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  • interaction
  • Flow cell experiments demonstrated a specific rolling interaction of I-GPI cells on bilayers containing purified full length ICAM-1 or ICAM-3. (ox.ac.uk)
  • This suggests that the I domain acts as a transient, Mg2+-dependent binding module that cooperates with another Mn2+-stimulated site in LFA-1 to give rise to the stable interaction of intact LFA-1 with ICAM-1. (ox.ac.uk)
  • cells
  • I-GPI cells bound soluble ICAM-1 (sICAM-1) with a low avidity and affinity. (ox.ac.uk)
  • The LFA-1 activating antibody MEM-83, or its Fab fragment, decreased the rolling velocity of I-GPI cells on ICAM-1-containing membranes. (ox.ac.uk)

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  • chemokine
  • Here, we used intravital microscopy of murine PLNs to study the role of thymus-derived chemotactic agent (TCA)-4 (secondary lymphoid tissue chemokine, 6Ckine, Exodus-2) in homing of adoptively transferred T cells from T-GFP mice, a transgenic strain that expresses green fluorescent protein (GFP) selectively in naive T lymphocytes (T(GFP) cells). (nih.gov)
  • He identified the human lymphocyte function-associated antigens 1-3, immunomodulatory HLA derived peptides (AllotrapTM), chemokine RANTES (CCL5), proinflammatrory and cytotoxic molecule granulysin (GNLY) and the transcription factor Kruppel-like factor 13 (KLF13). (wikipedia.org)
  • antibody
  • These uncontrolled human studies suggested that administration of this anti-LFA-1 antibody to HIV-1 infected individuals could provide a modest benefit by decreasing circulating HIV-1 RNA and increasing CD4+ T cell counts. (harvard.edu)
  • Conclusions: These results suggest that one possible mechanism of action of this anti-LFA-1 antibody is to inhibit HIV-1 replication via the production of a soluble antiviral factor that is induced upon binding to cells. (harvard.edu)
  • The LFA-1 activating antibody MEM-83, or its Fab fragment, decreased the rolling velocity of I-GPI cells on ICAM-1-containing membranes. (ox.ac.uk)
  • mechanism
  • Defining the mechanism for how these proteins function within a given pathway is important in understanding the integration and communication of signalling networks with one another. (biochemj.org)
  • Tumor
  • Development of clickable monophosphoryl lipid As towards semi-synthetic conjugates with tumor-associated carbohydrate antigens. (bioportfolio.com)
  • immunology
  • Play media In immunology, an immunological synapse (or immune synapse) is the interface between an antigen-presenting cell or target cell and a lymphocyte such as an effector T cell or Natural Killer cell. (wikipedia.org)
  • cell
  • Background: Lymphocyte Function-Associated Antigen-1 (LFA-1) likely plays a role in the pathogenesis of against HIV-1 and is known to facilitate cell-to-cell transmission of the virus. (harvard.edu)
  • Studies on the role of lymphocyte function-associated antigen 1 (LFA-1) in T cell activation. (semanticscholar.org)
  • 2 h after intracutaneous injection, luminal presentation of TCA-4 was detectable in a subset of HEVs, and LFA-1-mediated T(GFP) cell adhesion was restored in these vessels. (nih.gov)
  • Digitized QuickTime™ videos showing characteristic scenes from intravital microscopy experiments of TGFP cell behavior and TCA-4 staining in wild-type and plt/plt mice are available at http://www.jem.org/cgi/content/full/191/1/61/DC1 (see legends to Fig. 2, Fig. 4, Fig. 6, and Fig. 7). (nih.gov)
  • A). TNFα, measured by ELISA, present in supernatant of NK cells cultured for 6d+IL2 in medium alone (medium) or solvent of fluvastatin (solvent) or with fluvastatin (10-1.0-0.1 µM) and incubated with K562 HLAI− target cells, at the NK:target cell ratio of 2∶1. (nih.gov)
  • His research encompasses the cell adhesion molecules and chemotactic signals involved in lymphocyte migration in health and disease. (wikipedia.org)
  • Daniel M. Davis and Jack Strominger showed structured immune synapses for a different lymphocyte, the Natural Killer cell, and published this around the same time. (wikipedia.org)
