Lipid metabolism disorders. Medical search. Frequent questions

All lipids are hydrophobic and mostly insoluble in blood, so they require transport within lipoproteins. (msdmanuals.com)
Due to the hydrophobic nature of membrane lipids, triglycerides and cholesterols, they require special transport proteins known as lipoproteins. (wikipedia.org)
Chylomicrons are one sub-group of lipoproteins which carry the digested lipids from small intestine to the rest of the body. (wikipedia.org)
Disorders of the biogenesis and secretion of lipoproteins containing the B apolipoproteins. (medscape.com)
Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
It interacts with high-density lipoproteins (HDL) and influences cholesterol efflux, contributing to the body's lipid homeostasis. (prospecbio.com)

Frequent complications of obesity, changes in lipid metabolism in adipocytes. (ukaachen.de)
Our laboratory wants to understand how lipid signaling is regulated, and why changes in lipid metabolism can lead to disease. (stjude.org)

In vivo and in vitro studies have shown that extracts of different pomegranate fractions (peels, flowers, juice, and seeds) regulate lipid metabolism in metabolic-disorder-associated diseases such as atherosclerosis, nonalcoholic fatty liver disease, and type 2 diabetes, helping to alleviate the development of diseases. (nih.gov)
This review summarizes the main findings about the effects of different pomegranate fraction extracts on lipid metabolism in metabolic-disorder-associated diseases and analyses how pomegranate extracts achieve their effects. (nih.gov)
Disruptions to lipid metabolism can lead to diseases such as cancer and neurological disorders. (stjude.org)
Defects in sphingolipid metabolism are often associated with cancers and neurodegenerative diseases. (stjude.org)
Endocrine diseases are a heterogeneous group of disorders which can affect nearly any body system including the musculoskeletal system. (springer.com)
Rheumatic manifestations of endocrine disorders may present as a definite rheumatic disease (such as pseudogout in hyperparathyroidism), as rheumatic symptoms such as arthralgia and myalgia, as positive immune serology, or may mimic rheumatic diseases (e.g., skeletal abnormalities in hypoparathyroidism can mimic ankylosing spondylitis). (springer.com)
Rheumatic diseases are associated with endocrine disorders which may have an impact on the clinical aspects of those diseases. (springer.com)
Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)
Altered levels of SAA2 are associated with various diseases, including chronic inflammatory disorders, cancer, and metabolic syndromes. (prospecbio.com)

2017). The inhibition of hypothalamic inflammation by intracerebroventricular (ICV) administration of IKK2 inhibitor (IMD-0354) rectified PM2.5-induced glucose intolerance, IR, energy metabolism dysfunction, and attenuated peripheral inflammation in response to PM2.5 exposure (Song et al. (deepdyve.com)
With an increasing duration of exercise, glucose uptake by muscle begins to decline, and there is an increased dependency on free fatty acids for energy metabolism. (pfeiffertheface.com)
The Farese-Walther laboratory studies cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. (harvard.edu)

The impact of endocrine disorders on rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjögren's syndrome (SS) is reviewed. (springer.com)
Diabetes Mellitus is the most common of the endocrine disorders. (who.int)

How does exercise affect lipid metabolism? (pfeiffertheface.com)
Reduction of total cholesterols (TC) and LDL-C by dietary alterations and medications that affect lipid metabolism [ 14 ] is found to reduce the occurrence of atherosclerosis in animals and clinical cardiovascular events in human [ 15 ]. (hindawi.com)

Hypertension and disorders of lipid metabolism were the most frequent, whereas obesity, diabetes with complication, anxiety disorders, and the total number of conditions were the strongest risk factors for severe COVID-19 illness. (cdc.gov)
Essential hypertension (50.4%), disorders of lipid metabolism (49.4%), and obesity (33.0%) were the most common. (cdc.gov)
But in obesity, accumulation of lipids can cause fatty liver, resulting in cellular damage to the organ. (sciencedaily.com)
Obesity and overweight can cause metabolic disorders. (ukaachen.de)
Notoginsenosides can treat obesity by reducing lipid synthesis, inhibiting adipogenesis, promoting white adipose tissue browning, increasing energy consumption, and improving insulin sensitivity. (frontiersin.org)
In summary, we demonstrate that C3G enrichment in the HFHS diet attenuates short-term weight gain, decreases hepatic lipid content by suppressing key lipogenic gene expression and improves glucose homeostasis during obesity development, supporting the therapeutic utility of C3G as a bioactive phytonutrient to manage obesity-related complications. (researchgate.net)

