• apoptosis-induci
  • TNF-related apoptosis-inducing ligand (TRAIL/Apo2 ligand), along with FasL and TNFα, is one of three members of the TNF cytokine family that induce apoptosis. (jimmunol.org)
  • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor α family of cytokines that preferentially induces apoptosis in transformed cells, making it a promising cancer therapy. (bridgew.edu)
  • TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) activates the apoptotic pathway in tumor cells upon binding to its cognate agonistic receptors, death receptors 4 and 5 (DR4 and DR5). (aacrjournals.org)
  • The news reporters obtained a quote from the research from the Medical University of Silesia, "TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is an activator of apoptosis in tumor cells. (ustoo.org)
  • FasL
  • The apoptosis-inducing Fas ligand (FasL) is a type II transmembrane protein that is involved in the downregulation of immune reactions by activation-induced cell death (AICD) as well as in T cell-mediated cytotoxicity. (kuleuven.be)
  • death
  • In view of our results describing opposite consequences of PI3K inhibition on death receptor-mediated sensitivity, we conclude that investigating apoptosis induction by inhibitors of PI3K combined with death receptor ligands should take in account the effects on DR4 and DR5 individually to achieve optimal tumor cell killing. (aacrjournals.org)