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  • leukemia
  • Acute myeloid leukemia (AML) is a biologically, clinically and genetically heterogeneous disease characterized by increased proliferation and defective maturation affecting the cells of the myeloid lineage. (cmchaematology.org)
  • The backbone of AML treatment for the last 30 years has been the combination of daunorubicin and cytosine arabinoside (Ara-C). The BCR/ABL tyrosine kinase Imatinib mesylate (IM) is the mainstay of treatment for CML but does not eliminate primitive leukemia stem and progenitor cells. (cmchaematology.org)
  • Residual leukemia cells are a potential source of relapse, and there is considerable interest in identifying additional therapeutic targets to selectively induce apoptosis in leukemic stem and progenitor cells. (cmchaematology.org)
  • histamine
  • Release of large amounts of histamine from a mast cell can result in ulceration or perforation of the GI tract (stomach and intestines) causing pain, hemorrhage, delayed wound healing, shock, and dark blood in the stool (melena). (lbah.com)
  • People affected by mastocytosis are susceptible to itching, hives, and anaphylactic shock, caused by the release of histamine from mast cells. (wikipedia.org)
  • By releasing chemical "alarms" such as histamine, mast cells attract other key players of the immune defense system to areas of the body where they are needed. (wikipedia.org)
  • For example, the typical itching felt around a healing scab may be caused by histamine released by mast cells. (wikipedia.org)
  • Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems and contains many granules rich in histamine and heparin. (wikipedia.org)
  • Both are granulated cells that contain histamine and heparin, an anticoagulant. (wikipedia.org)
  • The Fc region of immunoglobulin E (IgE) becomes bound to mast cells and basophils and when IgE's paratopes bind to an antigen, it causes the cells to release histamine and other inflammatory mediators. (wikipedia.org)
  • monoclonal
  • Neither monoclonal mast cell activation syndrome (MMAS) or mast cell activation syndrome (MCAS) were classified anywhere in the 2008 WHO Guidelines as they were not yet recognized by the WHO as diseases. (mastattack.org)
  • Monoclonal antibodies are made by injecting the animal and then taking a specific sample of immune tissue, isolating a parent cell, and using the resulting immortalized line to create antibodies. (wikipedia.org)
  • tissue
  • Mast cell sarcoma with tissue eosinophilia arising in the ascending colon. (nih.gov)
  • Although immunotherapies targeting TAMs, lymphocytes and DCs have been investigated in some bone and soft tissue sarcomas [ 21 - 24 ], there has been little analysis of the number of these inflammatory cells in specific primary malignant bone tumours. (biomedcentral.com)
  • Plasm" means the substance that makes up something living, like what makes up a cell or a tissue. (mastattack.org)
  • The main cellular component of this tissue is the adipocyte, or fat cell. (wikipedia.org)
  • Although mast cells were once thought to be tissue resident basophils, it has been shown that the two cells develop from different hematopoietic lineages and thus cannot be the same cells. (wikipedia.org)
  • These granules also led him to the incorrect belief that they existed to nourish the surrounding tissue, so he named them Mastzellen (from German Mast, meaning 'fattening', as of animals). (wikipedia.org)
  • Basophils leave the bone marrow already mature, whereas the mast cell circulates in an immature form, only maturing once in a tissue site. (wikipedia.org)
  • Feline acne Feline eosinophilic granuloma Flea allergy dermatitis Hyperthyroidism Miliary dermatitis (feline eczema) Mange Nutritional skin disorders Bladder cancer Bone cancer Intestinal cancer Liver cancer Lymphoma in animals Mammary tumor Mast cell tumor Nose cancer Skin cancer Soft tissue sarcoma Stomach cancer Anal sacs impaction Cerebellar hypoplasia is a disorder found in cats and dogs in which the cerebellum is not completely mature at birth. (wikipedia.org)
  • The tumor is classified as a soft tissue sarcoma. (wikipedia.org)
