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  • koalas
  • A long time ago, zoologists/animal technicians/etc, noticed that their koalas werent dying from old age or falling out of trees or whatever- Koalas were dying from leukemias, others were getting lymphomas, and others were dying from complications of immunodeficiencies (a big one in koalas is chlamydia). (scienceblogs.com)
  • Since chlamydia is such a big deal in koalas, maybe their leukemias/lymphomas are the result of a different kind of koala-STD, like a koala-EBV or something. (scienceblogs.com)
  • 3- An ancestor of 'koalas' could have been infected from an ancestor of 'gibbons' a bazillion years ago, when both ancestors shared a common environment. (scienceblogs.com)
  • Just because koalas and gibbons are environmentally separated now doesnt mean they always were. (scienceblogs.com)
  • Studies have suggested that the virus is responsible for the very high incidence of chlamydosis, leukemia, and lymphoma seen in koalas [1,2,7, (kenyon.edu)
  • Koala immunodeficiency virus is perhaps the most significant health concern facing koalas today. (kenyon.edu)
  • The virus has a 100% prevalence in the blood and various tissues of koalas living in Southeast Queensland Australia [1, (kenyon.edu)
  • Though the virus is present in 100% of this mainland population, not all virus-carrying koalas express symptoms of the disease . (kenyon.edu)
  • Beyond the significance and importance of the mechanisms of evolution and proliferation of KoRV, rising public awareness of the virus has also started a key debate as to the conservation status of Koalas. (kenyon.edu)
  • The epidemiology of how koalas and gibbons came to share such similar viruses remains unclear. (wikipedia.org)
  • 80% of deaths of captive koalas in Queensland from leukaemia, lymphoma, malignant tumours and immune deficiency disorders have been attributed to the virus. (wikipedia.org)
  • In 2008, lead researcher Jon Hanger, said the virus was a threat that could lead to extinction of koalas in Queensland within 15 years, claiming 100% infection rates in studied populations that suggest an epidemic. (wikipedia.org)
  • strains
  • A team of researchers from The Scripps Research Institute (TSRI) and Janssen Research & Development (Janssen) has devised artificial peptide molecules that neutralize a broad range of influenza virus strains. (phys.org)
  • Based on analysis of strains found in four species of monkeys from Bioko Island, which was isolated from the mainland by rising sea levels about 11,000 years ago, it has been concluded that SIV has been present in monkeys and apes for at least 32,000 years, and probably much longer. (wikipedia.org)
  • While human immunodeficiency virus has a limited number of subtypes, SIV is now known to infect a few dozen species of non-human primates, and distinct strains are often associated with each species, or with a set of closely related species. (wikipedia.org)
  • herpes
  • Abnormal expression of only the CD34 part of a transgenic CD34/herpes simplex virus-thymidine kinase fusion protein is associated with ganciclovir resistance. (semanticscholar.org)
  • Following the promising pre-clinical and clinical results with the oncolytic herpes simplex virus (HSV) OncoVEX GM-CSF, we aimed to express RNAi triggers from oncolytic HSV, which although has the potential to improve treatment by silencing tumour-related genes, was not considered possible due to the highly oncolytic properties of HSV. (jove.com)
  • Herpes simplex virus type 1 (HSV-1) has demonstrated particular promise in this field, showing genetically engineered selective tumor replication and cytotoxicity in a wide variety of tumor types, without damaging healthy tissues. (surrey.ac.uk)
  • endogenous form
  • The primary method of viral proliferation is vertical transfer via an endogenous form of the virus, while evidence exists that the virus is transmitted horizontally as a membrane-enclosed virion only through close contact between individuals [2,7, (kenyon.edu)
  • mosquitoes
  • Recent transmission of the virus, possibly by mosquitoes, has reduced the koala population on Kangaroo Island by half . (kenyon.edu)
  • Classification
  • Though not used by the ICTV, Baltimore classification, which groups viruses together based on how they produce mRNA, is used in conjunction with the ICTV's work in modern virus classification. (wikipedia.org)