  • 174: 1: 277-83 Butcher EC, "Innovation: Can cell systems biology rescue drug discovery? (wikipedia.org)
  • cytokines
  • We determined that this soluble factor was not any of the cytokines or chemokines with known anti-HIV-1 activity. (harvard.edu)
  • constitutively
  • TCA-4 was constitutively presented on the luminal surface of HEVs, where it was required for LFA-1 activation on rolling T(GFP) cells. (nih.gov)
  • Autoimmune
  • Human endocrine thyroid epithelial cells (TEC) from autoimmune thyroiditis which express HLA Class II antigens have been shown to present autoantigens to T cells for a TEC-specific immune response. (ox.ac.uk)
  • Both ICAM-1 and LFA-3 were highly expressed in the autoimmune diseases, but not in non-toxic goitre. (ox.ac.uk)
  • To this end, they are studying the specialized homing mechanisms and functional properties of tissue infiltrating lymphocytes involved in local immune, autoimmune and regulatory responses in the GI tract (intestines, liver), skin, lungs, and other sites. (wikipedia.org)
  • inhibits
  • Binding to cells does appear to induce the production of a soluble factor that inhibits HIV-1 replication. (harvard.edu)
  • protein
  • TCR ESC proteins, including Lck (lymphocyte-specific kinase), ZAP-70 (ζ-chain-associated protein of 70 kDa), Vav1, LAT (linker for activation of T-cells) and SLP-76 [SH2 (Src homology 2)-domain-containing leukocyte protein of 76 kDa], form a multimolecular signalling complex that ultimately results in the activation of the ERK (extracellular-signal-regulated kinase)/MAPK (mitogen-activated protein kinase) pathway in T-cells. (biochemj.org)
  • All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. (wikipedia.org)
  • activation
  • However, LFA-1 was shed in a ligand-binding conformation, since it expressed KIM-127 and 24 activation epitopes and bound to solid-phase ICAM-1. (ox.ac.uk)
  • Predictive value of Thomsen-Friedenreich antigen activation for Streptococcus pneumoniae infection and severity in pediatric lobar pneumonia. (bioportfolio.com)
  • Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. (semanticscholar.org)
  • We conclude that TCA-4 is both required and sufficient for LFA-1 activation on rolling T cells in PLN HEVs. (nih.gov)
  • surface
  • In ICAM-2 and ICAM-1, the homologous Glu residue is present at the end of β-strand C and lies on a flatter surface on an edge of domain 1. (pnas.org)
  • To study the adhesive properties of the LFA-1 I domain, we stably expressed a GPI-anchored form of this I domain (I-GPI) on the surface of baby hamster kidney cells. (ox.ac.uk)
  • viral
  • When bound to virus prior to infection, there is no decrease in HIV-1 replication, suggesting it does not directly inhibit viral replication via virus binding. (harvard.edu)
  • Viral antigens ‎ (9 t.t. (wikimedia.org)
  • recruitment
  • 34: 8: 1106-14 Sato T, Thorlacius H, Johnston B, Staton TL, Xiang W, Littman DR, Butcher EC "Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver. (wikipedia.org)
  • immune response
  • Immune response to the hepatitis B antigen in the RTS,S/AS01 malaria vaccine, and co-administration with pneumococcal conjugate and rotavirus vaccines in African children: a randomized controlled trial. (bioportfolio.com)
  • ligands
  • These are about 35% identical in sequence to the first two IgSF domains of ICAM-1, ICAM-3, ICAM-4, and ICAM-5, which also function as ligands for LFA-1 ( 1 , 2 ). (pnas.org)
  • murine
  • Here, we based the route of immunization on our observations in murine models of enhanced antigen-specific T-cell proliferation and IFNγ production using intranodal injections when compared with subcutaneous or intravenous routes of immunization ( 10 ). (aacrjournals.org)
  • Tolerogenic DCs have been generated in the presence of 1,25(OH) 2 D 3 , the active form of vitamin D 3 , and of vitamin D 3 analogues from both human blood monocytes and murine bone marrow and shown to induce Treg ( 8 , 9 , 10 ). (jimmunol.org)
