Lysosome associated membrane glycoproteins. Medical search. Frequent questions

We hypothesized lysosome-associated membrane glycoprotein 1 (LAMP1, CD107a) to be a marker for fratricide in TCR transgenic CD8 + T cells. (oncotarget.com)
Conjugated LAMP1 antibodies are ideal for immunocytochemistry colocalization studies in lysosomes. (rndsystems.com)
Mature human LAMP1 is a 389 amino acid (aa) type I transmembrane glycoprotein. (rndsystems.com)
In addition to elevated surface Lamp1 (lysosome-associated membrane protein 1) expression, we also observed enhanced secretion of lysosomal components-phenotypes that we subsequently observed in C9orf72 loss-of-function macrophages. (elsevierpure.com)

Lysosome-associated membrane glycoproteins (LAMPs) are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. (wikipedia.org)
The purpose of this study was to identify membrane proteins of PMNs, and/or glomerular cells, as additional autoantigenic ANCA targets. (rupress.org)
Using these probes, evidence was provided that gp170/80-110 is identical with human lysosomal-associated membrane protein 2 (h-lamp-2), because both proteins were immunologically cross-reactive and screening of a cDNA expression library from human promyelocytic leukemia cells with anti-gp130 Ab yielded a clone derived from h-lamp-2. (rupress.org)
We identified a total of 587 glycoproteins, including 1239 glycopeptides, 526 monosaccharide components, and 8326 intact glycopeptides in glycoproteomics, as well as a total of 4496 proteins identified in proteomic analysis. (frontiersin.org)
Glycosylation is an important post-translational modification of proteins, and glycoproteins are widely involved in various important cellular biological processes and diseases ( 1 ). (frontiersin.org)
Exocytosis has vesicles that contain lipids and proteins combine with the cell membrane, which has the effect of increasing the overall size of the cell. (databasefootball.com)
Endocytosis serves the opposite function, removing proteins and lipids from the cell membrane and bringing them into the interior of the cell, decreasing the size of the cell membrane and the cell itself. (databasefootball.com)
There are different kinds of proteins associated with the cell membrane. (databasefootball.com)
Integral membrane proteins are those which are part of the membrane itself and are capable of passing through the membrane. (databasefootball.com)
The peripheral membrane proteins are only linked to the membrane through interactions with different proteins, they are exterior and not part of the membrane itself. (databasefootball.com)
Glycoproteins are proteins that have a carbohydrate chain linked to them, and they assist cells in communicating with other cells and transporting molecules across the cell membrane. (databasefootball.com)
Transport proteins, as the name implies, are responsible for transporting molecules through the cell membranes and into the body of the cell through the process of facilitated diffusion. (databasefootball.com)
The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. (neobiotechnologies.com)

Niemann-Pick C1 protein (NPC1) is a late-endosomal membrane protein involved in trafficking of LDL-derived cholesterol, Niemann-Pick disease type C, and Ebola virus infection. (duke.edu)
A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis: the lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells. (rupress.org)
When membrane protein fractions were prepared from PMNs and isolated human glomeruli, and immunoblotted with ANCA sera of NCGN patients, two bands with apparent molecular masses of 170 and 80-110 kD (gp170/80-110) were labeled in PMNs, and a 130-kD glycoprotein (gp130) in glomeruli. (rupress.org)
The p41 protein binds to proteases called cathepsins, preventing the enzymes from cleaving the Ebola glycoprotein, thus stopping the fusion of the virus with the endosome and the release of the viral genome into the cell, the team demonstrated. (the-scientist.com)
These charged residues of trans-membrane protein are always in the cytosol. (tu-muenchen.de)
The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. (icbinhibitor.com)
It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. (icbinhibitor.com)
Uvomorulin, lysosome-associated membrane protein-1 (LAMP-1), and laminin were recognized by surface GalTase and are, therefore, potential components in GalTase-specific adhesions. (tmc.edu)
The H4A3 monoclonal antibody specifically binds to CD107a which is also known as Lysosomal-associated membrane protein 1 (LAMP-1). (bdbiosciences.com)
LAMP-1 is a ~110 kDa type I transmembrane protein that is heavily glycosylated and widely expressed by cells primarily on the luminal surface of their lysosomes. (bdbiosciences.com)
Enzymes in the Golgi cisterna chemically modify protein molecules, creating glycoproteins by binding carbohydrate molecules. (doctor-dr.com)
Golgi vesicles may also house specific protein and glycoprotein molecules, which integrate into the plasma membrane gradually. (doctor-dr.com)
The primary defect in Dubin-Johnson syndrome is a mutation in an apical canalicular membrane protein responsible for the excretion of bilirubin and other nonbile salt organic anions. (medscape.com)

