• Solid Tumors
  • Clinical response is assessed by the Response Criteria in Solid Tumors (RECIST) v1.0. (clinicaltrials.gov)
  • Ascitic fluid was frozen at −20°C. Solid tumors were mechanically dissociated and either passed through a 0.1-mm sieve before cryopreservation in 10% DMSO/3.6% HS or incubated for 2 to 3 hours in culture medium supplemented with 0.14 units/mL Liberase Blendzymes (Roche). (aacrjournals.org)
  • While angiogenesis can reduce this affect, the partial pressure of oxygen is below 5 mm Hg (venous blood has a partial pressure of oxygen at 40 mm Hg) in more than 50% of locally advanced solid tumors. (wikipedia.org)
  • ovarian
  • Methods A large collection of primary ovarian tumors (HGSC, endometrioid, mucinous and clear cell) was analyzed by immunohistochemistry for the presence of TIL expressing CD103. (aacrjournals.org)
  • patients
  • Surgery: If the patients meet all of the requirements for the study they will undergo surgery to remove a tumor that can be used to grow the TIL product. (clinicaltrials.gov)
  • Follow up: Patients will return to the clinic for a physical exam, review of side effects, lab tests, and scans about every 1-3 months for the first year, and then every 6 months to 1 year as long as their tumors are shrinking. (clinicaltrials.gov)
  • We investigated the relationship between RCAS1 expression, density of tumor-infiltrating lymphocytes (TIL), and clinicopathological findings in 129 patients with T3 gastric carcinoma who underwent curative surgery. (springer.com)
  • This phase II trial studies how well tumor-infiltrating lymphocytes (TIL) after combination chemotherapy works in treating patients with melanoma that has spread to other places in the body. (clinicaltrials.gov)
  • Prior to TIL treatment, patients are given nonmyeloablative chemotherapy to deplete native lymphocytes that can inhibit the response. (wikipedia.org)
  • Tumor reduction of 50% or more was observed in about half of patients. (wikipedia.org)
  • Some patients experienced complete responses with no detectable tumor remaining years after treatment. (wikipedia.org)
  • Our findings indicate that CD8+ tumor-infiltrating lymphocyte density and programmed cell death 1 ligand 1 expression may serve as valuable predictive biomarkers in patients with papillary thyroid cancer. (ovid.com)
  • In patients with advanced cancer, tumors progress despite the presence of tumor-infiltrating lymphocytes (TIL). (aacrjournals.org)
  • Patients' tumors that were PD-L1 positive at baseline showed a significant decrease in PD-L1 expression at PROG ( P = 0.028), whereas patients' tumors that were PD-L1 negative at baseline showed a significant increase in PD-L1 expression at PROG ( P = 0.008) irrespective of treatment with BRAFi or Combi. (aacrjournals.org)
  • BRAFi-treated patients showed significant increases in CD4 + , CD8 + , and PD-1 + lymphocytes from PRE to EDT ( P = 0.001, P = 0.001, P = 0.017, respectively), and Combi-treated patients showed similar increases in CD4 + and CD8 + lymphocytes from PRE to EDT ( P = 0.017, P = 0.021). (aacrjournals.org)
  • These findings suggest that in ER-negative disease, the survival benefits of adjuvant therapy may be restricted to patients with poor tumor-specific immune responses. (aacrjournals.org)
  • CRS-207, a live-attenuated, double-deleted Listeria monocytogene engineered to express the tumor-associated antigen mesothelin, was administered with chemotherapy to 38 patients with MPM. (cancercommons.org)
  • lymph
  • The extent of disease is described in the standard cancer staging system, using the AJCC TNM system, based on the T stage (size and extent of tumour), N stage (extent of involvement of regional lymph nodes) and M stage (whether there is spread of the disease outside the region or not), and combined into an overall stage from I-IV. (wikipedia.org)
  • immunity
  • These data raise the possibility of an in situ T-cell immunostimulation in order to reactivate the Th1/Tc1 lymphocytes and to improve the intraocular anti-tumoral immunity. (arvojournals.org)
  • blood vessels
  • This tissue is not vascularized, which prevents tumors from growing greater than 2mm in diameter without inducing new blood vessels. (wikipedia.org)
  • These chemokines play an important role in promoting tumor death by blocking the formation of new blood vessels. (wikipedia.org)
  • 1988
  • Cases were registered by the Manitoba Breast Tumor Bank during the years 1988 to 2000 and had a minimum follow-up of 36 months. (aacrjournals.org)
  • recognize
  • In other instances, the normal peptide is presented at the cell surface and consequently the T lymphocytes that recognize the antigen have been eliminated by the central tolerance process that occurs in the thymus. (wikipedia.org)
  • cultures
  • Experimental Design:We used an agonistic anti-4-1BB antibody added during the initial tumor fragment cultures to provide in situ 4-1BB co-stimulation. (aacrjournals.org)
  • Phase
  • In the second phase, newly synthesized IFN-gamma induces tumor death (to a limited amount) as well as promoting the production of chemokines CXCL10, CXCL9 and CXCL11. (wikipedia.org)
  • Tumor cell variants which have acquired resistance to elimination then enter the escape phase. (wikipedia.org)
  • During the escape phase, tumor cell variants selected in the equilibrium phase have breached the host organism's immune defenses, with various genetic and epigenetic changes conferring further resistance to immune detection. (wikipedia.org)
  • fragments
  • Results: Addition of an agonistic anti-4-1BB antibody could activate 4-1BB signaling within early cultured tumor fragments and accelerated the rate of memory CD8+ TIL outgrowth that were highly enriched for melanoma antigen specificity. (aacrjournals.org)