• Gas chromatography/mass spectrometry (GC/MS) is a well-known instrumental technique used for the analysis of fire debris for accelerant detection. (astm.org)
  • Gas chromatography mass spectrometry is also available for the analysis of volatile compounds, as well as a state-of-the-art pipetting robot for automated sample preparation. (lu.se)
  • The analytical methods used to measure benzidine and its metabolites in biological materials are GC (NIOSH 1984b), gas chromatography/mass spectrometry (GC/MS) (Hsu et al. (cdc.gov)
  • Sector mass spectrometers known as calutrons were developed by Ernest O. Lawrence and used for separating the isotopes of uranium during the Manhattan Project. (wikipedia.org)
  • Calutron mass spectrometers were used for uranium enrichment at the Oak Ridge, Tennessee Y-12 plant established during World War II. (wikipedia.org)
  • 1 More than just a technological tweaking, it's an elegantly simple innovation that, MS experts say, could make mass spectrometers invaluable tools for applications ranging from field-site forensics to drug design to bomb detection. (the-scientist.com)
  • Scientific Instrument Services offer a wide range of supplies and services for the Varian mass spectrometers. (sisweb.com)
  • Modern flight-capable mass spectrometers, in combination with various sample processing, separation, and ionization techniques enable sensitive detection of chemical biosignatures. (frontiersin.org)
  • Modern commercially available mass spectrometers are able to accurately distinguish between molecules that differ by only a single atom in mass from a small molecule, but paradoxically to an outside observer, these devices struggle to detect the heaviest of molecules, typically those over 100,000 atomic mass units (for reference, water has a mass of 18 atomic mass units). (cmu.edu)
  • What sets this detector apart from others used in mass spectrometers is the fact that it's exceptionally cold. (cmu.edu)
  • Mass spectrometers are at the forefront of chemical analysis for small and large molecules, oceanic and interplanetary studies, forensic analysis, and clinical investigations. (purdue.edu)
  • Commercial benchtop mass spectrometers are restricted to primary and satellite labs because they are heavy, expensive, consume significant amounts of power and are not [physically] robust. (purdue.edu)
  • Miniature mass spectrometers mitigate these concerns while sacrificing some analytical performance. (purdue.edu)
  • Notwithstanding, miniature ion trap mass spectrometers such as the Mini 12, excel in chemical analysis because it has the same scan functions as its full-size counterpart allowing for qualitative and quantitative analysis in the lab and in the field. (purdue.edu)
  • The development of minimalistic ionization techniques known as ambient ionization has helped to encourage the removal of miniature mass spectrometers from the typical lab confines, to the field. (purdue.edu)
  • The Mass Spectrometry Primer, an 82-page paperback book, covers a wide range of topics related to the most wide spread of modern mass spectrometry practices and answers some frequently asked questions about the use and capabilities of mass spectrometers. (selectscience.net)
  • The first section examines who uses mass spectrometers, followed by how compounds are ionized in the source to be analyzed by mass spectrometers. (selectscience.net)
  • A description of the various types of mass spectrometers is followed by a discussion of the important topics of mass accuracy and resolution - or how well we can tell differences between closely related compounds. (selectscience.net)
  • In this guidebook, we will introduce polymeric material analysis solutions that make full use of JEOL's high-performance mass spectrometers. (jeolusa.com)
  • This is because mass spectrometers separate particles by calculating their different mass-to-charge ratios (m/z). (thermofisher.com)
  • Different analyzers are also combined in hybrid and tribrid mass spectrometers. (thermofisher.com)
  • Mass spectrometry is an analysis method that can be performed once using a single analyzer, or it can be performed in tandem between different mass analyzers (such as those found in hybrid or tribrid mass spectrometers). (thermofisher.com)
  • The general operation of mass spectrometers, including hybrid and tribrid mass spectrometers. (thermofisher.com)
  • Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. (wikipedia.org)
  • These ions (fragments) are then separated according to their mass-to-charge ratio, for example by accelerating them and subjecting them to an electric or magnetic field: ions of the same mass-to-charge ratio will undergo the same amount of deflection. (wikipedia.org)
  • Results are displayed as spectra of the signal intensity of detected ions as a function of the mass-to-charge ratio. (wikipedia.org)
  • Early spectrometry devices that measured the mass-to-charge ratio of ions were called mass spectrographs which consisted of instruments that recorded a spectrum of mass values on a photographic plate. (wikipedia.org)
  • A mass spectroscope is similar to a mass spectrograph except that the beam of ions is directed onto a phosphor screen. (wikipedia.org)
  • An extraction system removes ions from the sample, which are then targeted through the mass analyzer and into the detector. (wikipedia.org)
  • The differences in masses of the fragments allows the mass analyzer to sort the ions by their mass-to-charge ratio. (wikipedia.org)
  • A mass spectrometer ionizes the sample into gaseous ions and then identifies the ions by their mass-to-charge ratios and relative abundances. (sigmaaldrich.com)
  • A mass spectrometer works by converting individual molecules into ions and then analyzing the relative abundance of the generated ions. (sigmaaldrich.com)
  • From one complex sample, a mass spectrometer generates many ions. (sigmaaldrich.com)
  • The ions are then accelerated in an electromagnetic field and separated based on their mass-to-charge ( m/z ) ratios. (sigmaaldrich.com)
  • The instrument's detector records the ions in proportion to their relative abundance and generates a mass spectrum of the molecule. (sigmaaldrich.com)
  • Following World War II the techniques of manipulating very short electrical pulses allowed the construction of the time-of-flight mass spectrometer , in which a short emission of ions is released from the source and their arrival times recorded after having traversed a distance sufficiently long to sort out the different speeds. (britannica.com)
  • The application of superimposed radio frequency and constant potentials between four parallel rods can be shown to act as a mass separator in which only ions within a particular mass range will perform oscillations of constant amplitude and be collected at the far end of the analyzer. (britannica.com)
  • New applications and new developments have gone hand in hand to create a complex array of instruments, but all may be understood by tracing the ions through three basic elements: an ion source, a method of analyzing the ion beams according to their mass-to-charge ratio, and detectors capable of measuring or recording the currents of the beams. (britannica.com)
  • The obtained peptides are ionized, and ions separated according to their mass/charge ratio (m/z) thus finally detected and analyzed. (tigem.it)
  • Mass spectrometry refers to the generation and analysis of ions according to their mass-to-charge. (purdue.edu)
  • Parent ions of selected mass-to-charge ( m/z ) values, characteristic for petrol, are stored within the ion trap. (astm.org)
  • As a result, the m/z axis of the mass spectrum is equal to the mass of the ions, thus making it easy to interpret polymer distributions. (jeolusa.com)
  • The mass spectrum represents a profile of ions from molecules from discrete locations. (bruker.com)
  • The practice of simultaneous MS is frequently termed tandem mass spectrometry (MS/MS or MS 2 ) and refers to two or more reaction steps being performed on selected ions. (thermofisher.com)
  • In the first step of mass analysis, precursor ions are formed in the ion source and induced to fragment. (thermofisher.com)
  • Learn more about how mass analyzers separate, select and even fragment ions based on their distinct masses and charges. (thermofisher.com)
  • His doctoral work focused on development of new computational approaches towards small molecule mass spectrometry with a focus on microbial natural products drug discovery. (smith.edu)
  • This conference brings together scientists interested in all aspects of mass spectrometry, from academia and industry including mass spectrometry vendors, big pharma, and small and medium enterprises developing instrumentation, software, services, and applications. (metabolon.com)