Secondary lysosomes were separated from endosomes and plasma membrane on self-forming Percoll density gradients. (rupress.org)
Electron microscopy showed that, in cells expressing p41 , the glycoprotein remained trapped inside the endosomes that housed the engineered viruses after they were internalized by the cell. (the-scientist.com)

Horseradish peroxidase, taken up by fluid-phase pinocytosis, served as a vesicle contents marker to monitor transfer of endosomal contents into secondary lysosomes. (rupress.org)
It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. (icbinhibitor.com)
Storch S, Pohl S, Quitsch A, Falley K, Braulke T. C-terminal prenylation of the CLN3 membrane glycoprotein is required for efficient endosomal sorting to lysosomes. (ac.ir)
These CD38-containing vesicles, likely of endosomal origin, appear to be proximal to lysosomes but not co-localized with them. (ox.ac.uk)
Here we show that, under various conditions that cause injury to the lysosome membrane, components of the endosomal sorting complex required for transport (ESCRT) machinery are recruited. (biorxiv.org)

Background: This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. (icbinhibitor.com)

In yeast it (gene PHO8) is found in lysosome-like vacuoles and in mammals, it is a glycoprotein attached to the membrane by a GPI-anchor. (expasy.org)
Examples of organelles with their own membranes include vacuoles, lysosomes , and the Golgi apparatus. (databasefootball.com)
Vacuoles and lysosomes use a membrane to encase a variety of different substances for transport or, in the case of the lysosome, elimination. (databasefootball.com)

It is expressed in lysosomal and plasma membranes of macrophages, NK and T-cells, and with LAMP2, is essential for the formation of phagolysosomes. (rndsystems.com)
LAMP2 is a member of a family of membrane glycoproteins. (nsjbio.com)

Gp170/80-110 was localized primarily in granule membranes of resting PMNs, and was translocated to the cell surfaces by activation with FMLP. (rupress.org)
It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. (neobiotechnologies.com)

We conclude that the cell is equipped with an endogenous mechanism for lysosome repair which protects against lysosomal damage-induced cell death but which also provides a potential advantage for intracellular pathogens. (biorxiv.org)
CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. (neobiotechnologies.com)

Such lysosomes are therefore engulfed by autophagic membranes in the process known as lysophagy, which is initiated by recognition of luminal glycoprotein domains by cytosolic lectins such as Galectin-3. (biorxiv.org)

Specificity: This antibody recognizes a glycoprotein of 110kDa, which is identified as CD68. (icbinhibitor.com)

A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. (wakehealth.edu)

also CD107a) is a 100‑130 kDa member of the LAMP family of glycoproteins. (rndsystems.com)

Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. (umassmed.edu)

The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. (neobiotechnologies.com)
Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein. (bdbiosciences.com)
Recombinant Platelet Membrane Glycoprotein IV (GP4) The exact identification of the HIV-1 envelope glycoprotein (Env) liable for productive medical an infection might be instrumental in elucidating the molecular foundation of HIV-1 transmission and in designing efficient vaccines. (sirp-a.com)

This glycoprotein provides selectins with carbohydrate ligands. (nsjbio.com)
Glycolipids are found on the surface of the cell membrane, and they have carbohydrate sugars attached to them. (databasefootball.com)

A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation. (stanford.edu)
The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells. (ox.ac.uk)

A molecule is bundled in a membrane secretory vesicle that migrates to the cell's surface and "pops open" to release its contents into the environment outside the cell when it is ready to go. (doctor-dr.com)

GalTase-based adhesions are formed by recognition and binding to terminal N-acetylglucosamine (GlcNAc) residues on its glycoprotein counterpart on adjacent cell surfaces. (tmc.edu)

Radioactive galactose, covalently bound to cell surface glycoconjugates on mouse macrophage cells, P388D1, was used as a membrane marker to study the composition, and the kinetics of exchange, of plasma membrane-derived constituents in the membrane of secondary lysosomes. (rupress.org)
Besides, lysosome-associated membrane glycoprotein 2 emerge as a new RBCs marker with diagnostic and prognostic potential for metastatic BC patients. (selectbiosciences.com)

