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  • cells
  • Giving low doses of chemotherapy, such as fludarabine phosphate, and TBI before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. (clinicaltrials.gov)
  • Why are CD8+ T Cells that Re-Express CD45RA Associated with Lymphoma Relapse? (takedowncancer.org)
  • Sorafenib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer. (clinicaltrials.gov)
  • Briefly, peripheral blood mononuclear cells (PBMCs) are isolated from routine phlebotomy samples and then cultured in defined growth factors to yield a highly proliferative erythrocyte progenitor cell population that is remarkably amenable to reprogramming. (jove.com)
  • Potential uses of human iPSCs include modeling pathogenesis of human genetic diseases, autologous cell therapy after gene correction, and personalized drug screening by providing a source of patient-specific and symptom relevant cells. (jove.com)
  • In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses. (wikipedia.org)
  • Expression of type I and III IFNs can be induced in virtually all cell types upon recognition of viral components, especially nucleic acids, by cytoplasmic and endosomal receptors, whereas type II interferon is induced by cytokines such as IL-12, and its expression is restricted to immune cells such as T cells and NK cells. (wikipedia.org)
  • A virus-infected cell releases viral particles that can infect nearby cells. (wikipedia.org)
  • However, the infected cell can prepare neighboring cells against a potential infection by the virus by releasing interferons. (wikipedia.org)
  • Unlike most non-Hodgkin lymphomas (which are generally B cell related), CTCL is caused by a mutation of T cells. (wikipedia.org)
  • Cardiac arrest Cytokine release syndrome Tumor lysis syndrome, causing acute renal failure Infections Hepatitis B reactivation Other viral infections Progressive multifocal leukoencephalopathy (PML) Immune toxicity, with depletion of B cells in 70% to 80% of lymphoma patients Pulmonary toxicity Bowel obstruction and perforation Two patients with systemic lupus erythematosus died of progressive multifocal leukoencephalopathy (PML) after being treated with rituximab. (wikipedia.org)
  • They include: Cell growth and division absent the proper signals Continuous growth and division even given contrary signals Avoidance of programmed cell death Limitless number of cell divisions Promoting blood vessel construction Invasion of tissue and formation of metastases The progression from normal cells to cells that can form a detectable mass to outright cancer involves multiple steps known as malignant progression. (wikipedia.org)
  • In January 2016 Juno announced it had acquired AbVitro, allowing it to use next-generation single cell sequencing platforms to complement its ability to create T cells engineered to target a broad array of cancer targets. (wikipedia.org)
  • Most normal cells will undergo a programmed form of rapid cell death (apoptosis) when critical functions are altered and malfunctioning. (wikipedia.org)
  • further explanation needed] According to the CDC definition, a patient has AIDS if they are infected with HIV and have either: a CD4+ T-cell count below 200 cells/µL a CD4+ T-cell percentage of total lymphocytes of less than 15% or one of the defining illnesses. (wikipedia.org)
  • Therefore, canonical PRC1 complexes and PRC2 can act together to repress gene transcription and maintain this repression through cell division (i.e. the repressed state is also present in daughter cells). (wikipedia.org)
  • Maintenance of embryonic stem cells (ES) Lineage-specific genes are genes that will define the final identity of the differentiated cell. (wikipedia.org)
  • The lack of the normal distribution of these B cells is one basis for demonstrating clonality, the key element for establishing a diagnosis of any B cell malignancy (B cell non-Hodgkin lymphoma). (wikipedia.org)
  • The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. (wikipedia.org)
  • Cancers
  • Cancers are a large family of diseases that involve abnormal cell growth with the potential to invade or spread to other parts of the body. (wikipedia.org)
  • genes
  • In ATL cell lines, complete DNA methylation of 5'-LTR was associated with transcriptional silencing of viral genes. (biomedcentral.com)
  • These factors act, at least partly, by changing the genes of a cell. (wikipedia.org)
  • Most oncogenes began as proto-oncogenes, normal genes involved in cell growth and proliferation or inhibition of apoptosis. (wikipedia.org)
  • If normal genes promoting cellular growth, through mutation, are up-regulated, (gain of function mutation) they will predispose the cell to cancer and are thus termed oncogenes. (wikipedia.org)
  • The human genome may encode over 1000 miRNAs, which are abundant in many mammalian cell types and appear to target about 60% of the genes of humans and other mammals. (wikipedia.org)
  • receptor
  • Resulting iPSCs were further characterized and deemed free of transfected DNA, integrated transgene DNA, and lack detectable gene rearrangements such as those within the immunoglobulin heavy chain and T cell receptor loci of more differentiated cell types. (jove.com)
  • Interferon type I: All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α/β receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains. (wikipedia.org)
  • It targets the programmed cell death 1 (PD-1) receptor of lymphocytes. (wikipedia.org)