  • Interpretation of mass spectra and data treatment will also be covered, together with practical aspects of mass spectrometry method development. (lu.se)
  • Kocher, T. & Superti-Furga, G. Mass spectrometry-based functional proteomics: from molecular machines to protein networks. (nature.com)
  • Proteomic analysis and discovery using affinity proteomics and mass spectrometry. (lu.se)
  • The ability to couple mass spectrometry to other separation techniques such as capillary electrophoresis, GC, and HPLC makes it a versatile analytical tool for the simultaneous separation and identification of analytes. (sigmaaldrich.com)
  • This mass spectrometer is coupled with a Dionex Ultimate 3000 HPLC system and an innovative Captive electrospray source. (boisestate.edu)
  • this was followed by MALDI mass spectrometry (MS), which showed the presence of six or fewer resolved protein components above 20 kDa in each RP-HPLC fraction, giving a total of 93 MS resolved peaks. (unboundmedicine.com)
  • Peptide maps of tryptic digests of HPLC fractions were obtained from a tandem quadrupole time-of-flight mass spectrometer (MALDI QqTOF MS) and were submitted to the ProFound search engine. (unboundmedicine.com)
  • TY - JOUR T1 - Characterization of wheat gluten proteins by HPLC and MALDI TOF mass spectrometry. (unboundmedicine.com)
  • Is PNGase A compatible with downstream analysis such as HPLC and Mass Spectrometry? (neb.com)
  • PNGase A is supplied in a glycerol-free storage buffer to allow for compatibility with downstream analysis such as HPLC and/or Mass Spectrometry due to the fact that glycerol is not tolerated in such instruments. (neb.com)
  • This course covers modern mass spectrometry with a particular focus on the analysis of low molecular weight analytes. (lu.se)
  • Babu, M., Krogan, N.J., Awrey, D.E., Emili, A. & Greenblatt, J.F. Systematic characterization of the protein interaction network and protein complexes in Saccharomyces cerevisiae using tandem affinity purification and mass spectrometry. (nature.com)
  • Cross-linking technology combined with tandem mass spectrometry (MS-MS) is a powerful method that provides a rapid solution to the discovery of protein-protein interactions and protein structures. (nih.gov)
  • We studied the problem of detecting cross-linked peptides and cross-linked amino acids from tandem mass spectral data. (nih.gov)
  • and the second step finds the best cross-linked amino acids in these two peptide sequences that are optimally correlated to a given tandem mass spectrum. (nih.gov)
  • An interchain cross-link between two beta subunits was found in two tandem mass spectra. (nih.gov)
  • A team of scientists the Sports Medicine Research and Testing Laboratory at the University of Utah have developed a test that makes use of liquid chromatography-tandem mass spectrometry. (science20.com)
  • A high-performance liquid chromatography-tandem mass spectrometry method for quantifying active toxin, where the amount of toxin can be correlated to the amount of product peptides, is also described. (cdc.gov)
  • Course organizer Peter Spégel Center for Analysis and Synthesis Department of Chemistry Lund University course gives theoretical and practical knowledge on how mass spectrometry can be used in qualitative and quantitative analyses of small molecules. (lu.se)
  • Such nanomechanical mass sensing reached extremely low mass limits of detection 6 . (nature.com)
  • Today, mass spectrometry is a well-established detection method that offers a multitude of benefits, such as selectivity, sensitivity, and multi-sample analysis. (sigmaaldrich.com)
  • Detection and Identification of Explosives by Mass Spectrometry (D.D. Fetterolf). (routledge.com)
  • Here, we delve into the search for extraterrestrial chemical and morphological biosignatures and examine several possible approaches to agnostic life detection using mass spectrometry. (frontiersin.org)
  • Now, in a study published last month online in the journal ACS Nano and funded by the National Science Foundation, Bier's group has demonstrated the use of a Superconducting Tunnel Junction cryodetector for ultra-high mass nanoparticle analysis that gets around this massive problem of detection. (cmu.edu)