  • Immunohistochemistry (IHC) involves the process of selectively imaging antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues. (wikipedia.org)
  • Preparation of the sample is critical to maintain cell morphology, tissue architecture and the antigenicity of target epitopes. (wikipedia.org)
  • Although there is no dense collagen network in adipose tissue, groups of adipose cells are kept together by collagen fibers and collagen sheets in order to keep fat tissue under compression in place (for example, the sole of the foot). (wikipedia.org)
  • benign
  • Pilomatrixoma, malignant Pilomatricoma, malignant Matrical carcinoma M8120/0 Transitional cell papilloma, benign Transitional papilloma M8120/1 Urothelial papilloma, NOS Papilloma of baldder (C67. (wikipedia.org)
  • heparin
  • These results suggest that the MST-derived enzyme is probably unique to the production of heparin in mast cells. (umassmed.edu)
  • High risks for both include anaphylaxis, severe bleeding from heparin release, seizures, organ damage from mast cell accumulation, even multiple system failure in severe cases. (professionalzebra.com)
  • differentiation
  • The first in vitro differentiation and growth of a pure population of mouse mast cells has been carried out using conditioned medium derived from concanavalin A-stimulated splenocytes. (wikipedia.org)
  • Later, it was discovered that T cell-derived interleukin 3 was the component present in the conditioned media that was required for mast cell differentiation and growth. (wikipedia.org)
  • Cluster of differentiation (CD) molecules are markers on the cell surface, as recognized by specific sets of antibodies, used to identify the cell type, stage of differentiation and activity of a cell. (wikipedia.org)
  • blood vessels
  • Mast cells surround nerves and blood vessels, and are oftentimes found at the interface between the environment and the pet. (lbah.com)
  • Researchers also think mast cells may have a role in the growth of blood vessels (angiogenesis). (wikipedia.org)
  • Mast cells are present in most tissues characteristically surrounding blood vessels and nerves, and are especially prominent near the boundaries between the outside world and the internal milieu, such as the skin, mucosa of the lungs, and digestive tract, as well as the mouth, conjunctiva, and nose. (wikipedia.org)
  • tumour
  • A moderate or heavy leukocyte infiltrate was more commonly seen in conventional high-grade osteosarcoma, undifferentiated pleomorphic sarcoma and giant cell tumour of bone (GCTB) than in Ewing sarcoma, chordoma and chondrosarcoma. (biomedcentral.com)
  • MCs were identified mainly at the periphery of sarcomas, including the osteolytic tumour-bone interface. (biomedcentral.com)
  • Specific inflammatory cell components have been shown to produce both positive and negative effects on tumour growth and spread. (biomedcentral.com)
  • Immunohistochemistry
  • On immunohistochemistry, these cells have trilinear coexpression including the epithelial marker cytokeratin, the mesenchymal markers desmin and vimentin, and the neuronal marker neuron-specific enolase. (wikipedia.org)
  • Tumor Cells
  • Tumor cells have hyperchromatic nuclei with increased nuclear/cytoplasmic ratio. (wikipedia.org)
  • Their atomic investigation of mutant KIT receptor which emphasized on the EAL region provided a better insight into the understanding of the sunitinib resistance mechanism of the KIT receptor and could help to discover new therapeutics for KIT-based resistant tumor cells in GIST therapy. (wikipedia.org)
  • histiocytoma
  • Embryonal Sarcoma, also known as undifferentiated sarcoma , is related to undifferentiated embryonal sarcoma of the liver and fibrous histiocytoma , and has symptoms including fever An important gene associated with Embryonal Sarcoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Endometrial cancer and PI3K-Akt signaling pathway . (malacards.org)
  • Epidermal invasion by cells of histiocytoma frequently occurs and intra-epidermal nests of histiocytes resemble Pautrier's aggregates, characteristically found in epidermotropic lymphoma (Mycosis Fungoides or MF). (wikipedia.org)
  • microenvironment