Triglycerides (TGs) and cholesterol contribute most to disease, although all lipids are physiologically important. (msdmanuals.com)
The majority of lipids found in the human body from ingesting food are triglycerides and cholesterol. (wikipedia.org)
In the cytosol of epithelial cells, triglycerides and cholesterol are packaged into bigger particles called chylomicrons which are amphipathic structures that transport digested lipids. (wikipedia.org)
The aim of this work is to correlate the levels of cholesterol, triglycerides, apolipoproteins A-B, LI and autonomic dysfunction to depression, anxiety, anxious-depressive disorder and eating disorders. (biomedcentral.com)
Cholesterol is a fat (also called a lipid) that your body needs to work properly. (stlukes-stl.com)
Incorporation of functional HN-F glycoprotein-containing complexes into newcastle disease virus is dependent on cholesterol and membrane lipid raft integrity. (umassmed.edu)
It is used to treat people who have high cholesterol levels, including people who have certain inherited cholesterol disorders. (medbroadcast.com)
For children 10 to 17 years of age who are taking this medication to treat inherited cholesterol disorders, the recommended dose ranges from 10 mg to 20 mg daily. (medbroadcast.com)
FABPs bind free fatty acids, cholesterol, and retinoids, and are involved in intracellular lipid transport. (rndsystems.com)

If you have one of these disorders, you may not have enough enzymes to break down lipids. (medlineplus.gov)
Lipid metabolism often begins with hydrolysis, which occurs with the help of various enzymes in the digestive system. (wikipedia.org)
Digestion is the first step to lipid metabolism, and it is the process of breaking the triglycerides down into smaller monoglyceride units with the help of lipase enzymes. (wikipedia.org)
Fatty acid oxidation disorders are lipid metabolism disorders that are caused by a lack or deficiency of the enzymes needed to break down fats, resulting in delayed mental and physical development. (msdmanuals.com)
Children who have a fatty acid oxidation disorder are missing or have a deficiency of the enzymes needed to break down (metabolize) fats. (msdmanuals.com)
His laboratory discovered genes that encode enzymes critical for neutral lipid metabolism, including the DGAT enzymes which mediate triglyceride (TG) synthesis. (harvard.edu)

Some FABP polymorphisms have been associated with disorders of lipid metabolism and the development of atherosclerosis. (rndsystems.com)
Dysregulation of SAA2 has been associated with atherosclerosis and metabolic disorders, highlighting its importance in maintaining cardiovascular health and metabolic balance. (prospecbio.com)

ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per- and polyfluoroalkyl substances: An integrated approach. (bvsalud.org)
A combination of in silico toxicological analyses, bioinformatics approaches, animal experiments , and in vitro assays was used to explore the molecular initiating events (MIEs) and key events (KEs) in PFAS-induced hepatic lipid metabolism disorders . (bvsalud.org)
Transcriptome -based bioinformatic annotation and analyses identified that transcriptional upregulation of hepatic acyl-CoA oxidase 1 (ACOX1) in PPAR α-regulated peroxisomal ß- oxidation pathway was the KE involved with PFOA/PFOS-perturbed hepatic lipid metabolic pathways in humans , mice and rats . (bvsalud.org)

Amelioration of oxidative stress and the inflammatory response is considered an important reason underlying the regulation of lipid metabolism by pomegranate extracts. (nih.gov)
Despite well-known roles of lipin-1 in lipid biosynthesis and transcriptional regulation, the pathogenic mechanisms leading to rhabdomyolysis remain unknown. (nih.gov)
Dietary fatty acids (FA) are components of the lipids, which contribute to membrane structure, energy input, and biological functions related to cellular signaling and transcriptome regulation. (nature.com)
Regulation of carbohydrate metabolism / editor, Rivka Beitner. (who.int)

Sphingolipids are one of the major membrane lipids in mammalian cells. (stjude.org)

