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  • treatment
  • The commitment of cells to apoptosis caused by H2O2 was characterized by an early increase of lipoxygenase activity, of ultraweak luminescence and of membrane lipid peroxidation, which reached 720, 350 and 300% of controls, respectively, at 6 h after H2O2 treatment. (glycosciences.de)
  • tissues
  • This speculation has been supported by the demonstration of lipoxygenase activity in a number of different tissues following stimulation. (springer.com)
  • For example, pulmonary tissues synthesize the peptido-leukotrienes (LTC 4 , D 4 and E 4 ), which are products of 5-lipoxygenase, in response to immunological challenge. (springer.com)
  • decrease
  • An LTA 4 H inhibitor would decrease LTB 4 production and may thus have therapeutic potential in all of the abovementioned diseases. (aspetjournals.org)
  • While 5α-reductase inhibitors appear to decrease low-grade cancer risk they do not affect high-grade cancer risk and thus are not recommended for prevention. (wikipedia.org)
  • efficacy
  • The purpose of this research project was to determine the efficacy of the cyclooxygenase (COX) and lipoxygenase (LOX) inhibitors, alone or in combination, to prevent OH-BBN-induced urinary bladder cancers in female Fischer-344 rats. (aacrjournals.org)
  • activity
  • Structural signatures characteristic of high-, medium-, and low-efficiency inhibitors of the catalytic activity of 15-lipoxygenase (15-LOG) have been revealed using the SARD-21 (Structure Activity Relationship & Design) computer system. (springer.com)
  • expression
  • Sub-human primates, although not extensively examined, appear to have 12-lipoxygenase expression patterns that resemble those of sub-primate mammals or humans depending on the closeness of there genetic relateness to these species. (wikipedia.org)
  • human
  • Sub-primate mammals, such as the mouse, rat, rabbit, cow, and pig, express platelet type 12-lipoxygenase but also a leukocyte type 12-lipoxygenase (also termed 12/15-lipoxygenase, 12/15-LOX or 12/15-LO) which is an ortholog of, and metabolically equivalent to, human 15-LO-1 in that it forms predominantly 15(S)-HpETE with 12(S)-HpETE as a minor product. (wikipedia.org)
  • Mice also express an epidermal type 15-lipoxygenase (e-12LO) which has 50.8% amino acid sequence identity to human 15-LOX-2 and 49.3% sequence indetity to mouse Arachidonate 8-lipoxygenase. (wikipedia.org)
  • products
  • Leukotriene B4, along with some of the mono-hydroxy lipoxygenase products is chemotactic and it has been suggested that LTB4 production by activated PMNs represents a local control mechanism for the accumulation of leukocytes at inflammatory sites. (springer.com)
  • cancer
  • Aspirin and caffeic acid, (COX and LOX inhibitors, respectively) were also modestly effective and noneffective respectively in inhibiting urinary bladder cancer. (aacrjournals.org)
  • treatment
  • The commitment of cells to apoptosis caused by H2O2 was characterized by an early increase of lipoxygenase activity, of ultraweak luminescence and of membrane lipid peroxidation, which reached 720, 350 and 300% of controls, respectively, at 6 h after H2O2 treatment. (glycosciences.de)
  • thus
  • [ 5 , 6 ] Both SPEB and NAPlr bind plasmin, protecting it from physiological inhibitors, and thus could cause chemotaxis of inflammatory cells and degradation of glomerular basement membranes. (medscape.com)
  • While 5α-reductase inhibitors appear to decrease low-grade cancer risk they do not affect high-grade cancer risk and thus are not recommended for prevention. (wikipedia.org)
  • kidney
  • 2.Zhicheng Xiao, Jing Zhang, Xiaogang Peng, Yanjun Dong, Lixin Jia, Huihua Li,Jie Du: The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation. (54doctor.net)
  • human
  • 1990). The extracellular domain of TNF receptor fragments cloned from U-937 human histiocytic lymphoma cell lines resembled not only the TNF inhibitor, but also the extracellular domain of nerve growth factor receptor, suggesting that all are members of a family of polypeptide hormone receptors (DAYER, 1991). (unu.edu)
  • 1992) demonstrated that genes for 12-lipoxygenase and 15-lipoxygenase are located on human chromosome 17, whereas the most unrelated lipoxygenase (5-lipoxygenase) was mapped to chromosome 10. (wikipedia.org)
  • active
  • The active metabolite of Paracetamol believed to provide most or all of its analgesic effects AM404 is a COX inhibitor and this is believed to provide part of its effect. (wikipedia.org)