• aggressive
  • CMML is among the most aggressive chronic leukemias, and there are fewer effective therapies than for most other hematologic malignancies. (uptodate.com)
  • Aggressive NK-cell leukemia is a disease with an aggressive, systemic proliferation of natural killer cells (NK cells) and a rapidly declining clinical course. (wikipedia.org)
  • child has leukemia
  • To determine whether a child has leukemia, a doctor will do a physical examination to check for signs of infection, anemia, abnormal bleeding, and swollen lymph nodes. (kidshealth.org)
  • When a child has leukemia, the cells do not respond to the signals telling them when to stop and when to produce cells, regardless of the available space. (wikipedia.org)
  • involve
  • To limit the risk of prenatal radiation exposure as a trigger for leukemia (especially ALL), women who are pregnant or who suspect that they might be pregnant should always inform their doctors before undergoing tests or medical procedures that involve radiation (such as X-rays). (kidshealth.org)
  • infection
  • Because their infection-fighting white blood cells are defective, kids with leukemia may have more viral or bacterial infections than usual. (kidshealth.org)
  • 1 As the leukemia spreads, infection, anemia or easy bleeding may occur due to a diminished number of healthy blood cells. (novartis.com)
  • closely related
  • Similar to the closely related pediatric disease juvenile myelomonocytic leukemia (JMML), a large fraction of CMML cases display hypersensitivity to granulocyte macrophage colony-stimulating factor (GM-CSF) in vitro, which likely contributes to the monocytosis characteristic of the disease [ 11-13 ]. (uptodate.com)
  • abnormal
  • Occasionally, the spread of leukemia to the brain can cause headaches , seizures , balance problems , or abnormal vision. (kidshealth.org)
  • Leukemia is a type of cancer of the blood cells in which the growth and development of the blood cells are abnormal. (medicinenet.com)
  • progresses
  • As leukemia progresses, the cancer interferes with the body's production of other types of blood cells, including red blood cells and platelets. (kidshealth.org)
  • Treatment
  • What was the treatment for your leukemia? (medicinenet.com)
  • Immediate treatment is required in acute leukemia because of the rapid progression and accumulation of the malignant cells, which then spill over into the bloodstream and spread to other organs of the body. (wikipedia.org)
  • Whereas acute leukemia must be treated immediately, chronic forms are sometimes monitored for some time before treatment to ensure maximum effectiveness of therapy. (wikipedia.org)
  • cell
  • Chronic myelomonocytic leukemia (CMML) is a malignant hematopoietic stem cell disorder with clinical and pathological features of both a myeloproliferative neoplasm (MPN) and myelodysplastic syndrome (MDS). (uptodate.com)
  • It is divided in two main categories: T-cell LGL leukemia (T-LGLL) and natural-killer (NK)-cell LGL leukemia (NK-LGL)L. As the name suggests, T-cell large granular lymphocyte leukemia is characterized by involvement of cytotoxic-T cells). (wikipedia.org)
  • The postulated cells of origin of T-LGLL leukemia are transformed CD8+ T-cell with clonal rearrangements of β chain T-cell receptor genes for the majority of cases and a CD8- T-cell with clonal rearrangements of γ chain T-cell receptor genes for a minority of cases. (wikipedia.org)
  • As Virchow was uncertain of the cause of the white blood cell excess, he used the purely descriptive term 'leukemia' (Greek: 'white blood') to refer to the condition. (news-medical.net)
  • This condition may be contrasted with leukemids, which are skin lesions that occur with leukemia, but which are not related to leukemic cell infiltration. (wikipedia.org)
  • The requirements for diagnosing ANKL are as follows: Immature-looking NK cells Certain immunophenotypes Germline configuration genes: TCR-β and IgH Restricted cytotoxicity The T-cell receptor (TCR) is an important factor when ANKL is being diagnosed along with T-cell leukemia. (wikipedia.org)
  • genetic
  • Also, children who have inherited certain genetic problems - such as Li-Fraumeni syndrome, Down syndrome , Klinefelter syndrome , neurofibromatosis , ataxia telangectasia, or Fanconi's anemia - have a higher risk of developing leukemia. (kidshealth.org)
  • child's
  • But a number of other factors, including the child's age and leukemia characteristics, can also affect outlook. (cancer.org)
  • rare
  • With acute leukemias, children who are free of the disease after 5 years are very likely to have been cured, because it's very rare for these cancers to return after this long. (cancer.org)
  • For chronic leukemias, which are rare in children, 5-year survival rates are less helpful, because some children may live for a long time with the leukemia without actually being cured. (cancer.org)
  • CLL is another form of chronic leukemia, but is extremely rare in children. (wikipedia.org)