• Cells
  • Bach's major contribution to transplant science was the invention of a technique to mix cells from donor material to cells from the patient. (wikipedia.org)
  • amplifier T l's a T lymphocyte of the CD8 cell type that modifies a developing immune response by releasing nonspecific signals to which other T lymphocytes (either effector or suppressor cells) respond. (thefreedictionary.com)
  • These lymphocytes are important in graft rejection and killing of tumor cells and virus-infected host cells. (thefreedictionary.com)
  • In this study, we investigate the interaction between monocyte-derived dendritic cells and T cells in patients with sarcoidosis compared to normal controls (n = 8 each) by examining the kinetics of autologous and allogeneic mixed leucocyte reactions over 9-10 days. (ox.ac.uk)
  • DCs were also generated in co-cultures with LNCaP cells in the presence of antiPSA antibodies. (ox.ac.uk)
  • Human CTL generated in unidirectional mixed lymphocyte culture against AW24+ donor lymphocytes clearly lysed P815-HLA-AW24+ transfectant target cells, but not untransfected P815(HTR) controls. (unil.ch)
  • Neuroglia;Astrocytes;Microglia;Inflammation;AMP-Activated Protein Kinases;AICA ribonucleotide;NF-kappa B;Cytokines;Macrophages, Peritoneal;Cells, Cultured;Rats, Sprague-Dawley;Models, Animal;Nitric Oxide Synthase;Nitric Oxide Synthase Type. (musc.edu)
  • No MLR occurred when the Responder cells came from thymectomized animals, whereas bursectomized chicken leukocytes reacted in culture demonstrating that T-cells were the major cell type in Responder cell populations. (wikipedia.org)
  • The assay set-up consists of purifying responder lymphocytes from peripheral blood, thymus, lymph nodes or spleen and co-culturing with stimulator cells. (wikipedia.org)
  • Stimulator cell populations that also contain T-cells (Two way mixed lymphocyte reaction) will replicate in the presence of the Responder cells, therefore for a One way mixed lymphocyte reaction, stimulator cells are prevented from replicating by irradiation or treatment with mitomycin C, a DNA crosslinker to prevent cell replication. (wikipedia.org)
  • In this technique a donor's blood cells are MHC typed by mixing them with serum containing the anti-HLA antibodies. (wikipedia.org)
  • The characteristic histologic lesions of MCF are lymphocytic arteritis with necrosis of the blood vessel wall and the presence of large T lymphocytes mixed with other cells. (wikipedia.org)
  • Attempts to use T cells to treat transplanted murine tumors required cultivating and manipulating T cells in culture. (wikipedia.org)
  • Comparative genomic hybridization is a molecular cytogenetic method for analysing copy number variations (CNVs) relative to ploidy level in the DNA of a test sample compared to a reference sample, without the need for culturing cells. (wikipedia.org)
  • The authors painted a series of individual human chromosomes from a DNA library with two different fluorophores in different proportions to test the technique, and also applied CGH to genomic DNA from patients affected with either Downs syndrome or T-cell prolymphocytic leukemia as well as cells of a renal papillary carcinoma cell line. (wikipedia.org)
  • All T cells begin as CD4-CD8-TCR- cells at the DN (double-negative) stage, where an individual cell will rearrange its T cell receptor genes to form a unique, functional molecule, which they, in turn, test against cells in the thymic cortex for a minimal level of interaction with self-MHC. (wikipedia.org)
  • If suspected, a test can be done to detect the presence of the male Y-chromosomes in some circulating white blood cells of the subject. (wikipedia.org)
  • proliferation
  • The addition of active PSA to DC cultures significantly inhibited the generation and maturation of DC, as assessed by the levels of expression of CD83, CD80, CD86 and HLA DR. The ability of DC to induce T-cell proliferation, which depends on the expression of co-stimulatory and major histocompatibility complex molecules, was also suppressed in PSA treated DC cultures. (ox.ac.uk)
  • Tumor