  • Mass spectrometry has four essential functions, which are ionization, separation (filtering), detection and analysis. (thermofisher.com)
  • We describe a statistical measure, Mass Distance Fingerprint, for automatic de novo detection of predominant peptide mass distances, i.e. , putative protein modifications. (lu.se)
  • Nanomechanical mass spectrometry has proven to be well suited for the analysis of high mass species such as viruses. (nature.com)
  • Still, the use of one-dimensional devices such as vibrating beams forces a trade-off between analysis time and mass resolution. (nature.com)
  • A complete workflow for the intact and middle-up mass analysis of reduced and non-reduced monoclonal antibodies based on SEC-MS with sample preparation by protein-A affinity clean-up. (sigmaaldrich.com)
  • Scientists at Purdue University, led by Graham Cooks, professor of analytical chemistry, recently reported a novel method for processing samples for mass spectrometry (MS) analysis. (the-scientist.com)
  • The environmental mass spectrometry laboratory has over 30 years of experience in the analysis of soil and sediments, and gas samples. (ncl.ac.uk)
  • The environmental mass spectrometry laboratory can perform both routine and bespoke GC and GC-MS analysis with integrated liquid and pyrolysis autosamplers, and gas sampling valves. (ncl.ac.uk)
  • Forensic Drug Testing by Mass Spectrometric Analysis of Hair (W.A. Baumgartner, C.-C. Cheng, T.D. Donahue, G.F. Hayes, V.A. Hill, and H. Scholtz). (routledge.com)
  • Affinity purification-mass spectrometry and network analysis to understand protein-protein interactions. (nature.com)
  • Typical preparation steps include sectioning a sample into thin, flat slices because flatness is required to guarantee optimal laser focus, a key parameter in reliable analysis," Benjamin Bartels, the first author of the study and PhD student in the Mass Spectrometry Research Group, points out. (labmanager.com)
  • Instruments for LC MS/MS analysis consist of a Nano LC1200 coupled via a nano-electrospray ionization source to the quadrupole-based Q Exactive HF benchtop mass spectrometer. (tigem.it)
  • Working at such small scales means it can be difficult to make different particles identical, and mass spectrometry could be a useful analysis to test the quality of the manufacturing. (cmu.edu)
  • Throughout these projects, the mass spectrometer was transported to the sample rather than the sample to the instrument thus emphasizing the importance of a robust analytical instrument capable of qualitative and quantitative analysis. (purdue.edu)
  • To achieve these goals, the mass spectrometer was adapted to the problem by varying the ionization method, building new hardware, or even modifying the data analysis system. (purdue.edu)
  • Analysis of complex mixtures with gas chromatography coupled with high-resolution time-of-flight mass spectrometry (GC-HRTOFMS) can produce a large amount of data. (jeolusa.com)
  • A new software program was recently reported that integrates all of the available mass spectrometric information from GC-HRTOFMS analysis into a concise report. (jeolusa.com)
  • The different approaches to sample labeling and mass spectrometry analysis. (thermofisher.com)
  • The main objective of SMART-WORKFLOW is to integrate the last advances in high resolution mass spectrometry (HRMS) and statistical analysis of data to develop and optimize a smart methodology (workflow) for the assessment of the overall quality of wastewater treatment. (europa.eu)
  • Describe the most common mass spectrometry applications, including possibilities and limitations for analysis. (lu.se)
  • Carry out a mass spectrometry analysis and handle the aquired data using common mass spectrometry software. (lu.se)
  • Practical parts including protein and peptide sample preparations, deposition with different techniques and the use of chromatographic separations for complex samples prior to mass spectrometry analysis. (lu.se)
  • Title : Isothiazolinone Content of US Consumer Adhesives: Ultrahigh-Performance Liquid Chromatographic Mass Spectrometry Analysis Personal Author(s) : Goodier, Molly C.;Zang, Lun-Yi;Siegel, Paul D.;Warshaw, Erin M. (cdc.gov)
  • This sensitive and robust triple quadrupole mass spectrometer is used for analysis of low (ppb) levels of environmental compounds and biomarkers. (lu.se)