  • deaths
  • In just a few days, a bird flu virus has led to the deaths of more than 400,000 turkeys and chickens on 10 farms in a southwest Indiana county that's the state's largest turkey producer. (phys.org)
  • cell
  • Donor lymphocyte infusions (DLI) following allogeneic stem cell transplantation are known to mediate graft-versus-leukemia effect (GVL). (semanticscholar.org)
  • While both types of viruses replicated in most of the mesothelioma cell lines tested, the mouse-derived virus was not effective in a mesothelioma cell line called ACC-MESO-1. (survivingmesothelioma.com)
  • cause
  • Extensive studies in sooty mangabeys have established that SIVsmm infection does not cause any disease in these African primates, despite high levels of circulating virus. (wikipedia.org)
  • Recent
  • It appears that this evolution of this dynamic is fairly recent, as the isolated (since 1920) koala population on Kangaroo island, showed no incidence of the virus until very recently . (kenyon.edu)
  • Asian
  • A new paper from an MIT-led team demonstrates that Alaska can offer a significant foothold for Asian flu viruses, enabling them to enter North America. (phys.org)
  • exogenous
  • The virus is thought to be a recently introduced exogenous virus that is also integrating into the koala genome (becoming endogenous). (wikipedia.org)
  • Therefore, KoRVB will remain exogenous and more pathogenic than KoRVA, because the deleterious effects it causes in its hosts will not be selected against to the extent they would in a virus capable of integrating into the germ line. (wikipedia.org)
  • infection
  • Dimmock NJ (1982) Initial stages in infection with animal viruses. (springer.com)
  • Extensive studies in sooty mangabeys have established that SIVsmm infection does not cause any disease in these African primates, despite high levels of circulating virus. (wikipedia.org)
  • In 2008, lead researcher Jon Hanger, said the virus was a threat that could lead to extinction of koalas in Queensland within 15 years, claiming 100% infection rates in studied populations that suggest an epidemic. (wikipedia.org)
  • infects
  • Only time will tell, but two Florida Gulf Coast University researchers have patented a potential treatment for the illness and are leading the charge toward a vaccine against the mosquito-borne virus that infects hundreds of millions of people around the world each year. (ufl.edu)
  • viral
  • The system is useful for detecting viral RNA-containing cells in the presence of an excess of virus-negative cells and for determining which type of cell in a heterogenous population is expressing viral RNA. (semanticscholar.org)
  • Following transfection of viral RNA, infectious virus could be recovered from all non-permissive cells, except from Madin-Darby canine kidney cells. (springer.com)
  • Viral DNA sequence analysis showed intact open reading frames and pathogenic DNA motifs strongly suggesting that KoRV is an active replicating endogenous virus that can also produce infectious virions. (wikipedia.org)
  • whereas
  • Treatment of cells with proteases increased FCV binding, whereas phospholipase had no effect on virus attachment. (springer.com)
  • cells
  • Professors Sharon Isern and Scott Michael, virologists who teach in the Department of Biological Sciences, discovered a way to inhibit the virus from infecting new cells by attaching a small protein, or peptide, to the pathogen. (ufl.edu)
  • Cells in suspension at 4°C bound virus more efficiently than cells in monolayers at 4°C or 37°C. High initial binding rate was observed in monolayers or cells in suspension and proceeded to a maximum at 90 min, although half maximal binding was observed as early as 15 min. (springer.com)
  • Baltimore
  • Though not used by the ICTV, Baltimore classification, which groups viruses together based on how they produce mRNA, is used in conjunction with the ICTV's work in modern virus classification. (wikipedia.org)
  • study
  • As expected, the XMRV virus research has stimulated interest in a host of studies to see if the initial study results can be replicated and to discover treatments for XMRV. (psychologytoday.com)
  • research
  • Scientists have identified a virus that can weaken the ability of a fungus to avoid pairing with other incompatible fungi, according to new research published in PLOS Pathogens. (phys.org)