  • Pembrolizumab is an immunoglobulin G4, with a variable region against the human programmed cell death 1 receptor, a humanized mouse monoclonal [228-L-proline(H10-S>P)]γ4 heavy chain (134-218') disulfide and a humanized mouse monoclonal κ light chain dimer (226-226:229-229)-bisdisulfide. (wikipedia.org)
  • In December 2014 the company signed an agreement with Opus Bio, Inc for a chimeric antigen receptor (CAR-T) cell product candidate targeting CD22. (wikipedia.org)
  • The trials will assess combinations of MEDI4736 and one of Juno's CD19 directed chimeric antigen receptor T cell candidates. (wikipedia.org)
  • Later in the same month the company launched a collaboration, with Editas Medicine, to create CAR-T and high-affinity T cell receptor therapies to treat cancer, with the potential to generate up to $737 million-plus for Editas. (wikipedia.org)
  • Leukemia inhibitory factor receptor has been shown to interact with Glycoprotein 130. (wikipedia.org)
  • Maturation
  • In August the company announced it would license rights from Memorial Sloan Kettering Cancer Center and Eureka Therapeutics for a novel, fully human binding domain targeting B-cell maturation antigen. (wikipedia.org)
  • peripheral blood
  • In the mid-1990s, my research group began to devise a method to establish endothelial cell cultures from human peripheral blood, with an ultimate goal of examining interindividual heterogeneity of endothelial biology. (jci.org)
  • Tumors
  • Gather important data regarding the inter- and intra-patient variability of effector cell trafficking into these tumors. (clinicaltrials.gov)
  • Tumors develop when this balance is disrupted by mutations that either boost the rate of cellular multiplication, or that protect the aberrant cell from appropriate programmed death. (oasisofhope.com)
  • In children, acute lymphoblastic leukemia and brain tumors are most common except in Africa where non-Hodgkin lymphoma occurs more often. (wikipedia.org)
  • stem
  • Once iPSC colonies exhibit typical human embryonic stem cell (hESC) morphology, they are gently transferred to individual iMEF-coated tissue culture plates for continued growth and expansion. (jove.com)
  • viral
  • Once integrated, HTLV-1 continues to exist only as a provirus which can spread from cell to cell through a viral synapse. (wikipedia.org)
  • The lipid outer envelope is of host cell origin but contains viral transmembrane and surface proteins. (wikipedia.org)
  • tissues
  • miRNA research revealed different sets of miRNAs expressed in different cell types and tissues and multiple roles for miRNAs in plant and animal development and in many other biological processes. (wikipedia.org)
  • diseases
  • According to the medicalnewstoday cancer is a class of diseases characterized by out-of-control cell growth. (melandriaromero.net)
  • Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. (wikipedia.org)
  • commonly
  • While the majority of miRNAs are located within the cell, some miRNAs, commonly known as circulating miRNAs or extracellular miRNAs, have also been found in extracellular environment, including various biological fluids and cell culture media. (wikipedia.org)
  • protein
  • the phosphorylated eIF-2 forms an inactive complex with another protein, called eIF2B, to reduce protein synthesis within the cell. (wikipedia.org)
  • When it binds to this protein it triggers cell death. (wikipedia.org)
  • Pembrolizumab is a therapeutic antibody that binds to and blocks the PD-1, programmed cell death protein 1 located on lymphocytes. (wikipedia.org)
  • Alkaline phosphatase in E. coli is located in the periplasmic space and can thus be released using techniques that weaken the cell wall and release the protein. (wikipedia.org)
  • The unregulated expression of this protein activates other proteins that are involved in cell cycle and cell division which can cause a cell to grow and divide uncontrollably (the cell becomes cancerous). (wikipedia.org)
  • cancer
  • Some of these "oncogenic" (cancer-causing mutations) boost the intensity of growth signals that cause the cell to multiply, or disable key proteins that restrain these growth signals. (oasisofhope.com)
  • abnormal
  • That is because many mutations that boost growth signals are somehow "sensed" by the cell as abnormal, inducing the cell to commit suicide. (oasisofhope.com)
  • mutation
  • But occasionally a mutation arises that is not only tolerated by the cell, but increases the capacity of the cell to survive, proliferate and migrate. (oasisofhope.com)
  • proteins
  • Oncogenes play an important role in the regulation or synthesis of proteins linked to tumorigenic cell growth. (wikipedia.org)
  • growth
  • But, this protective apoptotic response can sometimes be "vetoed" if the cell is exposed to excessive levels of certain growth-promoting hormones that suppress apoptosis. (oasisofhope.com)
  • mutations
  • These phenotypes were unexpectedly linked to mutations in the gene encoding a subunit of the Go-Ichi-Ni-San (GINS) complex, which is essential for DNA replication prior to cell division. (jci.org)
  • Most of these mutations are either innocuous, having no significant impact on the behavior or survival of the cell, or are deleterious to the cell, dooming it to an early death. (oasisofhope.com)
  • different
  • CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. (wikipedia.org)
  • results
  • Together, the results of this study lay the groundwork for future studies to explore the role of DNA replication in immune cell generation and function. (jci.org)