  • For accurate quantitative or qualitative analysis, mass spectrometry is today combined with different chromatographic techniques. (lu.se)
  • Mass spectrometry for small molecules includes an overview of mass spectrometric techniques that can be used for analysis of low molecular weight analytes in both the gas and liquid phase. (lu.se)
  • Practical parts include analysis of own or supplied samples by chromatography and mass spectrometry, with subsequent data analysis and identification of sample components. (lu.se)
  • Generating and analyzing overlapping peptides through multienzymatic digestion is an efficient procedure for de novo protein using from bottom-up mass spectrometry (MS). Despite improved instrumentation and software, de novo MS data analysis remains challenging. (lu.se)
  • Thermal Analysis and Mass Spectrometry. (cdc.gov)
  • Metabolon is proud to participate in the 71st ASMS Conference on Mass Spectrometry and Allied Topics being held in Houston, Texas from June 4 - 8, 2023. (metabolon.com)
  • Chalmers Mass Spectrometry Infrastructure, CMSI, is a Chalmers infrastructure that provides access to mass spectrometry analyses to researchers both within and outside Chalmers. (chalmers.se)
  • The Chalmers Mass Spectrometry Infrastructure (CMSI) is a Chalmers infrastructure with the goal of providing cutting edge and efficient quantitative mass spectrometry and structural identification analyses for researchers at Chalmers and beyond. (chalmers.se)
  • The infrastructure will provide a combination of service analyses and supported analyses for training students in analytical mass spectrometry. (chalmers.se)
  • Forensic Applications of Mass Spectrometry combines the most current developments in applications of mass spectrometry techniques to forensic analyses. (routledge.com)
  • Quantitative analyses can be obtained for most elements in the mass range 5-250 amu (practically 7 Li to 238 U). (lu.se)
  • HTX Imaging's patented TM-Sprayer™ Tissue MALDI Sample Preparation System is designed to provide the highest quality matrix deposition on the two-dimensional biological samples, and can be integrated with any MALDI Mass Spectrometer platform. (boisestate.edu)
  • The JMS-S3000 SpiralTOF™-plus Ultra-High Mass Resolution MALDI-TOFMS System time-of-flight optics design utilizes a figure-eight ion trajectory to allow a 17m flight path to fit in an extremely small console. (jeolusa.com)
  • Pyrolysis gas chromatograph quadrupole mass spectrometer (Py-GC-QMS) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOFMS) are powerful tools for analyzing polymeric materials. (jeolusa.com)
  • Additionally, when MALDI is used with a high-resolution TOFMS, the accurate mass of each ion in the polymer series can be used to calculate their elemental compositions. (jeolusa.com)
  • MALDI-TOF mass spectrometry has emerged as a rapid, cost-efficient and clinically effective tool for identifying pathogens. (beckmancoulter.com)
  • In this webinar, "The Use of MALDI-TOF in the Clinical Laboratory: Effectiveness and Challenges," Dr. Elizabeth Palavecino shares her laboratory's clinical experience with MALDI-TOF mass spectrometry. (beckmancoulter.com)
  • MALDI mass spectrometry is a technology that allows molecular measurements to be taken directly from tissue surfaces at specified coordinates without requiring antibodies or specialized reagents. (bruker.com)
  • In this webinar, we will discuss histology-directed MALDI mass spectrometry and how this workflow has been used to diagnose invasive melanoma. (bruker.com)
  • She currently serves as the Director of Mass Spectrometry at Frontier Diagnostics, where she develops MALDI-based assays for clinical diagnostics. (bruker.com)
  • In Experiment 1, we treated rats with 10 g/L MnCl2 in drinking water for 60 or 90 days and used inductively coupled plasma mass spectrometry to quantify the increase in Mn levels in three regions of the cochlea and three brain regions. (cdc.gov)
  • Tutorial book on mass spectrometry, instrumentation and mainly fragmentation of organic compounds. (nist.gov)
  • In this study, state-of-the-art instrumentation two-dimensional gas chromatography (GC × GC) coupled photoionization─time of flight mass spectrometry was employed to investigate the composition of dodecene products produced from olefin oligomerization. (jeolusa.com)