Pathway defects in lipoprotein synthesis, processing, and clearance can lead to accumulation of atherogenic lipids in plasma and endothelium. (msdmanuals.com)
Here we show that primary myoblasts from lipin-1-deficient patients exhibit a dramatic decrease in LPIN1 expression and phosphatidic acid phosphatase 1 activity, and a significant accumulation of lipid droplets (LD). (nih.gov)
2007). Emerging evidence from both epidemiological and experimental studies indicates the adverse consequences of PM2.5 exposure on diabetes, including worsening of whole-body insulin sensitivity, glucose tolerance impairment, lipid accumulation, and glucose metabolism dysfunction (Hwang et al. (deepdyve.com)
We have shown that an endogenous peptide, catestatin, can directly suppress glucose production from hepatocytes and can indirectly suppress lipid accumulation in liver as well as macrophage-mediated inflammation in obese mice," said Sushil K. Mahata, PhD, professor of medicine at UC San Diego School of Medicine. (sciencedaily.com)

Inheritance of Single-Gene Disorders Genes are segments of deoxyribonucleic acid (DNA) that contain the code for a specific protein that functions in one or more types of cells in the body or code for functional RNA molecules. (msdmanuals.com)
Wild type Males require the FA desaturase genes to maintain lipid stores. (tamu.edu)
Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. (snpedia.com)

It binds both fatty acids and bile acids and has roles in fatty acid transport and metabolism. (rndsystems.com)
Bile salts are released in the duodenum in response to cholecystokinin release occurring in the presence of lipid compounds within the ingesta. (medscape.com)
Bile salts aid in forming lipid micelles, which create a hydrophilic surface with a hydrophobic core of lipid molecules, including FFA. (medscape.com)

He trained in medicine at the University of Colorado School of Medicine, and completed a research fellowship in Endocrinology and Metabolism at the University of California, San Francisco and the Gladstone Institutes. (harvard.edu)

Other types of lipids found in the body are fatty acids and membrane lipids. (wikipedia.org)
Specifically, we investigate the membrane lipid biology of proteins as well as the functionality of ion channels and receptors. (stjude.org)
More broadly, the lab investigates the mechanisms by which cells regulate the abundance of lipids, how they store lipids to buffer fluctuations in their availability, and how these processes function in membrane biology and cell physiology. (harvard.edu)
Its oils are rich sources of unsaturated fatty acids, such as monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids, which are previously associated with the prevention of health disorders because of their anti-inflammatory effects and cell membrane properties and structure 2 . (nature.com)
Absorption of lipid compounds into the enterocyte for biochemical usage occurs through diffusion across the cellular membrane and also through lipid transporters that are located on the luminal side of the enterocyte. (medscape.com)

Lipid metabolism is the synthesis and degradation of lipids in cells, involving the breakdown and storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes. (wikipedia.org)
An inherited metabolic disorder that is characterized by impaired synthesis and degradation of amino acids. (mcw.edu)

Since lipids are hydrophobic molecules, they need to be solubilized before their metabolism can begin. (wikipedia.org)

We therefore investigated the effects of PM2.5 exposure on insulin resistance and the disorders of hepatic glucose and lipid metabolism via hypothalamic inflammation. (deepdyve.com)
Therefore, our current finding indicates an important role of hypothalamic inflammation in PM2.5 exposure-mediated hepatic glucose and lipid metabolism disorder. (deepdyve.com)
But further studies are needed to uncover how CST suppresses liver inflammation to improve metabolism. (sciencedaily.com)
SAA2, once viewed as a marker of acute inflammation, has transcended its initial role, emerging as a versatile regulator in immunity, metabolism, and tissue repair. (prospecbio.com)
For example, heart disease may be due to a combination of processes such as glucose metabolism, lipid disorders, high blood pressure and inflammation. (cdc.gov)
The pathogenic mechanisms reported in the literature for VX comprise inflammation, virus, local trauma, lipid metabolism disorders and immunological changes 7,12,15 . (bvsalud.org)

