• protein
  • The impairment of protein degradation pathways, including both the ubiquitin-proteasome system and the autophagy-lysosome pathway also play an important role during the development of Lewy body diseases. (mdpi.com)
  • Affected members of the first family, including cases 1 and 2 reported here, are known to have 717 valine to isoleucine mutation of the amyloid precursor protein (APP) gene, while the genetic background of the disease has not been clarified yet in the second family. (springer.com)
  • Lin, W.L., M. Castanedes-Casey, and D.W. Dickson, Transactivation response DNA-binding protein 43 microvasculopathy in frontotemporal degeneration and familial Lewy body disease. (wikipedia.org)
  • Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease. (wikipedia.org)
  • inclusions
  • LBD are characterized by the presence on intraneuronal proteinaceous inclusions called Lewy bodies (LBs) with AS as their main component. (mdpi.com)
  • Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado-Joseph disease. (wikipedia.org)
  • Diagnosis
  • Biopsy of the submandibular gland then also may be able to provide a more accurate diagnosis of dementia with Lewy bodies during life," explained lead investigator Thomas G. Beach, MD, PhD, Head and Senior Scientist at the Civin Laboratory for Neuropathology, Director of the Brain and Body Donation Program, Banner Sun Health Research Institute (BSHRI), Phoenix, Arizona. (eurekalert.org)
  • patients
  • A CSF AD profile was observed in 25% of DLB patients, compared with only 9% of PDD and 3% of PD without dementia.Within DLB, patients with a CSF AD profile were older, more often female, performed worse on the Mini-Mental State Examination, and had shorter disease duration compared with patients with normal CSF. (lu.se)
  • Faced with a serious disease, patients want to know the answer to a difficult question: "How long will I live? (disabled-world.com)
  • The population-based study found that patients with these diseases died about two years earlier than the general population. (disabled-world.com)
  • They compared 461 patients with these diseases to 452 patients in the general population -- all in Olmsted County, Minnesota. (disabled-world.com)
  • Among patients with synucleinopathies, neurodegenerative disease was the most frequent cause of death at 31.5 percent. (disabled-world.com)
  • synucleinopathies
  • This helps understanding on how these diseases work," Dr. Savica says, noting that the paper is among the first comprehensive studies of the survival and cause of death of people with synucleinopathies, compared with the general population. (disabled-world.com)