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  • pulmonary
  • On post operative day 1 (24 hours following lung transplant), the investigators will evaluate whether extravascular lung water measured at 24 hours correlates with pulmonary edema determined by reviewers of the CXR blinded to the extravascular lung water measurement. (clinicaltrials.gov)
  • 24 hours following lung transplant, the investigators will evaluate whether the combination of extravascular lung water and pulmonary permeability measurements at 24 hours correlate with the presence and severity of primary graft dysfunction (PGD) at 24 hours. (clinicaltrials.gov)
  • The median extravascular lung water and pulmonary permeability measurements will be calculated. (clinicaltrials.gov)
  • The combinations of above/below median extravascular lung water with above/below median pulmonary permeability will be correlated to the presence of PGD. (clinicaltrials.gov)
  • The investigators will compare whether immediate (time 0) post operative measurements of the combination of extravascular lung water and pulmonary permeability can predict the later onset (24 hours) of primary graft dysfunction. (clinicaltrials.gov)
  • Ventilated patients with otherwise healthy lungs seldom develop ventilator-associated lung-injury while those with pulmonary inflammation are predisposed to such injury , . (plos.org)
  • damage to vascular endothelium by factors that disrupt pulmonary surfactant and decrease lung compliance. (medchrome.com)
  • TRALI
  • Leukocyte filters may prevent TRALI for those patients whose lung injury is due to leukoagglutination of the donor white blood cells, but because most TRALI is due to donor antibodies to leukocytes, filters are not helpful in TRALI prevention. (wikipedia.org)
  • tissues
  • Furthermore, compared with normal rats, wet-to-dry (W/D) values of lung tissues and circulating EMP levels were increased in the treatment group, while PAK4 and CD11c protein amounts were reduced. (hindawi.com)
  • Severe injury to alveoli causes swelling of the tissues (edema) in the lungs, bleeding of the alveoli, loss of surfactant (decrease in lung compliance) and complete alveoli collapse (biotrauma). (wikipedia.org)
  • broken ribs may perforate the lung, or the tissue may be torn due to shearing forces that result from different rates of acceleration or deceleration of different tissues of the lung. (wikipedia.org)
  • injury caused by pressure Barotrauma is physical damage to body tissues caused by a difference in pressure between a gas space inside, or in contact with the body, and the surrounding gas or fluid. (wikipedia.org)
  • alveoli
  • High doses of the corticosteroid methylprednisolone given intramuscularly before and concomitantly with bleomycin administration prevented the influx of alveolar macrophages into the lungs, diminishing both the number of macrophages present in the alveoli and the total lung content of TGF-beta. (uptodate.com)
  • Lacerations of the lung tissue can also occur by compression of the alveoli against the ribs or spine. (wikipedia.org)
  • VALI
  • VALI is the appropriate term in most situations because it is virtually impossible to prove what actually caused the lung injury in the hospital. (wikipedia.org)
  • By opening the lung and keeping the lung open RACE (and VALI) is reduced. (wikipedia.org)
  • occur
  • citation needed] The lungs are a radiosensitive organ, and radiation pneumonitis can occur leading to pulmonary insufficiency and death (100% after exposure to 50 gray of radiation), in a few months. (wikipedia.org)
  • Leukoagglutination and pooling of granulocytes in the recipient's lungs may occur, with release of the contents of leukocyte granules, and resulting injury to cellular membranes, endothelial surfaces, and potentially to lung parenchyma. (wikipedia.org)
  • Lung injuries can also occur during rapid decompression, although the risk of injury is lower than with explosive decompression. (wikipedia.org)
  • capillaries
  • PMN migration into the lung proceeds by several steps upon an inflammatory stimulus: first, accumulation of PMNs in the capillaries, then transendothelial migration into the lung interstitium and finally, transepithelial migration into the alveolar space. (hindawi.com)
  • It is typically provoked by an acute injury to the lungs that results in flooding of the lungs' microscopic air sacs responsible for the exchange of gases such as oxygen and carbon dioxide with capillaries in the lungs. (wikipedia.org)
  • infection
  • Specifically, the researchers found that immune cells called, "natural killer T cells," may reduce the overwhelming numbers of another type of immune cell, called "inflammatory monocytes," which when present in large numbers, lead to lung injury at the end stage of severe flu infection. (medindia.net)
  • Using highly-sensitive fluorescent antibody technology, this study was one of the first to document the sequential changes in innate immune response in the lungs during severe flu infection. (medindia.net)
  • These findings essentially provide a "road map" of the chronological changes in the lungs during severe flu infection. (medindia.net)
  • Unlike contusions, hematomas do not usually interfere with gas exchange in the lung, but they do increase the risk of infection and abscess formation. (wikipedia.org)
