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  • active
  • An active immune environment within the tumor often indicates a better prognosis as can be determined by the Immunological constant of rejection. (wikipedia.org)
  • Solid Tumors
  • Clinical response is assessed by the Response Criteria in Solid Tumors (RECIST) v1.0. (clinicaltrials.gov)
  • While angiogenesis can reduce this affect, the partial pressure of oxygen is below 5 mm Hg (venous blood has a partial pressure of oxygen at 40 mm Hg) in more than 50% of locally advanced solid tumors. (wikipedia.org)
  • vitro
  • Description of T cell growth factor interleukin-2 (IL-2) in 1976 allowed T lymphocytes to be grown in vitro, often without loss of effector functions. (wikipedia.org)
  • patients
  • Surgery: If the patients meet all of the requirements for the study they will undergo surgery to remove a tumor that can be used to grow the TIL product. (clinicaltrials.gov)
  • Follow up: Patients will return to the clinic for a physical exam, review of side effects, lab tests, and scans about every 1-3 months for the first year, and then every 6 months to 1 year as long as their tumors are shrinking. (clinicaltrials.gov)
  • We investigated the relationship between RCAS1 expression, density of tumor-infiltrating lymphocytes (TIL), and clinicopathological findings in 129 patients with T3 gastric carcinoma who underwent curative surgery. (springer.com)
  • Prior to TIL treatment, patients are given nonmyeloablative chemotherapy to deplete native lymphocytes that can inhibit the response. (wikipedia.org)
  • Tumor reduction of 50% or more was observed in about half of patients. (wikipedia.org)
  • Some patients experienced complete responses with no detectable tumor remaining years after treatment. (wikipedia.org)
  • Phase
  • In the second phase, newly synthesized IFN-gamma induces tumor death (to a limited amount) as well as promoting the production of chemokines CXCL10, CXCL9 and CXCL11. (wikipedia.org)
  • Tumor cell variants which have acquired resistance to elimination then enter the escape phase. (wikipedia.org)
  • During the escape phase, tumor cell variants selected in the equilibrium phase have breached the host organism's immune defenses, with various genetic and epigenetic changes conferring further resistance to immune detection. (wikipedia.org)
  • blood vessels
  • This tissue is not vascularized, which prevents tumors from growing greater than 2mm in diameter without inducing new blood vessels. (wikipedia.org)
  • These chemokines play an important role in promoting tumor death by blocking the formation of new blood vessels. (wikipedia.org)
  • recognize
  • In other instances, the normal peptide is presented at the cell surface and consequently the T lymphocytes that recognize the antigen have been eliminated by the central tolerance process that occurs in the thymus. (wikipedia.org)
  • receptor
  • Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, Fitz LJ, Malenkovich N, Okazaki T, Byrne MC et al (2000) Engagement of the Pd-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. (springer.com)
  • prognosis
  • The TIL mileau has been demonstrated tobe associated with better prognosis, more chemosensitivity, and more cases of optimal residual tumor achievedduring primary cytoreduction. (waocp.org)
  • lymph
  • These cancer characteristics are described as the size of the tumor (T), whether or not the tumor has spread to the lymph nodes (N) in the armpits, neck, and inside the chest, and whether the tumor has metastasized (M) (i.e. spread to a more distant part of the body). (wikipedia.org)
  • melanoma patients
  • The recent young-TIL approach, in which TIL are minimally cultured in vitro, not selected for tumor recognition, before rapid expansion and infusion to metastatic melanoma patients, has lead to objective response rates comparable to previous trials relying on TIL screened for tumor recognition, with no added toxicities. (clinicaltrials.gov)
  • Patients
  • Patients exhibit an increase in the production of both CD4+ and CD8+ T-lymphocytes. (hindawi.com)
  • Importantly, survival was improved in MCC patients whose tumors had higher vascular E-selectin expression. (blogspot.com)
  • Surgery: If the patients meet all of the requirements for the study they will undergo surgery to remove a tumor that can be used to grow the TIL product. (clinicaltrials.gov)
  • Follow up: Patients will return to the clinic for a physical exam, review of side effects, lab tests, and scans about every 1-3 months for the first year, and then every 6 months to 1 year as long as their tumors are shrinking. (clinicaltrials.gov)
  • An objective tumor response was observed in 2 of the 5 patients treated and one other patient had stable disease following treatment. (oncolink.org)
  • destruction
  • Advancing infection is accompanied by further CD4+ T-lymphocyte destruction and worsening of the immune status. (hindawi.com)
  • In secondary cicatricial alopecias, destruction of the hair follicle is incidental to a non-follicle-directed process or external injury, such as severe infections, burns, radiation, tumors, or traction. (wikipedia.org)
  • occurs
  • In other instances, the normal peptide is presented at the cell surface and consequently the T lymphocytes that recognize the antigen have been eliminated by the central tolerance process that occurs in the thymus. (wikipedia.org)
  • data
  • These data suggest that one mechanism of immune evasion in MCC may be restriction of T cell entry into the tumor. (blogspot.com)
  • Based on the mass cytometry data, they model and analyze how complex cell phenotypes in tumors are controlled, with the hope that this will enable targeted modulation that interferes with tumor development. (fluidigm.com)
  • Analysis of the macrophage population and signaling in a tumor may provide useful clinical data. (wikipedia.org)
  • involves
  • The company's patented technology involves utilization of oncolytic viruses for enhancement of tumor T-cell therapy. (cbinsights.com)
  • type
  • The major categories are the histopathological type, the grade of the tumor, the stage of the tumor, and the expression of proteins and genes. (wikipedia.org)
  • classical
  • There are two major types of Hodgkin lymphoma: classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. (wikipedia.org)
  • Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testicle or, more rarely, the mediastinum or other extra-gonadal locations. (wikipedia.org)
  • analysis
  • Active surveillance consists of periodic history and physical examinations, tumor marker analysis, and radiographic imaging. (wikipedia.org)
  • cases
  • MALT lymphoma may be difficult to distinguish from reactive infiltrates, and in some cases, multiple endoscopies are required before a confident diagnosis is reached. (wikipedia.org)