The subcellular distribution of the CI-MPR was also altered in CLN3 cells, since it accumulated within the Trans-Golgi network (TGN) and did not progress into the lysosomes. (ac.ir)
The Golgi apparatus is a membrane organelle located near the nucleus, consisting of stacked cisternae or sacs. (doctor-dr.com)
Lysosomes contain membrane walls and are vesicles that detach from the Golgi apparatus. (doctor-dr.com)

A component of the lipids in animal cells is cholesterol, which is dispersed in between the phospholipids and parts of the membrane. (databasefootball.com)
The cholesterol helps hold the cell membrane together and prevent the membrane from becoming too stiff by limiting how closely the lipids can be to one another. (databasefootball.com)
Smooth ER also produces membrane lipids that are incorporated into the cell membrane. (doctor-dr.com)

Synthesis and recognition of the consociate glycoprotein component was next investigated. (tmc.edu)
We have determined in F9 cells that dissociating GalTase adhesion by galactosylation of and release of the consociate glycoproteins induces differentiation, as defined by increased laminin synthesis. (tmc.edu)
Vitamin A helps maintain epithelial tissues and is important for lysosome stability and glycoprotein synthesis. (msdmanuals.com)

Nevertheless, even more lately, a defensive function of PrPC provides been hypothesized in Testosterone levels lymphocytes under oxidative tension (Aude-Garcia oxidase (COX-IV), lysosome-associated membrane layer glycoprotein (Light fixture-1), transferrin receptor (Compact disc71), and the endoplasmic reticulum (Er selvf?lgelig)/mitochondria-associated mem-brane (MAM)Cassociated glycoprotein calnexin (Body 3D). (liveconscience.com)

After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. (umassmed.edu)

As analyzed by NaDodSO4 PAGE, labeled molecules of Mr 160-190 kD were depleted and of Mr 100-120 kD were enriched in lysosome membrane compared with the relative composition of label on the cell surface. (rupress.org)

A molecular understanding of membrane traffic has broad implications for our understanding of growth control in cancer, receptor trafficking errors in heart disease, regulation of insulin secretion in diabetes and synaptic vesicle biogenesis and transport in neurological disorders. (stanford.edu)
This particle recognizes the N-terminal signal-sequence of the nascent polypeptide chain and then transports it to the ER membrane where the complex, consisting of SRP, polypeptide chain and ribosome, is recognized by the ER membrane bound signal recognition particle receptor (SR). After this recognition the polypeptide chain is imported into the ER lumen via the SEC channel in an ATP dependent process. (tu-muenchen.de)
We also analysed the machinery responsible for lysosomal hydrolase transport to the lysosome and found increased stability of CIMPR, a major receptor implicated in the transport of hydrolases. (ac.ir)
They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. (umassmed.edu)
Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. (umassmed.edu)

Dystrophin-glycoprotein complex bridges the inner cytoskeleton (F-actin) and the basal lamina. (medscape.com)
The cell membrane also serves as an anchor point for the cytoskeleton of the cell in some organisms, and it attaches to the cell wall in plant cells. (databasefootball.com)
Cytoskeleton Minoxidil condition as a must for PrPC P4HB trafficking On the basis of prior function helping the crucial function of microtubular network condition in number element trafficking throughout the cell cytoplasm (Sorice at 4C for 10 minutes to precipitate the large membrane layer fractions (overflowing in mitochondria). (liveconscience.com)

Vesicles pinch off from the last cisterna and move to the plasma membrane for secretion, releasing their contents outside the cell. (doctor-dr.com)

By contrast, gp130 was localized in the surface membranes of endothelial cells of human glomerular and renal interstitial capillaries, rather than in lysosomes, as found for h-lamp-2. (rupress.org)
In addition, cell surface EGFR levels and recycling to the cell membrane were increased. (ac.ir)
Prion disease is certainly apparently credited to the transformation of a regular cell surface area glycoprotein (PrPC) into a conformationally changed isoform (PrPSc) that is certainly contagious in the lack of nucleic acidity. (liveconscience.com)
Surface GalTase recognized several surface glycoproteins in a pattern that changes with differentiation. (tmc.edu)
Sawada R, Lowe JB, Fukuda M. E-selectin-dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels. (bdbiosciences.com)
A structural classification of the variant surface glycoproteins of the African trypanosome. (wroc.pl)

