The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. (wikipedia.org)
NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts. (ox.ac.uk)
Does not cross-react with TNF-beta, lymphotoxin and receptor bound TNF-alpha. (lsbio.com)
Human Lymphotoxin beta receptor (L Tbeta R, TNFRSF3) is a member of the TNF receptor superfamily with similarilty to CD120a(TNFR1) and CD120b(TNFR2). (ancell.com)
By employing single-cell transcriptomics, endothelial fate mapping, and functional multiplex immune profiling, we demonstrate that antiangiogenic immune-modulating therapies evoke transdifferentiation of postcapillary venules into inflamed high-endothelial venules (HEVs) via lymphotoxin/lymphotoxin beta receptor (LT/LTβR) signaling. (utu.fi)
The lymphotoxin beta receptor (LTβR) belongs to the TNF receptor superfamily and is essential for the organogenesis of secondary lymphoid organs as well as the coordination of an effective immune response against invading pathogens. (sfi-dgfi-2023.fr)
Tumor necros3
Lymphotoxin-beta (LT-beta) also known as tumor necrosis factor C (TNF-C) is a protein that in humans is encoded by the LTB gene. (wikipedia.org)
Lymphotoxin-alpha (LT-α) or tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the LTA gene . (wikidoc.org)
Lymphotoxin alpha, a member of the tumor necrosis factor family , is a cytokine produced by lymphocytes . (wikidoc.org)
However, these studies utilized mice with complete LTα gene deficiency that did not allow to distinguish effects of soluble versus membrane-associated LT. LTB has been shown to interact with Lymphotoxin alpha. (wikipedia.org)
Association of tumor necrosis factors-beta gene polymorphism with endometriosis in women in Guangdong Province]. (cdc.gov)
Effect of gene polymorphism of TNF-beta on the concentration of TNF in serum of patient with endometriosis]. (cdc.gov)
Lymphocytes1
TNF-beta, or lymphotoxin, is produced by lymphocytes. (medscape.com)
Membrane1
Lymphotoxin beta is a type II membrane protein of the TNF family. (wikipedia.org)
Serum4
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Lymphotoxin Beta (LTb) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. (hudsen.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Lymphotoxin Beta (LTb) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. (hudsen.org)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Lymphotoxin Beta (LTb) in samples from serum, plasma, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (hudsen.org)
Description: A sandwich ELISA kit for detection of Lymphotoxin Beta from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (hudsen.org)
Using an adenoviral vector encoding kinase-deficient NIK, we have investigated the role of NIK in LPS, IL-1, TNF-alpha, and lymphotoxin (LT) betaR signaling in primary human cells and TNF-alpha expression from rheumatoid tissue. (ox.ac.uk)
Histological changes in the trachea were accompanied by increased mRNA expression of interleukin (IL)-4, tumour necrosis factor alpha, lymphotoxin beta, lymphotactin and Rantes, as well as TDI-specific IgG antibodies and elevated levels of total IgE. (cdc.gov)
Lymphotoxin-beta (LT-beta) also known as tumor necrosis factor C (TNF-C) is a protein that in humans is encoded by the LTB gene. (wikipedia.org)
Using reverse transcriptase polymerase chain reaction (RT-PCR) analysis of the tumor, we found elevated levels of IL-6 mRNA as expected, but also elevated levels of tumor necrosis factor beta (TNF-beta) and gamma interferon (gamma-IFN) mRNA. (nih.gov)
Association between lymphotoxin-(alpha) (tumor necrosis factor-(beta)) intron polymorphism and predisposition to severe sepsis is modified by gender and age. (ajbm.net)
TNF alpha is closely related to the 25kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. (nsjbio.com)
The human tumor necrosis factor locus (TNF locus) is located within the major histocompatibility complex between the class III genes and HLA-B. We recently characterized and studied two closely linked highly informative dinucleotide repeats (AC/GT)n (designated TNFa) and (TC/GA)k (designated TNFb) in the upstream region of the human TNF-beta (lymphotoxin) gene. (ox.ac.uk)
Superfamily1
The non-canonical pathway is triggered by particular members of the TNFR superfamily, such as lymphotoxin-beta (LT-beta) or BAFF. (uni-freiburg.de)
Protein3
Lymphotoxin beta is a type II membrane protein of the TNF family. (wikipedia.org)
Human Beta-Tubulin 3 is a 50,432 dalton structural protein (450 amino acid) expressed in neurons of the PNS and CNS. (aveslabs.com)
Cytokines1
Because these cytokines are mediators of immune regulation and inflammation, we propose that TNF-beta and gamma-IFN also play an important role in the pathophysiology of Castleman's disease. (nih.gov)
Tumour3
Histological changes in the trachea were accompanied by increased mRNA expression of interleukin (IL)-4, tumour necrosis factor alpha, lymphotoxin beta, lymphotactin and Rantes, as well as TDI-specific IgG antibodies and elevated levels of total IgE. (cdc.gov)
HLA class II induction in human islet cells by interferon-gamma plus tumour necrosis factor or lymphotoxin. (ox.ac.uk)
The cytotoxins tumour necrosis factor (TNF) and lymphotoxin (LT) synergize with IFN-gamma in a number of activities. (ox.ac.uk)
Antibody1
Bulk Order Inquiry for Anti-Beta-Tubulin 3 Antibody ------- (please add any order requirements, including desired quantity, timing, etc. (aveslabs.com)
Intron1
Here, we combine these four markers together with a biallelic TC/GA repeat in the first intron of the TNF-beta gene (TNFc) and a biallelic NcoI RFLP (TNFn) to type 105 cell lines from the American Society of Histocompatibility and Immunogenetics Workshop and the Center for Human Polymorphism Studies reference panels of HLA typing cell lines. (ox.ac.uk)
Antigens1
In type I diabetes, islet beta cells, the target of the autoimmune process, selectively express class II antigens. (ox.ac.uk)
Gamma1
But in contrast to most other cell types, islet beta cells are not stimulated to express class II by interferon-gamma (IFN-gamma) and thus the conditions under which this induction occurs have been particularly elusive. (ox.ac.uk)
Member1
Lymphotoxin (LT)-α, a member of the TNF family, is recognized as an important mediator in different aspects of lymphoid organ development. (edu.au)
Regulation1
7. RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF. (nih.gov)
Human1
16. Pociot F, Molvig J, Wogensen L, Worsaae H, Nerup J. A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro . (ajbm.net)
Inflammatory1
Lymphotoxin-α (LTA) is a cytokine involved in inflammatory reactions. (edu.pl)