  • When activated, a mast cell can either selectively release (piecemeal degranulation) or rapidly release (anaphylactic degranulation) "mediators", or compounds that induce inflammation, from storage granules into the local microenvironment. (wikipedia.org)
  • diseases
  • Under the 2008 WHO guidelines, mast cell diseases were classified as myeloproliferative neoplasms along with several other diseases. (mastattack.org)
  • The other diseases also included in this category make too many myeloid cells too quickly, like essential thrombocythemia, in which the body makes too many platelets. (mastattack.org)
  • WHO recognized that mast cell diseases differed from the other myeloproliferative neoplasms in specific ways. (mastattack.org)
  • So all mast cell diseases were put together. (mastattack.org)
  • liver
  • 2) the protein overexpressed in COS cells in its full-length transmembrane form or as a soluble secreted protein A chimera displayed ratios of N-deacetylase to N-sulfotransferase activities that were 4-8-fold higher than that observed for the enzyme found in liver that is involved in the biosynthesis of heparan sulfate. (umassmed.edu)
  • squamous
  • This stratified squamous epithelium is maintained by cell division within the stratum basale, in which differentiating cells slowly displace outwards through the stratum spinosum to the stratum corneum, where cells are continually shed from the surface. (wikipedia.org)
  • M8043/3 Small cell carcinoma, fusiform cell M8044/3 Small cell carcinoma, intermediate cell M8045/3 Combined small cell carcinoma Mixed small cell carcinoma Combined small cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma M8046/3 Non-small cell carcinoma (C34. (wikipedia.org)
  • Anal intraepithelial neoplasia, grade III (C21.1) AIN III (C21.1) M8078/3 Squamous cell carcinoma with horn formation M8080/2 Queyrat erythroplasia (C60. (wikipedia.org)
  • Intraepidermal squamous cell carcinoma, Bowen type (C44. (wikipedia.org)
  • M8083/3 Basaloid squamous cell carcinoma M8084/3 Squamous cell carcinoma, clear cell type M8090/1 Basal cell tumor (C44. (wikipedia.org)
  • Mixed basal-squamous cell carcinoma M8095/3 Metatypical carcinoma M8096/0 Intraepidermal epithelioma of Jadassohn (C44. (wikipedia.org)
  • papillary
  • Papillary urothelial carcinoma, non-invasive M8130/3 Papillary transitional cell carcinoma (C67. (wikipedia.org)
  • Papillary urothelial carcinoma M8131/3 Transitional cell carcinoma, micropapillary ( C67. (wikipedia.org)
  • degranulation
  • citation needed] When too many mast cells exist in a person's body and undergo degranulation, the additional chemicals can cause a number of symptoms which can vary over time and can range in intensity from mild to severe. (wikipedia.org)
  • Other membrane activation events can either prime mast cells for subsequent degranulation or act in synergy with FcεRI signal transduction. (wikipedia.org)
  • immune
  • Genetic ablation of the B cell surface glycoprotein CD19 severely impairs the humoral immune response.While CD19 is not required for antigen-mediated activation of receptor proximal tyrosines kinases, it is critical for activation of phosphatidylinositol 3-kinase (PI3-kinase).Antigen-induced CD19-dependent PI3-kinase activation is required for normal phosphoinositide hydrolysis and Ca2+ mobilization responses. (nih.gov)
  • Genetic ablation of the B cell surface glycoprotein CD19 severely impairs the humoral immune response. (nih.gov)
  • Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing, angiogenesis, immune tolerance, defense against pathogens, and blood-brain barrier function. (wikipedia.org)
  • As a result, mast cells are coated with IgE, which is produced by plasma cells (the antibody-producing cells of the immune system). (wikipedia.org)
  • stem cell
  • Another major area of research in our laboratory is personalizing the conditioning regimen used in preparing patients for haematopoietic stem cell transplantation. (cmchaematology.org)
  • citation needed] Mast cells express a cell surface receptor, c-kit (CD117), which is the receptor for stem cell factor (scf). (wikipedia.org)
  • Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a receptor tyrosine kinase protein that in humans is encoded by the KIT gene. (wikipedia.org)