It may also function in the protection, maintenance, and adhesion of the lysosome. (nsjbio.com)

After adding these transposons to flasks of human cells, Bruchez introduced viruses engineered to express an Ebola glycoprotein, killing most of the cells. (the-scientist.com)
When the cells are exposed to an Ebola-mimicking virus, the p41-bound cathepsins are unable to cleave off the virus's glycoprotein, stopping it from fusing with the membrane and thus trapping it inside the endosome. (the-scientist.com)
One isoform in particular, p41 , could keep CD74 knockout cells alive in the face of the virus with the Ebola glycoprotein. (the-scientist.com)
Moreover, we identify a distinct, N-terminal, higher affinity interaction interface between LRRK2 phosphorylated Rab8 and Rab10 termed 'Site #2', that can retain LRRK2 on membranes in cells to catalyze multiple, subsequent phosphorylation events. (stanford.edu)
Furthermore, CD38 expression in CD38-deficient pancreatic AR42J cells remodels Ca(2+)-signaling pathways in these cells by restoring Ca(2+) mobilization from lysosomes during CCK-induced Ca(2+) signaling. (ox.ac.uk)
Cholesterol isn't a part of the cell membrane in plant cells , only animal cells. (databasefootball.com)

Concurrently, the fraction of plasma membrane-derived label in secondary lysosomes increased by first order kinetics (k = [56 min]-1) from less than 0.1% (background level) to a steady-state level of approximately 2.5% of the total label. (rupress.org)

Interference with ESCRT recruitment abolishes lysosome repair and causes otherwise reversible lysosome damage to become cell lethal. (biorxiv.org)

Although the cell membrane is the most well-known membrane in a cell, some of the organelles found within a cell also have their own respective membranes. (databasefootball.com)

Cathepsin B in numerous human disease mechanisms involves its translocation from acidic lysosomes of pH 4.6 to neutral pH 7.2 of cellular locations, including the cytosol and extracellular environment. (bvsalud.org)

Limited and selective transfer of plasma membrane glycoproteins to membrane of secondary lysosomes. (rupress.org)
The results indicate that endocytosis-derived transfer of plasma membrane constituents to secondary lysosomes is a limited and selective process, and that only approximately 1% of internalized membrane is recycled via a membrane pool of secondary lysosomes. (rupress.org)
Pieces of the ER periodically separate and add to other membrane-bound organelles, including the plasma membrane. (doctor-dr.com)
The molecular makeup of the plasma membrane and the membrane that forms the walls of the ER is almost identical. (doctor-dr.com)
and the PLASMA MEMBRANE . (nih.gov)

The cell membrane is a thin membrane that encases the cytoplasm of the cell , and holds the cytoplasm (as well as the cell's organelles) within it, separating the interior of the cell from the outside environment. (databasefootball.com)
To make their research easier, they have been split into the membrane organelles and the nonmembranous organelles, two major types. (doctor-dr.com)
The term "membranous organelles" refers to organelles that are specialist sacs or canals made of cell membrane. (doctor-dr.com)
Instead of membrane, the nonmembranous organelles are made of microscopic filaments or other nonmembranous materials. (doctor-dr.com)

These glycoproteins are widely involved in important biological processes, such as antigen presentation, cytokine production and glycosylation progression. (frontiersin.org)

Specific staining was localized to lysosomes. (rndsystems.com)

CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. (neobiotechnologies.com)

Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. (bdbiosciences.com)

Type 1 requires an N-terminal signal sequence and an intrinsic stop transfer anchor sequence which will be the part which is inserted in the membrane. (tu-muenchen.de)

Anatomy43

Organisms16

Diseases4

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes45

Disciplines and Occupations3

Technology, Industry, Agriculture6

Information Science4

Health Care1

LAMP14

Proteins13

Protein13

Endosomes2

Endosomal5

Transmembrane glycoprotein1

Vacuoles3

LAMP22

Granule membranes2

Intracellular2

Luminal1

Antibody1

Primarily1

CD107a1

Endogenous1

Platelet3

Carbohydrate2

Activation2

Molecule1

Residues1

Marker2

Golgi3

Lipids3

Synthesis3

Lymphocytes1

Degradation1

Molecules1

Receptor5

Cytoskeleton3

Secretion1

Surface6

Adhesion1

Cells6

Fraction1

Recruitment1

Found1

Human1

Plasma5

Organelles4

Biological1

Specific1

Member1

Mouse1

Type1