Mitochondria, the major cellular site for lipid oxidation, are strongly associated with cellular oxidative and inflammatory status and are likely to be a target for pomegranate extract action. (nih.gov)
The plaques contain lipids, inflammatory cells, smooth muscle. (msdmanuals.com)
Our data suggest that the pathogenic mechanism of rhabdomyolysis in lipin-1-deficient patients combines the predisposing constitutive impairment of lipid metabolism and its exacerbation by pro-inflammatory cytokines. (nih.gov)
The functional enrichment analysis detected TF linked to lipid homeostasis and inflammatory response, such as RXRA , EGFR , and SREBP2 precursor. (nature.com)

However, a substantial increase in serum triglyceride levels should raise the possibility of another lipid disorder. (medscape.com)
Triglyceride is the most abundant dietary lipid compound found throughout the diet and is the method with which energy is stored in the body. (medscape.com)

Lipid metabolism disorders, such as Gaucher disease and Tay-Sachs disease , involve lipids. (medlineplus.gov)
Subjects with familial dyslipidemia, heart disease and psychotic disorders were excluded from the study. (biomedcentral.com)
Nonalcoholic fatty liver disease (NAFLD), a liver injury disease caused by metabolic disorders [ 1 ], includes nonalcoholic fatty liver (NAFL), nonalcoholic steatohepatitis (NASH), liver fibrosis and cirrhosis, and even hepatocellular carcinoma (HCC) [ 2 ]. (hindawi.com)
We have developed expertise in in vivo investigation of lipid and glucose metabolism, insulin secretion and sensitivity, and vascular biology and in human physiological studies, leading to discovery of attractive drug targets that have been either patented or being investigated for their utility in treatment of fatty liver disease and diabetes in 2 clinical trials in the outlier populations of Fars/Iran. (yale.edu)
Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond a lipid panel is unknown. (stlukes-stl.com)
Genest J, Libby P. Lipoprotein disorders and cardiovascular disease. (stlukes-stl.com)
Rheumatoid arthritis is the most common coexisting autoimmune disorder in patients with Grave's disease and Hashimoto thyroiditis. (springer.com)
Bob Farese Jr. is an expert in how lipid synthesis and storage may lead to disease-and an accomplished amateur photographer. (harvard.edu)
Man who underwent Roux-en-Y gastric bypass at age 26, subsequently diagnosed with Crohn's disease, involving jejunum, ileum and colon, at age 42 when he presented with large volume diarrhoea and rectal bleeding. (medscape.com)

These molecules could be therapeutic targets for the skeletal disorders. (austinpublishinggroup.com)
Among the molecules we identified in this study, there are some whose suppression ameliorated skeletal disorders under pathological conditions but did not affect physiological conditions, indicating that targeting on these molecules may lead to an ideal treatment without side effects on physiological functions. (austinpublishinggroup.com)
Fatty acids are the main compound of lipids, which are a class of molecules present in animals and vegetal cell types. (nature.com)

Furthermore, our results are consistent with the fact that endurant individuals rely preferentially on lipid metabolism, because oxidative phosphorylation of fatty acids in muscle mitochondria produces a high yield of ATP, necessary for prolonged contraction of muscle fibers. (pfeiffertheface.com)

Age-related metabolic changes can exacerbate these neurological disorders resulting in behavioral decline. (tamu.edu)
Understanding how different fuels affect behavioral decline can elucidate fundamental principles underlying neurological disorders. (tamu.edu)

In fatty acid oxidation disorders, both parents of the affected child carry a copy of the abnormal gene. (msdmanuals.com)
Because usually two copies of the abnormal gene are necessary for the disorder to occur, usually neither parent has the disorder. (msdmanuals.com)
An abnormal result may mean you have high lipid (fat) levels in your blood. (stlukes-stl.com)
which means only one copy of the abnormal gene can cause the disorder in boys. (merckmanuals.com)
In 2013, the American Heart Association reported that proportions of American adults aged 20 or above had abnormal blood lipid serum profile (details are shown in Table 1 ) [ 4 ]. (hindawi.com)
Average percentage of abnormal blood lipid levels among Americans at age 20 or above [ 4 ]. (hindawi.com)

