• T]he strong cytotoxic effect of Thujaplicin on murine P388 lymphocytic leukemia cell line [CLL, chronic lymphocytic leukemia] should be emphasized. (oil-testimonials.com)
  • Bioassay-guided (murine P388 lymphocytic leukemia and human cancer cell lines) separation of an ethyl acetate extract prepared from the inky cap fungus Coprinus cinereus led to the isolation of three new sesquiterpenes, 7,7a-diepicoprinastatin 1 (1), 14-hydroxy-5-desoxy-2S,3S,9R-illudosin (2), and 4,5-dehydro-5-deoxyarmillol (3), together with the known armillol (4). (elsevierpure.com)
  • In vivo development and in vitro characterization of a subclone of murine P388 leukemia resistant to bis(diphenylphosphine)ethane. (aspetjournals.org)
  • Cyclobutane 2 led to modest inhibition of the murine P388 leukemia cell line. (elsevierpure.com)
  • The compound 1 was further characterized with different techniques to gain more complete data and then tested for anticancer activity test against P-388 murine leukemia cells. (ijournalse.org)
  • Anticancer activity tests against P-388 murine leukemia cells revealed that compound 1 has an IC 50 of 2.35 µg/mL, confirming that the compound is categorized as an active anticancer agent and suggesting that the compound has promising potential that deserves further investigations. (ijournalse.org)
  • It has an inhibitory effect on P388 leukemia cells and can prolong survival. (focusherb.com)
  • Its main anti-tumor activity is concentrated on neuroectodermal tumors, liver cancer, lung squamous cell carcinoma, skin Merkel cell carcinoma, gastric cancer, leukemia and other tumors. (focusherb.com)
  • The in vivo antitumoral/antileukemic activity was evaluated using the following panel of tumor lines: P-388 leukemia, sarcoma (S-37), Ehrlich ascitic tumor (EAT), Lewis lung carcinoma (LLC), MB-F10 melanoma and ADC-755 mammary adenocarcinoma. (greenmedinfo.com)
  • The coordinated gold compound, 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S-triethylphosphine-gold (auranofin) was found to be effective in increasing the life span of C57BL x DBA/2 F1 mice inoculated with the lymphocytic leukemia P388. (nih.gov)
  • 770-fold from the P-388 lymphocytic leukemia tumor cell line. (nih.gov)
  • 13. Doxorubicin cytotoxicity to P388 lymphocytic leukemia as determined by alkaline elution and established assays. (nih.gov)
  • An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene. (nih.gov)
  • T]he strong cytotoxic effect of Thujaplicin on murine P388 lymphocytic leukemia cell line [CLL, chronic lymphocytic leukemia] should be emphasized. (oil-testimonials.com)
  • Continuation of a detailed investigation of cancer cell growth inhibitory (P388 lymphocytic leukemia) fractions (trace) from H. erecta has revealed the presence (10 -5 to 10 -7 % yield) of cytotoxic pentacyclic sesterterpenes. (elsevierpure.com)
  • 1. [In vitro evaluation of the chemosensitivity of an experimental murine leukemia rendered resistant in vivo to adriamycin]. (nih.gov)
  • 2. [A short term test suitable for in vitro prediction of the drug sensitivity of human leukemias: a preliminary study on murine experimental neoplasms]. (nih.gov)
  • 4. Mechanism of acquired resistance to methotrexate in P388 murine leukemia cells and in their doxorubicin-resistant subline. (nih.gov)
  • 7. Murine splenocyte migration inhibition assay I. Detection of differential responses to murine leukemia P388 and its adriamycin-resistant subline P388/ADR. (nih.gov)
  • 9. Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by perhexiline maleate. (nih.gov)
  • 10. Differential effect of collaterally sensitive antimetabolites on P388 murine leukemia sensitive and resistant to adriamycin in vitro. (nih.gov)
  • 18. Anthracycline resistance in P388 murine leukemia and its circumvention by calcium antagonists. (nih.gov)
  • Purification Of Active Compounds From Kecapi Leaves That Have Potential As Anticancer Fon IN Vitro On Murine Cells Leukemia A P-388. (uisu.ac.id)
  • Using a Topo I-deficient murine B lymphoma-derived subclone (P388-45/C) selected for its resistance to high dosage of the antitumor drug camptothecin, we show that Topo I depletion results in the hypophosphorylation of SR proteins and impairs exonic splicing enhancer (ESE)-dependent but not constitutive splicing. (hal.science)
  • The cell inhibition activities of several Annonaceous acetogenins, covering the three major structural classes of bis-adjacent, bis-non-adjacent, and single tetrahydrofuran (THF) ring compounds and their respective ketolactone rearrangement products, were tested in an in vitro disk diffusion assay against three murine (P388, PO3, and M17/Adr) and two human (H8 and H125) cancerous cell lines as well as a non-cancerous immortalized rat GI epithelial cell line (I18). (cancer.org)