  • The emphasis is on understanding the fundamental processes involved, the instrumentation used, including different ionization sources and mass analyzers, and interpretation of generated data. (lu.se)
  • In 1953 the West German physicists Wolfgang Paul and Helmut Steinwedel described the development of a quadrupole mass spectrometer . (britannica.com)
  • The Netzsch Jupiter STA 449C is a thermogravimetric analyser interfaced to an Aeolos QMS 403 quadrupole mass spectrometer. (ncl.ac.uk)
  • A variety of mass spectrometer types, including magnetic sector, quadrupole, time-of-flight, and ion trap, have and will continue to deepen our understanding of the formation and evolution of exploration targets like the surfaces and atmospheres of planets and their moons. (frontiersin.org)
  • Trapped ion mobility spectrometry (TIMS) combined with quadrupole time of flight mass spectrometry (Q-TOF). (lu.se)
  • Different types of mass analysers will also be discussed, including the quadrupole, the 3d and linear ion traps, the time of flight, the orbitrap and the Fourier transform ion cyclotron resonance mass analysers, and their combinations. (lu.se)
  • A Mettler vacuum recording thermoanalyzer interfaced with a Finnigan Model 1050 quadrupole mass spectrometer is described and several applications using the system are given. (cdc.gov)
  • Bruker Q-TOF Mass Spectrometer is located in the mass spectrometer is located in the BRC, room 215 in the Mathematics Building on the campus of Boise State University. (boisestate.edu)
  • Bruker HCT Ion Trap Mass Spectrometer from Bruker Daltonics is located in the Analytical Lab, room 363 in the Science building on the Boise State University campus. (boisestate.edu)
  • In the ion chamber of a mass spectrometer, each individual molecule is ionized to form a molecular ion, having one electron less than the parent molecule. (sigmaaldrich.com)
  • Electron impact has remained the most widely used method of ionization in mass spectrometry. (britannica.com)
  • We use gas chromatography (GC) to resolve complex mixtures of gases, and volatile and semi-volatile compounds, coupled with mass spectrometry (GC-MS) and other detectors such as flame ionisation (FID) and electron capture (ECD). (ncl.ac.uk)
  • This is because it's difficult to accelerate these heavy particles to high enough velocities to generate the electron emissions necessary when they impact on a conventional mass spectrometer detector to calculate their mass-to-charge ratio. (cmu.edu)
  • A gold nanoparticle colliding with the top surface of a superconducting tunnel junction cryodetector with 20,000 electron volts of kinetic energy and the resulting ultra-high mass spectrum. (cmu.edu)
  • For the data sets used in this study, known mass differences are detected at electron mass accuracy or better. (lu.se)
  • The laboratory also has LC-MS systems and a thermogravimetric analyser interfaced to a mass spectrometer (TGA-MS). (ncl.ac.uk)
  • Prospective Evaluation of a Matrix-assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry System in a Hospital Clinical Microbiology Laboratory for Identification of Bacteria and Yeasts: A Bench-by-bench Study for Assessing the Impact on Time to Identification and Cost-effectiveness. (beckmancoulter.com)
  • Due to the sensitivity of mass spectrometry, it is widely used to measure very low molecular weights at extremely low concentrations, below nanograms per milliliter (ng/mL). (sigmaaldrich.com)
  • The IMS CORE Lab is included in the Division of Imaging Mass Spectrometry of the Maastricht MultiModal Molecular Imaging Institute M4I . (maastrichtuniversity.nl)
  • Routine work includes determination of molecular formula and accurate mass with an accuracy of ± 1 mDa of compounds with m/z up to 3000 mDa. (lu.se)
  • An Easy nL nano liquid chromatographic system is coupled to the mass spectrometer through the nanoelectrospray source for protein characterization. (boisestate.edu)
  • Thermospray techniques used in conjunction with mass spectrometry (MS) with or without high performance liquid chromatographic separation have proven useful for the determination of thermally labile compounds such as toxicant metabolites (Korfmacher et al. (cdc.gov)