  • Syngeneic lymphocytes were transferred from rodents heavily immunized against the tumor to inhibit growth of small established tumors, becoming the first example of ACT. (wikipedia.org)
  • Lymphocytes infiltrating the stroma of growing, transplantable tumors provided a concentrated source of tumor-infiltrating lymphocytes (TIL) and could stimulate regression of established lung and liver tumors. (wikipedia.org)
  • Antibody
  • In contrast, the cultured lymphoblasts (CLB) were efficiently lysed by specific antibody and C′ and by CTL in the presence of concanavalin A. In addition, CLB did not inhibit cytotoxicity against LB in a cold target competition assay, indicating that CLB and LB differ in the expression of certain surface molecules. (naver.com)
  • dendritic
  • MATERIALS AND METHODS: Human dendritic cell (DC) cultures were generated from CD34+ hematopoietic precursors in the presence of PSA. (ox.ac.uk)
  • Tuberculin
  • Tuberculin skin testing (TST) has been used for years as an aid in diagnosing latent tuberculosis infection (LTBI) and includes measurement of the delayed type hypersensitivity response 48-72 hours after intradermal injection of PPD. (wikipedia.org)
  • Bach
  • By 1975 Bach had improved his technique so that the test would not take days anymore, but hours. (wikipedia.org)
  • Genes
  • CGH does, however, allow for the exploration of all 46 human chromosomes in single test and the discovery of deletions and duplications, even on the microscopic scale which may lead to the identification of candidate genes to be further explored by other cytological techniques. (wikipedia.org)
  • survival
  • We suggest that the extended survival in an allogeneic tumour‐bearing host of cultured, hence weakly immunogenic, anti‐tumour CTL, will enable them the in vivo implementation of their anti‐tumour activity. (naver.com)
  • species
  • Freemartinism is the normal outcome of mixed-sex twins in all cattle species that have been studied, and it also occurs occasionally in other mammals including sheep, goats and pigs. (wikipedia.org)
  • A freemartin is the normal outcome of mixed twins in all cattle species which have been studied. (wikipedia.org)
  • A variety of tests are used in the detection HHV-6, some of which do not differentiate the two species. (wikipedia.org)
  • cellular
  • They are divided on the basis of ontogeny and function into two classes, B and T lymphocytes, responsible for humoral and cellular immunity, respectively. (thefreedictionary.com)
  • Origin of B- and T-lymphocytes responsible for cellular and humoral immunity. (thefreedictionary.com)
  • This study was undertaken to search for possible mechanisms by which T‐cell lines become non‐immunogenic and refractory to cellular‐mediated lysis during culture. (naver.com)
  • contrast
  • In contrast, peak AK activity against both K562 and the auto LCL was weaker in the secondary, compared to the primary culture. (jimmunol.org)
  • days
  • Genetic testing for the Y-chromosome can be performed within days of birth and can aid in the early identification of a sterile female bovine. (wikipedia.org)
  • cell
  • Most are small lymphocytes 7-10 μm in diameter with a round or slightly indented heterochromatic nucleus that almost fills the entire cell and a thin rim of basophilic cytoplasm that contains few granules. (thefreedictionary.com)
  • normal
  • Some of the patients exhibited parallel decreases in both CML and MLR tests, while others showed decreased CML responses but normal MLR responses. (biomedsearch.com)
  • host
  • In 2002, lymphodepletion using a nonmyeloablative chemotherapy regimen administered immediately before TIL transfer increased cancer regression, as well as the persistent oligoclonal repopulation of the host with the transferred lymphocytes. (wikipedia.org)
  • specific
  • A higher intensity of the test sample colour in a specific region of a chromosome indicates the gain of material of that region in the corresponding source sample, while a higher intensity of the reference sample colour indicates the loss of material in the test sample in that specific region. (wikipedia.org)
  • It comes as a dried powder which is mixed with a specific liquid before being injected either just under the skin or into a muscle. (wikipedia.org)