibers and collagen sheets in order to keep fat tissue under compression in place (for example, the sole of the foot). (wikipedia.org)
  • lymph
  • Interdigitating dendritic cell tumor with breast and cervical lymph-node involvement: a case report and review of the literature. (nih.gov)
  • Mast cells collect in various tissues and can affect organs where mast cells do not normally inhabit such as the liver, spleen and lymph nodes, and organs which have normal populations but numbers are increased. (wikipedia.org)
  • liver
  • Embryonal Sarcoma, also known as undifferentiated sarcoma , is related to undifferentiated embryonal sarcoma of the liver and fibrous histiocytoma , and has symptoms including fever An important gene associated with Embryonal Sarcoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Endometrial cancer and PI3K-Akt signaling pathway . (malacards.org)
  • 2) the protein overexpressed in COS cells in its full-length transmembrane form or as a soluble secreted protein A chimera displayed ratios of N-deacetylase to N-sulfotransferase activities that were 4-8-fold higher than that observed for the enzyme found in liver that is involved in the biosynthesis of heparan sulfate. (umassmed.edu)
  • differentiation
  • The first in vitro differentiation and growth of a pure population of mouse mast cells has been carried out using conditioned medium derived from concanavalin A-stimulated splenocytes. (wikipedia.org)
  • Later, it was discovered that T cell-derived interleukin 3 was the component present in the conditioned media that was required for mast cell differentiation and growth. (wikipedia.org)
  • Cluster of differentiation (CD) molecules are markers on the cell surface, as recognized by specific sets of antibodies, used to identify the cell type, stage of differentiation and activity of a cell. (wikipedia.org)
  • blood vessels
  • Researchers also think mast cells may have a role in the growth of blood vessels (angiogenesis). (wikipedia.org)
  • Mast cells are present in most tissues characteristically surrounding blood vessels and nerves, and are especially prominent near the boundaries between the outside world and the internal milieu, such as the skin, mucosa of the lungs, and digestive tract, as well as the mouth, conjunctiva, and nose. (wikipedia.org)
  • organs
  • When looked at basically, the main difference between SM and MCAD is MCAD patients have the normal amount of mast cells in their bodies, they are just hyperactive and hypersensitive vs SM patients have too many mast cells throughout their bodies and they build up in various organs and cause issues. (professionalzebra.com)
  • Tumor Cells
  • Tumor cells have hyperchromatic nuclei with increased nuclear/cytoplasmic ratio. (wikipedia.org)
  • Their atomic investigation of mutant KIT receptor which emphasized on the EAL region provided a better insight into the understanding of the sunitinib resistance mechanism of the KIT receptor and could help to discover new therapeutics for KIT-based resistant tumor cells in GIST therapy. (wikipedia.org)
  • histiocytoma
  • Canine cutaneous histiocytoma (derived from specialised epidermic dendritic cells, the Langerhans cells) 2. (wikipedia.org)
  • Epidermal invasion by cells of histiocytoma frequently occurs and intra-epidermal nests of histiocytes resemble Pautrier's aggregates, characteristically found in epidermotropic lymphoma (Mycosis Fungoides or MF). (wikipedia.org)
  • diseases
  • The other diseases also included in this category make too many myeloid cells too quickly, like essential thrombocythemia, in which the body makes too many platelets. (mastattack.org)
  • Neither monoclonal mast cell activation syndrome (MMAS) or mast cell activation syndrome (MCAS) were classified anywhere in the 2008 WHO Guidelines as they were not yet recognized by the WHO as diseases. (mastattack.org)
  • So all mast cell diseases were put together. (mastattack.org)
  • squamous
  • This stratified squamous epithelium is maintained by cell division within the stratum basale, in which differentiating cells slowly displace outwards through the stratum spinosum to the stratum corneum, where cells are continually shed from the surface. (wikipedia.org)
  • M8043/3 Small cell carcinoma, fusiform cell M8044/3 Small cell carcinoma, intermediate cell M8045/3 Combined small cell carcinoma Mixed small cell carcinoma Combined small cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma M8046/3 Non-small cell carcinoma (C34. (wikipedia.org)