  • The prevalence of mass spectrometry in every corner of science is due to its high selectivity and sensitivity, wide chemical scope and to its adaptable nature. (purdue.edu)
  • Over the past century, mass spectrometry development has been influenced by scientists from all disciplines. (purdue.edu)
  • We are a service facility equipped with unique technology and experienced scientists in the field of mass spectrometry. (lu.se)
  • The use of the term mass spectroscopy is now discouraged due to the possibility of confusion with light spectroscopy. (wikipedia.org)
  • Scientific Instrument Services, Inc. provides replacement detectors for your Varian mass spectrometer. (sisweb.com)
  • Laser ablation electrospray ionization (LAESI) is a method that can be applied in mass spectrometry imaging to investigate the distribution of many different chemical compounds found in a biological sample. (labmanager.com)
  • 4 usually cause human botulism (A, B, E, and F). We developed a rapid, mass spectrometry-based method (Endopep-MS) to detect and differentiate active BoNTs A, B, E, and F. This method uses the highly specific protease activity of the toxins with target peptides specific for each toxin serotype. (cdc.gov)
  • The product peptides derived from the endopeptidase activities of BoNTs are detected by matrix-assisted laser-desorption ionization time-of-flight mass spectrometry. (cdc.gov)
  • First, the digested proteome is exposed to these antibodies, whereby motif-containing peptides are enriched, which then are detected and identified by mass spectrometry. (lu.se)
  • Dunham, W.H., Mullin, M. & Gingras, A.C. Affinity-purification coupled to mass spectrometry: basic principles and strategies. (nature.com)
  • Mass spectrometry is among the most powerful analytical techniques available for protein characterization. (kbibiopharma.com)
  • KBI's state-of-the-art mass spectrometry core facility delivers unparalleled structural characterization services to our clients. (kbibiopharma.com)
  • In support of biotherapeutics across the board, KBI's Mass Spectrometry Core Facility has championed the characterization and management of proteins, active pharmaceutical ingredients (APIs), and impurities through identification, characterization, assessment, and quantitation. (kbibiopharma.com)
  • We recently sat down with Michael J. Nold, Ph.D., Senior Director of KBI's Mass Spectrometry Core Facility in Durham, North Carolina, to discuss how advanced Mass Spectrometry plays a significant analytical role in the characterization and quantitation of APIs and impurities in complex biotherapeutics. (kbibiopharma.com)
  • Advanced analytical capabilities, including mass spectrometry, are critical for the characterization of active pharmaceutical ingredients (APIs) and managing a diverse population of impurities. (kbibiopharma.com)
  • Describe the principles of mass spectrometry, including the basic design of the instrument and its operation. (lu.se)
  • Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. (who.int)
  • In these experiments, a trained pathologist annotates regions of interest, and mass spectra can be collected directly from those regions. (bruker.com)
  • By collecting mass spectra from tissues with known pathology, a machine learning classification model can be trained to classify spectra taken from regions of tissue with unknown pathological states. (bruker.com)
  • The method's focus is to globally detect mass differences, not to assign peptide sequences or modifications to individual spectra. (lu.se)
  • Custom-built laser source for mass spectrometry imaging: By means of improved Laser Ablation Electrospray Ionization (LAESI) the surfaces of non-flat samples-for example this coarse piece of savoy cabbage-can now be chemically analyzed. (labmanager.com)
  • Comparison of Two Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Methods with Conventional Phenotypic Identification for Routine Identification of Bacteria to the Species Level. (beckmancoulter.com)
  • The results are presented as a mass spectrum, a plot of intensity as a function of the mass-to-charge ratio. (wikipedia.org)
  • A mass spectrum is a type of plot of the ion signal as a function of the mass-to-charge ratio. (wikipedia.org)
  • Jo learns how to obtain a mass spectrum. (chemistryviews.org)
  • Mass spectrometry (MS) is an analytical technique that uses mass-to-charge ( m/z ) ratio to identify compounds in a sample. (sigmaaldrich.com)
