• The purpose of this preliminary study was to compare the extent of lipid peroxidation, as evidenced by thiobarbituric acid-reactive substances (TBARS) and \alpha-tocopherol concentration in the neoplastic mammary tissue, among dogs with mammary cancer fed with different kinds of diet (commercial or homemade). (tubitak.gov.tr)
  • The increased lipid peroxidation due to oxidative stress induction (increased TBARS and decreased \alpha-tocopherol concentration) found in neoplastic compared to normal mammary tissue of dogs with mammary cancer was similar in both groups of dogs fed with a different kind of diet, commercial or homemade. (tubitak.gov.tr)
  • Abstract: The inhibition of lipid peroxidation by Pleurotus ostreatus was established using Thiobarbituric (TBARS) assay. (ac.lk)
  • There exist a possibility that ergosterol can inhibit the peroxidation of common fatty acids present in egg yolk substrate (which was used for TBARS assay). (ac.lk)
  • In the body, it tends to reflect damage to cell membranes and is assessed by biomarkers thought to represent lipid peroxidation (MDA and TBARS). (examinecdn.com)
  • The aim of this study was to investigate the content of 2-thiobarbituric acid reactive substances (TBARS) in the various plant oils (rapeseed oil, olive oil, rice oil) with the use of rosemary essential oil (Etja, Elblag, Poland) as antioxidant agent by monitoring the lipid peroxidation during one month storage period. (org.ua)
  • We therefore aimed to investigate peroxidation, measured as thiobarbituric the correlation between hypercholesterol- acid-reactive substance (TBARS). (who.int)
  • The lipid peroxidation (TBARS) and the enzymatic activity of catalase (CAT) were measured in the cardiac muscle. (bvsalud.org)
  • In summary, findings in the present study confirmed that BP-QDs induce ferroptosis via increasing lipid peroxidation and iron accumulation in vitro and in vivo.PMID:3748. (medworm.com)
  • This process, also called lipid peroxidation, has long been implicated in degenerative disease, but only recently has this been linked via a specific type of cell death called ferroptosis. (theprattgroup.org)
  • This minireview summarises current research on iron toxicity, lipid peroxidation and ferroptosis in the pathomechanisms of ICH, the underlying molecular mechanisms of ferroptosis and the potential for combined therapeutic strategies. (bmj.com)
  • Ferroptosis by Lipid Peroxidation: The Tip of the Iceberg? (elsevierpure.com)
  • Ferroptosis is a type of cell death caused by radical-driven lipid peroxidation, leading to membrane damage and rupture. (dfg-ferroptosis.net)
  • Here we show that enzymatically produced sulfane sulfur (S 0 ) species, specifically hydropersulfides, scavenge endogenously generated free radicals and, thereby, suppress lipid peroxidation and ferroptosis. (dfg-ferroptosis.net)
  • Lipid Peroxidation of the Docosahexaenoic Acid/Arachidonic Acid Ratio Relating to the Social Behaviors of Individuals with Autism Spectrum Disorder: The Relationship with Ferroptosis. (bvsalud.org)
  • The unbeneficial DHA/ARA ratio induced ferroptosis via lipid peroxidation . (bvsalud.org)
  • Importantly, the aggregate-membrane interaction that drives ferroptosis depends both on the conformational structure of the aggregate, as well as the oxidation state of the lipid membrane. (elsevierpure.com)
  • This suggests a role for ferroptosis in Parkinson's disease, and highlights a new mechanism by which lipid peroxidation causes cell death. (elsevierpure.com)
  • An alternative, pharmaceutical method employs the isotope effect on lipid peroxidation of deuterated polyunsaturated fatty acids (PUFAs) at the methylene bridges (bis-allylic sites) between double bonds, which leads to the inhibition of the chain reaction. (wikipedia.org)
  • Hemorrhoid therapy with medicinal plants: Astringency and inhibition of lipid peroxidation as Key factors. (scialert.net)
  • D. P. Dissanayake, D.T.U. Abeytunga, N.S. Vasudewa, W.D. Ratnasooriya Inhibition of lipid peroxidation by extracts of Pleurotus ostreatus. (ac.lk)
  • All three extracts showed inhibition of lipid peroxidation. (ac.lk)
  • The results from theoretical investigation support the experimental observation of the capability of lipid peroxidation inhibition by ergosterol. (ac.lk)
  • Inhibition of lipid peroxidation by extracts/subfractions of Chickrassy (Chukrasia tabularis A. Juss. (csircentral.net)
  • Targeted inhibition of lipid peroxidation prevents the aggregate-membrane interaction, abolishes aberrant calcium fluxes, and restores physiological calcium signaling. (elsevierpure.com)