  • Anal intraepithelial neoplasia, grade III (C21.1) AIN III (C21.1) M8078/3 Squamous cell carcinoma with horn formation M8080/2 Queyrat erythroplasia (C60. (wikipedia.org)
  • Intraepidermal squamous cell carcinoma, Bowen type (C44. (wikipedia.org)
  • M8083/3 Basaloid squamous cell carcinoma M8084/3 Squamous cell carcinoma, clear cell type M8090/1 Basal cell tumor (C44. (wikipedia.org)
  • Mixed basal-squamous cell carcinoma M8095/3 Metatypical carcinoma M8096/0 Intraepidermal epithelioma of Jadassohn (C44. (wikipedia.org)
  • papillary
  • Papillary urothelial carcinoma, non-invasive M8130/3 Papillary transitional cell carcinoma (C67. (wikipedia.org)
  • Papillary urothelial carcinoma M8131/3 Transitional cell carcinoma, micropapillary ( C67. (wikipedia.org)
  • symptoms
  • Symptoms are often caused by degranulation or the release of substances (granules) stored in the mast cells. (mastocytosis.eu)
  • citation needed] When too many mast cells exist in a person's body and undergo degranulation, the additional chemicals can cause a number of symptoms which can vary over time and can range in intensity from mild to severe. (wikipedia.org)
  • degranulation
  • When activated, a mast cell can either selectively release (piecemeal degranulation) or rapidly release (anaphylactic degranulation) "mediators", or compounds that induce inflammation, from storage granules into the local microenvironment. (wikipedia.org)
  • Other membrane activation events can either prime mast cells for subsequent degranulation or act in synergy with FcεRI signal transduction. (wikipedia.org)
  • immune
  • Genetic ablation of the B cell surface glycoprotein CD19 severely impairs the humoral immune response.While CD19 is not required for antigen-mediated activation of receptor proximal tyrosines kinases, it is critical for activation of phosphatidylinositol 3-kinase (PI3-kinase).Antigen-induced CD19-dependent PI3-kinase activation is required for normal phosphoinositide hydrolysis and Ca2+ mobilization responses. (nih.gov)
  • Genetic ablation of the B cell surface glycoprotein CD19 severely impairs the humoral immune response. (nih.gov)
  • Mast cells are part of our immune system. (mastocytosis.eu)
  • As explained, mast cells are part of every single person's immune system. (mastocytosis.eu)
  • Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing, angiogenesis, immune tolerance, defense against pathogens, and blood-brain barrier function. (wikipedia.org)
  • As a result, mast cells are coated with IgE, which is produced by plasma cells (the antibody-producing cells of the immune system). (wikipedia.org)
  • granules
  • Mast cells were first described by Paul Ehrlich in his 1878 doctoral thesis on the basis of their unique staining characteristics and large granules. (wikipedia.org)
  • stem cell
  • Another major area of research in our laboratory is personalizing the conditioning regimen used in preparing patients for haematopoietic stem cell transplantation. (cmchaematology.org)
  • citation needed] Mast cells express a cell surface receptor, c-kit (CD117), which is the receptor for stem cell factor (scf). (wikipedia.org)
  • Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a receptor tyrosine kinase protein that in humans is encoded by the KIT gene. (wikipedia.org)
  • When this receptor binds to stem cell factor (SCF) it forms a dimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. (wikipedia.org)
  • receptor
  • Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. (nih.gov)
  • Here we show that CD19 plays a key accessory role in B cell antigen receptor signaling independent of CR2 coligation and define molecular circuitry by which this function is mediated. (nih.gov)
  • Thus, CD19 functions as a B cell antigen receptor accessory molecule that modifies antigen receptor signaling in a qualitative manner. (nih.gov)
  • Mast cells express a high-affinity receptor (FcεRI) for the Fc region of IgE, the least-abundant member of the antibodies. (wikipedia.org)
  • CD117 is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. (wikipedia.org)
  • antigen
  • Tyrosine phosphorylation of signaling molecules upon antigen stimulation of the CD19-negative and CD19-positive cell lines. (nih.gov)
  • The allergen binds to the antigen-binding sites, which are situated on the variable regions of the IgE molecules bound to the mast cell surface. (wikipedia.org)