  • The Mass Distance Fingerprint is calculated from high accuracy measured peptide masses. (lu.se)
  • Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) is a method that allows the study of protein complexes, in particular chromatin and transcription factor complexes, in a rapid and robust manner by mass spectrometry (MS). The method can be used in parallel with chromatin immunoprecipitation-sequencing (ChIP-seq) experiments to provide information on both the cistrome and interactome for a given protein. (nature.com)
  • This paper describes a method of analyzing arson accelerants using gas chromatography coupled with ion trap mass spectrometry/mass spectrometry (GC/MS/MS). Petrol was investigated as an accelerant. (astm.org)
  • Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. (nature.com)
  • Basic data handling of mass spectrometry data for protein identification, assessment of PTMs and determination of amino acid sequences. (lu.se)
  • Dr. Elizabeth Palavecino is professor of pathology, director of clinical microbiology and co-director of the clinical and translational mass spectrometry center at Wake Forest School of Medicine. (beckmancoulter.com)
  • Manual and automated mass spectrometry acquisition of intact protein and peptide mass determination and determination of peptide sequence information. (lu.se)
  • Mass spectrometry at different levels (intact, middle, peptide) can be a valuable tool, and can now be used in a regulated environment thanks to advances in both hardware and software. (brighttalk.com)
  • Learn how Orbitrap technology has revolutionized mass spectrometry for over a decade. (thermofisher.com)
  • An alternative approach consists in using nanomechanical resonators to determine the mass of individual particles accreting on their surface by measuring the induced frequency shift. (nature.com)
  • One such technology, mass spectrometry, has improved to the point that particles 1,000,000 times the mass of a miniscule hydrogen atom can be weighed. (cmu.edu)
  • The evolution of mass spectrometry has been marked by an ever-increasing number of applications in science and technology. (britannica.com)
  • Forensic Applications of Pyrolysis-Mass Spectrometry (T.O. Munson). (routledge.com)
  • Glycoprotein Denaturing Buffer (containing SDS and DTT) is not compatible with Mass Spectrometry applications, and often times hard to remove from the reaction. (neb.com)
  • Access our extensive collection of mass spectrometry workflows, scientific applications, technical handbooks, webinars and more. (thermofisher.com)
  • Mass spectrometres with different designs and their advantages and shortcomings in different applications will be covered. (lu.se)
  • The course gives an introduction in how to use protein mass spectrometry as a tool in protein science. (lu.se)
  • Mass spectrometry is used in many different fields and is applied to pure samples as well as complex mixtures. (wikipedia.org)
  • Benjamin Bartels and Aleš Svatoš, who heads the Mass Spectrometry Research Group, have therefore adapted the LAESI technique to non-flat surfaces to open up the possibility of performing chemical imaging of samples with pronounced three-dimensional shapes while maintaining the reliability of classical measurements. (labmanager.com)
  • High-resolution mass spectrometry is a powerful tool used at KBI Biopharma for analytical strategies concerning complex samples. (kbibiopharma.com)
  • Samples must be ionized (or charged) before they can be manipulated by electric and magnetic fields within the mass spectrometer. (thermofisher.com)
  • Make an experimental plan for preparing and analyzing protein and peptide samples using mass spectrometry. (lu.se)
  • Plan and execute the best suited sample preparations and mass spectrometry acquisition. (lu.se)
  • A mass spectrometer consists of three components: an ion source, a mass analyzer, and a detector. (wikipedia.org)
  • These functions are coordinated by the following components: the ion source, mass analyzer, detector and software. (thermofisher.com)
  • This mass spectrometer ionizes molecules and then uses an electric field to accelerate them over a certain distance to measure their "mass-to-charge ratio. (cmu.edu)
  • The HCT is a robust and easy to use mass spectrometer. (boisestate.edu)