  • When this receptor binds to stem cell factor (SCF) it forms a dimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. (wikipedia.org)
  • receptor
  • Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. (nih.gov)
  • Here we show that CD19 plays a key accessory role in B cell antigen receptor signaling independent of CR2 coligation and define molecular circuitry by which this function is mediated. (nih.gov)
  • Thus, CD19 functions as a B cell antigen receptor accessory molecule that modifies antigen receptor signaling in a qualitative manner. (nih.gov)
  • Mast cells express a high-affinity receptor (FcεRI) for the Fc region of IgE, the least-abundant member of the antibodies. (wikipedia.org)
  • CD117 is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. (wikipedia.org)
  • carcinomas
  • The identification of a molecular basis for GIST led to the exclusion of many tumors that had been considered as GIST previously, and also the incorporation of a much larger number of tumors that had been labeled as other types of sarcomas and undifferentiated carcinomas. (wikipedia.org)
  • tumor cells
  • University of Florida (UF) researchers have developed a DNA nanotrain that fast-tracks its payload of cancer-fighting drugs and bioimaging agents to tumor cells deep within the body. (regenerativemedicine.net)
  • The pseudocapsule is made up of viable tumor cells and is not a fibrous response by host cells. (vin.com)
  • The viable tumor cells project from the pseudocapsule into surrounding tissue and these cells are left behind by marginal resection. (vin.com)
  • However, some body parts contain multiple types of tissue, so for greater precision, cancers are additionally classified by the type of cell that the tumor cells originated from. (wikipedia.org)
  • leukemia
  • We ve precisely targeted leukemia, lung, and liver cancer cells, and because the DNA probes are so precise in targeting only specific types of cancer cells we ve seen dramatic reduction in drug toxicity in comparison to standard chemotherapies, which don t discriminate well between cancerous and healthy cells. (regenerativemedicine.net)
  • Moving forward, we are working to identify optimum dosage using mouse models for T-cell leukemia, lung and liver cancers, and triple negative breast cancer. (regenerativemedicine.net)
  • Lymphoma and leukemia: These two classes of cancer arise from cells that make blood. (wikipedia.org)
  • antigen
  • Hematopoietic progenitor cell antigen CD34 also known as CD34 antigen is a protein that in humans is encoded by the CD34 gene. (wikipedia.org)
  • Adjuvants accomplish this task by mimicking specific sets of evolutionarily conserved molecules, so called PAMPs, which include liposomes, lipopolysaccharide (LPS), molecular cages for antigen, components of bacterial cell walls, and endocytosed nucleic acids such as double-stranded RNA (dsRNA), single-stranded DNA (ssDNA), and unmethylated CpG dinucleotide-containing DNA. (wikipedia.org)
  • Spurred into action, the DC picks up the antigen and speeds to a lymph node, where it sticks tightly to a helper T cell and presumably induces an immune response. (wikipedia.org)
  • In the lymph nodes, DCs mince the engulfed pathogen and then express the pathogen clippings as antigen on their cell surface by coupling them to a special receptor known as a major histocompatibility complex (MHC). (wikipedia.org)
  • When the T cell receptor is engaged by the specific antigen presented by MHC, Lck acts to phosphorylate the intracellular chains of the CD3 and ζ-chains of the TCR complex, allowing another cytoplasmic tyrosine kinase called ZAP-70 to bind to them. (wikipedia.org)
  • feline
  • The etiology is generally not known with some notable exceptions such as those associated with infestations with the parasite Spirocerca lupi , those induced by the feline sarcoma virus and those thought to be associated with feline vaccinations (Vaccine Associated Sarcomas, VAS). (vin.com)
  • protein
  • The AP-1 subunit Jun was identified as a novel oncoprotein of avian sarcoma virus, and Fos-associated p39 protein was identified as the transcript of the cellular Jun gene. (wikipedia.org)