  • DMAB was active in the National Cancer Institute in vivo anticancer drug screen for tumor model L1210 leukemia in BDF1 mice. (nih.gov)
  • Esophageal cancer chemotherapy drug etoposide injection can cure more than half of L1210 leukemia in mice, on the S37, S180 tumor inhibition rate of 61% - 72%, so that the survival of mice suffering from leukemia P1534 compared with the control group increased by 83% - 110% of mice Lewis lung cancer lung metastasis was inhibited. (cancerlive.net)
  • The metallocene dihalides are a relatively new class of small, hydrophobic organometallic anticancer agents that exhibit antitumour properties against numerous cell lines including leukemias P388 and L1210, colon 38 and Lewis lung carcinomas, B16 melanoma, solid and fluid Ehrlich ascites tumours and several human colon and lung carcinomas transplanted into athymic mice. (eurekaselect.com)
  • 14. In vivo circumvention of vincristine resistance in mice with P388 leukemia using a novel compound, AHC-52. (nih.gov)
  • In vivo administration of PDX-101 increased median survival in mice carrying P388 leukemia cells from 9 to 16 days. (medscape.com)
  • As many consider P388 an "artificial" model (an "in vivo test tube"), further studies were performed with A2780 human xenografts in mice. (medscape.com)
  • When these analogues were separated into mitomycin C and mitomycin A subsets, the former gave a correlation only with E½, whereas the latter (which differ little in their E½ values) gave a correlation only with log P. These correlations are in contrast to those made in the P388 leukemia assay in mice wherein the most active mitomycin C and mitomycin A analogues were the most hydrophilic ones. (arizona.edu)
  • When the compounds were injected i.p., alpha- and gamma-tocotrienols were effective against sarcoma 180, Ehrlich carcinoma, and IMC carcinoma, and gamma-tocotrienol showed a slight life-prolonging effect in mice with Meth A fibrosarcoma, but thetocotrienols had no antitumor activity against P388 leukemia at doses of 5-40 mg/kg/d. (tocotrienolresearch.org)
  • while the 3-acethyl-ursolic [3-acethyl-oleanolic] acids with IC 50 = 37.9 µg/mL showed two-fold more potent then their parent triterpenes (IC 50 = 53.5 µg/mL) in the inhibition of P388 leukemia cell growth. (ugm.ac.id)
  • Employing P388 leukemia and human tumor cell line-guided bioassay techniques, two new moderate inhibitors of cancer cells were isolated and named sesterstatins 4 (1a, P388 ED 50 4.9 μg/mL) and 5 (1b, DU-145 prostate GI 50 1.9 μg/mL). (elsevierpure.com)
  • 6. Resistance to adriamycin: relationship of cytotoxicity to drug uptake and DNA single- and double-strand breakage in cloned cell lines of adriamycin-sensitive and -resistant P388 leukemia. (nih.gov)
  • 12. Intracellular adriamycin levels and cytotoxicity in adriamycin-sensitive and adriamycin-resistant P388 mouse leukemia cells. (nih.gov)
  • 3. In vivo characteristics of resistance and cross-resistance of an adriamycin-resistant subline of P388 leukemia. (nih.gov)
  • Overexpression of the multidrug resistance proteins P-glycoprotein (Pgp), multidrug resistance protein (MRP-1), breast cancer resistance protein (BCRP), and lung resistance protein (LRP) is associated with treatment failure in acute myeloid leukemia (AML) and other malignancies. (aacrjournals.org)
  • Leucemia linfocítica experimental inducida originalmente en ratones DBA/2 mediante una clase de pintura que contiene metilcolantreno. (bvsalud.org)
  • Because the efflux transporter P-glycoprotein (P-gp) is involved in the absorption, distribution, and excretion of many drugs and often participates in drug-drug interactions, we studied the effect of a crude kava extract and the main kavalactones kavain, dihydrokavain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin on the P-gp-mediated efflux of calcein-acetoxymethylester in the P-gp-overexpressing cell line P388/dx and the corresponding cell line P388. (nih.gov)
  • Our results indicate that NBPQD is able to alleviate leukemia and it is worthy of further characterization as a potential anti-leukemic drug. (japsonline.com)
  • Causes of leukemia are diverse and they could be familial, infectious, physical, or chemical depending on the cell type and the individual variations from one patient to another ( Pui, 1995 ). (japsonline.com)