  • Inhibition of lipid peroxidation, and reduction of iron-dependent accumulation of free radicals, further prevents oligomer-induced toxicity in human neurons. (elsevierpure.com)
  • Such D-PUFAs, for example, 11,11-D2-ethyl linoleate, suppress lipid peroxidation even at relatively low levels of incorporation into membranes. (wikipedia.org)
  • The chemical products of this oxidation are known as lipid peroxides or lipid oxidation products (LOPs). (wikipedia.org)
  • When the lipids deteriorate due to oxidation, lipid peroxidation occurs. (vedantu.com)
  • A form of oxidation that influences lipids. (examinecdn.com)
  • We hypothesized that rosemary essential oil would inhibit or reduce lipid oxidation in plant oils due to the antioxidative properties. (org.ua)
  • The reduction of the lipid oxidation was the highest at 40 days as compared to the start of the study. (org.ua)
  • Rosemary and oxygen scavenger in active packaging for prevention of high-pressure induced lipid oxidation in pork patties. (org.ua)
  • Cadmium a very toxic and ubiquitous metal and ethanol (95%) are known to induce lipid peroxidation (Traore et al . (scialert.net)
  • In the aftermath of ICH, iron overload within the perihaematomal region can induce lethal reactive oxygen species (ROS) production and lipid peroxidation, which contribute to secondary brain injury. (bmj.com)
  • α-synuclein oligomers further induce lipid peroxidation. (elsevierpure.com)
  • The end products of lipid peroxidation are reactive aldehydes, such as malondialdehyde (MDA) and 4-hydroxynonenal (HNE), the second one being known also as "second messenger of free radicals" and major bioactive marker of lipid peroxidation, due to its numerous biological activities resembling activities of reactive oxygen h species. (wikipedia.org)
  • The most common initiators in this step of lipid peroxidation are substances from the reactive oxygen family. (vedantu.com)
  • Lipid hydroperoxides and acid-reactive molecules are also produced during the propagation process. (vedantu.com)
  • It can be engulfed by microglia and infiltrating macrophages in the perihematomal zone and metabolised into ferrous/ferric iron, which induces the formation of lethal reactive oxygen species (ROS) and lipid peroxidation. (bmj.com)
  • Further study of reactive oxygen species was conducted using analysis of cellular H2O2 generation, lipid peroxidation of cellular membranes and DNA damage. (cdc.gov)
  • It is the process in which free radicals "steal" electrons from the lipids in cell membranes, resulting in cell damage. (wikipedia.org)
  • The ascorbate-dependent lipid peroxidation in the microsomal fraction of at term placentas and fetal membranes were studied. (karger.com)
  • The results indicate that the ascorbate-dependent lipid peroxidation in the fetal membranes is specific for prostaglandin synthetase activity and that these tissues are a major site of prostaglandin synthesis. (karger.com)
  • The ROS cause damage to nucleic acids, proteins and lipid membranes, and eventually cell death. (bmj.com)
  • In summary, we report that peroxidation of polyunsaturated fatty acids underlies the incorporation of β-sheet-rich aggregates into the membranes, and that additionally induces neuronal death. (elsevierpure.com)
  • S. Slathia, A. Sharma and S. Choudhary, "Influence of Exogenously Applied Epibrassinolide and Putrescine on Protein Content, Antioxidant Enzymes and Lipid Peroxidation in Lycopersicon esculentum under Salinity Stress," American Journal of Plant Sciences , Vol. 3 No. 6, 2012, pp. 714-720. (scirp.org)
  • The effect of submaximal exercises with different intensities on the blood lipid peroxidation and antioxidant enzymes activities. (ksep-es.org)
  • The purpose of this study is to examine the effects of various exercise intensities on the change of lipid peroxidation and antioxidant enzymes activities. (ksep-es.org)
  • The present study had evaluated the protective effect of hydroalcoholic (50-50: v/v) and aqueous extracts of L. kerstingii and M. oleifera against lipid peroxidation induced in vivo and in vitro by either cadmium or ethanol. (scialert.net)
  • A feeding study was conducted to show the in vivo effects of the juices on lipid peroxidation in a sensitive Drosophila melanogaster stock. (hw.ac.uk)
  • This study demonstrates that the effects of berry antioxidants on lipid peroxidation are easily and rapidly tested in vivo with the sensitive Drosophila model. (hw.ac.uk)