  • Lung symptoms in a patient who is taking a medicinal drug that can cause pulmonary toxicity should not automatically lead to a diagnosis of "pulmonary toxicity due to the medicinal drug", because some patients can have another (i.e., simultaneous) lung disease, e.g. an infection of the lungs not related to the medicinal drugs the patient is taking. (wikipedia.org)
  • toxicity
  • Paraquat (PQ) has been demonstrated that the main target organ for the toxicity is the lung. (hindawi.com)
  • The primary target organ for PQ toxicity is the lung as a consequence of its accumulation, against a concentration gradient, through the highly developed polyamine uptake system [ 1 - 3 ]. (hindawi.com)
  • We used 18-fluorodeoxyglucose (FDG) positron emission tomography (PET) scanning in a patient with Hodgkin's disease who developed bleomycin lung toxicity following the 4(th) cycle of chemotherapy. (uptodate.com)
  • Pulmonary toxicity is the medical name for side effects on the lungs. (wikipedia.org)
  • inflammatory
  • Therefore, in this lung injury process induced by PAK4 inhibitor, the protective effects of simvastatin were reflected by intestinal mucosal barrier protection, inflammatory response regulation via CD11c+ cells, and cytoskeleton stabilization. (hindawi.com)
  • infiltration
  • LAM involves lung tissue infiltration with smooth muscle-like cells with mutations of the tuberous sclerosis complex gene (TSC2). (wikipedia.org)
  • fluid
  • The injury is diagnosed when collections of air or fluid are found on a CT scan of the chest. (wikipedia.org)
  • On a CT scan, pulmonary lacerations show up in a contused area of the lung, typically appearing as cavities filled with air or fluid that usually have a round or ovoid shape due to the lung's elasticity. (wikipedia.org)
  • fibrosis
  • Thus agent with both antioxidant and regulating fibrosis properties would have favorable value in the treatment of paraquat-induced lung injury. (hindawi.com)
  • damage
  • Oxidative damage to the lung appears important in the pathophysiology of lung injury, and antioxidants may ameliorate the process [ 4,8 ]. (uptodate.com)
  • Therefore, the present study was designed to evaluate the effects of PDTC in a rodent model of acute lung injury induced by PQ and observe its potential therapeutic effect in order to provide scientific basis for the treatment strategy of paraquat-induced lung damage. (hindawi.com)
  • The researchers found that mice lacking STIM1 in endothelial cells were protected from the lipopolysaccharide-induced lung damage. (medpagetoday.com)
  • So a free-diver can dive to 10 metres (33 feet) and safely ascend without exhaling, because the gas in the lungs had been inhaled at atmospheric pressure, whereas a diver who inhales at 10 metres and ascends without exhaling has lungs containing twice the amount of gas at atmospheric pressure and is very likely to suffer life-threatening lung damage. (wikipedia.org)
  • Oleic acid is also used to induce lung damage in certain types of animals, for the purpose of testing new drugs and other means to treat lung diseases. (wikipedia.org)
  • chest
  • Extravascular lung water measurement offers information not otherwise available by other methods such as chest radiography, arterial blood gas, and chest auscultation at the bedside. (hindawi.com)
  • Data from experimental studies suggest that EVLW on chest radiography may only be detectable when the lung water increases by more than 35% [ 8 ]. (hindawi.com)
  • Violent compression of the chest can cause lacerations by rupturing or shearing the lung tissue. (wikipedia.org)
  • As the lung contusion clears (usually within two to four days), lacerations begin to become visible on chest X-ray. (wikipedia.org)
  • Side effects on the lungs can be very varied, and can include signs and symptoms that are either clinical, or radiological (i.e., seen on chest X-ray or CT), or both. (wikipedia.org)
  • traumatic
  • Because the lung is elastic, the tear forms a round cyst called a traumatic air cyst that may be filled with air, blood, or both and that usually shrinks over a period of weeks or months. (wikipedia.org)
  • trauma
  • The risk of venous thromboembolism (VTE) is very high in trauma patients, secondary to tissue injury, venous status from immobilization, and thrombophilia. (centerwatch.com)
  • organ
  • It is used to support a single failing organ system (the lungs) and cannot reverse any underlying disease process (such as terminal cancer). (wikipedia.org)
  • Sirolimus, also known as rapamycin, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection and to treat a rare lung disease called lymphangioleiomyomatosis. (wikipedia.org)
  • disease
  • Make a difference by delivering research, education and advocacy to those impacted by lung disease. (lung.org)
  • The Neonatal Lung Injury & Pulmonary Hypertension Focus Group is a research group dedicated to improving the health of infants with pulmonary disease through innovative basic science, clinical, and translational research. (nationwidechildrens.org)
  • On May 28, 2015, the FDA approved sirolimus to treat lymphangioleiomyomatosis (LAM), a rare, progressive lung disease that primarily affects women of childbearing age. (wikipedia.org)