After subsequent studies, regucalcin has been established to play a pivotal role in maintaining cell homeostasis and protecting it from disorders in various types of cells and tissues. (novapublishers.com)
Treatment of fatty acid oxidation disorders varies depending on the type of fatty substances that accumulate in the blood and tissues. (msdmanuals.com)
They represent 10% to 20% of cellular lipids, and in certain specialized tissues, such as myelin sheaths, they can account for ~25% of the lipids. (stjude.org)

Dietary TG metabolism begins in the stomach and duodenum, where TGs are broken into monoglycerides (MGs) and FFAs by gastric lipase, emulsification due to vigorous stomach peristalsis, and pancreatic lipase. (msdmanuals.com)
These findings demonstrated that key TF related to lipid metabolism could be modulated by dietary inclusion of soybean oil. (nature.com)

The majority of lipid digestion and absorption, however, occurs once the fats reach the small intestines. (wikipedia.org)
The second step in lipid metabolism is absorption of fats. (wikipedia.org)

Lipids are vital for both cellular structure and function. (stjude.org)

Lipids are fats or fat-like substances. (medlineplus.gov)

Structure and function of lipid droplet assembly complexes. (harvard.edu)
Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum. (harvard.edu)
Seipin forms a flexible cage at lipid droplet formation sites. (harvard.edu)

Glucose measurements are used in the diagnosis and treatment of pancreatic islet cell carcinoma and of carbohydrate metabolism disorders, including diabetes mellitus, neonatal hypoglycemia, and idiopathic hypoglycemia. (cdc.gov)
The term Diabetes Mellitus stands for a group of disorders defined by Hyperglycaemia. (who.int)

This book will provide information regarding regucalcin that plays a pivotal role in cell homeostasis and disorder. (novapublishers.com)

Lipids are fats that are either absorbed from food or synthesized by the liver. (msdmanuals.com)

and PAR-07-048 and PAR-07-049 , to stimulate the discovery, design, development and testing of novel compounds aimed at prevention or treatment of nervous system disorders. (nih.gov)
Triglycerides are lipid compounds composed of a glycerol esterified to 3 fatty acid chains of varying length and composition. (medscape.com)

Lipid catabolism is accomplished by a process known as beta oxidation which takes place in the mitochondria and peroxisome cell organelles. (wikipedia.org)

Despite significant social demand for more information of the etiology of the disorders, the molecular mechanisms have not yet been fully elucidated. (austinpublishinggroup.com)

Most cases were women, had Roux-en-Y surgery years prior to diagnosis and few IBD-related complications. (medscape.com)

Rare congenital X-linked disorder of lipid metabolism. (bvsalud.org)

12 demonstrated that VX has macrophages containing lipids within them, anD after immunohistochemical studies, they confirmed the macrophagic origin of the xanthoma cells 13-14 , in which their cytoplasm is PAS-positive 2 . (bvsalud.org)

It also plays an important role in fat metabolism and in the utilization of amino acids. (usz.ch)

Identification of two pathways mediating protein targeting from ER to lipid droplets. (harvard.edu)

Lipid metabolism also occurs in plants, though the processes differ in some ways when compared to animals. (wikipedia.org)
Initially identified as a biomarker of acute-phase reactions, research on SAA2 has expanded, revealing its involvement in various physiological processes, including immunity, lipid metabolism, and tissue repair. (prospecbio.com)

Diseases6

Chemicals and Drugs1

Phenomena and Processes1

Lipoproteins6

Changes in lipid metabolism2

Diseases10

Energy metabolism3

Endocrine disorders2

Affect lipid metabolism2

Obesity6

Cholesterol9

Enzymes6

Atherosclerosis2

Hepatic lipid3

Regulation4

Sphingolipids1

Accumulation4

Genes3

Bile3

Endocrinology and Metabolism1

Membrane5

Synthesis and degradation2

Hydrophobic1

Inflammation6

Inflammatory4

Triglyceride2

Disease9

Molecules3

Oxidative1

Neurological Disorders2

Abnormal6

Tissues3

Dietary2

Absorption2

Cellular1

Substances1

Droplet3

Diabetes mellitus2

Homeostasis1

Fats1

Compounds2

Mitochondria1

Etiology1

Complications1

Congenital1

Cells1

Amino acids1

Pathways1

Processes2