  • Hence, we hypothesized that a combination of conjugated double bonds and an n-3 highly unsaturated fatty acid may produce a stronger antitumor effect, and we have previously shown that conjugated EPA (CEPA), prepared by alkaline treatment of EPA, induces strong and selective apoptosis in vitro and in vivo, with the mechanism proceeding via lipid peroxidation. (elsevierpure.com)
  • E ditor -The paper by Ogihara et al 1 adds to our understanding of the pathogenesis of chronic lung disease (CLD) associated with high plasma concentrations of aldehyde lipid peroxidation products on the first day of life in preterm infants, a common complication of neonatal intensive care. (bmj.com)
  • To investigate whether H. pylori can cause lipid peroxidation in lymphocytes in vitro and to look for experimental evidence of lipid peroxidation induced by H. pylori , the lipid peroxide (LPO) level in peripheral blood lymphocytes was measured using the thiobarbituric acid fluorescence method. (aku.edu)
  • We study the molecular mechanisms of lipid peroxidation in order to better understand the origin of the products that are observed from the various classes of lipid (i.e. monounsaturated and polyunsaturated fatty acids, cholesterol and its derivatives and plasmalogens). (theprattgroup.org)
  • Burbach, J. A. / Localization of lipid peroxidation-derived protein epitopes in the porcine corpus luteum . (johnshopkins.edu)
  • RÉSUMÉ L'objectif de la présente étude était d'évaluer l'efficacité d'un programme d'exercice sur tapis roulant électronique sur le malondialdéhyde, en tant que marqueur de la peroxydation lipidique et sur une enzyme antioxydante, le glutathion peroxydase, chez des adolescents atteints du Syndrome de Down. (who.int)
  • Hypercholesterolaemia is frequently sayed on the same day for the determination associated with enhanced lipid peroxida- of glutathione peroxidase activity and lipid tion [3]. (who.int)
  • The present study investigated the concentration of lipid peroxidation biomarkers in patients with OSA in comparison with nonapneic controls and the effects of results with nasal continuous positive airway pressure (nCPAP) on these biomarkers. (drcalapai.com)
  • 01). Stepwise regression analysis revealed that RDI was an independent significant predictor of all 3 lipid-peroxidation biomarkers. (drcalapai.com)
  • Urine samples (27 workers) were collected after 8 h exposure and analyzed for PAH metabolites and effect biomarkers (8-oxodG for DNA oxidative damage, 4-HNE-MA for lipid peroxidation, 3-HPMA for acrolein). (lu.se)
  • This radical is also an unstable species that reacts with another free fatty acid, producing a different fatty acid radical and a lipid peroxide, or a cyclic peroxide if it had reacted with itself. (wikipedia.org)
  • Hypercholesterolemic rabbits had high plasma and erythrocyte lipid peroxide levels as compared to control rabbits. (istanbul.edu.tr)
  • At the end of this period, plasma and erythrocyte lipid peroxide levels were significantly decreased in the group injected with thymosin F5. (istanbul.edu.tr)
  • Antioxidants provide protection to living organisms from damage caused by uncontrolled production of ROS and concomitant lipid peroxidation, protein damage and DNA stand breaking. (intechopen.com)
  • After 24 h of exposure to different doses (4-32 μg/mL) of BP-QDs, intracellular lipid peroxidation and iron overload occurred in Beas-2B cells. (medworm.com)
  • This experiment was designed to investigate the lipid peroxidation and histological effects of chronic fluorosis on first- and second-generation rat kidney tissues. (fluoridealert.org)
  • Lipid peroxidation is a crucial mechanism that occurs in both plants and mammals. (vedantu.com)
  • Lipid peroxidation was significantly higher in the chorion and amnion compared to the placenta. (karger.com)
  • These animals do not survive past embryonic day 8, indicating that the removal of lipid hydroperoxides is essential for mammalian life. (wikipedia.org)
  • This represents the first direct in situ evidence that protein modification by lipid peroxidation products occurs during the natural luteal life span. (johnshopkins.edu)
  • Evidence for lipid peroxidation in obstructive sleep apnea. (drcalapai.com)
  • Additionally, this process is brought on by the interaction of lipids with substances associated with oxygen. (vedantu.com)
  • The energy barriers for peroxidation with triplet oxygen at HF/3-21 G level of theory for ergosterol and linoleic acid (trans, trans) were 231.85 kJmol1 and 420.52 kJmol-1 respectively. (ac.lk)
  • 01). We speculate that perivascular lipid/protein modification of the diaphragm in sepsis results from the action of neutrophil-derived free radicals, while myocyte-derived radicals cause NT/4HN formation along the muscle perimeter. (uky.edu)