  • tumor
  • T-lymphocyte turnover is promoted by the production of interleukin-6, interleukin-1, interleukin-2, and tumor necrosis factor (TNF)- α , all of which promote HIV replication [ 1 ]. (hindawi.com)
  • Patients with evidence of a vaccine-induced, tumor-specific T-cell proliferative or IFNγ response 1 week after vaccination had a markedly better recurrence-free survival (RFS) at 5 years (63% versus 18%, P = 0.037) than nonresponders. (aacrjournals.org)
  • monocytes
  • With the implicit understanding that monocytes and granulocytes represent distinct cell lineages, this chapter reviews laboratory procedures which can be utilized to assess their functions and phenotypes. (asmscience.org)
  • Two-dimensional dot plots illustrating the separation of monocytes and granulocytes (and lymphocytes) by their inherent light-scattering properties (forward-angle light scatter versus right-angle light scatter) (left) or the combination of a light-scattering property (right-angle light scatter) and a specific lineage-defining surface antigen (CD14-PE)(right). (asmscience.org)
  • peptide
  • Supertypes are groups of human leukocyte antigen (HLA) alleles which bind overlapping sets of peptides due to sharing specific residues at the anchor positions-the B and F pockets-of the peptide-binding region (PBR). (springer.com)
  • B and T lymphocytes are tested for their affinity for self MHC/peptide complexes before leaving the primary lymphoid organs and entering into the periphery. (wikipedia.org)
  • bacteria
  • Immunosenescence can also be sometimes envisaged as the result of the continuous challenge of the unavoidable exposure to a variety of antigens such as viruses and bacteria. (wikipedia.org)
  • hepatitis
  • Hepatitis is caused by many factors including alcohol, viruses, drugs, immune injury, and idiopathic factors and has remained a serious human health problem throughout the world [ 1 , 2 ]. (hindawi.com)
  • These are subunit vaccines, consisting of specific protein antigens (such as tetanus or diphtheria toxoid) or recombinant protein components (such as the hepatitis B surface antigen). (wikipedia.org)
  • recombinant
  • Stimulation of 2',5'-oligoadenylate synthetase activity in sheep endometrium during pregnancy, by intrauterine infusion of ovine trophoblast protein-1, and by intramuscular administration of recombinant bovine interferon-alpha I1. (thefreedictionary.com)
  • clinical
  • The Proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions. (wikipedia.org)
  • microorganisms
  • RPE acts as an important outer barrier to prevent the movement of pathogenic microorganisms (including HIV-1) from the blood into the eye. (hindawi.com)
  • complex
  • Recently the role of Tat, the transactivator protein of HIV-1, which plays critical and complex roles in both the HIV-1 replication cycle and the pathogenesis of HIV-1 infection, is the object of research. (hindawi.com)
  • Still, they can perform complex functions including chemokine-production (in CD1c+ myeloid DCs), cross-presentation (in CD141+ myeloid DCs), and IFNalpha production (in CD303+ plasmacytoid DCs). (wikipedia.org)
  • infection
  • Early infection consists of stage 1 (localized skin infection), followed within days to weeks by stage 2 (disseminated infection). (asmscience.org)
  • also emphasizes the role of HIV-1 Tat protein in the development of ocular complications during HIV infection [ 6 ]. (hindawi.com)
  • However, only about 1-5% of infected persons are thought to develop cancer as a result of the infection with HTLV-I over their lifetimes. (wikipedia.org)
  • The infection rate is about 1% in Papua New Guinea, the Solomon Islands, and Vanuatu, where the genotype C predominates. (wikipedia.org)
  • thus
  • Thus, we used eight male, 8 months old sheep, weighing on average 30 kg, from which 15 mL/kg of whole blood was collected and stored in CPDA-1 bags. (biomedcentral.com)
  • Thus, the host develops a tolerance for this antigen, or a self tolerance. (wikipedia.org)