  • Lck then phosphorylates and activates ZAP-70, which in turn phosphorylates another molecule in the signaling cascade called LAT (short for Linker of Activated T cells), a transmembrane protein that serves as a docking site for a number of other proteins, the most important of which are Shc-Grb2-SOS, PI3K, and phospholipase C (PLC). (wikipedia.org)
  • The N-terminal tail of Lck is myristoylated and palmitoylated, which tethers the protein to the plasma membrane of the cell. (wikipedia.org)
  • diagnoses
  • Fine needle cytology is an extremely valuable, easily performed, screening test to rule out common differential diagnoses such as lipoma, mast cell tumor, abscess etc. (vin.com)
  • morphology
  • If eosinophilia is present on repeat testing, it is appropriate to thoroughly review the remainder of the CBC for other abnormalities and ask the laboratory to review a well made peripheral smear for red cell, white cell, and platelet morphology. (oncologynurseadvisor.com)
  • Preparation of the sample is critical to maintain cell morphology, tissue architecture and the antigenicity of target epitopes. (wikipedia.org)
  • differentiation
  • AP-1 transcription factor has been shown to have a hand in a wide range of cellular processes, including cell growth, differentiation, and apoptosis. (wikipedia.org)
  • AP-1 has been shown to be involved in cell differentiation in several systems. (wikipedia.org)
  • abnormal
  • Cancer is a group of diseases that involve abnormal increases in the number of cells, with the potential to invade or spread to other parts of the body. (wikipedia.org)
  • arise
  • GISTs arise in the smooth muscle pacemaker interstitial cell of Cajal, or similar cells. (wikipedia.org)
  • GISTs are thought to arise from interstitial cells of Cajal (ICC), that are normally part of the autonomic nervous system of the intestine. (wikipedia.org)
  • tissues
  • Immunohistochemistry (IHC) involves the process of selectively imaging antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues. (wikipedia.org)
  • antibodies
  • GENTAUR suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as GRAP2, 1_330aa, Human, His tag, E.coli. (antibody-antibodies.com)
  • Monoclonal antibodies are made by injecting the animal and then taking a specific sample of immune tissue, isolating a parent cell, and using the resulting immortalized line to create antibodies. (wikipedia.org)
  • differentiate
  • DNA nanotechnology holds great promise as a new way to deliver chemotherapy directly to cancer cells, but until now, scientists have not been able to direct nanotherapies to consistently differentiate cancer cells from healthy ones. (regenerativemedicine.net)
  • growth
  • C-fos has also been shown to increase in expression in response to the introduction of growth factors in the cell, further supporting its suggested involvement in the cell cycle. (wikipedia.org)
  • It supports the growth of B cells and is antagonistic to regulatory T cells. (wikipedia.org)
  • GIST
  • In the gut, however, a mass staining positive for CD117 is likely to be a GIST, arising from ICC cells. (wikipedia.org)
  • receptor
  • It associates with the cytoplasmic tails of the CD4 and CD8 co-receptors on T helper cells and cytotoxic T cells, respectively, to assist signaling from the T cell receptor (TCR) complex. (wikipedia.org)
  • undergo
  • Both epidermal keratinocytes and Langerhans cells undergo apoptotic changes as a consequence of UV-induced DNA damage. (cancertherapyadvisor.com)
  • T cells can then recognize these clippings and undergo a cellular transformation resulting in their own activation. (wikipedia.org)
  • Additionally
  • Additionally, upon T cell activation, a fraction of kinase active Lck, translocates from outside of lipid rafts (LR) to inside lipid rafts where it interacts with and activates LR-resident Fyn, which is involved in further downstream signaling activation. (wikipedia.org)
  • types
  • Some types of cancer are named for the size and shape of the cells under a microscope, such as giant cell carcinoma, spindle cell carcinoma, and small-cell carcinoma. (wikipedia.org)
  • gene
  • The function of Lck has been studied using several biochemical methods, including gene knockout (knock-out mice), Jurkat cells deficient in Lck (JCaM1.6), and siRNA-mediated RNA interference. (wikipedia.org)