  • Lipid synthesis occurs in the liver of the human body . (vedantu.com)
  • The effect of the extract was studied on lipid peroxidation and antioxidant parameters in liver and gastrocnemius muscle of rats on attaining the rectal temperature (T(rec)) of 23 degrees C during C-H-R exposure and after recovery (T(rec)37 degrees C) from C-H-R-induced hypothermia. (nih.gov)
  • Sulfur and lipid combine to generate sulpholipids. (vedantu.com)
  • On the other hand, it's unclear whether dietary lipid peroxides are bioavailable and play a role in disease, as a healthy human body has protective mechanisms in place against such hazards. (wikipedia.org)
  • Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. (elsevierpure.com)
  • Lipid peroxyl radicals combine with other molecules that contain comparable radicals to create non-radical products during the process known as termination. (vedantu.com)
  • We propose that increased S 0 biosynthesis is an adaptive cellular response to radical-driven lipid peroxidation, potentially representing a primordial radical protection system. (dfg-ferroptosis.net)
  • In addition, end-products of lipid peroxidation may be mutagenic and carcinogenic. (wikipedia.org)
  • Polyphenols and polyphenol-rich fractions of plants have been reported to have protective effects against lipid peroxidation, most probably by serving as scavengers of free radicals and/or by chelating metal ions. (csircentral.net)
  • 0.01) effects of cloudberry juice on lipid peroxidation. (hw.ac.uk)
  • In addition, activation of the mutant p53 was also induced by CEPA, and these effects showed lipid-peroxidation dependency. (elsevierpure.com)
  • This is the first such gene expression analysis of the effects of CEPA, and our results confirm that CEPA induces lipid peroxidation, activates mutant p53, and causes p53-dependent apoptosis in DLD-1 cells. (elsevierpure.com)
  • Similar results were found in the kidney even though lipid peroxidation is slightly increased by ethanol in this organ. (scialert.net)
  • In recent years, development of immunochemical detection of HNE-histidine adducts opened more advanced methodological possibilities for qualitative and quantitative detection of lipid peroxidation in various human and animal tissues[full citation needed] as well as in body fluids, including human serum and plasma samples. (wikipedia.org)
  • The objective of this study was to examine the impact of daily pecan consumption for 8 weeks on fasting and postprandial lipid peroxidation, total antioxidant capacity (TAC), and tocopherols in adults at higher risk for cardiovascular disease (CVD) (hypercholesterolemia or elevated adiposity). (physiciansweekly.com)
  • We hypothesized that daily pecan consumption would result in increased fasting γ-tocopherol, increased fasting and postprandial TAC, and decreased fasting and postprandial lipid peroxidation. (physiciansweekly.com)
  • At least two of these bands were closely associated with extracted oxidized human low-density lipoprotein (LDL) and with 4-HNE-conjugated human apoprotein B. These results demonstrate the presence of lipid peroxidation-derived protein epitopes within the porcine CL and show that one or more of these may be an oxidized. (johnshopkins.edu)
  • At the end of the 4-mo experimental period, nine randomly chosen male rats (F1) were sacrificed, and the kidneys were removed for the histological and lipid peroxidation examinations. (fluoridealert.org)
  • The purpose of the present study was to localize sites of lipid peroxidation and protein nitrosylation within the septic diaphragm. (uky.edu)
  • The objectives of the present study were to 1) determine by immunological techniques whether lipid peroxidation-derived protein epitopes (i.e. (johnshopkins.edu)
  • In this study, we examined CEPA-induced gene expression in DLD-1 colorectal adenocarcinoma human cells carrying a mutant p53, in order to understand the details of CEPA-induced apoptosis via lipid peroxidation. (elsevierpure.com)
  • This group was retested to confirm important role in the pathophysiology of their blood lipid status before participating several vascular diseases, including athero- in the study. (who.int)
  • Free radicals are responsible for lipid peroxidation and have received much attention recently in connection with a variety of pathologies such as cancer (Zhu et al . (scialert.net)
  • Helicobacter pylori-induced lipid peroxidation in peripheral blood lym" by Xue-Gong Fan, Javed Yakoob et al. (aku.edu)
  • The ultrafine particles also caused significant increases in H2O2 production by monocytes and lipid peroxidation. (cdc.gov)